Tubulin inhibitor 6_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.205423
MYH9 myosin, heavy chain 9, non-muscle 0.125614
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.104956
GOLGA4 golgin A4 0.0968172
POTEF POTE ankyrin domain family, member F 0.0891774
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0779241
APP amyloid beta (A4) precursor protein 0.0756197
PCBP2 poly(rC) binding protein 2 0.0726403
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.068783
SMAD3 SMAD family member 3 0.0682279
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0658632
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0611218
SNX9 sorting nexin 9 0.0597725
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0586775
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0571436
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0571335
CANX calnexin 0.054784
HELZ helicase with zinc finger 0.0545675
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0526036
TPM3 tropomyosin 3 0.0514091
EIF4A2 eukaryotic translation initiation factor 4A2 0.0511361
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.050187
EEF2 eukaryotic translation elongation factor 2 0.0500177
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0483964
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0478736
DIAPH1 diaphanous-related formin 1 0.0476958
KDM6A lysine (K)-specific demethylase 6A 0.046933
TTC3 tetratricopeptide repeat domain 3 0.0449195
GOLGB1 golgin B1 0.0440419
ADAM9 ADAM metallopeptidase domain 9 0.0428113
CCNL1 cyclin L1 0.0427745
OGA O-GlcNAcase 0.0409827
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0409435
UGCG UDP-glucose ceramide glucosyltransferase 0.0406568
FNDC3B fibronectin type III domain containing 3B 0.040601
SETD2 SET domain containing 2 0.040542
TXNRD1 thioredoxin reductase 1 0.0399128
USP9X ubiquitin specific peptidase 9, X-linked 0.03957
AKAP9 A kinase (PRKA) anchor protein 9 0.0393384
SETD5 SET domain containing 5 0.0392532
SLMAP sarcolemma associated protein 0.039191
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0391349
ZNF292 zinc finger protein 292 0.0388135
TMF1 TATA element modulatory factor 1 0.0385789
MAP2K1 mitogen-activated protein kinase kinase 1 0.037996
ECT2 epithelial cell transforming 2 0.0375941
SET SET nuclear proto-oncogene 0.0372647
FXR1 fragile X mental retardation, autosomal homolog 1 0.0370036
WWC1 WW and C2 domain containing 1 0.0362035
PDIA6 protein disulfide isomerase family A, member 6 0.0361829
MATR3 matrin 3 0.0359675
RNF145 ring finger protein 145 0.0357811
COPA coatomer protein complex, subunit alpha 0.0355589
AXL AXL receptor tyrosine kinase 0.0354815
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0353502
KDM2A lysine (K)-specific demethylase 2A 0.0346157
KIF1B kinesin family member 1B 0.034583
SEC24D SEC24 family member D 0.0344386
SPAG9 sperm associated antigen 9 0.0334998
RBM5 RNA binding motif protein 5 0.0332849
SEPTIN9 septin 9 0.0330821
SFPQ splicing factor proline/glutamine-rich 0.0328578
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0326434
CCDC93 coiled-coil domain containing 93 0.032058
BIRC6 baculoviral IAP repeat containing 6 0.0317606
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0312594
SEC31A SEC31 homolog A (S. cerevisiae) 0.0311951
IPO7 importin 7 0.0311472
AFF4 AF4/FMR2 family, member 4 0.0309274
NRIP1 nuclear receptor interacting protein 1 0.0308145
CALR calreticulin 0.0308122
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.030806
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0307145
ANKRD36 ankyrin repeat domain 36 0.0307056
IQGAP1 IQ motif containing GTPase activating protein 1 0.0306074
SBF2 SET binding factor 2 0.0306
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0303963
JMJD1C jumonji domain containing 1C 0.0301538
DSPP dentin sialophosphoprotein 0.030142
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0301045
APLP2 amyloid beta (A4) precursor-like protein 2 0.0299123
FNIP1 folliculin interacting protein 1 0.0295635
GARS1 glycyl-tRNA synthetase 1 0.0295276
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0294463
SDC4 syndecan 4 0.0294282
EIF4B eukaryotic translation initiation factor 4B 0.0293638
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0293019
UBA6 ubiquitin-like modifier activating enzyme 6 0.0290127
PICALM phosphatidylinositol binding clathrin assembly protein 0.029008
RAD23B RAD23 homolog B (S. cerevisiae) 0.0288304
HDLBP high density lipoprotein binding protein 0.0287989
KMT2E lysine (K)-specific methyltransferase 2E 0.028658
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0285482
CLTC clathrin, heavy chain (Hc) 0.0285356
ITCH itchy E3 ubiquitin protein ligase 0.0284245
COG6 component of oligomeric golgi complex 6 0.0282035
ECPAS Ecm29 proteasome adaptor and scaffold 0.0279882
SEC23A Sec23 homolog A (S. cerevisiae) 0.0279
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.027899
ATXN2 ataxin 2 0.0278945

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.170359
TPT1 tumor protein, translationally-controlled 1 -0.150506
RPL35A ribosomal protein L35a -0.113439
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111405
MT2A metallothionein 2A -0.0826425
RPS24 ribosomal protein S24 -0.0752908
PTMA prothymosin, alpha -0.0688196
RPL37A ribosomal protein L37a -0.0656648
RPS19 ribosomal protein S19 -0.0617563
RPLP2 ribosomal protein, large, P2 -0.0606831
RPS8 ribosomal protein S8 -0.0604824
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0602099
RPS29 ribosomal protein S29 -0.0598663
HMGA2 high mobility group AT-hook 2 -0.0594083
FTL ferritin, light polypeptide -0.0581212
RPL34 ribosomal protein L34 -0.0578732
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.05719
CD44 CD44 molecule (Indian blood group) -0.0550846
RPL23 ribosomal protein L23 -0.0543925
RPS27A ribosomal protein S27a -0.0538008
DLC1 DLC1 Rho GTPase activating protein -0.05358
RPS12 ribosomal protein S12 -0.0520804
S100A10 S100 calcium binding protein A10 -0.0520494
RPS6 ribosomal protein S6 -0.0511025
RPL9 ribosomal protein L9 -0.0504308
RPL31 ribosomal protein L31 -0.0504228
RPL28 ribosomal protein L28 -0.0501726
RPLP1 ribosomal protein, large, P1 -0.0497012
RPS25 ribosomal protein S25 -0.0474606
RAD51B RAD51 paralog B -0.047063
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0465576
RPL12 ribosomal protein L12 -0.046189
CCND1 cyclin D1 -0.0450054
RPL32 ribosomal protein L32 -0.0427209
RPS13 ribosomal protein S13 -0.0411942
RPL38 ribosomal protein L38 -0.0407989
RPS11 ribosomal protein S11 -0.0403722
FHIT fragile histidine triad -0.0401481
GNAS GNAS complex locus -0.04012
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0394603
PCED1B PC-esterase domain containing 1B -0.0391384
RPS23 ribosomal protein S23 -0.0388525
RPS16 ribosomal protein S16 -0.0387759
RPL19 ribosomal protein L19 -0.037201
BICD1 bicaudal D homolog 1 (Drosophila) -0.0366807
RPS17 ribosomal protein S17 -0.0366066
RPL11 ribosomal protein L11 -0.0358337
MAML2 mastermind-like 2 (Drosophila) -0.0357722
RPL7A ribosomal protein L7a -0.0356447
RPS14 ribosomal protein S14 -0.0355728
RPS3 ribosomal protein S3 -0.0345531
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0343498
EGFR epidermal growth factor receptor -0.0343425
RPL26 ribosomal protein L26 -0.0335714
VCL vinculin -0.0334911
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0334805
RPL35 ribosomal protein L35 -0.033359
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0329905
ATG7 autophagy related 7 -0.0323031
RPS15 ribosomal protein S15 -0.0318672
RPS21 ribosomal protein S21 -0.0316148
WSB1 WD repeat and SOCS box containing 1 -0.0314667
WWOX WW domain containing oxidoreductase -0.030643
HMGB1 high mobility group box 1 -0.0304779
TUBB4B tubulin, beta 4B class IVb -0.0304618
TUBB tubulin, beta class I -0.0303534
HMGA1 high mobility group AT-hook 1 -0.0300725
RPLP0 ribosomal protein, large, P0 -0.0297412
S100A6 S100 calcium binding protein A6 -0.0297407
MKI67 marker of proliferation Ki-67 -0.0295749
NT5E 5'-nucleotidase, ecto (CD73) -0.0285644
IGFBP3 insulin-like growth factor binding protein 3 -0.0285006
PRELID2 PRELI domain containing 2 -0.0283228
RPL13A ribosomal protein L13a -0.028153
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.027535
RPS20 ribosomal protein S20 -0.0270365
RPL36 ribosomal protein L36 -0.0269523
RPS5 ribosomal protein S5 -0.0265863
RPL36A ribosomal protein L36a -0.0264184
RPL30 ribosomal protein L30 -0.0262528
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.0261749
RPS10 ribosomal protein S10 -0.0260669
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0257165
AHNAK2 AHNAK nucleoprotein 2 -0.02563
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0252485
GPR39 G protein-coupled receptor 39 -0.0246356
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0244906
H1-0 H1.0 linker histone -0.0244619
LAMA4 laminin, alpha 4 -0.0242469
SLC38A2 solute carrier family 38, member 2 -0.024036
RPL27 ribosomal protein L27 -0.0238265
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0237549
IER3 immediate early response 3 -0.0236834
SPATA13 spermatogenesis associated 13 -0.0236722
VDAC1 voltage-dependent anion channel 1 -0.0236079
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0232456
S100A4 S100 calcium binding protein A4 -0.0226849
THSD4 thrombospondin, type I, domain containing 4 -0.0225686
S100A9 S100 calcium binding protein A9 -0.0224704
RPL37 ribosomal protein L37 -0.0224256