Tubulin inhibitor 6_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.094513
POTEF POTE ankyrin domain family, member F 0.0850193
PDE4D phosphodiesterase 4D, cAMP-specific 0.0790719
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0745951
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0700547
ANXA1 annexin A1 0.0671687
PCBP2 poly(rC) binding protein 2 0.0611558
ZNF608 zinc finger protein 608 0.0555829
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0538298
KMT2E lysine (K)-specific methyltransferase 2E 0.0523206
ZEB1 zinc finger E-box binding homeobox 1 0.0512803
EIF4A2 eukaryotic translation initiation factor 4A2 0.0512607
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0505627
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0449917
MYOF myoferlin 0.0438316
PDE4B phosphodiesterase 4B, cAMP-specific 0.0436087
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0415288
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0397232
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0386684
SOX6 SRY (sex determining region Y)-box 6 0.0379843
SSBP2 single-stranded DNA binding protein 2 0.0374088
FER1L6 fer-1-like family member 6 0.0371328
WAC WW domain containing adaptor with coiled-coil 0.0360902
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0354374
TACC2 transforming, acidic coiled-coil containing protein 2 0.0351693
DSCAM Down syndrome cell adhesion molecule 0.0344418
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0335197
PDGFC platelet derived growth factor C 0.033518
ECT2 epithelial cell transforming 2 0.0333737
YAP1 Yes-associated protein 1 0.0330725
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.032503
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.032435
APLP2 amyloid beta (A4) precursor-like protein 2 0.0312144
TPM3 tropomyosin 3 0.0304922
FAM91A1 family with sequence similarity 91, member A1 0.0302544
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0302491
VMP1 vacuole membrane protein 1 0.0302149
EPS8 epidermal growth factor receptor pathway substrate 8 0.0300219
INTS6 integrator complex subunit 6 0.0297076
TSC22D1 TSC22 domain family, member 1 0.0295848
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0283646
ACTG1 actin gamma 1 0.0281775
FXR1 fragile X mental retardation, autosomal homolog 1 0.0281717
ZSWIM6 zinc finger, SWIM-type containing 6 0.0277267
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0275013
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0274246
AHCYL2 adenosylhomocysteinase-like 2 0.027412
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0273618
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0271893
EML4 echinoderm microtubule associated protein like 4 0.0270904
AEBP2 AE binding protein 2 0.0268002
DIAPH1 diaphanous-related formin 1 0.0266455
WNK1 WNK lysine deficient protein kinase 1 0.0265902
EZR ezrin 0.0265252
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0261706
RPS12 ribosomal protein S12 0.0261581
KMT2C lysine (K)-specific methyltransferase 2C 0.0261426
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0255671
ENO1 enolase 1, (alpha) 0.025477
HSPA8 heat shock 70kDa protein 8 0.0254396
RRM2 ribonucleotide reductase M2 0.0254
RCOR1 REST corepressor 1 0.0252457
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0252018
FAM168A family with sequence similarity 168, member A 0.0251593
USP47 ubiquitin specific peptidase 47 0.025157
CORO1C coronin, actin binding protein, 1C 0.0250459
MACROD2 MACRO domain containing 2 0.0248964
BRD2 bromodomain containing 2 0.0247519
N4BP2L2 NEDD4 binding protein 2-like 2 0.0246564
ZFAND3 zinc finger, AN1-type domain 3 0.0245514
MLIP muscular LMNA-interacting protein 0.0245386
RBM5 RNA binding motif protein 5 0.0239959
CRY1 cryptochrome circadian clock 1 0.0239907
SOX9 SRY (sex determining region Y)-box 9 0.0239253
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0237027
SGMS2 sphingomyelin synthase 2 0.0236251
ATOSA atos homolog A 0.0232711
CCNL1 cyclin L1 0.0230061
CCNY cyclin Y 0.0229489
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0226548
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0223257
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0222527
B2M beta-2-microglobulin 0.0211137
FNIP1 folliculin interacting protein 1 0.0209327
VEGFA vascular endothelial growth factor A 0.0208753
SFPQ splicing factor proline/glutamine-rich 0.0207695
GPBP1 GC-rich promoter binding protein 1 0.0206184
HDGF hepatoma-derived growth factor 0.0204369
SEPTIN9 septin 9 0.0203805
PLK2 polo-like kinase 2 0.0203783
RPL3 ribosomal protein L3 0.0203193
ANLN anillin, actin binding protein 0.0203142
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0202674
UBC ubiquitin C 0.0202081
PUM1 pumilio RNA-binding family member 1 0.020143
PICALM phosphatidylinositol binding clathrin assembly protein 0.0199834
KIF5C kinesin family member 5C 0.0199273
JMJD1C jumonji domain containing 1C 0.0198469
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0197826
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0191808

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181464
PTMA prothymosin, alpha -0.151856
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132408
TPT1 tumor protein, translationally-controlled 1 -0.11794
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.105924
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0995091
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0893856
TXNRD1 thioredoxin reductase 1 -0.0884425
FLNB filamin B, beta -0.087992
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0843724
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0838882
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0807427
TMSB4X thymosin beta 4, X-linked -0.0787167
NBEA neurobeachin -0.070522
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.070313
RPL34 ribosomal protein L34 -0.066598
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.063427
S100A6 S100 calcium binding protein A6 -0.0630517
BMP10 bone morphogenetic protein 10 -0.0626806
RPS24 ribosomal protein S24 -0.0612482
RPLP0 ribosomal protein, large, P0 -0.0586796
CCND1 cyclin D1 -0.0577974
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0573636
RPLP1 ribosomal protein, large, P1 -0.0557364
RPS23 ribosomal protein S23 -0.0556753
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0556077
RPL11 ribosomal protein L11 -0.0554373
RPL35A ribosomal protein L35a -0.0553235
DLG1 discs, large homolog 1 (Drosophila) -0.0528401
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0507812
OSMR oncostatin M receptor -0.0507409
PYGB phosphorylase, glycogen; brain -0.0503333
S100A4 S100 calcium binding protein A4 -0.0501448
RPS21 ribosomal protein S21 -0.0499887
NF1 neurofibromin 1 -0.0497377
NFIA nuclear factor I/A -0.0479025
GOLGA4 golgin A4 -0.0469693
GNAS GNAS complex locus -0.0468512
SMYD3 SET and MYND domain containing 3 -0.0448716
RPL12 ribosomal protein L12 -0.0441327
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.043747
CAMKMT calmodulin-lysine N-methyltransferase -0.043509
RPL32 ribosomal protein L32 -0.0416069
ZBTB20 zinc finger and BTB domain containing 20 -0.0412666
EXOC6B exocyst complex component 6B -0.0397014
RPL31 ribosomal protein L31 -0.0396934
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0373507
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0370917
S100A10 S100 calcium binding protein A10 -0.0354672
ENOSF1 enolase superfamily member 1 -0.0353918
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0353826
ADNP activity-dependent neuroprotector homeobox -0.0353794
RPL26 ribosomal protein L26 -0.0353288
RPS6 ribosomal protein S6 -0.0351609
RPS19 ribosomal protein S19 -0.0349104
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0343418
ANK2 ankyrin 2, neuronal -0.0339703
EFNA5 ephrin-A5 -0.0338925
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0338741
SLC38A2 solute carrier family 38, member 2 -0.0337942
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.033657
NAP1L1 nucleosome assembly protein 1-like 1 -0.0334369
MYL12B myosin, light chain 12B, regulatory -0.0334285
SPRY4 sprouty homolog 4 (Drosophila) -0.0333706
TMSB10 thymosin beta 10 -0.0332664
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.033244
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0330825
RHBDD1 rhomboid domain containing 1 -0.03184
PNISR PNN-interacting serine/arginine-rich protein -0.0316448
METTL15 methyltransferase like 15 -0.0312645
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0311698
RTN4 reticulon 4 -0.0310146
TMEM263 transmembrane protein 263 -0.0309006
SBF2 SET binding factor 2 -0.0305489
NEBL nebulette -0.0303378
RRBP1 ribosome binding protein 1 -0.0301834
TBC1D22A TBC1 domain family, member 22A -0.0300019
RPL13A ribosomal protein L13a -0.0297496
RPS27A ribosomal protein S27a -0.0297002
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0291529
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.028821
PGK1 phosphoglycerate kinase 1 -0.0287126
FKBP10 FK506 binding protein 10, 65 kDa -0.0285131
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0278586
ARL4C ADP-ribosylation factor-like 4C -0.0278437
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0277878
RPL9 ribosomal protein L9 -0.0275226
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0272855
DIAPH2 diaphanous-related formin 2 -0.0272591
SREBF2 sterol regulatory element binding transcription factor 2 -0.0269778
ACBD6 acyl-CoA binding domain containing 6 -0.026793
RPL27A ribosomal protein L27a -0.0262692
HJURP Holliday junction recognition protein -0.0261688
DGKH diacylglycerol kinase, eta -0.0254736
MAP4 microtubule-associated protein 4 -0.0252468
VCL vinculin -0.0250639
RPL5 ribosomal protein L5 -0.0250309
GPHN gephyrin -0.0249209
EHBP1 EH domain binding protein 1 -0.0248863
TTC28 tetratricopeptide repeat domain 28 -0.0248859