Tubulin inhibitor 6_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0973914
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0899098
HDAC9 histone deacetylase 9 0.0684193
JARID2 jumonji, AT rich interactive domain 2 0.0622208
VEGFA vascular endothelial growth factor A 0.0606455
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0593909
STC1 stanniocalcin 1 0.0582921
CXCL8 chemokine (C-X-C motif) ligand 8 0.0567372
ARRDC3 arrestin domain containing 3 0.0561086
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0560093
CEMIP cell migration inducing protein, hyaluronan binding 0.0550046
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0548953
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0534038
SMAD3 SMAD family member 3 0.0500265
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0491507
FAM20C family with sequence similarity 20, member C 0.048767
ZBTB38 zinc finger and BTB domain containing 38 0.0481871
GLS2 glutaminase 2 (liver, mitochondrial) 0.0481693
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0479288
EXT1 exostosin glycosyltransferase 1 0.0471839
ASPH aspartate beta-hydroxylase 0.0461008
CLIC4 chloride intracellular channel 4 0.0441885
FNIP1 folliculin interacting protein 1 0.0440714
ZSWIM6 zinc finger, SWIM-type containing 6 0.0438394
CD109 CD109 molecule 0.0414203
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.041197
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.041116
NAV2 neuron navigator 2 0.0404322
LPP LIM domain containing preferred translocation partner in lipoma 0.03929
RUNX1 runt-related transcription factor 1 0.0373827
IFI44L interferon-induced protein 44-like 0.0358556
MMP2 matrix metallopeptidase 2 0.0355533
TENT5A terminal nucleotidyltransferase 5A 0.0354482
SDC4 syndecan 4 0.0350235
DST dystonin 0.0348357
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0347796
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0346524
AHNAK AHNAK nucleoprotein 0.0342702
SOD2 superoxide dismutase 2, mitochondrial 0.03401
TRIO trio Rho guanine nucleotide exchange factor 0.0339281
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0330865
FNDC3B fibronectin type III domain containing 3B 0.0329956
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0324859
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0323404
SP100 SP100 nuclear antigen 0.0323367
APLP2 amyloid beta (A4) precursor-like protein 2 0.0321538
TRIP12 thyroid hormone receptor interactor 12 0.0317731
FAT1 FAT atypical cadherin 1 0.0312263
CAMTA1 calmodulin binding transcription activator 1 0.031002
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0307404
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0306693
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0297662
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0284689
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0284552
NRIP1 nuclear receptor interacting protein 1 0.028303
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0281932
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0281584
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0278114
FHIT fragile histidine triad 0.0275871
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.027022
B2M beta-2-microglobulin 0.0265602
SFPQ splicing factor proline/glutamine-rich 0.0258776
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0248467
ZC3H11A zinc finger CCCH-type containing 11A 0.0248466
GOLGB1 golgin B1 0.0247095
ZCCHC7 zinc finger, CCHC domain containing 7 0.0245684
PCBP3 poly(rC) binding protein 3 0.0245094
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0231273
HPCAL1 hippocalcin-like 1 0.0229684
EEF2 eukaryotic translation elongation factor 2 0.0229667
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.022934
USP34 ubiquitin specific peptidase 34 0.0229086
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0228268
PCBP2 poly(rC) binding protein 2 0.022666
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0226041
PTK2 protein tyrosine kinase 2 0.0225973
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0225922
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.02256
NAV1 neuron navigator 1 0.0224845
PDLIM5 PDZ and LIM domain 5 0.0221946
TOP1 topoisomerase (DNA) I 0.022001
OGA O-GlcNAcase 0.0219757
COL7A1 collagen, type VII, alpha 1 0.0219281
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0219248
HLA-E major histocompatibility complex, class I, E 0.0217646
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0217177
NPAS2 neuronal PAS domain protein 2 0.0216161
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0215762
COL5A1 collagen, type V, alpha 1 0.0215264
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0212526
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0211651
OSBPL8 oxysterol binding protein-like 8 0.0211272
MYH9 myosin, heavy chain 9, non-muscle 0.0209627
IQGAP1 IQ motif containing GTPase activating protein 1 0.0207444
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0207386
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0206509
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0205899
ANKRD10 ankyrin repeat domain 10 0.0204219
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0203966
AKAP9 A kinase (PRKA) anchor protein 9 0.0203311

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.286295
FN1 fibronectin 1 -0.284744
TMSB10 thymosin beta 10 -0.0956234
COL1A1 collagen, type I, alpha 1 -0.0953894
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0893622
MT2A metallothionein 2A -0.0882078
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0846334
FTL ferritin, light polypeptide -0.0735123
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0733826
NDRG1 N-myc downstream regulated 1 -0.0658293
FRMD4A FERM domain containing 4A -0.0640299
PTMA prothymosin, alpha -0.0585659
ZMYND8 zinc finger, MYND-type containing 8 -0.0433105
TPM1 tropomyosin 1 (alpha) -0.0418422
ZEB1 zinc finger E-box binding homeobox 1 -0.0391375
COL1A2 collagen, type I, alpha 2 -0.0391227
PGK1 phosphoglycerate kinase 1 -0.0373971
TPT1 tumor protein, translationally-controlled 1 -0.0366903
GNAS GNAS complex locus -0.0366182
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0346038
IFI6 interferon, alpha-inducible protein 6 -0.0343905
RPL35A ribosomal protein L35a -0.0336759
S100A6 S100 calcium binding protein A6 -0.0335239
RRBP1 ribosome binding protein 1 -0.0335133
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0290971
TFPI2 tissue factor pathway inhibitor 2 -0.0285398
S100A10 S100 calcium binding protein A10 -0.0283307
NRP1 neuropilin 1 -0.0280995
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0277719
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0274643
HLA-B major histocompatibility complex, class I, B -0.0273611
WSB1 WD repeat and SOCS box containing 1 -0.0271584
RPLP1 ribosomal protein, large, P1 -0.0270804
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0258406
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0258044
RPS19 ribosomal protein S19 -0.0255906
IFITM3 interferon induced transmembrane protein 3 -0.0253665
RPS21 ribosomal protein S21 -0.0250981
IER3 immediate early response 3 -0.0241118
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0241084
TGFBI transforming growth factor, beta-induced, 68kDa -0.0225865
CD44 CD44 molecule (Indian blood group) -0.0224922
PKM pyruvate kinase, muscle -0.0223098
IGFBP5 insulin-like growth factor binding protein 5 -0.0222724
MKI67 marker of proliferation Ki-67 -0.0222717
CENPF centromere protein F, 350/400kDa -0.0222332
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0221744
TPM4 tropomyosin 4 -0.0221637
RPL37A ribosomal protein L37a -0.0220194
RPLP2 ribosomal protein, large, P2 -0.021939
VCAN versican -0.0215163
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0214095
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0214048
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0211524
SEC61G Sec61 gamma subunit -0.0210548
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0209454
SMC4 structural maintenance of chromosomes 4 -0.0204801
BRWD3 bromodomain and WD repeat domain containing 3 -0.0204389
RPS6 ribosomal protein S6 -0.0202941
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0199483
CAVIN1 caveolae associated protein 1 -0.0197736
RPL36 ribosomal protein L36 -0.0197207
TNNC1 troponin C type 1 (slow) -0.0197171
RPS25 ribosomal protein S25 -0.0196137
SEPTIN7 septin 7 -0.0194098
PDE4D phosphodiesterase 4D, cAMP-specific -0.0193269
DIAPH3 diaphanous-related formin 3 -0.0190713
S100A9 S100 calcium binding protein A9 -0.0189509
CD63 CD63 molecule -0.0186118
S100A11 S100 calcium binding protein A11 -0.0185837
RPS29 ribosomal protein S29 -0.0185329
HLA-C major histocompatibility complex, class I, C -0.0184927
PDIA3 protein disulfide isomerase family A, member 3 -0.0183845
RPL34 ribosomal protein L34 -0.0182624
EHD2 EH-domain containing 2 -0.0182305
PTPRF protein tyrosine phosphatase, receptor type, F -0.0180643
CALD1 caldesmon 1 -0.018042
RPS27A ribosomal protein S27a -0.0179972
SERF2 small EDRK-rich factor 2 -0.0179348
NREP neuronal regeneration related protein -0.0178619
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0174535
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0172558
DNAAF9 dynein axonemal assembly factor 9 -0.0172004
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0170895
TPX2 TPX2, microtubule-associated -0.0170802
RPL31 ribosomal protein L31 -0.0170704
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0170574
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0168961
COL6A1 collagen, type VI, alpha 1 -0.0168813
TUBB tubulin, beta class I -0.0167984
MAML2 mastermind-like 2 (Drosophila) -0.0167538
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0167289
RPL28 ribosomal protein L28 -0.0166486
FAM162A family with sequence similarity 162, member A -0.0166335
MEF2A myocyte enhancer factor 2A -0.0164725
PFN1 profilin 1 -0.0164367
TAGLN2 transgelin 2 -0.01633
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0161302
CENPE centromere protein E, 312kDa -0.0158231
CTSD cathepsin D -0.0157205