Tubulin inhibitor 6_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in A498 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tubulin inhibitor 6_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPC6 glypican 6 0.121907
ASPH aspartate beta-hydroxylase 0.120485
EXT1 exostosin glycosyltransferase 1 0.120184
FNDC3B fibronectin type III domain containing 3B 0.0864948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0753101
MYH9 myosin, heavy chain 9, non-muscle 0.0750616
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0740092
SPAG9 sperm associated antigen 9 0.0725563
TRIO trio Rho guanine nucleotide exchange factor 0.0659822
NAV2 neuron navigator 2 0.0594146
FRMD4A FERM domain containing 4A 0.0576431
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0537371
SPTBN1 spectrin, beta, non-erythrocytic 1 0.052498
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0517057
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0511648
PDLIM5 PDZ and LIM domain 5 0.0511405
ZFAND3 zinc finger, AN1-type domain 3 0.0490008
SMAD3 SMAD family member 3 0.0480406
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0476259
SOD2 superoxide dismutase 2, mitochondrial 0.0459384
NAMPT nicotinamide phosphoribosyltransferase 0.0450676
COG5 component of oligomeric golgi complex 5 0.0440505
NRIP1 nuclear receptor interacting protein 1 0.0432511
APP amyloid beta (A4) precursor protein 0.0427942
AHNAK AHNAK nucleoprotein 0.042701
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0421451
FMNL2 formin-like 2 0.041006
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0397936
PTK2 protein tyrosine kinase 2 0.039782
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0394516
LPP LIM domain containing preferred translocation partner in lipoma 0.0392022
RNF213 ring finger protein 213 0.038805
ATP13A3 ATPase type 13A3 0.0368633
UBA6 ubiquitin-like modifier activating enzyme 6 0.0365069
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.036323
JAK1 Janus kinase 1 0.0362918
BIRC6 baculoviral IAP repeat containing 6 0.0355387
SUCO SUN domain containing ossification factor 0.0354263
ZCCHC7 zinc finger, CCHC domain containing 7 0.0353181
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0349961
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.034699
MYOF myoferlin 0.0335739
CALU calumenin 0.0334269
CTBP2 C-terminal binding protein 2 0.0333772
IQGAP1 IQ motif containing GTPase activating protein 1 0.0329762
SEPTIN9 septin 9 0.0324809
ZSWIM6 zinc finger, SWIM-type containing 6 0.0323777
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0320426
DOCK5 dedicator of cytokinesis 5 0.0313624
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0312576
RAI14 retinoic acid induced 14 0.0311706
RAB10 RAB10, member RAS oncogene family 0.0311072
ANXA5 annexin A5 0.030707
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0306459
ANKRD17 ankyrin repeat domain 17 0.030105
ANKRD11 ankyrin repeat domain 11 0.0300196
GLS2 glutaminase 2 (liver, mitochondrial) 0.0297228
SEC24D SEC24 family member D 0.0296832
CADM1 cell adhesion molecule 1 0.0295399
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0294176
TPM3 tropomyosin 3 0.0291448
CANX calnexin 0.0291212
NUP98 nucleoporin 98kDa 0.0291144
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0288968
UBE2H ubiquitin-conjugating enzyme E2H 0.0288351
TPST1 tyrosylprotein sulfotransferase 1 0.0288032
TTC3 tetratricopeptide repeat domain 3 0.0286964
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0285124
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0284593
NFE2L2 nuclear factor, erythroid 2-like 2 0.0284369
ALCAM activated leukocyte cell adhesion molecule 0.0281339
COG6 component of oligomeric golgi complex 6 0.0280842
VCL vinculin 0.0279293
MACF1 microtubule-actin crosslinking factor 1 0.0272253
UBQLN1 ubiquilin 1 0.0271869
COPA coatomer protein complex, subunit alpha 0.0265965
MBNL2 muscleblind-like splicing regulator 2 0.0262984
PRKCA protein kinase C, alpha 0.0262519
PMM2 phosphomannomutase 2 0.0262029
INTS6 integrator complex subunit 6 0.0261275
ECPAS Ecm29 proteasome adaptor and scaffold 0.0260233
PLEC plectin 0.0260105
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0259322
SEC31A SEC31 homolog A (S. cerevisiae) 0.0256998
HELZ helicase with zinc finger 0.0255746
KYNU kynureninase 0.0255214
SHB Src homology 2 domain containing adaptor protein B 0.0255133
RAB1A RAB1A, member RAS oncogene family 0.0254684
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0249621
MARCHF6 membrane associated ring-CH-type finger 6 0.0248675
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0248462
COL4A2 collagen, type IV, alpha 2 0.0248413
UBAP2 ubiquitin associated protein 2 0.0247827
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0246676
GOLGB1 golgin B1 0.024376
ANKRD33B ankyrin repeat domain 33B 0.0243643
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0242205
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0241539
MX1 MX dynamin-like GTPase 1 0.0240848
ELOVL5 ELOVL fatty acid elongase 5 0.0239905

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.088435
RPS6 ribosomal protein S6 -0.0782642
FTL ferritin, light polypeptide -0.0733083
RPS8 ribosomal protein S8 -0.0729028
RPL35A ribosomal protein L35a -0.0728259
MT2A metallothionein 2A -0.0710761
RPL37A ribosomal protein L37a -0.0687893
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0673658
TPT1 tumor protein, translationally-controlled 1 -0.0672329
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0657351
RPLP2 ribosomal protein, large, P2 -0.0585318
RPL28 ribosomal protein L28 -0.0560516
PTMA prothymosin, alpha -0.0524757
HSPB1 heat shock 27kDa protein 1 -0.0513757
RPL23 ribosomal protein L23 -0.0510846
RPS27A ribosomal protein S27a -0.0485208
RPS12 ribosomal protein S12 -0.0475664
RPS19 ribosomal protein S19 -0.046623
RPS13 ribosomal protein S13 -0.0454812
RPL12 ribosomal protein L12 -0.0446303
POTEF POTE ankyrin domain family, member F -0.0444112
RPLP1 ribosomal protein, large, P1 -0.0440418
EIF1 eukaryotic translation initiation factor 1 -0.042775
RPL26 ribosomal protein L26 -0.0421593
TMSB10 thymosin beta 10 -0.0419904
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0418411
RPS24 ribosomal protein S24 -0.0409992
FTH1 ferritin, heavy polypeptide 1 -0.0401918
B2M beta-2-microglobulin -0.0387654
RPS27 ribosomal protein S27 -0.0377742
CTSD cathepsin D -0.0374413
PFN1 profilin 1 -0.0370714
RPL31 ribosomal protein L31 -0.0370252
RPS3 ribosomal protein S3 -0.03683
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0366807
RPL34 ribosomal protein L34 -0.0358986
RPL36A ribosomal protein L36a -0.0333615
CCL2 chemokine (C-C motif) ligand 2 -0.0331159
RPL9 ribosomal protein L9 -0.0329892
RPS20 ribosomal protein S20 -0.0324412
RPS14 ribosomal protein S14 -0.0314828
RPL7A ribosomal protein L7a -0.0313681
PLIN2 perilipin 2 -0.0302736
RPS23 ribosomal protein S23 -0.0301536
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0298353
HLA-B major histocompatibility complex, class I, B -0.0294741
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0292524
RPL35 ribosomal protein L35 -0.0290306
RPL37 ribosomal protein L37 -0.0287667
RPL36 ribosomal protein L36 -0.0281187
RPS16 ribosomal protein S16 -0.0280513
S100A9 S100 calcium binding protein A9 -0.0280361
RPS25 ribosomal protein S25 -0.0269689
RPS17 ribosomal protein S17 -0.0267141
LITAF lipopolysaccharide-induced TNF factor -0.0264565
RPL19 ribosomal protein L19 -0.0263426
RPS21 ribosomal protein S21 -0.0260365
RPL38 ribosomal protein L38 -0.0258848
RPL11 ribosomal protein L11 -0.0258259
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0253102
RACK1 receptor for activated C kinase 1 -0.0244969
RPS11 ribosomal protein S11 -0.0235851
RPS29 ribosomal protein S29 -0.0234515
RPL30 ribosomal protein L30 -0.0233383
RPLP0 ribosomal protein, large, P0 -0.02311
TPM1 tropomyosin 1 (alpha) -0.0224064
RPS15 ribosomal protein S15 -0.0219646
RPL8 ribosomal protein L8 -0.0212685
RPL18 ribosomal protein L18 -0.0211495
S100A11 S100 calcium binding protein A11 -0.020885
RPS2 ribosomal protein S2 -0.0204953
RPS5 ribosomal protein S5 -0.0188429
RPL27A ribosomal protein L27a -0.0187603
IFITM3 interferon induced transmembrane protein 3 -0.0185939
S100A10 S100 calcium binding protein A10 -0.0185628
RPL5 ribosomal protein L5 -0.018106
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0178667
VDAC1 voltage-dependent anion channel 1 -0.0178562
GDF15 growth differentiation factor 15 -0.0178212
HMGA1 high mobility group AT-hook 1 -0.0175073
IFI6 interferon, alpha-inducible protein 6 -0.0174187
TUBB4B tubulin, beta 4B class IVb -0.017408
MGST1 microsomal glutathione S-transferase 1 -0.0173817
PKM pyruvate kinase, muscle -0.0172906
G0S2 G0/G1 switch 2 -0.0172814
RPL27 ribosomal protein L27 -0.0172252
HMGB1 high mobility group box 1 -0.0171874
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0171854
POMP proteasome maturation protein -0.0170171
HLA-A major histocompatibility complex, class I, A -0.0169256
DSTN destrin (actin depolymerizing factor) -0.0168406
RPL13A ribosomal protein L13a -0.0167555
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0167028
RPL15 ribosomal protein L15 -0.0166855
TUBA1B tubulin, alpha 1b -0.0165162
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0162429
KRT10 keratin 10, type I -0.0159789
EIF5B eukaryotic translation initiation factor 5B -0.015947
RPL10A ribosomal protein L10a -0.0159419
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0153388