Tubulin inhibitor 6_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0886512
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0787889
ZCCHC7 zinc finger, CCHC domain containing 7 0.076988
AKAP12 A kinase (PRKA) anchor protein 12 0.0745478
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0718082
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0591317
TXNRD1 thioredoxin reductase 1 0.0564593
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0553089
PCBP2 poly(rC) binding protein 2 0.0545584
INTS6 integrator complex subunit 6 0.0537175
COPA coatomer protein complex, subunit alpha 0.053712
MCL1 myeloid cell leukemia 1 0.0532427
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0526573
JMJD1C jumonji domain containing 1C 0.0522208
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0518036
TRIP12 thyroid hormone receptor interactor 12 0.0512251
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0496935
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0495212
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0489049
RAB7A RAB7A, member RAS oncogene family 0.0484454
KDM2A lysine (K)-specific demethylase 2A 0.0453723
ACTG1 actin gamma 1 0.0448296
NFE2L2 nuclear factor, erythroid 2-like 2 0.0438691
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0437536
FBXO11 F-box protein 11 0.0435055
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0433113
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0418343
SFPQ splicing factor proline/glutamine-rich 0.0413565
HOMER1 homer scaffolding protein 1 0.0404659
TPM3 tropomyosin 3 0.0398378
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0398012
NABP1 nucleic acid binding protein 1 0.0394804
PDLIM5 PDZ and LIM domain 5 0.0392205
ELL2 elongation factor, RNA polymerase II, 2 0.0389281
MACF1 microtubule-actin crosslinking factor 1 0.0388129
NIPBL Nipped-B homolog (Drosophila) 0.0377677
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0375755
DOCK5 dedicator of cytokinesis 5 0.0375237
CCNL1 cyclin L1 0.037516
ZSWIM6 zinc finger, SWIM-type containing 6 0.0371421
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0370069
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0369216
SND1 staphylococcal nuclease and tudor domain containing 1 0.0368402
RBM39 RNA binding motif protein 39 0.0366237
ANO6 anoctamin 6 0.0361966
HSPA8 heat shock 70kDa protein 8 0.0358117
YBX3 Y box binding protein 3 0.0357627
WNK1 WNK lysine deficient protein kinase 1 0.035762
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0352663
GOLGB1 golgin B1 0.0350382
MORF4L2 mortality factor 4 like 2 0.034972
AHNAK AHNAK nucleoprotein 0.0348778
RRM2 ribonucleotide reductase M2 0.0346352
BZW1 basic leucine zipper and W2 domains 1 0.0345589
USP34 ubiquitin specific peptidase 34 0.0345042
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0341465
EXT1 exostosin glycosyltransferase 1 0.0337976
EEF2 eukaryotic translation elongation factor 2 0.0333021
CANX calnexin 0.0332282
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.032957
VMP1 vacuole membrane protein 1 0.0328006
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0320222
SPRED2 sprouty-related, EVH1 domain containing 2 0.0319445
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0318334
YAP1 Yes-associated protein 1 0.0316853
KTN1 kinectin 1 (kinesin receptor) 0.0313514
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.031149
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0304711
EIF4B eukaryotic translation initiation factor 4B 0.0304515
ATF6 activating transcription factor 6 0.0302793
SPAG9 sperm associated antigen 9 0.0301721
TLN1 talin 1 0.0301689
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0294946
CLTC clathrin, heavy chain (Hc) 0.0293593
AEBP2 AE binding protein 2 0.0290917
STK4 serine/threonine kinase 4 0.0290415
ZNF638 zinc finger protein 638 0.0286228
PUM1 pumilio RNA-binding family member 1 0.0283435
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0281251
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0280091
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0279554
ZFAND3 zinc finger, AN1-type domain 3 0.0272781
MYH9 myosin, heavy chain 9, non-muscle 0.0271467
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0271243
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0268278
SEC31A SEC31 homolog A (S. cerevisiae) 0.0267471
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0265627
WNT2B wingless-type MMTV integration site family, member 2B 0.0264301
GRAMD1B GRAM domain containing 1B 0.0259967
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0259609
WWTR1 WW domain containing transcription regulator 1 0.025716
R3HDM2 R3H domain containing 2 0.0255115
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0254569
ZFC3H1 zinc finger, C3H1-type containing 0.0253517
EXOC6B exocyst complex component 6B 0.0251603
CAMKMT calmodulin-lysine N-methyltransferase 0.0251228
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0250695
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0249663
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0246861
GON4L gon-4-like (C. elegans) 0.024365

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230672
TMSB10 thymosin beta 10 -0.0991059
PTMA prothymosin, alpha -0.0974022
RPL37A ribosomal protein L37a -0.0906899
RPL35A ribosomal protein L35a -0.0850179
RPS3 ribosomal protein S3 -0.0806432
RPS12 ribosomal protein S12 -0.0741516
RPS8 ribosomal protein S8 -0.0676628
RPS29 ribosomal protein S29 -0.0672452
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.066802
RPS27 ribosomal protein S27 -0.0646944
VIM vimentin -0.063413
RPLP2 ribosomal protein, large, P2 -0.059536
RPL26 ribosomal protein L26 -0.056245
TPT1 tumor protein, translationally-controlled 1 -0.0554344
RPS21 ribosomal protein S21 -0.0536396
RPS19 ribosomal protein S19 -0.0531659
RPL12 ribosomal protein L12 -0.048486
RPLP1 ribosomal protein, large, P1 -0.0480686
RPS27A ribosomal protein S27a -0.0451594
RPL37 ribosomal protein L37 -0.0451169
RPS15 ribosomal protein S15 -0.0450972
IFI6 interferon, alpha-inducible protein 6 -0.0443794
RPL11 ribosomal protein L11 -0.0443251
RPL23 ribosomal protein L23 -0.041476
TPI1 triosephosphate isomerase 1 -0.040874
RPL36 ribosomal protein L36 -0.0408518
RPS6 ribosomal protein S6 -0.0395557
MT2A metallothionein 2A -0.0391166
RPL28 ribosomal protein L28 -0.0390693
RPS25 ribosomal protein S25 -0.0387644
RPS24 ribosomal protein S24 -0.0379431
RPL36A ribosomal protein L36a -0.0372858
HLA-B major histocompatibility complex, class I, B -0.0365755
PFN1 profilin 1 -0.0350776
RPL8 ribosomal protein L8 -0.0348648
RPL31 ribosomal protein L31 -0.0344778
RPS17 ribosomal protein S17 -0.0344706
RPL38 ribosomal protein L38 -0.0342541
RPL34 ribosomal protein L34 -0.0334494
RPL9 ribosomal protein L9 -0.0330107
RPS10 ribosomal protein S10 -0.0320037
RPS13 ribosomal protein S13 -0.0317518
FDPS farnesyl diphosphate synthase -0.0315578
FTL ferritin, light polypeptide -0.0309841
RPL19 ribosomal protein L19 -0.0305904
S100A11 S100 calcium binding protein A11 -0.0293686
GNAS GNAS complex locus -0.0289096
NAP1L1 nucleosome assembly protein 1-like 1 -0.028073
RPL5 ribosomal protein L5 -0.0271715
EGR1 early growth response 1 -0.0271527
RPS23 ribosomal protein S23 -0.0270879
RPS14 ribosomal protein S14 -0.0270232
RPL7A ribosomal protein L7a -0.0268491
BASP1 brain abundant, membrane attached signal protein 1 -0.0265958
RPL35 ribosomal protein L35 -0.0261908
RPL27 ribosomal protein L27 -0.0259548
WSB1 WD repeat and SOCS box containing 1 -0.025471
TPM2 tropomyosin 2 (beta) -0.0250269
RPS16 ribosomal protein S16 -0.0249216
ATP5F1E ATP synthase F1 subunit epsilon -0.0249199
TFPI2 tissue factor pathway inhibitor 2 -0.0245238
RPL13A ribosomal protein L13a -0.0242488
EIF5B eukaryotic translation initiation factor 5B -0.0242273
HMGA1 high mobility group AT-hook 1 -0.0241986
YBX1 Y box binding protein 1 -0.0232701
RPLP0 ribosomal protein, large, P0 -0.0230927
IGF2 insulin-like growth factor 2 -0.0229531
CCND1 cyclin D1 -0.0228927
RPS20 ribosomal protein S20 -0.0226944
RPL32 ribosomal protein L32 -0.02253
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0223394
RACK1 receptor for activated C kinase 1 -0.0217895
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0216421
PKM pyruvate kinase, muscle -0.0216302
LDHB lactate dehydrogenase B -0.0213878
S100A10 S100 calcium binding protein A10 -0.0210664
ZMYND8 zinc finger, MYND-type containing 8 -0.0203422
TUBA1B tubulin, alpha 1b -0.0203276
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0203153
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0202202
IER3 immediate early response 3 -0.0201209
PTPRF protein tyrosine phosphatase, receptor type, F -0.0199838
TAGLN2 transgelin 2 -0.0199121
RPS11 ribosomal protein S11 -0.0192511
S100A9 S100 calcium binding protein A9 -0.0192174
LATS2 large tumor suppressor kinase 2 -0.0189155
ATP5F1B ATP synthase F1 subunit beta -0.018796
RPL15 ribosomal protein L15 -0.0184499
UBB ubiquitin B -0.0182929
NCOA7 nuclear receptor coactivator 7 -0.0180622
BSG basigin (Ok blood group) -0.0178315
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0176624
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0176343
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0176219
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0173834
HSPB1 heat shock 27kDa protein 1 -0.0173651
S100A6 S100 calcium binding protein A6 -0.0171986
HLA-A major histocompatibility complex, class I, A -0.0171762
MYL12B myosin, light chain 12B, regulatory -0.0171163