Tubulin inhibitor 6_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPC6 glypican 6 0.0951858
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0833099
NAV2 neuron navigator 2 0.0789631
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0551352
LEF1 lymphoid enhancer-binding factor 1 0.0539853
APP amyloid beta (A4) precursor protein 0.0513582
EXOC4 exocyst complex component 4 0.0510518
ACTG1 actin gamma 1 0.0508994
TMEM178B transmembrane protein 178B 0.0503388
CD109 CD109 molecule 0.049723
ESYT2 extended synaptotagmin-like protein 2 0.0476157
MACF1 microtubule-actin crosslinking factor 1 0.0470029
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0462192
IFRD1 interferon-related developmental regulator 1 0.0459363
CDC73 cell division cycle 73 0.0453649
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0441949
ASPH aspartate beta-hydroxylase 0.0436055
DST dystonin 0.0432471
APLP2 amyloid beta (A4) precursor-like protein 2 0.0431549
UBE2H ubiquitin-conjugating enzyme E2H 0.0407766
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0396443
FMNL2 formin-like 2 0.0391052
BHLHE40 basic helix-loop-helix family, member e40 0.0390575
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0389672
NHSL1 NHS-like 1 0.0376692
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0375653
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0375071
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0374511
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0373987
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0369499
AFDN afadin, adherens junction formation factor 0.0369453
PRELID2 PRELI domain containing 2 0.0365096
VMP1 vacuole membrane protein 1 0.036038
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0351401
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0346183
NCAPG2 non-SMC condensin II complex, subunit G2 0.0345735
INTS6 integrator complex subunit 6 0.0342297
ZSWIM6 zinc finger, SWIM-type containing 6 0.0340341
GLS2 glutaminase 2 (liver, mitochondrial) 0.0338529
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0338501
MCL1 myeloid cell leukemia 1 0.0335448
CENPF centromere protein F, 350/400kDa 0.0335239
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0334747
PTK2 protein tyrosine kinase 2 0.0334644
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0326527
COPA coatomer protein complex, subunit alpha 0.0323751
MYH9 myosin, heavy chain 9, non-muscle 0.0320981
SETBP1 SET binding protein 1 0.0317767
CEMIP2 cell migration inducing hyaluronidase 2 0.0302977
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0301759
LDHA lactate dehydrogenase A 0.0298963
FNDC3B fibronectin type III domain containing 3B 0.0296599
TNIK TRAF2 and NCK interacting kinase 0.0295461
TPR translocated promoter region, nuclear basket protein 0.0295048
WWTR1 WW domain containing transcription regulator 1 0.029292
CLIC4 chloride intracellular channel 4 0.0291594
SHISA5 shisa family member 5 0.0289932
ARRDC3 arrestin domain containing 3 0.0282286
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0280946
NAV1 neuron navigator 1 0.0279559
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0278993
MRTFA myocardin related transcription factor A 0.0278089
SRPK2 SRSF protein kinase 2 0.0276384
TSC22D1 TSC22 domain family, member 1 0.0275865
SND1 staphylococcal nuclease and tudor domain containing 1 0.0275622
FLNB filamin B, beta 0.0274739
EPS8 epidermal growth factor receptor pathway substrate 8 0.0274724
TEX14 testis expressed 14 0.0273557
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0270853
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0266457
LRRC23 leucine rich repeat containing 23 0.0261332
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0260213
PDIA4 protein disulfide isomerase family A, member 4 0.0259619
CABIN1 calcineurin binding protein 1 0.0258492
FAF1 Fas (TNFRSF6) associated factor 1 0.0258201
HELZ helicase with zinc finger 0.0257125
ATXN1 ataxin 1 0.0253469
TLE4 transducin-like enhancer of split 4 0.0252379
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0249209
PAX3 paired box 3 0.0248495
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0247355
LPP LIM domain containing preferred translocation partner in lipoma 0.0244725
OSBPL10 oxysterol binding protein-like 10 0.0244554
PTPRG protein tyrosine phosphatase, receptor type, G 0.0244396
UTRN utrophin 0.0244219
IL1RAP interleukin 1 receptor accessory protein 0.0243102
SSBP3 single stranded DNA binding protein 3 0.0242623
NUP58 nucleoporin 58 0.0242035
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0240967
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0240092
WNK1 WNK lysine deficient protein kinase 1 0.0239564
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0239506
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0239353
ZNF638 zinc finger protein 638 0.0238767
PCBP2 poly(rC) binding protein 2 0.0236813
ANO6 anoctamin 6 0.0236736
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0234257
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0234234
PDLIM5 PDZ and LIM domain 5 0.0231441
ENO1 enolase 1, (alpha) 0.0230157

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.207754
VIM vimentin -0.203372
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.183693
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.168746
IGFBP5 insulin-like growth factor binding protein 5 -0.114502
TMSB10 thymosin beta 10 -0.108742
VGF VGF nerve growth factor inducible -0.106694
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0823951
IFI16 interferon, gamma-inducible protein 16 -0.0728639
GDF15 growth differentiation factor 15 -0.0704204
S100A6 S100 calcium binding protein A6 -0.0691047
AKAP12 A kinase (PRKA) anchor protein 12 -0.0673001
DCT dopachrome tautomerase -0.062903
HLA-B major histocompatibility complex, class I, B -0.0612212
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0583262
TPT1 tumor protein, translationally-controlled 1 -0.0500834
NAV3 neuron navigator 3 -0.0493089
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0485315
RPL37A ribosomal protein L37a -0.0478542
PTCHD4 patched domain containing 4 -0.0470026
CALD1 caldesmon 1 -0.0467321
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0460638
NLGN1 neuroligin 1 -0.0441777
CTSD cathepsin D -0.0431602
RPLP1 ribosomal protein, large, P1 -0.0421027
MTDH metadherin -0.0416277
FTL ferritin, light polypeptide -0.0412366
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0400486
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.038995
TAGLN2 transgelin 2 -0.0383155
PDIA3 protein disulfide isomerase family A, member 3 -0.0378144
RPS12 ribosomal protein S12 -0.0378045
TPI1 triosephosphate isomerase 1 -0.0374776
RPS19 ribosomal protein S19 -0.0368985
TMEM123 transmembrane protein 123 -0.0368821
PTMA prothymosin, alpha -0.0361722
RPS8 ribosomal protein S8 -0.0357972
NPC1 Niemann-Pick disease, type C1 -0.0348236
SCFD2 sec1 family domain containing 2 -0.0347302
TRIM2 tripartite motif containing 2 -0.0340095
RPLP2 ribosomal protein, large, P2 -0.0332459
RPS24 ribosomal protein S24 -0.0326472
GNAS GNAS complex locus -0.0315815
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0313651
RPL35A ribosomal protein L35a -0.0311161
PGK1 phosphoglycerate kinase 1 -0.0306442
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0306128
CD63 CD63 molecule -0.0305929
IER3 immediate early response 3 -0.0305149
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0304687
ZNF704 zinc finger protein 704 -0.0300341
IFI6 interferon, alpha-inducible protein 6 -0.0298629
VDAC1 voltage-dependent anion channel 1 -0.0296207
ARHGAP5 Rho GTPase activating protein 5 -0.029596
MAML3 mastermind-like 3 (Drosophila) -0.0294373
RPL34 ribosomal protein L34 -0.0293498
S100A10 S100 calcium binding protein A10 -0.0288186
HSPB1 heat shock 27kDa protein 1 -0.0285627
IFITM3 interferon induced transmembrane protein 3 -0.0283249
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0281692
RPL26 ribosomal protein L26 -0.027972
HMGA1 high mobility group AT-hook 1 -0.027545
WSB1 WD repeat and SOCS box containing 1 -0.0273535
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0273277
RPS3 ribosomal protein S3 -0.0262107
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0257219
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0256075
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0255712
PKM pyruvate kinase, muscle -0.0253684
NPR2 natriuretic peptide receptor 2 -0.0252658
PTPRF protein tyrosine phosphatase, receptor type, F -0.0252349
RPL37 ribosomal protein L37 -0.0249992
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0247673
PTPRD protein tyrosine phosphatase, receptor type, D -0.0242945
RPL9 ribosomal protein L9 -0.0239616
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0236631
RRBP1 ribosome binding protein 1 -0.0230288
COL19A1 collagen, type XIX, alpha 1 -0.0227755
RPL12 ribosomal protein L12 -0.0225483
MTPN myotrophin -0.0225143
RPL31 ribosomal protein L31 -0.0224036
A2M alpha-2-macroglobulin -0.0222809
RPS29 ribosomal protein S29 -0.0222782
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0222354
ZMYND8 zinc finger, MYND-type containing 8 -0.022083
HLA-A major histocompatibility complex, class I, A -0.0219323
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.021744
CCND1 cyclin D1 -0.0215633
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.021401
RPL30 ribosomal protein L30 -0.0212068
MARCKS myristoylated alanine-rich protein kinase C substrate -0.021002
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.021001
RPS6 ribosomal protein S6 -0.0209826
MT2A metallothionein 2A -0.0209249
RPL32 ribosomal protein L32 -0.0205991
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0205482
RPS27A ribosomal protein S27a -0.0202644
PTMS parathymosin -0.0201655
CD44 CD44 molecule (Indian blood group) -0.0201358
MAP1B microtubule-associated protein 1B -0.019996