| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.102045 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0796321 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0615928 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0572317 |
| FSTL1 | follistatin-like 1 | 0.0513507 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0480285 |
| POTEF | POTE ankyrin domain family, member F | 0.0468726 |
| HDAC9 | histone deacetylase 9 | 0.0459484 |
| CD44 | CD44 molecule (Indian blood group) | 0.0438474 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0438467 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0425829 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0418024 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0416188 |
| FLNA | filamin A, alpha | 0.0409359 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0391207 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0389297 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0389218 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0382997 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0382267 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0365434 |
| TMSB4X | thymosin beta 4, X-linked | 0.0361544 |
| APP | amyloid beta (A4) precursor protein | 0.0359067 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0333049 |
| NAV2 | neuron navigator 2 | 0.0325322 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0299181 |
| PLEC | plectin | 0.0281703 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0279979 |
| SQSTM1 | sequestosome 1 | 0.0276901 |
| TPM3 | tropomyosin 3 | 0.0274579 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0274452 |
| RUNX1 | runt-related transcription factor 1 | 0.0273593 |
| DST | dystonin | 0.0273138 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.027023 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0267699 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0257017 |
| MSN | moesin | 0.0249993 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0247513 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.024727 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0233516 |
| MB21D2 | Mab-21 domain containing 2 | 0.0227755 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0225105 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0219287 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0218816 |
| RND3 | Rho family GTPase 3 | 0.0217557 |
| ANO6 | anoctamin 6 | 0.0214645 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0211436 |
| HELZ | helicase with zinc finger | 0.0207997 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0200982 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0198243 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.019621 |
| ARRDC3 | arrestin domain containing 3 | 0.0192536 |
| ERBIN | erbb2 interacting protein | 0.0192503 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0190678 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0189291 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0189158 |
| TLE4 | transducin-like enhancer of split 4 | 0.0188442 |
| CORO1C | coronin, actin binding protein, 1C | 0.0187347 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0182314 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0182281 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0180831 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.017937 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0178477 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0177169 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0176954 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0176174 |
| LAMB1 | laminin, beta 1 | 0.0174811 |
| NCKAP1 | NCK-associated protein 1 | 0.0170828 |
| DTNA | dystrobrevin, alpha | 0.016794 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0164826 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0164404 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0162419 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0161926 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0161517 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0159288 |
| DOCK9 | dedicator of cytokinesis 9 | 0.0158579 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0157864 |
| RPL4 | ribosomal protein L4 | 0.0157628 |
| NUP58 | nucleoporin 58 | 0.0157231 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.015719 |
| RNF24 | ring finger protein 24 | 0.0156915 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0156312 |
| ADM | adrenomedullin | 0.0155986 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0155553 |
| PKM | pyruvate kinase, muscle | 0.0155436 |
| TUFT1 | tuftelin 1 | 0.01546 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0153791 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0152973 |
| KLF10 | Kruppel-like factor 10 | 0.0152545 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0151665 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.015081 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0150106 |
| FAT1 | FAT atypical cadherin 1 | 0.014473 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0143431 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0143064 |
| CLTC | clathrin, heavy chain (Hc) | 0.0143002 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0142258 |
| IL6ST | interleukin 6 signal transducer | 0.0141417 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0141093 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0141029 |
| SUCO | SUN domain containing ossification factor | 0.0141012 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.361855 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.29197 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.284352 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.17477 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.156756 |
| PLAT | plasminogen activator, tissue | -0.13572 |
| LOX | lysyl oxidase | -0.116697 |
| TMSB10 | thymosin beta 10 | -0.104625 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0914942 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0865641 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0655025 |
| PTMA | prothymosin, alpha | -0.0652651 |
| CSTB | cystatin B (stefin B) | -0.0640333 |
| LOXL2 | lysyl oxidase-like 2 | -0.0631768 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0625331 |
| SUCNR1 | succinate receptor 1 | -0.0588905 |
| HLA-B | major histocompatibility complex, class I, B | -0.0587774 |
| FN1 | fibronectin 1 | -0.0587544 |
| MYADM | myeloid-associated differentiation marker | -0.0525797 |
| NDRG1 | N-myc downstream regulated 1 | -0.0520468 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0516122 |
| COL1A2 | collagen, type I, alpha 2 | -0.0510758 |
| S100A6 | S100 calcium binding protein A6 | -0.0469953 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0446139 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0445532 |
| MT2A | metallothionein 2A | -0.0435527 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0429955 |
| NAV1 | neuron navigator 1 | -0.0428633 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0403057 |
| COL5A1 | collagen, type V, alpha 1 | -0.0398993 |
| PRSS23 | protease, serine, 23 | -0.0385898 |
| FBN1 | fibrillin 1 | -0.0374651 |
| B2M | beta-2-microglobulin | -0.0374392 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0361631 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0353523 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0350539 |
| PODXL | podocalyxin-like | -0.034271 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0340495 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0336919 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0335197 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0319389 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0318838 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0318578 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0306854 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.030601 |
| HLA-C | major histocompatibility complex, class I, C | -0.0303523 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0290279 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0290188 |
| FRMD4A | FERM domain containing 4A | -0.0288998 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0286393 |
| COL5A2 | collagen, type V, alpha 2 | -0.0281819 |
| MX2 | MX dynamin-like GTPase 2 | -0.028163 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0279968 |
| CD99 | CD99 molecule | -0.0278308 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0276394 |
| TAGLN2 | transgelin 2 | -0.0272428 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0268696 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0264007 |
| FTL | ferritin, light polypeptide | -0.0262957 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0262397 |
| LMNA | lamin A/C | -0.0257332 |
| JAZF1 | JAZF zinc finger 1 | -0.0256104 |
| EGFR | epidermal growth factor receptor | -0.0255922 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0252227 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0250215 |
| HLA-A | major histocompatibility complex, class I, A | -0.0244542 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0244374 |
| RPL35A | ribosomal protein L35a | -0.0244261 |
| RRBP1 | ribosome binding protein 1 | -0.0242331 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0242109 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0234605 |
| CUX1 | cut-like homeobox 1 | -0.023396 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0232708 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0231576 |
| CCND1 | cyclin D1 | -0.0228352 |
| S100A11 | S100 calcium binding protein A11 | -0.0227329 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0224903 |
| GNAS | GNAS complex locus | -0.0221206 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0219854 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0219568 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0217025 |
| GOLGA2 | golgin A2 | -0.021392 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0210504 |
| HLA-E | major histocompatibility complex, class I, E | -0.0209778 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0207144 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0205084 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0204188 |
| FRMD5 | FERM domain containing 5 | -0.0202714 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0199011 |
| S100A10 | S100 calcium binding protein A10 | -0.0195385 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0192661 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0191604 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0190609 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0190497 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0189645 |
| GOLGB1 | golgin B1 | -0.0186768 |
| MEIS2 | Meis homeobox 2 | -0.0185413 |
| CAVIN1 | caveolae associated protein 1 | -0.0184384 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0184044 |
| RPL37A | ribosomal protein L37a | -0.0183712 |
