| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | 0.0972273 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0853937 |
| VGF | VGF nerve growth factor inducible | 0.0614301 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0592875 |
| HSPA8 | heat shock 70kDa protein 8 | 0.058948 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0539214 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0512818 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0509058 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0474027 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0467714 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0466978 |
| HELZ | helicase with zinc finger | 0.0453209 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0438987 |
| DST | dystonin | 0.0405573 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0405019 |
| APP | amyloid beta (A4) precursor protein | 0.0403631 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0403515 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0403427 |
| CLTC | clathrin, heavy chain (Hc) | 0.0374134 |
| SMAD3 | SMAD family member 3 | 0.0371445 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0366001 |
| LPIN1 | lipin 1 | 0.0356624 |
| DNM3 | dynamin 3 | 0.0356174 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0355389 |
| SEPTIN9 | septin 9 | 0.0347035 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0337443 |
| SF3B3 | splicing factor 3b, subunit 3, 130kDa | 0.0332057 |
| AMOTL1 | angiomotin like 1 | 0.0328789 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0323162 |
| FMN1 | formin 1 | 0.0319137 |
| RUNX1 | runt-related transcription factor 1 | 0.0309914 |
| HPCAL1 | hippocalcin-like 1 | 0.0309858 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0304216 |
| MEF2A | myocyte enhancer factor 2A | 0.0303976 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0303067 |
| RPL4 | ribosomal protein L4 | 0.0302646 |
| MAP1B | microtubule-associated protein 1B | 0.0302019 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0292571 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0292553 |
| ASPH | aspartate beta-hydroxylase | 0.0289365 |
| FAM13A | family with sequence similarity 13, member A | 0.0289244 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0287727 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0285436 |
| DPH6 | diphthamine biosynthesis 6 | 0.0285092 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0280397 |
| USP34 | ubiquitin specific peptidase 34 | 0.0279214 |
| DNMBP | dynamin binding protein | 0.0277668 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.027487 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | 0.0268545 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0265566 |
| ANO6 | anoctamin 6 | 0.0252219 |
| WDR26 | WD repeat domain 26 | 0.0250738 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.025067 |
| ANGPTL4 | angiopoietin-like 4 | 0.0249009 |
| HMGA2 | high mobility group AT-hook 2 | 0.0247724 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0245699 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0243654 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0241513 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0239548 |
| RET | ret proto-oncogene | 0.0237753 |
| FAM107B | family with sequence similarity 107, member B | 0.0234606 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0233476 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0231484 |
| RCOR1 | REST corepressor 1 | 0.0230574 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0228897 |
| DGKH | diacylglycerol kinase, eta | 0.0228597 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0226304 |
| ACTN1 | actinin, alpha 1 | 0.022629 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0224627 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0223384 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0222944 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0219834 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0216803 |
| RPL3 | ribosomal protein L3 | 0.0216616 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0214875 |
| NBAS | neuroblastoma amplified sequence | 0.0213369 |
| DUSP10 | dual specificity phosphatase 10 | 0.0213131 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.021237 |
| MALT1 | MALT1 paracaspase | 0.0212125 |
| NBEA | neurobeachin | 0.0211995 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0211805 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.021158 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.021051 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0206407 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0203722 |
| NME7 | NME/NM23 family member 7 | 0.02025 |
| TOP1 | topoisomerase (DNA) I | 0.0202019 |
| NF1 | neurofibromin 1 | 0.0201677 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0200202 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0199768 |
| PAPOLA | poly(A) polymerase alpha | 0.0199522 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0198026 |
| AAK1 | AP2 associated kinase 1 | 0.0197683 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0197606 |
| NEK1 | NIMA-related kinase 1 | 0.0197354 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0196285 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0195557 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0195505 |
| TPM3 | tropomyosin 3 | 0.0195402 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0192223 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.22202 |
| PTMA | prothymosin, alpha | -0.119412 |
| LSAMP | limbic system-associated membrane protein | -0.114981 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0977222 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0908592 |
| RPL23 | ribosomal protein L23 | -0.0816469 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.081292 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0762598 |
| VIM | vimentin | -0.0681492 |
| RPL37A | ribosomal protein L37a | -0.0658572 |
| RPLP1 | ribosomal protein, large, P1 | -0.0656413 |
| RPL35A | ribosomal protein L35a | -0.0650993 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.062938 |
| EGR1 | early growth response 1 | -0.0551789 |
| VCL | vinculin | -0.0537273 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0513204 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.048173 |
| RPS24 | ribosomal protein S24 | -0.0467827 |
| RPS6 | ribosomal protein S6 | -0.0466494 |
| RPL26 | ribosomal protein L26 | -0.0453956 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0432869 |
| ACTG1 | actin gamma 1 | -0.0431297 |
| RPS27A | ribosomal protein S27a | -0.042133 |
| RPS12 | ribosomal protein S12 | -0.0404511 |
| RPS19 | ribosomal protein S19 | -0.0403859 |
| NRG1 | neuregulin 1 | -0.0400664 |
| RPL38 | ribosomal protein L38 | -0.0397952 |
| SYT1 | synaptotagmin I | -0.0396541 |
| RPS3 | ribosomal protein S3 | -0.0387577 |
| RAD51B | RAD51 paralog B | -0.0386657 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0377698 |
| FTL | ferritin, light polypeptide | -0.0373233 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0373091 |
| RPL31 | ribosomal protein L31 | -0.0367882 |
| RPL34 | ribosomal protein L34 | -0.0356146 |
| FN1 | fibronectin 1 | -0.035437 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0353302 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0351989 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0350105 |
| NREP | neuronal regeneration related protein | -0.0348461 |
| COL3A1 | collagen, type III, alpha 1 | -0.0344251 |
| PCNX4 | pecanex 4 | -0.0342393 |
| RPL13A | ribosomal protein L13a | -0.0331152 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0323438 |
| RPL37 | ribosomal protein L37 | -0.0322533 |
| TMSB10 | thymosin beta 10 | -0.0312538 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.030875 |
| RACK1 | receptor for activated C kinase 1 | -0.0306579 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0305459 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0294523 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0285869 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0277321 |
| RPL7A | ribosomal protein L7a | -0.0270487 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0268746 |
| RPL5 | ribosomal protein L5 | -0.0268539 |
| RPL19 | ribosomal protein L19 | -0.0265384 |
| S100A9 | S100 calcium binding protein A9 | -0.0265289 |
| GPC5 | glypican 5 | -0.0260477 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0259805 |
| CENPF | centromere protein F, 350/400kDa | -0.0257317 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0255476 |
| OSBPL1A | oxysterol binding protein-like 1A | -0.0254594 |
| RPL36 | ribosomal protein L36 | -0.025422 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0253175 |
| RPS17 | ribosomal protein S17 | -0.025244 |
| COL1A1 | collagen, type I, alpha 1 | -0.0251824 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0248079 |
| RPS2 | ribosomal protein S2 | -0.0246767 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0245607 |
| RPS27 | ribosomal protein S27 | -0.0245149 |
| IER3 | immediate early response 3 | -0.024463 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.0239622 |
| RPS29 | ribosomal protein S29 | -0.0238339 |
| RPL12 | ribosomal protein L12 | -0.0236325 |
| FRMD4A | FERM domain containing 4A | -0.0235641 |
| SEPTIN2 | septin 2 | -0.023495 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0233203 |
| RPS8 | ribosomal protein S8 | -0.0232717 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0231927 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0230398 |
| TPI1 | triosephosphate isomerase 1 | -0.0230093 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0228303 |
| RBM25 | RNA binding motif protein 25 | -0.0225223 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0225084 |
| TPM1 | tropomyosin 1 (alpha) | -0.0222334 |
| BRCA1 | breast cancer 1, early onset | -0.02218 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0221677 |
| H3-3B | H3.3 histone B | -0.0220165 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0220055 |
| STK38L | serine/threonine kinase 38 like | -0.0219817 |
| CNTN4 | contactin 4 | -0.0217585 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.021645 |
| NDRG1 | N-myc downstream regulated 1 | -0.0215459 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0214329 |
| SPAG16 | sperm associated antigen 16 | -0.0214205 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0214044 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0210149 |
| LMNA | lamin A/C | -0.0206005 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0204952 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0204348 |
