Tubulin inhibitor 6_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.188665
JARID2 jumonji, AT rich interactive domain 2 0.111039
MYO10 myosin X 0.110135
FN1 fibronectin 1 0.106767
MYH9 myosin, heavy chain 9, non-muscle 0.0989016
HMGA2 high mobility group AT-hook 2 0.0834218
RUNX1 runt-related transcription factor 1 0.0769683
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0765916
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0752213
ELL2 elongation factor, RNA polymerase II, 2 0.0721867
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0719894
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.071509
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0712515
CD44 CD44 molecule (Indian blood group) 0.0707613
ACTG1 actin gamma 1 0.0683978
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0679969
FNDC3A fibronectin type III domain containing 3A 0.064263
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0628815
SOD2 superoxide dismutase 2, mitochondrial 0.0609349
FNDC3B fibronectin type III domain containing 3B 0.0603319
TRIO trio Rho guanine nucleotide exchange factor 0.059066
FMNL2 formin-like 2 0.0590172
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0584313
SPAG9 sperm associated antigen 9 0.0580691
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0569094
INHBA inhibin, beta A 0.0550583
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0539116
ZSWIM6 zinc finger, SWIM-type containing 6 0.0535355
FAM13A family with sequence similarity 13, member A 0.0534616
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0507798
AKAP12 A kinase (PRKA) anchor protein 12 0.0502766
PCBP2 poly(rC) binding protein 2 0.0501547
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0491053
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0489981
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0480885
NAV2 neuron navigator 2 0.0469404
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0467332
CXCL8 chemokine (C-X-C motif) ligand 8 0.0458944
NOTCH2 notch 2 0.0455144
NAV1 neuron navigator 1 0.0450105
RASA2 RAS p21 protein activator 2 0.0444862
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0438867
EEF2 eukaryotic translation elongation factor 2 0.0434607
EXT1 exostosin glycosyltransferase 1 0.0434199
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0428847
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0414882
ATP13A3 ATPase type 13A3 0.0413468
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0408935
DST dystonin 0.039547
LOX lysyl oxidase 0.0388116
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0362827
VEGFA vascular endothelial growth factor A 0.0362174
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0360666
UBA6 ubiquitin-like modifier activating enzyme 6 0.0357561
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.035655
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0355164
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0353456
OGA O-GlcNAcase 0.0350914
LDHA lactate dehydrogenase A 0.0348283
ARRDC3 arrestin domain containing 3 0.0345913
MSN moesin 0.0341166
ZNF292 zinc finger protein 292 0.0340871
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0339768
PRELID2 PRELI domain containing 2 0.0339352
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0332224
SETD5 SET domain containing 5 0.0326104
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0325143
TTC3 tetratricopeptide repeat domain 3 0.0320358
MCL1 myeloid cell leukemia 1 0.031962
ASPH aspartate beta-hydroxylase 0.0317824
TPM3 tropomyosin 3 0.0317017
COL4A1 collagen, type IV, alpha 1 0.0315538
SEPTIN9 septin 9 0.0314439
APP amyloid beta (A4) precursor protein 0.0313723
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0311692
DSCAM Down syndrome cell adhesion molecule 0.0309592
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0308627
PICALM phosphatidylinositol binding clathrin assembly protein 0.030366
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0299045
STC2 stanniocalcin 2 0.0298013
ZNF638 zinc finger protein 638 0.0294777
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0293444
SNX9 sorting nexin 9 0.0292609
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.028405
NAMPT nicotinamide phosphoribosyltransferase 0.0281969
ZBTB38 zinc finger and BTB domain containing 38 0.0279566
SEC24D SEC24 family member D 0.0278401
COPA coatomer protein complex, subunit alpha 0.0277141
HDAC9 histone deacetylase 9 0.0265298
CALU calumenin 0.0258269
LIMS1 LIM and senescent cell antigen-like domains 1 0.0256515
SAMD4A sterile alpha motif domain containing 4A 0.0253883
GOLGB1 golgin B1 0.0250569
B2M beta-2-microglobulin 0.0250553
GOLGA4 golgin A4 0.0250166
EIF4A2 eukaryotic translation initiation factor 4A2 0.0246127
ANKRD12 ankyrin repeat domain 12 0.0245346
AKAP9 A kinase (PRKA) anchor protein 9 0.0244236
KDM4C lysine (K)-specific demethylase 4C 0.0243686
SMAD3 SMAD family member 3 0.024342

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.158479
PRKG1 protein kinase, cGMP-dependent, type I -0.143279
COL1A1 collagen, type I, alpha 1 -0.132471
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.119808
NALF1 NALCN channel auxiliary factor 1 -0.0983394
TPT1 tumor protein, translationally-controlled 1 -0.0977437
TMSB10 thymosin beta 10 -0.0864399
OXR1 oxidation resistance 1 -0.0835393
ADGRB3 adhesion G protein-coupled receptor B3 -0.0785715
CDH13 cadherin 13 -0.0563873
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.05458
TFPI2 tissue factor pathway inhibitor 2 -0.0531312
RPL35A ribosomal protein L35a -0.0485076
ABI3BP ABI family, member 3 (NESH) binding protein -0.0472671
PRSS23 protease, serine, 23 -0.0441914
PTMA prothymosin, alpha -0.0440473
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0425115
RPS24 ribosomal protein S24 -0.0397788
RPL37A ribosomal protein L37a -0.0397324
PRRX1 paired related homeobox 1 -0.0387926
IGF2 insulin-like growth factor 2 -0.0385068
KIAA1549L KIAA1549-like -0.0370508
RPL34 ribosomal protein L34 -0.0366278
CAVIN1 caveolae associated protein 1 -0.0365956
FTL ferritin, light polypeptide -0.0347896
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0331298
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0328685
RPS13 ribosomal protein S13 -0.0314558
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0313388
NCKAP5 NCK-associated protein 5 -0.0311851
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0307086
CCDC102B coiled-coil domain containing 102B -0.0304222
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0298315
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0294439
RPS8 ribosomal protein S8 -0.029085
RPLP2 ribosomal protein, large, P2 -0.0288321
DLC1 DLC1 Rho GTPase activating protein -0.0280388
HLA-B major histocompatibility complex, class I, B -0.0273008
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0272752
SAMD3 sterile alpha motif domain containing 3 -0.0270192
RPS25 ribosomal protein S25 -0.0268788
CAV1 caveolin 1, caveolae protein, 22kDa -0.0268553
RPL9 ribosomal protein L9 -0.0267495
RPS19 ribosomal protein S19 -0.0265846
WSB1 WD repeat and SOCS box containing 1 -0.026552
RPLP1 ribosomal protein, large, P1 -0.026493
RPS3 ribosomal protein S3 -0.0264489
RPL28 ribosomal protein L28 -0.0258331
RPS12 ribosomal protein S12 -0.0250433
PDE4D phosphodiesterase 4D, cAMP-specific -0.0249747
RPL12 ribosomal protein L12 -0.0248181
ZEB1 zinc finger E-box binding homeobox 1 -0.0246356
RPS27A ribosomal protein S27a -0.0245411
EMP1 epithelial membrane protein 1 -0.0242822
S100A6 S100 calcium binding protein A6 -0.0240584
TCEAL9 transcription elongation factor A like 9 -0.0239208
DIAPH2 diaphanous-related formin 2 -0.0235566
GLIS3 GLIS family zinc finger 3 -0.0230867
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0229985
CCND1 cyclin D1 -0.0227867
RPL11 ribosomal protein L11 -0.022767
PSD3 pleckstrin and Sec7 domain containing 3 -0.0227555
FRMD4A FERM domain containing 4A -0.0222637
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0222467
AFF3 AF4/FMR2 family, member 3 -0.0219985
RPL26 ribosomal protein L26 -0.0216006
RPS14 ribosomal protein S14 -0.0216001
RPL8 ribosomal protein L8 -0.02136
ANXA2 annexin A2 -0.0211221
RPS23 ribosomal protein S23 -0.0209022
RPL31 ribosomal protein L31 -0.0206171
COL6A3 collagen, type VI, alpha 3 -0.0205924
S100A10 S100 calcium binding protein A10 -0.0202548
RPL38 ribosomal protein L38 -0.0201863
GREM1 gremlin 1, DAN family BMP antagonist -0.0200486
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0197924
CALD1 caldesmon 1 -0.0194741
VCAN versican -0.0193
TPM1 tropomyosin 1 (alpha) -0.0192038
RPS21 ribosomal protein S21 -0.0191413
COL3A1 collagen, type III, alpha 1 -0.0191155
S100A9 S100 calcium binding protein A9 -0.0190746
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.019029
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0188998
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0188522
RPL23 ribosomal protein L23 -0.0187973
TTC23L tetratricopeptide repeat domain 23-like -0.0187635
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0187114
RPS29 ribosomal protein S29 -0.0186974
RPL36A ribosomal protein L36a -0.0186325
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0185103
GNAS GNAS complex locus -0.0184513
UBB ubiquitin B -0.0182061
TPM4 tropomyosin 4 -0.0177063
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0175407
EFCAB13 EF-hand calcium binding domain 13 -0.0174485
RPL36 ribosomal protein L36 -0.0171718
RPL13A ribosomal protein L13a -0.0171522
COL1A2 collagen, type I, alpha 2 -0.0170643
FKBP10 FK506 binding protein 10, 65 kDa -0.0170098