Tubulin inhibitor 6_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.19361
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.145007
LINGO2 leucine rich repeat and Ig domain containing 2 0.105456
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0812431
AKAP12 A kinase (PRKA) anchor protein 12 0.0740544
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0728887
ATXN1 ataxin 1 0.0701939
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0685717
HDAC9 histone deacetylase 9 0.066377
FNDC3B fibronectin type III domain containing 3B 0.0627693
DST dystonin 0.0624974
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0570432
SFTPA2 surfactant protein A2 0.0568178
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0553865
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0550643
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0544885
TPM3 tropomyosin 3 0.054232
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0539272
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0533334
ANGPTL4 angiopoietin-like 4 0.0531575
RUNX1 runt-related transcription factor 1 0.049218
DSCAM Down syndrome cell adhesion molecule 0.0489318
MSN moesin 0.048523
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0485012
NOTCH2 notch 2 0.0480978
CLIC4 chloride intracellular channel 4 0.0453206
LPP LIM domain containing preferred translocation partner in lipoma 0.0452884
ASPH aspartate beta-hydroxylase 0.045084
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0450601
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0439545
SEPTIN9 septin 9 0.0432283
OGA O-GlcNAcase 0.04194
OPHN1 oligophrenin 1 0.0416958
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.041532
EP300 E1A binding protein p300 0.0414385
AFF4 AF4/FMR2 family, member 4 0.0409061
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0408248
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0406709
ENO1 enolase 1, (alpha) 0.0403688
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0402649
GOLGB1 golgin B1 0.0401489
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0401051
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0399829
WWTR1 WW domain containing transcription regulator 1 0.0399738
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0398002
TXNRD1 thioredoxin reductase 1 0.0395585
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0392164
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0388025
MYH9 myosin, heavy chain 9, non-muscle 0.0382728
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0380611
ANKRD28 ankyrin repeat domain 28 0.0374623
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0373451
SH3KBP1 SH3-domain kinase binding protein 1 0.0373193
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0372952
CTTN cortactin 0.0366994
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0366295
IGF1R insulin-like growth factor 1 receptor 0.0362617
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0354007
PTPRM protein tyrosine phosphatase, receptor type, M 0.0351058
AKAP13 A kinase (PRKA) anchor protein 13 0.0347158
EPS8 epidermal growth factor receptor pathway substrate 8 0.0346113
DIAPH1 diaphanous-related formin 1 0.0343565
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0342939
PCBP2 poly(rC) binding protein 2 0.0342435
FRMD5 FERM domain containing 5 0.0342359
KDM4C lysine (K)-specific demethylase 4C 0.0340149
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.033935
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0332955
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0331611
MED13L mediator complex subunit 13-like 0.033114
SFPQ splicing factor proline/glutamine-rich 0.0329891
TRIP12 thyroid hormone receptor interactor 12 0.0327633
EMP1 epithelial membrane protein 1 0.0326019
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0322174
AHNAK AHNAK nucleoprotein 0.0321579
RAD51B RAD51 paralog B 0.0320246
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0319264
FER fer (fps/fes related) tyrosine kinase 0.031843
EXOC6B exocyst complex component 6B 0.0317912
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0316713
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.031006
NAV1 neuron navigator 1 0.0305455
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0302836
MACROD2 MACRO domain containing 2 0.0297941
MATR3 matrin 3 0.0297234
COMMD10 COMM domain containing 10 0.029573
RASAL2 RAS protein activator like 2 0.0295555
MACF1 microtubule-actin crosslinking factor 1 0.0293218
AMOTL1 angiomotin like 1 0.0291935
ZBTB20 zinc finger and BTB domain containing 20 0.0290237
RABGAP1L RAB GTPase activating protein 1-like 0.0290039
ACTN1 actinin, alpha 1 0.0289879
MED13 mediator complex subunit 13 0.0287853
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.0284517
IFI44L interferon-induced protein 44-like 0.0282675
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0282319
VMP1 vacuole membrane protein 1 0.0281377
ERBIN erbb2 interacting protein 0.0281165
RNF213 ring finger protein 213 0.0278677
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0278324

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119914
FN1 fibronectin 1 -0.103789
RPS3 ribosomal protein S3 -0.0921463
MT2A metallothionein 2A -0.0876811
RPL35A ribosomal protein L35a -0.0871207
LSAMP limbic system-associated membrane protein -0.0739383
VIM vimentin -0.0710051
RPL37A ribosomal protein L37a -0.0651622
PTMA prothymosin, alpha -0.0606715
RPLP2 ribosomal protein, large, P2 -0.0603309
RPS12 ribosomal protein S12 -0.059581
FTL ferritin, light polypeptide -0.0584927
RPS27A ribosomal protein S27a -0.0584233
RPLP1 ribosomal protein, large, P1 -0.053796
TPT1 tumor protein, translationally-controlled 1 -0.0491397
RPS13 ribosomal protein S13 -0.0467492
RPS6 ribosomal protein S6 -0.0460826
RPS8 ribosomal protein S8 -0.0459639
RPL12 ribosomal protein L12 -0.0450324
RPS29 ribosomal protein S29 -0.0441962
TNNC1 troponin C type 1 (slow) -0.0435909
RPL34 ribosomal protein L34 -0.0416214
RPL23 ribosomal protein L23 -0.0416063
RPS23 ribosomal protein S23 -0.0410377
NRG3 neuregulin 3 -0.0390874
RPL31 ribosomal protein L31 -0.0385555
RPS16 ribosomal protein S16 -0.0369271
RPS24 ribosomal protein S24 -0.0358758
RPS25 ribosomal protein S25 -0.034936
SREBF2 sterol regulatory element binding transcription factor 2 -0.0344404
RPL36 ribosomal protein L36 -0.0338888
RACK1 receptor for activated C kinase 1 -0.0328535
RPS19 ribosomal protein S19 -0.03232
RPL28 ribosomal protein L28 -0.0322498
RPS21 ribosomal protein S21 -0.0311257
TMSB10 thymosin beta 10 -0.0309282
VDAC1 voltage-dependent anion channel 1 -0.0304905
GSTO1 glutathione S-transferase omega 1 -0.0302306
RPS20 ribosomal protein S20 -0.0291081
RPLP0 ribosomal protein, large, P0 -0.0284201
PMEL premelanosome protein -0.0283831
RPS27 ribosomal protein S27 -0.0280994
RPL19 ribosomal protein L19 -0.0278169
RPL9 ribosomal protein L9 -0.0273937
NAP1L1 nucleosome assembly protein 1-like 1 -0.0270929
RPL38 ribosomal protein L38 -0.0265645
RPL32 ribosomal protein L32 -0.0262303
ICAM1 intercellular adhesion molecule 1 -0.0260924
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0260491
RPL7A ribosomal protein L7a -0.0260251
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0258814
RPS17 ribosomal protein S17 -0.025389
RPS15 ribosomal protein S15 -0.0241437
SLC38A1 solute carrier family 38, member 1 -0.024002
EIF1 eukaryotic translation initiation factor 1 -0.0238693
RPL36A ribosomal protein L36a -0.0230563
RPS14 ribosomal protein S14 -0.0226976
WSB1 WD repeat and SOCS box containing 1 -0.0222899
RPL11 ribosomal protein L11 -0.0219182
RPL27A ribosomal protein L27a -0.021854
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.021762
S100A9 S100 calcium binding protein A9 -0.0217226
CTSD cathepsin D -0.0213429
RPL30 ribosomal protein L30 -0.0212045
TFRC transferrin receptor -0.021178
FTH1 ferritin, heavy polypeptide 1 -0.0209691
RPL13A ribosomal protein L13a -0.0207937
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0205432
HMGA1 high mobility group AT-hook 1 -0.0204099
RPL8 ribosomal protein L8 -0.0200677
UBB ubiquitin B -0.019949
LITAF lipopolysaccharide-induced TNF factor -0.0188327
RPL35 ribosomal protein L35 -0.0187608
HSPB1 heat shock 27kDa protein 1 -0.0186036
RPS11 ribosomal protein S11 -0.0185082
KAZN kazrin, periplakin interacting protein -0.0184173
CSTB cystatin B (stefin B) -0.0182532
RPS10 ribosomal protein S10 -0.0180529
IFITM3 interferon induced transmembrane protein 3 -0.0178537
TUBB4B tubulin, beta 4B class IVb -0.0176047
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.01753
RPS2 ribosomal protein S2 -0.0173738
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0171561
RPL27 ribosomal protein L27 -0.017092
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0169916
DDTL D-dopachrome tautomerase-like -0.0169554
NACA nascent polypeptide-associated complex alpha subunit -0.0168982
TUBB tubulin, beta class I -0.0165158
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.016456
RPL26 ribosomal protein L26 -0.0162606
RPL37 ribosomal protein L37 -0.0161539
TENM1 teneurin transmembrane protein 1 -0.0156557
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0155608
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0154495
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0153159
KIF4A kinesin family member 4A -0.0151674
PRELID1 PRELI domain containing 1 -0.0149912
YBX1 Y box binding protein 1 -0.0148407
PRAME preferentially expressed antigen in melanoma -0.0148126
SERF2 small EDRK-rich factor 2 -0.0147178