Tubulin inhibitor 6_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.160497
SPTBN1 spectrin, beta, non-erythrocytic 1 0.13277
FNDC3B fibronectin type III domain containing 3B 0.126601
SMAD3 SMAD family member 3 0.106287
APLP2 amyloid beta (A4) precursor-like protein 2 0.0765856
ZSWIM6 zinc finger, SWIM-type containing 6 0.0735573
APP amyloid beta (A4) precursor protein 0.0706005
AHNAK AHNAK nucleoprotein 0.0676148
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0632669
MYOF myoferlin 0.0619599
DTNA dystrobrevin, alpha 0.0599431
DOCK5 dedicator of cytokinesis 5 0.0592132
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0571584
RUNX1 runt-related transcription factor 1 0.0555776
MYH9 myosin, heavy chain 9, non-muscle 0.0541371
MYO1E myosin IE 0.0540213
SDC4 syndecan 4 0.0528486
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.051633
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0513457
NRIP1 nuclear receptor interacting protein 1 0.0496657
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0485313
FAM107B family with sequence similarity 107, member B 0.0484844
ANKRD11 ankyrin repeat domain 11 0.046425
EFNA5 ephrin-A5 0.0453496
DSCAM Down syndrome cell adhesion molecule 0.0443918
ARRDC3 arrestin domain containing 3 0.0433386
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0425625
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0425413
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0414876
TRIO trio Rho guanine nucleotide exchange factor 0.0408722
APOL1 apolipoprotein L, 1 0.0402451
CANX calnexin 0.0402171
PPARD peroxisome proliferator-activated receptor delta 0.039975
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0398549
CMIP c-Maf inducing protein 0.0394313
LPP LIM domain containing preferred translocation partner in lipoma 0.0392382
ASPH aspartate beta-hydroxylase 0.0391055
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0389418
WWTR1 WW domain containing transcription regulator 1 0.0387972
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0386692
DST dystonin 0.0386588
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0377798
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0373932
VEGFA vascular endothelial growth factor A 0.0373009
VMP1 vacuole membrane protein 1 0.0369005
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0366675
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0366328
GOLGB1 golgin B1 0.0360757
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0360233
GRB10 growth factor receptor-bound protein 10 0.0359523
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0356972
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0351657
ARHGAP26 Rho GTPase activating protein 26 0.0347594
KIAA1217 KIAA1217 0.0344895
PHF3 PHD finger protein 3 0.034453
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0338443
EXT1 exostosin glycosyltransferase 1 0.0337376
OGA O-GlcNAcase 0.0337087
INTS6 integrator complex subunit 6 0.0324809
STC2 stanniocalcin 2 0.0324265
HLA-C major histocompatibility complex, class I, C 0.0323
BZW1 basic leucine zipper and W2 domains 1 0.0320288
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.031956
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0318605
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.031494
NPAS2 neuronal PAS domain protein 2 0.0314475
SEPTIN9 septin 9 0.0312821
TTC3 tetratricopeptide repeat domain 3 0.0311027
UBE2H ubiquitin-conjugating enzyme E2H 0.0310792
JAK1 Janus kinase 1 0.0308118
RAD51B RAD51 paralog B 0.0307699
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0305202
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0300253
KANSL1 KAT8 regulatory NSL complex subunit 1 0.02963
NABP1 nucleic acid binding protein 1 0.0295299
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0294904
AKAP12 A kinase (PRKA) anchor protein 12 0.0293422
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0291584
RAB10 RAB10, member RAS oncogene family 0.0291045
EIF4A2 eukaryotic translation initiation factor 4A2 0.0290412
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0289821
MACF1 microtubule-actin crosslinking factor 1 0.028726
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0287096
UBASH3B ubiquitin associated and SH3 domain containing B 0.0281561
PLEC plectin 0.0280793
TBC1D22A TBC1 domain family, member 22A 0.0279488
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0279177
GLS2 glutaminase 2 (liver, mitochondrial) 0.0278528
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0275256
HDAC9 histone deacetylase 9 0.0274673
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0274075
TPM3 tropomyosin 3 0.0273323
PCBP2 poly(rC) binding protein 2 0.027324
ALCAM activated leukocyte cell adhesion molecule 0.0272229
KYNU kynureninase 0.027177
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0266627
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0266314
BIRC3 baculoviral IAP repeat containing 3 0.0266299
HKDC1 hexokinase domain containing 1 0.0264453
DENND4A DENN/MADD domain containing 4A 0.0264435

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.255441
PTMA prothymosin, alpha -0.150638
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142808
MMP7 matrix metallopeptidase 7 -0.121968
MT2A metallothionein 2A -0.0993417
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0929459
FTL ferritin, light polypeptide -0.0835499
IFI27 interferon, alpha-inducible protein 27 -0.0819625
VIM vimentin -0.0812233
S100A6 S100 calcium binding protein A6 -0.0773223
NDRG1 N-myc downstream regulated 1 -0.0753471
TPT1 tumor protein, translationally-controlled 1 -0.0732567
HMGA1 high mobility group AT-hook 1 -0.0716691
KRT19 keratin 19, type I -0.0677376
MT1X metallothionein 1X -0.0629966
S100A10 S100 calcium binding protein A10 -0.0589354
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0573411
FTH1 ferritin, heavy polypeptide 1 -0.0566949
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.052684
TM4SF1 transmembrane 4 L six family member 1 -0.0517766
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0511937
RPL35A ribosomal protein L35a -0.0490988
RPS24 ribosomal protein S24 -0.0490599
WSB1 WD repeat and SOCS box containing 1 -0.0477662
RPLP1 ribosomal protein, large, P1 -0.04776
HLA-B major histocompatibility complex, class I, B -0.0469867
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0462962
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0462371
CNRIP1 cannabinoid receptor interacting protein 1 -0.0452284
ISG15 ISG15 ubiquitin-like modifier -0.0443545
CSTB cystatin B (stefin B) -0.0441179
RPS21 ribosomal protein S21 -0.0434447
SLC38A1 solute carrier family 38, member 1 -0.0426962
F3 coagulation factor III (thromboplastin, tissue factor) -0.0418656
TMSB4X thymosin beta 4, X-linked -0.0399114
RPS19 ribosomal protein S19 -0.0397029
B2M beta-2-microglobulin -0.0393217
PLAUR plasminogen activator, urokinase receptor -0.0383526
LY6E lymphocyte antigen 6 complex, locus E -0.0383524
PGK1 phosphoglycerate kinase 1 -0.0376433
S100A11 S100 calcium binding protein A11 -0.0371332
CP ceruloplasmin (ferroxidase) -0.036181
FAM162A family with sequence similarity 162, member A -0.0358157
RPS29 ribosomal protein S29 -0.0347574
IFI6 interferon, alpha-inducible protein 6 -0.0342883
RPL11 ribosomal protein L11 -0.0339743
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0333866
EIF1 eukaryotic translation initiation factor 1 -0.032731
RPS23 ribosomal protein S23 -0.0325481
RPL34 ribosomal protein L34 -0.0325339
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0325326
C15ORF48 chromosome 15 open reading frame 48 -0.0319579
IFITM1 interferon induced transmembrane protein 1 -0.0318313
PKM pyruvate kinase, muscle -0.031757
EGR1 early growth response 1 -0.0316507
RPL19 ribosomal protein L19 -0.0313431
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0312442
RPS8 ribosomal protein S8 -0.0311949
LAMB3 laminin, beta 3 -0.0309714
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0306477
PLAT plasminogen activator, tissue -0.0293279
IER3 immediate early response 3 -0.0289888
NPEPPS aminopeptidase puromycin sensitive -0.0288329
TAGLN2 transgelin 2 -0.0285287
GNAS GNAS complex locus -0.0280773
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0277704
NAMPT nicotinamide phosphoribosyltransferase -0.027753
OSMR oncostatin M receptor -0.0276376
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0274165
TUBB tubulin, beta class I -0.027348
JUP junction plakoglobin -0.0270636
H1-0 H1.0 linker histone -0.0268197
RPL23 ribosomal protein L23 -0.0266884
RPS14 ribosomal protein S14 -0.0264541
PFN1 profilin 1 -0.0257927
IFITM3 interferon induced transmembrane protein 3 -0.0251121
RPL37A ribosomal protein L37a -0.0250083
RPS6 ribosomal protein S6 -0.0247881
LMNA lamin A/C -0.0247653
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0241912
TSC22D2 TSC22 domain family, member 2 -0.024111
RPL9 ribosomal protein L9 -0.0238361
RPL31 ribosomal protein L31 -0.0237701
ZMYND8 zinc finger, MYND-type containing 8 -0.0235008
NCKAP5 NCK-associated protein 5 -0.0233581
RPS25 ribosomal protein S25 -0.0230801
CLDN4 claudin 4 -0.0229278
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.022867
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.022811
RPL36AL ribosomal protein L36a-like -0.022689
ANXA2 annexin A2 -0.0226071
RPS27A ribosomal protein S27a -0.022347
POTEF POTE ankyrin domain family, member F -0.022121
RPLP2 ribosomal protein, large, P2 -0.0218857
RTN4 reticulon 4 -0.0217999
RRBP1 ribosome binding protein 1 -0.0217045
RPL28 ribosomal protein L28 -0.0207714
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0206859
RPS27 ribosomal protein S27 -0.0205669
TPI1 triosephosphate isomerase 1 -0.0203701