Tubulin inhibitor 6_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.197313
PABPC1 poly(A) binding protein, cytoplasmic 1 0.141259
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.122545
ACTG1 actin gamma 1 0.109277
FNDC3B fibronectin type III domain containing 3B 0.0987982
TRIO trio Rho guanine nucleotide exchange factor 0.0967599
VEGFA vascular endothelial growth factor A 0.0966371
EXT1 exostosin glycosyltransferase 1 0.0773399
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0728034
LDHA lactate dehydrogenase A 0.0676194
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0654056
MYH9 myosin, heavy chain 9, non-muscle 0.0596154
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0594219
ARRDC3 arrestin domain containing 3 0.0554194
PTK2 protein tyrosine kinase 2 0.0516364
ZSWIM6 zinc finger, SWIM-type containing 6 0.0470133
PDE10A phosphodiesterase 10A 0.044531
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0444387
POTEF POTE ankyrin domain family, member F 0.044302
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0431984
PICALM phosphatidylinositol binding clathrin assembly protein 0.0420791
CXCL8 chemokine (C-X-C motif) ligand 8 0.0419959
APP amyloid beta (A4) precursor protein 0.0411825
MYO10 myosin X 0.0386384
MLF1 myeloid leukemia factor 1 0.0383035
NAV2 neuron navigator 2 0.0381165
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0374619
LPP LIM domain containing preferred translocation partner in lipoma 0.037093
ATP13A3 ATPase type 13A3 0.0367266
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0356279
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0352405
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0343209
FXR1 fragile X mental retardation, autosomal homolog 1 0.0341391
SDC4 syndecan 4 0.0339026
EIF4A2 eukaryotic translation initiation factor 4A2 0.0332514
MACF1 microtubule-actin crosslinking factor 1 0.0323238
TPM3 tropomyosin 3 0.0322042
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0320888
PCBP2 poly(rC) binding protein 2 0.0320419
EFNA5 ephrin-A5 0.0319206
JARID2 jumonji, AT rich interactive domain 2 0.0309633
ASPH aspartate beta-hydroxylase 0.0308701
RLF rearranged L-myc fusion 0.0301816
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.029951
VMP1 vacuole membrane protein 1 0.0292198
RICTOR RPTOR independent companion of MTOR, complex 2 0.0289445
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0287649
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0286816
GOLGA4 golgin A4 0.0283119
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0281406
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0274267
SPAG9 sperm associated antigen 9 0.0271489
BHLHE40 basic helix-loop-helix family, member e40 0.0269641
CCNL1 cyclin L1 0.0265031
ZFAND3 zinc finger, AN1-type domain 3 0.0261282
SFPQ splicing factor proline/glutamine-rich 0.0260544
MRTFA myocardin related transcription factor A 0.0258253
SHB Src homology 2 domain containing adaptor protein B 0.0256308
CALU calumenin 0.0254007
GOLGB1 golgin B1 0.025105
MSN moesin 0.0250103
RASA2 RAS p21 protein activator 2 0.0247215
AGO2 argonaute RISC catalytic component 2 0.0243941
SMAD3 SMAD family member 3 0.0241226
JAG1 jagged 1 0.024086
UGCG UDP-glucose ceramide glucosyltransferase 0.0239948
MED13L mediator complex subunit 13-like 0.0239221
ZBTB38 zinc finger and BTB domain containing 38 0.0239198
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0239025
WWTR1 WW domain containing transcription regulator 1 0.0238733
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0237898
NFE2L1 nuclear factor, erythroid 2-like 1 0.0236721
UBA6 ubiquitin-like modifier activating enzyme 6 0.0235351
ZEB1 zinc finger E-box binding homeobox 1 0.0235314
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0235125
COPB1 coatomer protein complex, subunit beta 1 0.0233412
DSPP dentin sialophosphoprotein 0.0231574
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0231352
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0231231
CCNY cyclin Y 0.0230175
TGFBI transforming growth factor, beta-induced, 68kDa 0.0229968
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0229121
B2M beta-2-microglobulin 0.0227107
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.022647
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0222815
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0220174
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0219775
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.02191
BZW1 basic leucine zipper and W2 domains 1 0.0218243
RAB7A RAB7A, member RAS oncogene family 0.0218209
HDAC9 histone deacetylase 9 0.0215415
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.021489
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0214409
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0211663
KDM2A lysine (K)-specific demethylase 2A 0.0210389
COL7A1 collagen, type VII, alpha 1 0.0209894
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0209532
GDI2 GDP dissociation inhibitor 2 0.0209352
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0207411
CSPP1 centrosome and spindle pole associated protein 1 0.0207243

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.282077
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.245144
TIMP3 TIMP metallopeptidase inhibitor 3 -0.198452
TMSB10 thymosin beta 10 -0.176629
COL1A1 collagen, type I, alpha 1 -0.107602
IGFBP3 insulin-like growth factor binding protein 3 -0.0897214
FN1 fibronectin 1 -0.0851239
FTL ferritin, light polypeptide -0.0821657
UBC ubiquitin C -0.0809919
NDRG1 N-myc downstream regulated 1 -0.0807992
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0765903
TM4SF1 transmembrane 4 L six family member 1 -0.0617268
PTMA prothymosin, alpha -0.0576259
CD44 CD44 molecule (Indian blood group) -0.0528157
PSD3 pleckstrin and Sec7 domain containing 3 -0.0520724
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0513614
IER3 immediate early response 3 -0.0493097
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0471634
COL1A2 collagen, type I, alpha 2 -0.046242
F3 coagulation factor III (thromboplastin, tissue factor) -0.0452786
ZBTB20 zinc finger and BTB domain containing 20 -0.0450697
INHBA inhibin, beta A -0.0441932
OSMR oncostatin M receptor -0.0397617
VCAN versican -0.0390323
LMAN1 lectin, mannose-binding, 1 -0.0355914
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0354906
RPS27A ribosomal protein S27a -0.0340878
RRBP1 ribosome binding protein 1 -0.0340789
S100A10 S100 calcium binding protein A10 -0.0340107
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0339224
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0335034
SLC38A2 solute carrier family 38, member 2 -0.0322859
S100A9 S100 calcium binding protein A9 -0.0316186
LOX lysyl oxidase -0.0302205
STC1 stanniocalcin 1 -0.0299634
PDIA3 protein disulfide isomerase family A, member 3 -0.0293324
PRELID2 PRELI domain containing 2 -0.0292679
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0286626
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0277972
ARL4C ADP-ribosylation factor-like 4C -0.0257207
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0248081
ABI3BP ABI family, member 3 (NESH) binding protein -0.0244064
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0242376
FKBP10 FK506 binding protein 10, 65 kDa -0.0242318
H1-0 H1.0 linker histone -0.0241007
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0232813
S100A6 S100 calcium binding protein A6 -0.0231547
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0219851
RPS24 ribosomal protein S24 -0.0219172
THY1 Thy-1 cell surface antigen -0.0216697
RPLP1 ribosomal protein, large, P1 -0.0211386
HLA-B major histocompatibility complex, class I, B -0.0209567
RPS5 ribosomal protein S5 -0.0207968
FBXO32 F-box protein 32 -0.020404
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0203491
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0201165
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0195857
CCDC80 coiled-coil domain containing 80 -0.019393
TPT1 tumor protein, translationally-controlled 1 -0.0191269
CANX calnexin -0.0189239
MT1X metallothionein 1X -0.0186931
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0183933
KDM3A lysine (K)-specific demethylase 3A -0.0182335
IL6 interleukin 6 -0.0179739
IFI16 interferon, gamma-inducible protein 16 -0.0179256
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0176894
PDIA4 protein disulfide isomerase family A, member 4 -0.0173021
NAMPT nicotinamide phosphoribosyltransferase -0.0170733
CALD1 caldesmon 1 -0.0169191
MMP3 matrix metallopeptidase 3 -0.0168471
RPL32 ribosomal protein L32 -0.0167658
HMGA1 high mobility group AT-hook 1 -0.0160446
STK17A serine/threonine kinase 17a -0.0158533
LMO4 LIM domain only 4 -0.0158034
SELENOK selenoprotein K -0.0157998
BTG1 B-cell translocation gene 1, anti-proliferative -0.0157981
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0156845
BBX bobby sox homolog (Drosophila) -0.0156632
WARS1 tryptophanyl-tRNA synthetase 1 -0.0156047
CAVIN1 caveolae associated protein 1 -0.015518
RPL12 ribosomal protein L12 -0.0154896
RPL34 ribosomal protein L34 -0.0153822
SEC61G Sec61 gamma subunit -0.0153412
RPS21 ribosomal protein S21 -0.0153116
RPS11 ribosomal protein S11 -0.0152352
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0151697
OXR1 oxidation resistance 1 -0.0151261
RPL31 ribosomal protein L31 -0.0150812
PTPRF protein tyrosine phosphatase, receptor type, F -0.0150348
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0149783
LMNA lamin A/C -0.014926
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0148462
DPYD dihydropyrimidine dehydrogenase -0.0146454
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0144307
PXDN peroxidasin -0.0143796
UBE2B ubiquitin-conjugating enzyme E2B -0.0143136
DPYSL2 dihydropyrimidinase-like 2 -0.014131
ZMYND8 zinc finger, MYND-type containing 8 -0.0140639
KLF6 Kruppel-like factor 6 -0.0140484
SKAP2 src kinase associated phosphoprotein 2 -0.013974