Tubulin inhibitor 6_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.165416
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.152589
CXCL8 chemokine (C-X-C motif) ligand 8 0.128874
SLTM SAFB-like, transcription modulator 0.116401
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.107856
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.105672
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.100685
ELL2 elongation factor, RNA polymerase II, 2 0.100321
LMO7 LIM domain 7 0.0994409
MCL1 myeloid cell leukemia 1 0.0985484
LAMC2 laminin, gamma 2 0.0927258
DSCAM Down syndrome cell adhesion molecule 0.0775251
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0774436
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0772196
FAM13A family with sequence similarity 13, member A 0.0755031
SPAG9 sperm associated antigen 9 0.0729892
ARRDC3 arrestin domain containing 3 0.0720081
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0687495
STC1 stanniocalcin 1 0.0682735
CEMIP cell migration inducing protein, hyaluronan binding 0.0682295
ENO1 enolase 1, (alpha) 0.0674101
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0639871
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0622153
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0604113
LDHA lactate dehydrogenase A 0.0598057
AGO2 argonaute RISC catalytic component 2 0.0593438
PCBP2 poly(rC) binding protein 2 0.0587968
SOD2 superoxide dismutase 2, mitochondrial 0.0578253
CES1 carboxylesterase 1 0.0572795
LOC112694756 uncharaterized LOC112694756 0.0548206
DOCK5 dedicator of cytokinesis 5 0.0535447
MYO1E myosin IE 0.0535003
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0527785
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0519849
GOLGB1 golgin B1 0.0503914
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0496932
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0492951
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0482931
NSUN6 NOP2/Sun domain family, member 6 0.0469183
GRAMD1B GRAM domain containing 1B 0.0467253
SMAD3 SMAD family member 3 0.0455396
EIF4A2 eukaryotic translation initiation factor 4A2 0.0453965
SAMD4A sterile alpha motif domain containing 4A 0.0448724
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0447912
TRIP12 thyroid hormone receptor interactor 12 0.0443978
TMCO3 transmembrane and coiled-coil domains 3 0.0442889
ANKRD12 ankyrin repeat domain 12 0.0431357
JMJD1C jumonji domain containing 1C 0.0419943
ACTG1 actin gamma 1 0.0413525
CANX calnexin 0.0410509
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0409236
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0406845
SEC31A SEC31 homolog A (S. cerevisiae) 0.040575
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0405677
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0399242
PYGL phosphorylase, glycogen, liver 0.0399028
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0398268
UBC ubiquitin C 0.0393113
GRB10 growth factor receptor-bound protein 10 0.0388203
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0373395
EXT1 exostosin glycosyltransferase 1 0.0370089
MSN moesin 0.0368411
RNF213 ring finger protein 213 0.0362023
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0361065
ERRFI1 ERBB receptor feedback inhibitor 1 0.0358823
EGR1 early growth response 1 0.0358221
CUL4A cullin 4A 0.0355757
HOMER1 homer scaffolding protein 1 0.0354599
HDLBP high density lipoprotein binding protein 0.0354096
ZNF638 zinc finger protein 638 0.0351678
HSPA8 heat shock 70kDa protein 8 0.0344507
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0340949
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0339284
SDC4 syndecan 4 0.0337341
TPM3 tropomyosin 3 0.0336057
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0335999
BZW1 basic leucine zipper and W2 domains 1 0.0335781
BLZF1 basic leucine zipper nuclear factor 1 0.0333471
ADAR adenosine deaminase, RNA-specific 0.0329766
KDM2A lysine (K)-specific demethylase 2A 0.0322235
USP34 ubiquitin specific peptidase 34 0.0321552
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0320263
ANO6 anoctamin 6 0.0315362
CDCP1 CUB domain containing protein 1 0.0314418
BIRC3 baculoviral IAP repeat containing 3 0.0312607
DSPP dentin sialophosphoprotein 0.0305698
MYH9 myosin, heavy chain 9, non-muscle 0.0299497
UBA6 ubiquitin-like modifier activating enzyme 6 0.0298572
ZC3H11A zinc finger CCCH-type containing 11A 0.0296799
FRY furry homolog (Drosophila) 0.0296782
NDRG1 N-myc downstream regulated 1 0.0295443
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0292993
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0291854
KIAA1217 KIAA1217 0.028698
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0282548
PAPOLA poly(A) polymerase alpha 0.0280286
SLC35F5 solute carrier family 35, member F5 0.02795
COPA coatomer protein complex, subunit alpha 0.0279391
TES testin LIM domain protein 0.0279286
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.0277002

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.114049
PTPRM protein tyrosine phosphatase, receptor type, M -0.0859389
TMSB10 thymosin beta 10 -0.0849622
RPL37A ribosomal protein L37a -0.0803134
RPL35A ribosomal protein L35a -0.06831
RPS3 ribosomal protein S3 -0.0675578
RPS12 ribosomal protein S12 -0.0669146
RPS25 ribosomal protein S25 -0.0643766
RPS27A ribosomal protein S27a -0.0560429
PDE4D phosphodiesterase 4D, cAMP-specific -0.0526266
S100P S100 calcium binding protein P -0.0507839
RPS24 ribosomal protein S24 -0.0506934
CAV1 caveolin 1, caveolae protein, 22kDa -0.0487746
FTL ferritin, light polypeptide -0.0479494
MT2A metallothionein 2A -0.0473038
H1-0 H1.0 linker histone -0.0420827
RPS29 ribosomal protein S29 -0.0397457
RPLP1 ribosomal protein, large, P1 -0.0388806
RPS8 ribosomal protein S8 -0.0377898
RPS23 ribosomal protein S23 -0.037455
THSD4 thrombospondin, type I, domain containing 4 -0.0356236
RPLP2 ribosomal protein, large, P2 -0.0353321
RPL34 ribosomal protein L34 -0.0345618
RIMS2 regulating synaptic membrane exocytosis 2 -0.0338985
S100A10 S100 calcium binding protein A10 -0.0329316
CSTB cystatin B (stefin B) -0.0322072
OSMR oncostatin M receptor -0.0312953
PTMA prothymosin, alpha -0.0311914
RPL38 ribosomal protein L38 -0.0302987
RPS13 ribosomal protein S13 -0.0293475
WSB1 WD repeat and SOCS box containing 1 -0.0271005
RPS17 ribosomal protein S17 -0.0270548
RPL9 ribosomal protein L9 -0.0270408
RPS19 ribosomal protein S19 -0.0267338
RPL12 ribosomal protein L12 -0.0264814
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.026289
VCL vinculin -0.0260554
RPS21 ribosomal protein S21 -0.025724
RPL26 ribosomal protein L26 -0.0254053
AKR1C1 aldo-keto reductase family 1, member C1 -0.0250524
RPL11 ribosomal protein L11 -0.0249794
CCND1 cyclin D1 -0.0249209
GNAS GNAS complex locus -0.0235715
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0234531
UGDH UDP-glucose 6-dehydrogenase -0.0234126
BRWD1 bromodomain and WD repeat domain containing 1 -0.0231667
RPL36A ribosomal protein L36a -0.0226908
GM2A GM2 ganglioside activator -0.0225936
S100A11 S100 calcium binding protein A11 -0.0221858
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0220225
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.021839
RPL36 ribosomal protein L36 -0.0218189
S100A9 S100 calcium binding protein A9 -0.0217111
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0216598
MGAT4C MGAT4 family, member C -0.0216433
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0215939
MAML3 mastermind-like 3 (Drosophila) -0.0208576
RPS27 ribosomal protein S27 -0.0207531
IGFBP5 insulin-like growth factor binding protein 5 -0.0206618
RAB27B RAB27B, member RAS oncogene family -0.0194331
RPL31 ribosomal protein L31 -0.0194174
SCEL sciellin -0.0191379
HMGA1 high mobility group AT-hook 1 -0.0190788
CUX1 cut-like homeobox 1 -0.0190647
DENND5B DENN/MADD domain containing 5B -0.0188422
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0183935
RPL28 ribosomal protein L28 -0.0181212
RPL13A ribosomal protein L13a -0.0180649
NTN4 netrin 4 -0.0179168
TAS2R14 taste receptor, type 2, member 14 -0.0178121
SDC1 syndecan 1 -0.01764
MGST1 microsomal glutathione S-transferase 1 -0.0174471
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.017382
RPL37 ribosomal protein L37 -0.0173632
RPS16 ribosomal protein S16 -0.0172939
KRT7 keratin 7, type II -0.0171298
CST3 cystatin C -0.0171044
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0170649
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0168812
RPS6 ribosomal protein S6 -0.0168383
IFI6 interferon, alpha-inducible protein 6 -0.0165462
ATP5MG ATP synthase membrane subunit g -0.0163722
NF1 neurofibromin 1 -0.0163547
PERP PERP, TP53 apoptosis effector -0.0163229
RPS14 ribosomal protein S14 -0.016259
SEC61G Sec61 gamma subunit -0.0160412
RPL10A ribosomal protein L10a -0.0158857
PRH1 proline-rich protein HaeIII subfamily 1 -0.0158428
UPP1 uridine phosphorylase 1 -0.01556
NDE1 nudE neurodevelopment protein 1 -0.015533
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0152752
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0151538
TNS3 tensin 3 -0.0151125
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0149465
EIF5B eukaryotic translation initiation factor 5B -0.014878
OCIAD2 OCIA domain containing 2 -0.0148332
MCU mitochondrial calcium uniporter -0.0145383
AHNAK2 AHNAK nucleoprotein 2 -0.0143298
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0141812
RPL30 ribosomal protein L30 -0.0141569