Tubulin inhibitor 6_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.107916
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0995487
FAM20C family with sequence similarity 20, member C 0.0950692
PDE4D phosphodiesterase 4D, cAMP-specific 0.0897803
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0856939
GRB10 growth factor receptor-bound protein 10 0.0856801
FNDC3B fibronectin type III domain containing 3B 0.0855837
SMAD3 SMAD family member 3 0.083731
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0798538
LOX lysyl oxidase 0.0785182
AKAP12 A kinase (PRKA) anchor protein 12 0.0765534
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0728476
NAV2 neuron navigator 2 0.0718488
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0712831
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0675205
EFNA5 ephrin-A5 0.0646123
PCBP2 poly(rC) binding protein 2 0.0622145
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0604933
SDK1 sidekick cell adhesion molecule 1 0.0602868
GLCCI1 glucocorticoid induced 1 0.0581859
DST dystonin 0.0545412
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0535345
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0520847
DOCK5 dedicator of cytokinesis 5 0.049815
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0488496
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0477583
CD44 CD44 molecule (Indian blood group) 0.0466839
ARHGAP5 Rho GTPase activating protein 5 0.044981
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.044325
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0437134
TRIO trio Rho guanine nucleotide exchange factor 0.0436455
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0433716
NTN4 netrin 4 0.0424225
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.041933
EXT1 exostosin glycosyltransferase 1 0.0415307
AHNAK AHNAK nucleoprotein 0.0402436
ATXN1 ataxin 1 0.0401116
LOXL2 lysyl oxidase-like 2 0.040064
ANTXR2 anthrax toxin receptor 2 0.0395035
MEF2A myocyte enhancer factor 2A 0.0392125
NPAS2 neuronal PAS domain protein 2 0.0390073
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0386944
MYO10 myosin X 0.0386909
SEPTIN9 septin 9 0.0383438
PRELID2 PRELI domain containing 2 0.0376265
HMGA2 high mobility group AT-hook 2 0.0366612
SOD2 superoxide dismutase 2, mitochondrial 0.0360393
CDH13 cadherin 13 0.0359533
NRP1 neuropilin 1 0.0355391
FER fer (fps/fes related) tyrosine kinase 0.0352568
ASPH aspartate beta-hydroxylase 0.0351188
IFI44L interferon-induced protein 44-like 0.0348766
ZC3H12C zinc finger CCCH-type containing 12C 0.0340292
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0338018
RUNX1 runt-related transcription factor 1 0.0332883
LRMDA leucine rich melanocyte differentiation associated 0.0332685
KSR1 kinase suppressor of ras 1 0.0331813
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.03249
ZSWIM6 zinc finger, SWIM-type containing 6 0.0324269
PDLIM5 PDZ and LIM domain 5 0.0321616
FNIP1 folliculin interacting protein 1 0.0313105
MAML3 mastermind-like 3 (Drosophila) 0.0312716
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0311143
MACF1 microtubule-actin crosslinking factor 1 0.0306439
HIPK2 homeodomain interacting protein kinase 2 0.0305494
EXOC6B exocyst complex component 6B 0.0296758
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0296339
RAI14 retinoic acid induced 14 0.0287444
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0286754
WLS wntless Wnt ligand secretion mediator 0.0286267
COL7A1 collagen, type VII, alpha 1 0.0285267
USP34 ubiquitin specific peptidase 34 0.0284738
NRG1 neuregulin 1 0.0284643
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0284214
DPYD dihydropyrimidine dehydrogenase 0.0280731
DSCAM Down syndrome cell adhesion molecule 0.0280334
RAD51B RAD51 paralog B 0.0279432
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0275484
MIPOL1 mirror-image polydactyly 1 0.0272994
LPP LIM domain containing preferred translocation partner in lipoma 0.0268322
EGFR epidermal growth factor receptor 0.0268311
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.026818
VEGFC vascular endothelial growth factor C 0.0266247
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0266235
ZNF638 zinc finger protein 638 0.0265072
ASCC3 activating signal cointegrator 1 complex subunit 3 0.02631
MSRB3 methionine sulfoxide reductase B3 0.0262537
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0260504
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0260235
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0258075
VMP1 vacuole membrane protein 1 0.0255817
APLP2 amyloid beta (A4) precursor-like protein 2 0.0253978
EHBP1 EH domain binding protein 1 0.025353
PSD3 pleckstrin and Sec7 domain containing 3 0.0252956
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0252805
SHB Src homology 2 domain containing adaptor protein B 0.0250951
HDAC9 histone deacetylase 9 0.0247472
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0245942
ETV6 ets variant 6 0.0245873
RERE arginine-glutamic acid dipeptide (RE) repeats 0.024551

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.208753
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181631
VIM vimentin -0.170761
FTL ferritin, light polypeptide -0.144062
PTMA prothymosin, alpha -0.100979
RPLP1 ribosomal protein, large, P1 -0.0817433
RPL35A ribosomal protein L35a -0.0664319
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0602317
NDRG1 N-myc downstream regulated 1 -0.0591901
TPT1 tumor protein, translationally-controlled 1 -0.0585678
NAMPT nicotinamide phosphoribosyltransferase -0.0571109
IER3 immediate early response 3 -0.0562989
EIF1 eukaryotic translation initiation factor 1 -0.055567
RPS24 ribosomal protein S24 -0.0518412
MT2A metallothionein 2A -0.0501244
ZMYND8 zinc finger, MYND-type containing 8 -0.0494956
RPS19 ribosomal protein S19 -0.0493132
RPL31 ribosomal protein L31 -0.0473405
WSB1 WD repeat and SOCS box containing 1 -0.0466113
RPS6 ribosomal protein S6 -0.044477
RPS29 ribosomal protein S29 -0.0426233
RPLP2 ribosomal protein, large, P2 -0.0423919
S100A6 S100 calcium binding protein A6 -0.0415952
RPL34 ribosomal protein L34 -0.0413376
BTG1 B-cell translocation gene 1, anti-proliferative -0.0410441
HMGA1 high mobility group AT-hook 1 -0.0397444
S100A10 S100 calcium binding protein A10 -0.0391114
TFPI2 tissue factor pathway inhibitor 2 -0.0377991
RPS23 ribosomal protein S23 -0.0375827
STC1 stanniocalcin 1 -0.0375217
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0371174
RPL37A ribosomal protein L37a -0.035708
RPS8 ribosomal protein S8 -0.0356198
RPS13 ribosomal protein S13 -0.0344425
RPS11 ribosomal protein S11 -0.0336108
C15ORF48 chromosome 15 open reading frame 48 -0.03266
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0326429
RPS21 ribosomal protein S21 -0.0324035
RPL28 ribosomal protein L28 -0.0308464
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.03056
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0305068
KDM3A lysine (K)-specific demethylase 3A -0.0304405
NAP1L1 nucleosome assembly protein 1-like 1 -0.0303174
RPL32 ribosomal protein L32 -0.0301394
RPS25 ribosomal protein S25 -0.0298715
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0290275
PDIA3 protein disulfide isomerase family A, member 3 -0.0289103
HLA-B major histocompatibility complex, class I, B -0.0288522
RPL36 ribosomal protein L36 -0.0287241
RPS16 ribosomal protein S16 -0.0279501
RPL38 ribosomal protein L38 -0.027763
WDR45B WD repeat domain 45B -0.0277502
FTH1 ferritin, heavy polypeptide 1 -0.0276358
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0276091
RPS5 ribosomal protein S5 -0.0275787
RPL19 ribosomal protein L19 -0.0275053
SLC38A1 solute carrier family 38, member 1 -0.0273691
RPL11 ribosomal protein L11 -0.0273145
PKM pyruvate kinase, muscle -0.0269958
S100A9 S100 calcium binding protein A9 -0.026305
VDAC1 voltage-dependent anion channel 1 -0.0260825
IFITM3 interferon induced transmembrane protein 3 -0.0253095
SEC61G Sec61 gamma subunit -0.0247496
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0246816
RPL23 ribosomal protein L23 -0.0246271
B2M beta-2-microglobulin -0.0246119
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0245905
GCC2 GRIP and coiled-coil domain containing 2 -0.0243721
RPL12 ribosomal protein L12 -0.0242004
GNAS GNAS complex locus -0.0241023
RPL9 ribosomal protein L9 -0.0235941
EGR1 early growth response 1 -0.0235489
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0234958
PRRC2C proline-rich coiled-coil 2C -0.0231006
IFI6 interferon, alpha-inducible protein 6 -0.0230336
RPS27 ribosomal protein S27 -0.0228464
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0224449
UGP2 UDP-glucose pyrophosphorylase 2 -0.0222717
RPL7A ribosomal protein L7a -0.0211545
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0209461
FAM13A family with sequence similarity 13, member A -0.0202444
RPL27A ribosomal protein L27a -0.0201996
RPL37 ribosomal protein L37 -0.0200699
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0200506
RIOK3 RIO kinase 3 -0.0197175
ELL2 elongation factor, RNA polymerase II, 2 -0.0195524
ENO2 enolase 2 (gamma, neuronal) -0.0195099
SRGN serglycin -0.0194187
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.019416
RPL36AL ribosomal protein L36a-like -0.0193886
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.019375
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0192105
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0191149
ADM adrenomedullin -0.0189455
PFN1 profilin 1 -0.0187129
TM4SF1 transmembrane 4 L six family member 1 -0.018587
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0184718
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0184593
DLG1 discs, large homolog 1 (Drosophila) -0.0182837
RPL15 ribosomal protein L15 -0.0180794