Tubulin inhibitor 6_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.168109
SNAP25 synaptosomal-associated protein, 25kDa 0.165441
MCL1 myeloid cell leukemia 1 0.10764
STC1 stanniocalcin 1 0.106088
SMOC1 SPARC related modular calcium binding 1 0.100238
GPC6 glypican 6 0.0928935
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0860946
INHBA inhibin, beta A 0.0821472
ACTG1 actin gamma 1 0.0810647
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.079957
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0645991
FNDC3A fibronectin type III domain containing 3A 0.0643462
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0601687
MYH9 myosin, heavy chain 9, non-muscle 0.0592711
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0582078
RORA RAR-related orphan receptor A 0.0576607
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0575726
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0555988
HOMER1 homer scaffolding protein 1 0.0537431
NBEA neurobeachin 0.0526807
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0503086
LCOR ligand dependent nuclear receptor corepressor 0.0501069
NRG1 neuregulin 1 0.0494205
DOCK5 dedicator of cytokinesis 5 0.0491476
CPE carboxypeptidase E 0.0486094
TENT5A terminal nucleotidyltransferase 5A 0.0474442
EFNA5 ephrin-A5 0.0471304
ST18 suppression of tumorigenicity 18, zinc finger 0.04535
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0442957
CNKSR3 CNKSR family member 3 0.0440206
VGF VGF nerve growth factor inducible 0.0437534
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0431293
ZSWIM6 zinc finger, SWIM-type containing 6 0.0429666
DGKD diacylglycerol kinase, delta 130kDa 0.0427544
ASPH aspartate beta-hydroxylase 0.0424059
ZFHX3 zinc finger homeobox 3 0.0410052
GRB10 growth factor receptor-bound protein 10 0.0403056
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0392024
ENO1 enolase 1, (alpha) 0.0388413
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0377685
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0374469
SVIL supervillin 0.0360848
ARFGEF3 ARFGEF family member 3 0.0360772
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0360079
SETX senataxin 0.0358441
SCG2 secretogranin II 0.0358265
CHGB chromogranin B 0.0357274
ANKH ANKH inorganic pyrophosphate transport regulator 0.0357051
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0354107
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0352663
RPH3AL rabphilin 3A-like (without C2 domains) 0.0341034
KIF26B kinesin family member 26B 0.0340495
AUTS2 autism susceptibility candidate 2 0.0340488
RERE arginine-glutamic acid dipeptide (RE) repeats 0.033942
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0338416
ERRFI1 ERBB receptor feedback inhibitor 1 0.033512
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0332538
ELL2 elongation factor, RNA polymerase II, 2 0.0332145
DENND4A DENN/MADD domain containing 4A 0.0331505
GMDS GDP-mannose 4,6-dehydratase 0.0331037
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0330282
BACE2 beta-site APP-cleaving enzyme 2 0.0326425
MCTP1 multiple C2 domains, transmembrane 1 0.032396
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.0321877
FAM13A family with sequence similarity 13, member A 0.0321371
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0316763
EYA2 EYA transcriptional coactivator and phosphatase 2 0.03137
COL22A1 collagen, type XXII, alpha 1 0.0312907
SDK1 sidekick cell adhesion molecule 1 0.0312505
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0312152
BIRC6 baculoviral IAP repeat containing 6 0.0310238
ARHGAP26 Rho GTPase activating protein 26 0.030114
TOP1 topoisomerase (DNA) I 0.0300373
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0295135
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0291294
ASIC2 acid sensing (proton gated) ion channel 2 0.0290853
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0290743
SCFD1 sec1 family domain containing 1 0.0289012
NAV2 neuron navigator 2 0.0288659
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0287206
BZW1 basic leucine zipper and W2 domains 1 0.0281056
SEC31A SEC31 homolog A (S. cerevisiae) 0.0278046
NCKAP5 NCK-associated protein 5 0.0278027
AGO2 argonaute RISC catalytic component 2 0.0276214
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0275612
NIPBL Nipped-B homolog (Drosophila) 0.0271474
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 0.0270819
SIK2 salt-inducible kinase 2 0.0269422
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0264128
RGS7 regulator of G-protein signaling 7 0.026399
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0263534
TRIO trio Rho guanine nucleotide exchange factor 0.0259513
AGO3 argonaute RISC catalytic component 3 0.0259322
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0258425
NANOS1 nanos homolog 1 (Drosophila) 0.0257911
ANKRD17 ankyrin repeat domain 17 0.025768
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0256592
NF1 neurofibromin 1 0.0255275
TSPYL2 TSPY-like 2 0.0254196
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0253041

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.167276
CENPF centromere protein F, 350/400kDa -0.0701596
RPS3 ribosomal protein S3 -0.0643385
TOP2A topoisomerase (DNA) II alpha 170kDa -0.059545
CALCA calcitonin-related polypeptide alpha -0.0574621
FTL ferritin, light polypeptide -0.0512222
RPS8 ribosomal protein S8 -0.0499681
RPS21 ribosomal protein S21 -0.0490228
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0479172
RPL37A ribosomal protein L37a -0.047511
RPL26 ribosomal protein L26 -0.0473362
TENM1 teneurin transmembrane protein 1 -0.0470527
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0445238
RPL35A ribosomal protein L35a -0.0381607
ADGRL2 adhesion G protein-coupled receptor L2 -0.036199
RPS29 ribosomal protein S29 -0.0342331
RPS12 ribosomal protein S12 -0.033798
RPS27A ribosomal protein S27a -0.0336119
RPL38 ribosomal protein L38 -0.0335257
RPL12 ribosomal protein L12 -0.0334226
TPT1 tumor protein, translationally-controlled 1 -0.0329099
RPS27 ribosomal protein S27 -0.0324309
RPS6 ribosomal protein S6 -0.0317708
RPS25 ribosomal protein S25 -0.0310427
RPL37 ribosomal protein L37 -0.0304125
GNAS GNAS complex locus -0.0295015
WSB1 WD repeat and SOCS box containing 1 -0.0293727
RPLP1 ribosomal protein, large, P1 -0.0292181
RPL36 ribosomal protein L36 -0.0292058
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0290006
NIPSNAP2 nipsnap homolog 2 -0.0277733
STMN1 stathmin 1 -0.0276262
RPL11 ribosomal protein L11 -0.0269325
RPS23 ribosomal protein S23 -0.0263141
TUBB4B tubulin, beta 4B class IVb -0.0261275
RPS16 ribosomal protein S16 -0.0259733
RPL23 ribosomal protein L23 -0.0258253
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0254401
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0254266
RPS17 ribosomal protein S17 -0.0253773
RPL30 ribosomal protein L30 -0.0253413
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0252116
IFI6 interferon, alpha-inducible protein 6 -0.0250541
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0249932
RPL34 ribosomal protein L34 -0.0247368
COX6C cytochrome c oxidase subunit VIc -0.0241741
S100A9 S100 calcium binding protein A9 -0.0241065
SASH1 SAM and SH3 domain containing 1 -0.0237214
ATP5F1E ATP synthase F1 subunit epsilon -0.0235867
RPL8 ribosomal protein L8 -0.0235737
RPLP2 ribosomal protein, large, P2 -0.0233656
UBB ubiquitin B -0.0228048
TUBA1B tubulin, alpha 1b -0.0227357
TUBB tubulin, beta class I -0.0227066
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0225752
MT2A metallothionein 2A -0.0224262
PEG10 paternally expressed 10 -0.0224116
SMC4 structural maintenance of chromosomes 4 -0.0223463
RPL36A ribosomal protein L36a -0.02194
ISG15 ISG15 ubiquitin-like modifier -0.0218135
RPS11 ribosomal protein S11 -0.0217195
RPS24 ribosomal protein S24 -0.0215786
RPL35 ribosomal protein L35 -0.0215507
NUF2 NUF2, NDC80 kinetochore complex component -0.0209041
RPS14 ribosomal protein S14 -0.02085
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0208471
SINHCAF SIN3-HDAC complex associated factor -0.0207648
RPL7A ribosomal protein L7a -0.0206553
YBX1 Y box binding protein 1 -0.0202249
GSTP1 glutathione S-transferase pi 1 -0.0199445
MIS18BP1 MIS18 binding protein 1 -0.0199319
AGMO alkylglycerol monooxygenase -0.0196001
EIF5B eukaryotic translation initiation factor 5B -0.0193645
TXNIP thioredoxin interacting protein -0.0189872
HMGB2 high mobility group box 2 -0.0187347
DNAH5 dynein, axonemal, heavy chain 5 -0.0187062
RPL19 ribosomal protein L19 -0.0186793
RAD51B RAD51 paralog B -0.0186175
FOXC1 forkhead box C1 -0.0183679
HMGB1 high mobility group box 1 -0.0183525
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0183044
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0181579
TXNRD1 thioredoxin reductase 1 -0.0177017
KNL1 kinetochore scaffold 1 -0.0176574
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0175901
H1-0 H1.0 linker histone -0.0174479
FAM162A family with sequence similarity 162, member A -0.0173439
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0172394
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0170986
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.016947
CDCA2 cell division cycle associated 2 -0.016913
RPL36AL ribosomal protein L36a-like -0.0167029
RPS19 ribosomal protein S19 -0.0166115
EXOC1 exocyst complex component 1 -0.0164934
RPS5 ribosomal protein S5 -0.0163855
TPR translocated promoter region, nuclear basket protein -0.0163727
SYT1 synaptotagmin I -0.0162546
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0158509
RPL7 ribosomal protein L7 -0.0158345
RPLP0 ribosomal protein, large, P0 -0.0157898