Tubulin inhibitor 6_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.115685
PCBP2 poly(rC) binding protein 2 0.088231
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0879952
EPS8 epidermal growth factor receptor pathway substrate 8 0.0815852
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0697446
EEF2 eukaryotic translation elongation factor 2 0.0673544
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0655474
FAT1 FAT atypical cadherin 1 0.0637546
ACTG1 actin gamma 1 0.0625679
EIF4A2 eukaryotic translation initiation factor 4A2 0.0575436
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0535692
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.052954
AKAP9 A kinase (PRKA) anchor protein 9 0.0516878
RPS12 ribosomal protein S12 0.0438667
DSPP dentin sialophosphoprotein 0.0429061
DSCAM Down syndrome cell adhesion molecule 0.0419516
KRT8 keratin 8, type II 0.0417842
LDHA lactate dehydrogenase A 0.0416573
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.039581
GOLGA4 golgin A4 0.0390374
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0366315
ESYT2 extended synaptotagmin-like protein 2 0.0359388
ARRDC3 arrestin domain containing 3 0.035502
EIF4B eukaryotic translation initiation factor 4B 0.0353303
PTPRG protein tyrosine phosphatase, receptor type, G 0.0345983
UBA6 ubiquitin-like modifier activating enzyme 6 0.03396
ENO1 enolase 1, (alpha) 0.0335061
MED13L mediator complex subunit 13-like 0.0333006
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0325946
KMT2C lysine (K)-specific methyltransferase 2C 0.0321444
SQSTM1 sequestosome 1 0.0318296
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0318011
ZNF638 zinc finger protein 638 0.0305867
EXT1 exostosin glycosyltransferase 1 0.030161
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0299613
POTEF POTE ankyrin domain family, member F 0.0299156
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.029835
SFPQ splicing factor proline/glutamine-rich 0.0298063
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0294472
RPL3 ribosomal protein L3 0.0293343
BRD2 bromodomain containing 2 0.0284376
ASPH aspartate beta-hydroxylase 0.0282302
RPL21 ribosomal protein L21 0.0279521
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0279035
PTBP3 polypyrimidine tract binding protein 3 0.0278609
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0271138
ARHGAP26 Rho GTPase activating protein 26 0.0266871
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0265505
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0264752
OGA O-GlcNAcase 0.0264198
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0264091
MYH9 myosin, heavy chain 9, non-muscle 0.026391
TPM3 tropomyosin 3 0.0262365
SOS1 son of sevenless homolog 1 (Drosophila) 0.0261729
SPAG9 sperm associated antigen 9 0.0261511
WNK1 WNK lysine deficient protein kinase 1 0.0261072
NRDC nardilysin convertase 0.025811
TXNRD1 thioredoxin reductase 1 0.0256705
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0253932
DDIT4 DNA-damage-inducible transcript 4 0.0253527
FXR1 fragile X mental retardation, autosomal homolog 1 0.0252619
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0252552
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0246705
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0244156
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0243637
SHROOM3 shroom family member 3 0.0242617
RNF145 ring finger protein 145 0.0242308
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0240629
TRIO trio Rho guanine nucleotide exchange factor 0.0238388
XPO1 exportin 1 0.0236561
PRELID2 PRELI domain containing 2 0.023496
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0229306
KDM2A lysine (K)-specific demethylase 2A 0.022812
KTN1 kinectin 1 (kinesin receptor) 0.0227366
TRIM2 tripartite motif containing 2 0.022345
PTEN phosphatase and tensin homolog 0.0222698
AFDN afadin, adherens junction formation factor 0.0219963
CCNL1 cyclin L1 0.0217295
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0215676
PARD3B par-3 family cell polarity regulator beta 0.0214712
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0213251
HSPA8 heat shock 70kDa protein 8 0.0211687
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0210715
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0208244
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0207785
ERBIN erbb2 interacting protein 0.0206264
NCKAP1 NCK-associated protein 1 0.0205214
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0202719
CHD1 chromodomain helicase DNA binding protein 1 0.0202577
EIF1 eukaryotic translation initiation factor 1 0.0201518
PDE8A phosphodiesterase 8A 0.020148
KDM4C lysine (K)-specific demethylase 4C 0.0200945
LRP6 low density lipoprotein receptor-related protein 6 0.0200204
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0199991
AUTS2 autism susceptibility candidate 2 0.0199738
ANO6 anoctamin 6 0.0198682
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0198538
ITGA6 integrin, alpha 6 0.0198075
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0197546
TSC22D2 TSC22 domain family, member 2 0.0197503

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.199638
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.187106
RPLP1 ribosomal protein, large, P1 -0.132163
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.120092
TMSB10 thymosin beta 10 -0.100857
PTPRR protein tyrosine phosphatase, receptor type, R -0.0973267
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0920041
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0897341
RPL34 ribosomal protein L34 -0.0894801
RPS24 ribosomal protein S24 -0.0880056
THSD4 thrombospondin, type I, domain containing 4 -0.0859823
PDE4D phosphodiesterase 4D, cAMP-specific -0.0816715
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0689367
RPL31 ribosomal protein L31 -0.0670498
F3 coagulation factor III (thromboplastin, tissue factor) -0.0668826
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0642903
GMDS GDP-mannose 4,6-dehydratase -0.0636264
RPS6 ribosomal protein S6 -0.0635864
TSPAN8 tetraspanin 8 -0.0604811
LMO7 LIM domain 7 -0.0578819
NPSR1 neuropeptide S receptor 1 -0.0577069
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0521304
ANXA2 annexin A2 -0.0507878
PTMA prothymosin, alpha -0.0503153
RPL35A ribosomal protein L35a -0.0482292
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0469836
KRT18 keratin 18, type I -0.0465853
IFI6 interferon, alpha-inducible protein 6 -0.0463283
RPS23 ribosomal protein S23 -0.0447519
RPS8 ribosomal protein S8 -0.0445198
KLF5 Kruppel-like factor 5 (intestinal) -0.0442105
RPS25 ribosomal protein S25 -0.043566
AOPEP aminopeptidase O (putative) -0.0435611
RPS19 ribosomal protein S19 -0.043343
PALLD palladin, cytoskeletal associated protein -0.0428764
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0416109
RRBP1 ribosome binding protein 1 -0.0415426
AGR2 anterior gradient 2 -0.0413299
RPL38 ribosomal protein L38 -0.0412732
RPS27A ribosomal protein S27a -0.0409565
PERP PERP, TP53 apoptosis effector -0.0393842
STAT1 signal transducer and activator of transcription 1, 91kDa -0.038881
RPL37A ribosomal protein L37a -0.0382625
EGFR epidermal growth factor receptor -0.0373127
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0371117
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0370682
PDIA3 protein disulfide isomerase family A, member 3 -0.0369689
S100A6 S100 calcium binding protein A6 -0.0367076
RPL32 ribosomal protein L32 -0.0364458
PTPRB protein tyrosine phosphatase, receptor type, B -0.0359204
MCU mitochondrial calcium uniporter -0.0358265
VCL vinculin -0.0358017
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0357363
RPS21 ribosomal protein S21 -0.0351476
FRMD5 FERM domain containing 5 -0.0343969
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0329808
RPS29 ribosomal protein S29 -0.0327554
S100A10 S100 calcium binding protein A10 -0.0323224
NT5C2 5'-nucleotidase, cytosolic II -0.0310359
RPS5 ribosomal protein S5 -0.0309642
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0305184
FERMT1 fermitin family member 1 -0.0299258
NRN1 neuritin 1 -0.0293906
CLIC5 chloride intracellular channel 5 -0.0292305
RPL6 ribosomal protein L6 -0.0291831
BACE2 beta-site APP-cleaving enzyme 2 -0.0291764
RPL26 ribosomal protein L26 -0.0291338
RPLP2 ribosomal protein, large, P2 -0.0291239
RPLP0 ribosomal protein, large, P0 -0.0285912
DSG2 desmoglein 2 -0.0283265
IFI27 interferon, alpha-inducible protein 27 -0.0281141
RPL11 ribosomal protein L11 -0.0277637
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0275926
XAF1 XIAP associated factor 1 -0.0273889
RPS11 ribosomal protein S11 -0.0272832
RPS14 ribosomal protein S14 -0.0272506
NPR2 natriuretic peptide receptor 2 -0.0269909
ACTN4 actinin, alpha 4 -0.0269374
RPL9 ribosomal protein L9 -0.0266574
FOXO3 forkhead box O3 -0.0266229
SERINC5 serine incorporator 5 -0.0259598
RPL12 ribosomal protein L12 -0.0257045
SVIL supervillin -0.0256173
ANO1 anoctamin 1, calcium activated chloride channel -0.0254197
SPON1 spondin 1, extracellular matrix protein -0.0253893
RPL8 ribosomal protein L8 -0.0251011
PSD3 pleckstrin and Sec7 domain containing 3 -0.0250594
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0250393
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0249256
INHBA inhibin, beta A -0.02476
CCND1 cyclin D1 -0.0246806
SP100 SP100 nuclear antigen -0.0244427
LAMA4 laminin, alpha 4 -0.0243044
TAS2R14 taste receptor, type 2, member 14 -0.0241747
P3H2 prolyl 3-hydroxylase 2 -0.024151
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.024115
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0239712
TPM4 tropomyosin 4 -0.0238461
RPS13 ribosomal protein S13 -0.0231859
RPS17 ribosomal protein S17 -0.0228011