Tubulin inhibitor 6_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tubulin inhibitor 6_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYO1E myosin IE 0.126541
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.125555
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.112308
FNDC3B fibronectin type III domain containing 3B 0.0906429
EXT1 exostosin glycosyltransferase 1 0.0875932
OGA O-GlcNAcase 0.0854363
DSCAM Down syndrome cell adhesion molecule 0.0816183
LMO7 LIM domain 7 0.0813626
ARHGAP21 Rho GTPase activating protein 21 0.0801185
MAST4 microtubule associated serine/threonine kinase family member 4 0.0787737
KYNU kynureninase 0.0785503
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0720124
ATXN1 ataxin 1 0.0701571
PDE4D phosphodiesterase 4D, cAMP-specific 0.0698321
TJP1 tight junction protein 1 0.0687362
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0676247
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0674183
BZW1 basic leucine zipper and W2 domains 1 0.0671584
ANXA2 annexin A2 0.0657258
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0651336
RBM39 RNA binding motif protein 39 0.0642338
PRRC2C proline-rich coiled-coil 2C 0.0613879
EGFR epidermal growth factor receptor 0.0604534
CLIP1 CAP-GLY domain containing linker protein 1 0.0575681
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0563471
PCBP2 poly(rC) binding protein 2 0.0554819
FAM13A family with sequence similarity 13, member A 0.054221
H3-3B H3.3 histone B 0.053255
BACE2 beta-site APP-cleaving enzyme 2 0.0523642
SQSTM1 sequestosome 1 0.0521243
TXNRD1 thioredoxin reductase 1 0.0488016
ZC3H11A zinc finger CCCH-type containing 11A 0.0471227
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0466229
RPL26 ribosomal protein L26 0.0452668
HOOK2 hook microtubule-tethering protein 2 0.0449689
ANKHD1 ankyrin repeat and KH domain containing 1 0.0443218
TOP1 topoisomerase (DNA) I 0.0439742
ENO1 enolase 1, (alpha) 0.0436153
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.042763
DSPP dentin sialophosphoprotein 0.0427178
RPS12 ribosomal protein S12 0.0425836
GRB10 growth factor receptor-bound protein 10 0.042321
HMGA2 high mobility group AT-hook 2 0.0422666
MXD1 MAX dimerization protein 1 0.0421796
SAMD4A sterile alpha motif domain containing 4A 0.0421233
ELL2 elongation factor, RNA polymerase II, 2 0.0415767
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0414773
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0406365
SPAG9 sperm associated antigen 9 0.0405816
UBE2H ubiquitin-conjugating enzyme E2H 0.0405025
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0402783
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0402735
RPS27A ribosomal protein S27a 0.0401079
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0400294
AHNAK AHNAK nucleoprotein 0.0398975
LAMB3 laminin, beta 3 0.0397688
LDHA lactate dehydrogenase A 0.0387187
PUM2 pumilio RNA-binding family member 2 0.0386205
GPBP1 GC-rich promoter binding protein 1 0.0385463
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.037349
RAB10 RAB10, member RAS oncogene family 0.0371596
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0371057
LIMCH1 LIM and calponin homology domains 1 0.0369315
RPL34 ribosomal protein L34 0.0367719
P4HB prolyl 4-hydroxylase, beta polypeptide 0.036391
GSK3B glycogen synthase kinase 3 beta 0.0360794
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0358472
ASPH aspartate beta-hydroxylase 0.0356297
VCL vinculin 0.0353465
PFKP phosphofructokinase, platelet 0.0353412
UGCG UDP-glucose ceramide glucosyltransferase 0.035239
FNDC3A fibronectin type III domain containing 3A 0.0352141
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0350476
RPS8 ribosomal protein S8 0.0345523
NCKAP1 NCK-associated protein 1 0.034394
DTNA dystrobrevin, alpha 0.0334797
EZR ezrin 0.0333688
INHBA inhibin, beta A 0.0333242
ANO6 anoctamin 6 0.0331994
SOD2 superoxide dismutase 2, mitochondrial 0.0330393
SIK3 SIK family kinase 3 0.0329739
RORA RAR-related orphan receptor A 0.0326202
CCNY cyclin Y 0.0323986
CTBP2 C-terminal binding protein 2 0.0322718
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0318648
FOXO3 forkhead box O3 0.0315953
CYTH1 cytohesin 1 0.0315683
IFIH1 interferon induced with helicase C domain 1 0.0313295
MED13L mediator complex subunit 13-like 0.031312
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0309521
SMYD3 SET and MYND domain containing 3 0.0308309
GDNF glial cell derived neurotrophic factor 0.0306853
CFLAR CASP8 and FADD-like apoptosis regulator 0.0306786
ATP11A ATPase, class VI, type 11A 0.0305729
RPLP2 ribosomal protein, large, P2 0.030532
PPARD peroxisome proliferator-activated receptor delta 0.0300749
FAM120A family with sequence similarity 120A 0.0300683
PICALM phosphatidylinositol binding clathrin assembly protein 0.0299064
TUFT1 tuftelin 1 0.0298698
MYOF myoferlin 0.0298265

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.0934371
IGFBP3 insulin-like growth factor binding protein 3 -0.0887024
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0830032
FTL ferritin, light polypeptide -0.0766914
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.075908
LAMC2 laminin, gamma 2 -0.0708454
SBF2 SET binding factor 2 -0.0706666
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0652969
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0645027
MCL1 myeloid cell leukemia 1 -0.062755
GPC6 glypican 6 -0.0623831
ZMYND8 zinc finger, MYND-type containing 8 -0.0621913
ANTXR2 anthrax toxin receptor 2 -0.0607514
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.055903
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0548896
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0541357
CATSPERB catsper channel auxiliary subunit beta -0.0531929
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.052765
LPP LIM domain containing preferred translocation partner in lipoma -0.0525109
SOS2 son of sevenless homolog 2 (Drosophila) -0.051989
RPL19 ribosomal protein L19 -0.0502157
SHB Src homology 2 domain containing adaptor protein B -0.0501591
CAPN2 calpain 2, (m/II) large subunit -0.0498921
SOX4 SRY (sex determining region Y)-box 4 -0.0496501
ZBTB20 zinc finger and BTB domain containing 20 -0.0494935
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0490761
AGFG1 ArfGAP with FG repeats 1 -0.0483339
CCNI cyclin I -0.0480234
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0476857
FN1 fibronectin 1 -0.0471208
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0466876
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0457622
STC1 stanniocalcin 1 -0.0456088
ZNF638 zinc finger protein 638 -0.0455163
RAB7A RAB7A, member RAS oncogene family -0.0455054
CSTB cystatin B (stefin B) -0.0448989
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0445583
PRKCA protein kinase C, alpha -0.0440662
MAP1B microtubule-associated protein 1B -0.0440334
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0436066
TPI1 triosephosphate isomerase 1 -0.0432395
EPSTI1 epithelial stromal interaction 1 (breast) -0.0432025
RFX7 regulatory factor X, 7 -0.0431655
KLF6 Kruppel-like factor 6 -0.0429353
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0427043
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.041448
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0410166
PKM pyruvate kinase, muscle -0.0406136
RREB1 ras responsive element binding protein 1 -0.0400669
CLMP CXADR-like membrane protein -0.0394818
TMSB10 thymosin beta 10 -0.0394177
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0389388
DENND1A DENN/MADD domain containing 1A -0.0387136
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0385685
PERP PERP, TP53 apoptosis effector -0.0384623
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0383352
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0378525
HDAC8 histone deacetylase 8 -0.0376905
ATOSA atos homolog A -0.0372477
BTBD10 BTB (POZ) domain containing 10 -0.0372011
SPPL3 signal peptide peptidase like 3 -0.0371659
RPS19 ribosomal protein S19 -0.0369459
MYO1D myosin ID -0.0368007
TRIP12 thyroid hormone receptor interactor 12 -0.0365851
HLA-A major histocompatibility complex, class I, A -0.0364504
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0362455
STAU1 staufen double-stranded RNA binding protein 1 -0.0359737
THOC2 THO complex 2 -0.0359407
CLDN7 claudin 7 -0.0358313
WASF2 WAS protein family, member 2 -0.0354399
RBM47 RNA binding motif protein 47 -0.0353457
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.034956
TXNIP thioredoxin interacting protein -0.0348083
ATP11B ATPase, class VI, type 11B -0.0346987
SRPK2 SRSF protein kinase 2 -0.0346739
HLA-B major histocompatibility complex, class I, B -0.0345975
ACTN1 actinin, alpha 1 -0.0344604
MT2A metallothionein 2A -0.0342365
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0341467
NKTR natural killer cell triggering receptor -0.0340354
ZNF217 zinc finger protein 217 -0.0339516
NT5C2 5'-nucleotidase, cytosolic II -0.0333449
SSH2 slingshot protein phosphatase 2 -0.0332978
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0327608
MRPS6 mitochondrial ribosomal protein S6 -0.0326961
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0326872
RAI14 retinoic acid induced 14 -0.0325535
TM9SF3 transmembrane 9 superfamily member 3 -0.0324629
RNF24 ring finger protein 24 -0.0321647
RAD51B RAD51 paralog B -0.0321646
PRRC2B proline-rich coiled-coil 2B -0.0321554
S100A9 S100 calcium binding protein A9 -0.032139
XPO1 exportin 1 -0.0320744
RPLP1 ribosomal protein, large, P1 -0.0320717
CD44 CD44 molecule (Indian blood group) -0.0319228
CLIC4 chloride intracellular channel 4 -0.0318306
UBE3A ubiquitin protein ligase E3A -0.0317895
TBC1D5 TBC1 domain family, member 5 -0.031729
ANKRD36C ankyrin repeat domain 36C -0.0315067
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0314756