Tubulin inhibitor 6_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.107321
ACTG1 actin gamma 1 0.103571
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0993539
SMAD3 SMAD family member 3 0.0819588
DSCAM Down syndrome cell adhesion molecule 0.0701048
AHNAK AHNAK nucleoprotein 0.0531278
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0521889
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0521349
KYNU kynureninase 0.0515845
PCBP2 poly(rC) binding protein 2 0.0510747
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0507918
TRIO trio Rho guanine nucleotide exchange factor 0.0507144
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0494981
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0488349
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0478045
NAV2 neuron navigator 2 0.0477562
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0463603
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0457019
PDLIM5 PDZ and LIM domain 5 0.045588
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0447031
FMNL2 formin-like 2 0.0437191
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.042813
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0412841
MYH9 myosin, heavy chain 9, non-muscle 0.0410438
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0401808
NFE2L2 nuclear factor, erythroid 2-like 2 0.0395374
OGA O-GlcNAcase 0.0394643
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0393446
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0387062
FNDC3B fibronectin type III domain containing 3B 0.0378422
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0376083
ETNK1 ethanolamine kinase 1 0.0359946
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.035872
NRIP1 nuclear receptor interacting protein 1 0.0358229
MYOF myoferlin 0.0353183
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0350116
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0341042
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0339616
RASA2 RAS p21 protein activator 2 0.0337482
EREG epiregulin 0.0337232
TMEM156 transmembrane protein 156 0.0335137
AKAP13 A kinase (PRKA) anchor protein 13 0.0328368
SPAG9 sperm associated antigen 9 0.0328326
DGKD diacylglycerol kinase, delta 130kDa 0.0324433
PDZD8 PDZ domain containing 8 0.0324229
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0324132
SLC35F3 solute carrier family 35, member F3 0.0323442
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0317379
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0312501
USP47 ubiquitin specific peptidase 47 0.0305537
WDR43 WD repeat domain 43 0.0301957
ARHGAP26 Rho GTPase activating protein 26 0.0301699
GLS2 glutaminase 2 (liver, mitochondrial) 0.0301025
SAMD4A sterile alpha motif domain containing 4A 0.0299501
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0298481
PICALM phosphatidylinositol binding clathrin assembly protein 0.0297193
SMYD3 SET and MYND domain containing 3 0.0296402
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0284826
FNIP1 folliculin interacting protein 1 0.028454
TNIP1 TNFAIP3 interacting protein 1 0.028435
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0277462
BIRC6 baculoviral IAP repeat containing 6 0.0274119
EEF2 eukaryotic translation elongation factor 2 0.0272887
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0266455
RBPMS RNA binding protein with multiple splicing 0.0264886
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0263003
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0258617
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0257884
RUNX1 runt-related transcription factor 1 0.025783
PSME4 proteasome (prosome, macropain) activator subunit 4 0.025663
TPM3 tropomyosin 3 0.0255509
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0254417
UGCG UDP-glucose ceramide glucosyltransferase 0.025303
GPATCH2L G patch domain containing 2-like 0.0250731
CA8 carbonic anhydrase VIII 0.0248537
ECT2 epithelial cell transforming 2 0.0246635
SET SET nuclear proto-oncogene 0.0244984
IGF1R insulin-like growth factor 1 receptor 0.024415
UBASH3B ubiquitin associated and SH3 domain containing B 0.0243977
PUM2 pumilio RNA-binding family member 2 0.0242707
PRELID2 PRELI domain containing 2 0.0241659
ARHGAP5 Rho GTPase activating protein 5 0.024081
RAB10 RAB10, member RAS oncogene family 0.023795
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0231894
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0231609
QKI QKI, KH domain containing, RNA binding 0.0230061
LMO7 LIM domain 7 0.0227181
NCEH1 neutral cholesterol ester hydrolase 1 0.0225299
SH3KBP1 SH3-domain kinase binding protein 1 0.0224934
APP amyloid beta (A4) precursor protein 0.0222307
EIF4B eukaryotic translation initiation factor 4B 0.0222084
AGO2 argonaute RISC catalytic component 2 0.0220529
USP9X ubiquitin specific peptidase 9, X-linked 0.021357
ADAM9 ADAM metallopeptidase domain 9 0.0213037
NBAS neuroblastoma amplified sequence 0.021203
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0211564
GOLGA4 golgin A4 0.0210825
NPAS2 neuronal PAS domain protein 2 0.0210607
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0210462
UBA6 ubiquitin-like modifier activating enzyme 6 0.0209844

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.317095
IGFBP3 insulin-like growth factor binding protein 3 -0.176692
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.158897
VIM vimentin -0.157115
PDE4D phosphodiesterase 4D, cAMP-specific -0.147095
NDRG1 N-myc downstream regulated 1 -0.13347
IGFBP4 insulin-like growth factor binding protein 4 -0.125184
FTL ferritin, light polypeptide -0.108797
PTMA prothymosin, alpha -0.0952585
RPS19 ribosomal protein S19 -0.0937951
RPLP1 ribosomal protein, large, P1 -0.0820427
RPS6 ribosomal protein S6 -0.0705125
KRT81 keratin 81, type II -0.0704704
TPT1 tumor protein, translationally-controlled 1 -0.0658863
EIF1 eukaryotic translation initiation factor 1 -0.064331
FTH1 ferritin, heavy polypeptide 1 -0.0602185
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.05642
S100A10 S100 calcium binding protein A10 -0.0563101
AKR1C2 aldo-keto reductase family 1, member C2 -0.0527383
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0526689
EGR1 early growth response 1 -0.05228
RPS24 ribosomal protein S24 -0.0522332
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0507726
S100A6 S100 calcium binding protein A6 -0.0502998
RPL31 ribosomal protein L31 -0.0467971
PKM pyruvate kinase, muscle -0.0464586
CA12 carbonic anhydrase XII -0.0462482
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0456308
ANXA4 annexin A4 -0.0437562
ZMYND8 zinc finger, MYND-type containing 8 -0.0430769
RPL23 ribosomal protein L23 -0.042474
MT2A metallothionein 2A -0.0405222
MAML3 mastermind-like 3 (Drosophila) -0.0399342
IFI6 interferon, alpha-inducible protein 6 -0.0396104
RPL35A ribosomal protein L35a -0.038469
RPL19 ribosomal protein L19 -0.0381839
EHBP1 EH domain binding protein 1 -0.0379901
RIN2 Ras and Rab interactor 2 -0.0374746
RPS23 ribosomal protein S23 -0.0373374
RNF213 ring finger protein 213 -0.0371724
RPL34 ribosomal protein L34 -0.0368864
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0360418
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0358784
IGFBP1 insulin-like growth factor binding protein 1 -0.0357809
HLA-B major histocompatibility complex, class I, B -0.0356452
RPL28 ribosomal protein L28 -0.035574
RPS29 ribosomal protein S29 -0.0350753
RPS16 ribosomal protein S16 -0.034796
ZBTB20 zinc finger and BTB domain containing 20 -0.0347415
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0343834
SLC38A1 solute carrier family 38, member 1 -0.0343526
RPS11 ribosomal protein S11 -0.0341744
RPS13 ribosomal protein S13 -0.0332883
LMNA lamin A/C -0.032998
EFNA5 ephrin-A5 -0.0328022
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0320948
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0316014
RPLP2 ribosomal protein, large, P2 -0.0314772
HMGA1 high mobility group AT-hook 1 -0.031102
RPS27A ribosomal protein S27a -0.0309843
TPM1 tropomyosin 1 (alpha) -0.0301445
RPS14 ribosomal protein S14 -0.0300346
RPS5 ribosomal protein S5 -0.0289267
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0288466
BTG1 B-cell translocation gene 1, anti-proliferative -0.0283589
B2M beta-2-microglobulin -0.0277018
RPL8 ribosomal protein L8 -0.0274067
OSMR oncostatin M receptor -0.0272938
RPS8 ribosomal protein S8 -0.0263235
ISG15 ISG15 ubiquitin-like modifier -0.0260912
RPL38 ribosomal protein L38 -0.0256273
FBXO11 F-box protein 11 -0.0256212
IFIH1 interferon induced with helicase C domain 1 -0.0254638
RPS27 ribosomal protein S27 -0.0253113
SP100 SP100 nuclear antigen -0.025078
MCL1 myeloid cell leukemia 1 -0.0249506
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0244439
ARL4C ADP-ribosylation factor-like 4C -0.0244047
ZFHX3 zinc finger homeobox 3 -0.0240504
RPL32 ribosomal protein L32 -0.0239039
AUTS2 autism susceptibility candidate 2 -0.0237831
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0235555
MYO1E myosin IE -0.0233589
ASTN2 astrotactin 2 -0.0229382
RRBP1 ribosome binding protein 1 -0.0228137
MYADM myeloid-associated differentiation marker -0.0226253
WSB1 WD repeat and SOCS box containing 1 -0.0224774
AKAP12 A kinase (PRKA) anchor protein 12 -0.0224758
CP ceruloplasmin (ferroxidase) -0.0223912
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0222471
HIP1 huntingtin interacting protein 1 -0.0217926
RPL36A ribosomal protein L36a -0.0215602
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0215388
S100A11 S100 calcium binding protein A11 -0.0214214
RPS21 ribosomal protein S21 -0.0213911
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0211975
RIGI RNA sensor RIG-I -0.0210338
PYGL phosphorylase, glycogen, liver -0.0209317
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0206909
UBB ubiquitin B -0.0202722