| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.0748669 |
| YAP1 | Yes-associated protein 1 | 0.0719706 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0456831 |
| TENM3 | teneurin transmembrane protein 3 | 0.0407202 |
| WWOX | WW domain containing oxidoreductase | 0.0407081 |
| POTEF | POTE ankyrin domain family, member F | 0.0402948 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0393288 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0376396 |
| RRM2 | ribonucleotide reductase M2 | 0.0372317 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0367445 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0366802 |
| PCDH9 | protocadherin 9 | 0.0359273 |
| EPHA6 | EPH receptor A6 | 0.0354184 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0354174 |
| CLTC | clathrin, heavy chain (Hc) | 0.0339236 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0324855 |
| MGAT4C | MGAT4 family, member C | 0.030741 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.030426 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0300592 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0296448 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0292698 |
| PEG10 | paternally expressed 10 | 0.0281278 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0280153 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0278806 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0277858 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0275604 |
| MPG | N-methylpurine-DNA glycosylase | 0.0269481 |
| BRD2 | bromodomain containing 2 | 0.0264583 |
| SKIL | SKI-like proto-oncogene | 0.0256839 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0252276 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.023608 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0232907 |
| NCKAP1 | NCK-associated protein 1 | 0.0231622 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0229553 |
| ATP11A | ATPase, class VI, type 11A | 0.0228095 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.022787 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0222179 |
| CPOX | coproporphyrinogen oxidase | 0.0219487 |
| TBK1 | TANK-binding kinase 1 | 0.0217874 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0216019 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0211653 |
| FOXM1 | forkhead box M1 | 0.0206699 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0204245 |
| CALR | calreticulin | 0.0202899 |
| ARRDC3 | arrestin domain containing 3 | 0.0202632 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0202082 |
| RPL3 | ribosomal protein L3 | 0.0201439 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0200246 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0198212 |
| XPO1 | exportin 1 | 0.0194697 |
| LDHA | lactate dehydrogenase A | 0.0192766 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0191563 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0189499 |
| GASK1B | golgi associated kinase 1B | 0.018872 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0183969 |
| GOLIM4 | golgi integral membrane protein 4 | 0.0183757 |
| PCBP2 | poly(rC) binding protein 2 | 0.0183447 |
| MEF2C | myocyte enhancer factor 2C | 0.0179354 |
| AXIN2 | axin 2 | 0.017853 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0177645 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0176667 |
| PRELID2 | PRELI domain containing 2 | 0.0174911 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0171999 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0171528 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0166465 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0165875 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0165769 |
| TFG | TRK-fused gene | 0.0165006 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0164441 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.016397 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0163689 |
| FAM169A | family with sequence similarity 169, member A | 0.0162009 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0161533 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0159458 |
| RPL4 | ribosomal protein L4 | 0.015925 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0157352 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0157085 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0156561 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0153188 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0152578 |
| MED13L | mediator complex subunit 13-like | 0.0152514 |
| ATP11B | ATPase, class VI, type 11B | 0.015143 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.0150073 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0148218 |
| COPA | coatomer protein complex, subunit alpha | 0.0146205 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0145187 |
| HELZ | helicase with zinc finger | 0.0144839 |
| IPO7 | importin 7 | 0.0144657 |
| PDE7A | phosphodiesterase 7A | 0.0143897 |
| ZNF638 | zinc finger protein 638 | 0.0143259 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0141226 |
| YBX1 | Y box binding protein 1 | 0.0141144 |
| CUL4B | cullin 4B | 0.0140434 |
| KIAA0319 | KIAA0319 | 0.0139657 |
| MLF1 | myeloid leukemia factor 1 | 0.0139502 |
| OGA | O-GlcNAcase | 0.0137854 |
| PAPOLA | poly(A) polymerase alpha | 0.0137327 |
| PER1 | period circadian clock 1 | 0.0136836 |
| SON | SON DNA binding protein | 0.0136313 |
| SNX13 | sorting nexin 13 | 0.0136212 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.190614 |
| AREG | amphiregulin | -0.150568 |
| PTMA | prothymosin, alpha | -0.111801 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0994799 |
| EHBP1 | EH domain binding protein 1 | -0.0804609 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0758758 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0718313 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0659149 |
| RASAL2 | RAS protein activator like 2 | -0.0647563 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0621408 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0587936 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.056931 |
| CLDN1 | claudin 1 | -0.0560681 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0554115 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0552778 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0548903 |
| SBF2 | SET binding factor 2 | -0.0529181 |
| TMSB10 | thymosin beta 10 | -0.0499717 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0499321 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0489911 |
| ANXA1 | annexin A1 | -0.0486376 |
| PCDH7 | protocadherin 7 | -0.0471128 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0457297 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.045239 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0438483 |
| NABP1 | nucleic acid binding protein 1 | -0.0429702 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0428968 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0426917 |
| RPL35A | ribosomal protein L35a | -0.0425501 |
| NEBL | nebulette | -0.0417188 |
| EGFR | epidermal growth factor receptor | -0.0409879 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0399749 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.03793 |
| RPS27A | ribosomal protein S27a | -0.037506 |
| RPS6 | ribosomal protein S6 | -0.0369391 |
| SYT1 | synaptotagmin I | -0.0369233 |
| GCG | glucagon | -0.0368706 |
| RPS3 | ribosomal protein S3 | -0.0362837 |
| ACTG1 | actin gamma 1 | -0.0360378 |
| CMIP | c-Maf inducing protein | -0.0358634 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0356294 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0336461 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0335782 |
| RPL26 | ribosomal protein L26 | -0.0332974 |
| RPS24 | ribosomal protein S24 | -0.0330944 |
| NF1 | neurofibromin 1 | -0.0328201 |
| EGR1 | early growth response 1 | -0.0327412 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0327328 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0322877 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0322249 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0318744 |
| ZNF804A | zinc finger protein 804A | -0.0312876 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0309965 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.03088 |
| TSPAN5 | tetraspanin 5 | -0.0307952 |
| RPL37A | ribosomal protein L37a | -0.030769 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0302378 |
| TMEM123 | transmembrane protein 123 | -0.0302237 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0300565 |
| HMGA1 | high mobility group AT-hook 1 | -0.0296865 |
| EDN1 | endothelin 1 | -0.0295016 |
| R3HDM2 | R3H domain containing 2 | -0.0291813 |
| ANKRD28 | ankyrin repeat domain 28 | -0.028942 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0282837 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0279919 |
| RTN4 | reticulon 4 | -0.027664 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0275813 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0273108 |
| USP34 | ubiquitin specific peptidase 34 | -0.0270162 |
| RPL7A | ribosomal protein L7a | -0.0269808 |
| RPL37 | ribosomal protein L37 | -0.0269631 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0269372 |
| CUX1 | cut-like homeobox 1 | -0.0269001 |
| DTNA | dystrobrevin, alpha | -0.0268565 |
| MAP4 | microtubule-associated protein 4 | -0.0266921 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0265937 |
| RPL11 | ribosomal protein L11 | -0.026551 |
| BPTF | bromodomain PHD finger transcription factor | -0.0263952 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.026171 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0256125 |
| LMO7 | LIM domain 7 | -0.0255459 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0254116 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0251964 |
| RPL34 | ribosomal protein L34 | -0.0250742 |
| SRPK2 | SRSF protein kinase 2 | -0.0245345 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0240054 |
| RPLP1 | ribosomal protein, large, P1 | -0.0236301 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0236119 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0235627 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0234455 |
| TMEM41B | transmembrane protein 41B | -0.0230613 |
| MTAP | methylthioadenosine phosphorylase | -0.0229612 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0228306 |
| PHF20 | PHD finger protein 20 | -0.022029 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.021993 |
| BRI3BP | BRI3 binding protein | -0.021914 |
| RPS8 | ribosomal protein S8 | -0.021597 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0214422 |
| R3HDM1 | R3H domain containing 1 | -0.0213653 |
| RPS12 | ribosomal protein S12 | -0.0213277 |
