Tubulin inhibitor 6_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.211918
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.197915
DTNA dystrobrevin, alpha 0.181496
EXT1 exostosin glycosyltransferase 1 0.166187
PABPC1 poly(A) binding protein, cytoplasmic 1 0.133975
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.113343
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0903737
RUNX1 runt-related transcription factor 1 0.0864035
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0848226
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.08314
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0816247
MYO10 myosin X 0.078102
SAMD4A sterile alpha motif domain containing 4A 0.0777662
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0764702
MCTP1 multiple C2 domains, transmembrane 1 0.0758775
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0750002
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0747315
CALD1 caldesmon 1 0.0716666
EEF2 eukaryotic translation elongation factor 2 0.0716068
LDHA lactate dehydrogenase A 0.0715411
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0676262
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0663441
GLS2 glutaminase 2 (liver, mitochondrial) 0.0658371
NUP58 nucleoporin 58 0.0631502
AHNAK AHNAK nucleoprotein 0.0607719
JMJD1C jumonji domain containing 1C 0.0603739
APP amyloid beta (A4) precursor protein 0.0603273
SPAG9 sperm associated antigen 9 0.0566141
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0560776
EIF4B eukaryotic translation initiation factor 4B 0.0552811
PCBP2 poly(rC) binding protein 2 0.0550989
PICALM phosphatidylinositol binding clathrin assembly protein 0.0546263
MARCHF4 membrane associated ring-CH-type finger 4 0.0536008
HSPA8 heat shock 70kDa protein 8 0.0533084
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0508255
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0504599
LIMA1 LIM domain and actin binding 1 0.0490683
OSBPL8 oxysterol binding protein-like 8 0.0477224
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0475215
HDAC9 histone deacetylase 9 0.0471449
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0471448
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0468187
RTN4 reticulon 4 0.0458723
KDM3A lysine (K)-specific demethylase 3A 0.0457513
FRMD6 FERM domain containing 6 0.0456339
TPM3 tropomyosin 3 0.0455723
KTN1 kinectin 1 (kinesin receptor) 0.0452259
ADAM9 ADAM metallopeptidase domain 9 0.0450646
DST dystonin 0.0445274
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0444761
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0442307
ATP13A3 ATPase type 13A3 0.0435413
RPL4 ribosomal protein L4 0.0433851
USP34 ubiquitin specific peptidase 34 0.0430908
EIF1 eukaryotic translation initiation factor 1 0.042278
RAD21 RAD21 homolog (S. pombe) 0.0418688
ZFAND3 zinc finger, AN1-type domain 3 0.0418657
ERBIN erbb2 interacting protein 0.0416998
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0414864
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0414722
TLE4 transducin-like enhancer of split 4 0.0412098
MYH9 myosin, heavy chain 9, non-muscle 0.0411561
LOC112694756 uncharaterized LOC112694756 0.0408507
CORO1C coronin, actin binding protein, 1C 0.04058
TRIP12 thyroid hormone receptor interactor 12 0.0397124
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0395268
WDR45B WD repeat domain 45B 0.0387377
EIF4A2 eukaryotic translation initiation factor 4A2 0.0387222
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0387204
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0382381
ZEB1 zinc finger E-box binding homeobox 1 0.0382145
TFRC transferrin receptor 0.0378906
TSC22D2 TSC22 domain family, member 2 0.0376507
CFAP251 cilia and flagella associated protein 251 0.0376315
ZSWIM6 zinc finger, SWIM-type containing 6 0.037621
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0370719
NAV3 neuron navigator 3 0.0368048
ELL2 elongation factor, RNA polymerase II, 2 0.0362588
HOOK2 hook microtubule-tethering protein 2 0.0361099
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0360373
ASPH aspartate beta-hydroxylase 0.035499
GOLGA4 golgin A4 0.0352384
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0350299
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0347121
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0345779
PUM2 pumilio RNA-binding family member 2 0.0341215
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0340812
RLF rearranged L-myc fusion 0.0337292
MED13L mediator complex subunit 13-like 0.0334614
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0331811
YBX3 Y box binding protein 3 0.0331468
UGCG UDP-glucose ceramide glucosyltransferase 0.0331348
CD163L1 CD163 molecule-like 1 0.0327072
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0326013
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0323413
PUM1 pumilio RNA-binding family member 1 0.0322211
DIAPH1 diaphanous-related formin 1 0.0320652
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0319538
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.031927
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0317232

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.189257
VIM vimentin -0.175759
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.166554
MMP12 matrix metallopeptidase 12 -0.114377
LSAMP limbic system-associated membrane protein -0.103192
GPC6 glypican 6 -0.0911638
CDH13 cadherin 13 -0.0909462
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0852769
PHACTR1 phosphatase and actin regulator 1 -0.0715556
PTCHD4 patched domain containing 4 -0.0684012
PDE4D phosphodiesterase 4D, cAMP-specific -0.0664857
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0662586
NALF1 NALCN channel auxiliary factor 1 -0.0615824
TPT1 tumor protein, translationally-controlled 1 -0.0601592
PRKG1 protein kinase, cGMP-dependent, type I -0.059756
AKAP12 A kinase (PRKA) anchor protein 12 -0.0514531
PTPRD protein tyrosine phosphatase, receptor type, D -0.0504059
NAV1 neuron navigator 1 -0.0495661
KIAA1549L KIAA1549-like -0.0490782
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0490017
FN1 fibronectin 1 -0.0479438
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0456952
EGR1 early growth response 1 -0.0452198
C2CD2 C2 calcium-dependent domain containing 2 -0.0423532
RPL35A ribosomal protein L35a -0.041242
RPL37A ribosomal protein L37a -0.0411753
ALCAM activated leukocyte cell adhesion molecule -0.0409215
TENM2 teneurin transmembrane protein 2 -0.0409203
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0396902
RAD51B RAD51 paralog B -0.0396323
NDRG1 N-myc downstream regulated 1 -0.038124
RPS19 ribosomal protein S19 -0.0378865
MT2A metallothionein 2A -0.0373894
RPLP2 ribosomal protein, large, P2 -0.0370996
RPS24 ribosomal protein S24 -0.0361199
EFNA5 ephrin-A5 -0.0359358
ZNF804A zinc finger protein 804A -0.0354762
NTM neurotrimin -0.0347826
HMGA1 high mobility group AT-hook 1 -0.0343814
FOXP1 forkhead box P1 -0.0326323
TNNC1 troponin C type 1 (slow) -0.0326291
RNF213 ring finger protein 213 -0.0325285
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0320996
DNER delta/notch-like EGF repeat containing -0.0320202
BNC2 basonuclin 2 -0.0319772
KIAA1217 KIAA1217 -0.0319277
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0317456
RPS23 ribosomal protein S23 -0.0299041
SAMD3 sterile alpha motif domain containing 3 -0.0298565
PTMA prothymosin, alpha -0.0286914
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0285086
RPS27A ribosomal protein S27a -0.0284718
VEPH1 ventricular zone expressed PH domain-containing 1 -0.028295
COL6A1 collagen, type VI, alpha 1 -0.0280737
MBD5 methyl-CpG binding domain protein 5 -0.0273581
GNAS GNAS complex locus -0.0265233
IFI16 interferon, gamma-inducible protein 16 -0.0259552
NLGN1 neuroligin 1 -0.0257822
RPL9 ribosomal protein L9 -0.0252458
RPLP1 ribosomal protein, large, P1 -0.0250657
RPS6 ribosomal protein S6 -0.0245276
VCAN versican -0.0244439
DIAPH3 diaphanous-related formin 3 -0.0234677
RPS21 ribosomal protein S21 -0.0234574
MAML3 mastermind-like 3 (Drosophila) -0.0234443
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0234351
EGFR epidermal growth factor receptor -0.0233476
PRSS23 protease, serine, 23 -0.0233069
RPS29 ribosomal protein S29 -0.022801
FNDC3B fibronectin type III domain containing 3B -0.0227304
ARHGAP18 Rho GTPase activating protein 18 -0.0225869
TRPS1 trichorhinophalangeal syndrome I -0.0225617
PFN1 profilin 1 -0.0223464
PCDH11X protocadherin 11 X-linked -0.0221083
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0219582
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.021757
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0217283
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0216612
ADGRB3 adhesion G protein-coupled receptor B3 -0.0214799
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0214407
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0214324
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0210393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0208782
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0206987
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0206542
TBC1D5 TBC1 domain family, member 5 -0.0205861
SBF2 SET binding factor 2 -0.020404
CSMD3 CUB and Sushi multiple domains 3 -0.0203636
LMNA lamin A/C -0.0200724
RPS13 ribosomal protein S13 -0.0200025
CFAP20DC CFAP20 domain containing -0.0199243
SLC38A2 solute carrier family 38, member 2 -0.0198125
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0196536
EHBP1 EH domain binding protein 1 -0.0195705
CCDC80 coiled-coil domain containing 80 -0.0194591
RPS25 ribosomal protein S25 -0.0192518
COL6A2 collagen, type VI, alpha 2 -0.019215
RPL38 ribosomal protein L38 -0.019158
RNF144A ring finger protein 144A -0.0183813
RPL28 ribosomal protein L28 -0.0177519