Tubulin inhibitor 6_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDK12 cyclin-dependent kinase 12 0.0640411
ACTG1 actin gamma 1 0.0637459
NCOA3 nuclear receptor coactivator 3 0.0629194
ITCH itchy E3 ubiquitin protein ligase 0.0627392
ZMYND8 zinc finger, MYND-type containing 8 0.0577839
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0538313
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0513619
CEMIP cell migration inducing protein, hyaluronan binding 0.0513308
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.048382
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0476717
LPP LIM domain containing preferred translocation partner in lipoma 0.0467081
VMP1 vacuole membrane protein 1 0.0466769
NRIP1 nuclear receptor interacting protein 1 0.0457534
KDM2A lysine (K)-specific demethylase 2A 0.0448831
TRIO trio Rho guanine nucleotide exchange factor 0.0443987
SMYD3 SET and MYND domain containing 3 0.0427598
DUSP16 dual specificity phosphatase 16 0.0423664
ADARB1 adenosine deaminase, RNA-specific, B1 0.0420703
DOCK5 dedicator of cytokinesis 5 0.0419466
APP amyloid beta (A4) precursor protein 0.0397415
EXT1 exostosin glycosyltransferase 1 0.0387234
FBXL20 F-box and leucine-rich repeat protein 20 0.0379485
BZW1 basic leucine zipper and W2 domains 1 0.0374278
FNDC3A fibronectin type III domain containing 3A 0.0364705
LIMCH1 LIM and calponin homology domains 1 0.0363664
YAP1 Yes-associated protein 1 0.0363004
TC2N tandem C2 domains, nuclear 0.0357258
SERINC3 serine incorporator 3 0.0348902
DIAPH1 diaphanous-related formin 1 0.0346419
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0336204
VCP valosin containing protein 0.0319216
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.031752
LARP4B La ribonucleoprotein domain family, member 4B 0.0315892
CTNND1 catenin (cadherin-associated protein), delta 1 0.0304315
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0303834
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0295724
PTPRK protein tyrosine phosphatase, receptor type, K 0.0293647
CEP250 centrosomal protein 250kDa 0.0292633
ANKRD36C ankyrin repeat domain 36C 0.0291842
MYO1B myosin IB 0.0284494
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0284209
PTK2 protein tyrosine kinase 2 0.0279449
TXNRD1 thioredoxin reductase 1 0.0276801
MYH9 myosin, heavy chain 9, non-muscle 0.0275262
STX16 syntaxin 16 0.0270291
MED13L mediator complex subunit 13-like 0.0266614
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0264387
SDC4 syndecan 4 0.0263236
ANKRD17 ankyrin repeat domain 17 0.025739
CSNK1D casein kinase 1, delta 0.0256871
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0255844
HSPA8 heat shock 70kDa protein 8 0.0253738
AFF1 AF4/FMR2 family, member 1 0.0252729
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0251953
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0251423
PLK2 polo-like kinase 2 0.0249782
RAB22A RAB22A, member RAS oncogene family 0.0249409
TPD52 tumor protein D52 0.0244429
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0244222
NCOA6 nuclear receptor coactivator 6 0.0242044
MBNL2 muscleblind-like splicing regulator 2 0.0240991
SRCIN1 SRC kinase signaling inhibitor 1 0.023991
PAWR PRKC, apoptosis, WT1, regulator 0.0239732
IQGAP1 IQ motif containing GTPase activating protein 1 0.0234965
DSPP dentin sialophosphoprotein 0.0234802
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0233428
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0231274
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0230717
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0230258
ATXN1 ataxin 1 0.0229802
KIAA1217 KIAA1217 0.0229493
MYOF myoferlin 0.022886
USP9X ubiquitin specific peptidase 9, X-linked 0.0228416
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0227002
SFPQ splicing factor proline/glutamine-rich 0.0225505
UNC13B unc-13 homolog B (C. elegans) 0.0225075
IPO7 importin 7 0.0224798
GSK3B glycogen synthase kinase 3 beta 0.0223553
SGMS1 sphingomyelin synthase 1 0.0222355
ZSWIM6 zinc finger, SWIM-type containing 6 0.0222159
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0221852
STRN3 striatin, calmodulin binding protein 3 0.022106
MYO10 myosin X 0.0219652
ZFAND3 zinc finger, AN1-type domain 3 0.0219176
THSD4 thrombospondin, type I, domain containing 4 0.0218098
SEPTIN9 septin 9 0.0217986
ESYT2 extended synaptotagmin-like protein 2 0.0216434
ZFR zinc finger RNA binding protein 0.0213881
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0212552
NIPBL Nipped-B homolog (Drosophila) 0.0210724
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.021043
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.020978
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0209646
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0206344
ZC3H11A zinc finger CCCH-type containing 11A 0.0205478
AHNAK AHNAK nucleoprotein 0.0204908
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0204535
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0202551
EZR ezrin 0.0199715
FNDC3B fibronectin type III domain containing 3B 0.0198387

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.292512
RPL19 ribosomal protein L19 -0.203975
RPS3 ribosomal protein S3 -0.115224
TPT1 tumor protein, translationally-controlled 1 -0.0977365
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0859941
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0790175
PTMA prothymosin, alpha -0.0762526
RPL35A ribosomal protein L35a -0.0760576
IFI6 interferon, alpha-inducible protein 6 -0.0746962
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0664144
RPL37A ribosomal protein L37a -0.0656371
RPS12 ribosomal protein S12 -0.0638819
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0609302
RPS8 ribosomal protein S8 -0.0591486
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0535617
RPL12 ribosomal protein L12 -0.0499321
RPS19 ribosomal protein S19 -0.0442264
RPL37 ribosomal protein L37 -0.0425049
RPS24 ribosomal protein S24 -0.0407527
RPL9 ribosomal protein L9 -0.0394108
RPS29 ribosomal protein S29 -0.0391293
TMSB10 thymosin beta 10 -0.0389824
RPL34 ribosomal protein L34 -0.0382639
RPL26 ribosomal protein L26 -0.0375938
RPLP2 ribosomal protein, large, P2 -0.0375767
RPS6 ribosomal protein S6 -0.0371259
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0369977
RPLP1 ribosomal protein, large, P1 -0.0362477
RPL7A ribosomal protein L7a -0.0358382
RPS13 ribosomal protein S13 -0.0355513
S100A9 S100 calcium binding protein A9 -0.0349998
CATSPERB catsper channel auxiliary subunit beta -0.0348822
EIF1 eukaryotic translation initiation factor 1 -0.0342468
RPS27 ribosomal protein S27 -0.0336943
FDPS farnesyl diphosphate synthase -0.0329756
RPS25 ribosomal protein S25 -0.0328076
RPL28 ribosomal protein L28 -0.0326735
B2M beta-2-microglobulin -0.0324481
RPS17 ribosomal protein S17 -0.0318176
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.03167
FASN fatty acid synthase -0.0314803
RPL11 ribosomal protein L11 -0.0313513
RPL30 ribosomal protein L30 -0.0312159
RPS27A ribosomal protein S27a -0.0311266
RPS16 ribosomal protein S16 -0.0307959
TUBA1B tubulin, alpha 1b -0.0299801
SERF2 small EDRK-rich factor 2 -0.0295554
RPS14 ribosomal protein S14 -0.0289445
INTS6 integrator complex subunit 6 -0.0283197
S100P S100 calcium binding protein P -0.0278947
RPL31 ribosomal protein L31 -0.0278441
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0277161
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.027079
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0267596
RPL36 ribosomal protein L36 -0.0263378
FTL ferritin, light polypeptide -0.0261294
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0258348
RPL27A ribosomal protein L27a -0.0254249
RPL35 ribosomal protein L35 -0.0251536
MDK midkine (neurite growth-promoting factor 2) -0.0248091
S100A8 S100 calcium binding protein A8 -0.024793
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.024107
RPL15 ribosomal protein L15 -0.0233382
RPS20 ribosomal protein S20 -0.0232149
TUBB4B tubulin, beta 4B class IVb -0.0229219
FADS2 fatty acid desaturase 2 -0.0227296
EGR1 early growth response 1 -0.0226681
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0223299
RPS15 ribosomal protein S15 -0.0222543
NDUFA4 NDUFA4, mitochondrial complex associated -0.021911
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0218142
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0216867
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0216326
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.0214638
EIF5B eukaryotic translation initiation factor 5B -0.0213758
RPS10 ribosomal protein S10 -0.0205596
DNAH14 dynein, axonemal, heavy chain 14 -0.0202335
RPL13A ribosomal protein L13a -0.0201502
SQLE squalene epoxidase -0.0198896
DENND1A DENN/MADD domain containing 1A -0.0198833
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0196106
RPL8 ribosomal protein L8 -0.0193667
COX6C cytochrome c oxidase subunit VIc -0.0192025
RPS23 ribosomal protein S23 -0.0190157
RPL36A ribosomal protein L36a -0.0189761
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0188519
RACK1 receptor for activated C kinase 1 -0.0187365
DNHD1 dynein heavy chain domain 1 -0.0185093
CCNI cyclin I -0.0184667
ATP5F1B ATP synthase F1 subunit beta -0.0183472
MYL12B myosin, light chain 12B, regulatory -0.0181694
NDRG1 N-myc downstream regulated 1 -0.0181043
PBX1 pre-B-cell leukemia homeobox 1 -0.0180898
DCAF7 DDB1 and CUL4 associated factor 7 -0.0180422
MIEN1 migration and invasion enhancer 1 -0.0178359
TPI1 triosephosphate isomerase 1 -0.0177127
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0176792
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.017465
SLC38A2 solute carrier family 38, member 2 -0.0174625
RPL10A ribosomal protein L10a -0.0173865