| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.18048 |
| EXT1 | exostosin glycosyltransferase 1 | 0.112538 |
| SMAD3 | SMAD family member 3 | 0.0890168 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0853836 |
| RNF213 | ring finger protein 213 | 0.0676958 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0618633 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0588897 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0567262 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0558299 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0439827 |
| IFNGR1 | interferon gamma receptor 1 | 0.041964 |
| MYO5B | myosin VB | 0.0395331 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0360197 |
| MYO1E | myosin IE | 0.0358795 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0355844 |
| FAT1 | FAT atypical cadherin 1 | 0.0349418 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0349107 |
| MCU | mitochondrial calcium uniporter | 0.0348934 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0342111 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0330131 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0328876 |
| ASPH | aspartate beta-hydroxylase | 0.0326414 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0324956 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0323073 |
| INTS6 | integrator complex subunit 6 | 0.0314636 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0313813 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0310454 |
| KYNU | kynureninase | 0.0300528 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.028888 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0283735 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0281364 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0280475 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0270834 |
| PDZD8 | PDZ domain containing 8 | 0.0268581 |
| EFNB2 | ephrin-B2 | 0.0255762 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0253646 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0252516 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0251916 |
| ETV6 | ets variant 6 | 0.0250383 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0242569 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0240245 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0238787 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0235536 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0234499 |
| HSPA8 | heat shock 70kDa protein 8 | 0.023401 |
| HKDC1 | hexokinase domain containing 1 | 0.0232837 |
| TRIM2 | tripartite motif containing 2 | 0.0232521 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0232317 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0231416 |
| TJP1 | tight junction protein 1 | 0.0228081 |
| STK24 | serine/threonine kinase 24 | 0.0223722 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0219601 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0213553 |
| ATXN1 | ataxin 1 | 0.0208554 |
| TMEM65 | transmembrane protein 65 | 0.0206504 |
| TRERF1 | transcriptional regulating factor 1 | 0.0206119 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0203783 |
| MYO10 | myosin X | 0.0194704 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0194378 |
| SEPTIN9 | septin 9 | 0.0191455 |
| ADAR | adenosine deaminase, RNA-specific | 0.0190646 |
| NCKAP5 | NCK-associated protein 5 | 0.0188412 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0184523 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0180583 |
| FNIP1 | folliculin interacting protein 1 | 0.0179192 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0176052 |
| EXPH5 | exophilin 5 | 0.0176019 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0175869 |
| MUC13 | mucin 13, cell surface associated | 0.0174072 |
| PHF3 | PHD finger protein 3 | 0.0174044 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0172475 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0172081 |
| SIK3 | SIK family kinase 3 | 0.0171339 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0171263 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0170599 |
| KIF16B | kinesin family member 16B | 0.0170447 |
| RBM47 | RNA binding motif protein 47 | 0.0170229 |
| FNIP2 | folliculin interacting protein 2 | 0.016988 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0169172 |
| TOX3 | TOX high mobility group box family member 3 | 0.0168859 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0168839 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0168677 |
| MSI2 | musashi RNA-binding protein 2 | 0.0166569 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.016652 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0165213 |
| RUNX1 | runt-related transcription factor 1 | 0.016372 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0161872 |
| SUCO | SUN domain containing ossification factor | 0.0159551 |
| CLTC | clathrin, heavy chain (Hc) | 0.0157616 |
| NEBL | nebulette | 0.0155613 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0155435 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0152755 |
| DST | dystonin | 0.0152746 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0151917 |
| SERINC5 | serine incorporator 5 | 0.0150565 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0149733 |
| PLPP3 | phospholipid phosphatase 3 | 0.014932 |
| PLSCR2 | phospholipid scramblase 2 | 0.0146322 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0143625 |
| POF1B | premature ovarian failure, 1B | 0.0143032 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.12432 |
| B2M | beta-2-microglobulin | -0.117059 |
| PTMA | prothymosin, alpha | -0.110122 |
| RPL35A | ribosomal protein L35a | -0.0673143 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0631344 |
| LYZ | lysozyme | -0.0609764 |
| EGR1 | early growth response 1 | -0.0600617 |
| HLA-B | major histocompatibility complex, class I, B | -0.0578322 |
| AREG | amphiregulin | -0.0575438 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0571744 |
| FTL | ferritin, light polypeptide | -0.0562756 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0542085 |
| RPS6 | ribosomal protein S6 | -0.0541152 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0501547 |
| SQSTM1 | sequestosome 1 | -0.0492368 |
| NDRG1 | N-myc downstream regulated 1 | -0.0470016 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0463764 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0432411 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0432008 |
| RPL37A | ribosomal protein L37a | -0.0412138 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0402258 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0393369 |
| RPL23 | ribosomal protein L23 | -0.0392274 |
| CCNL1 | cyclin L1 | -0.0390729 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0376341 |
| RPLP1 | ribosomal protein, large, P1 | -0.0371381 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0371203 |
| HLA-A | major histocompatibility complex, class I, A | -0.0366957 |
| TMSB10 | thymosin beta 10 | -0.0339462 |
| TXNIP | thioredoxin interacting protein | -0.0335338 |
| RPL26 | ribosomal protein L26 | -0.0333642 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0331788 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0330932 |
| EZR | ezrin | -0.0328098 |
| RPS3 | ribosomal protein S3 | -0.032431 |
| RPS12 | ribosomal protein S12 | -0.0317991 |
| MT2A | metallothionein 2A | -0.0308581 |
| RPS19 | ribosomal protein S19 | -0.0300006 |
| RPL31 | ribosomal protein L31 | -0.0299122 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0294558 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0282138 |
| RPL34 | ribosomal protein L34 | -0.0279132 |
| TPM4 | tropomyosin 4 | -0.0277739 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0273875 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0273138 |
| RPL11 | ribosomal protein L11 | -0.026693 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0262282 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0259709 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0258168 |
| VIM | vimentin | -0.0257686 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0257497 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0257252 |
| ITGA6 | integrin, alpha 6 | -0.0254268 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0251758 |
| HLA-E | major histocompatibility complex, class I, E | -0.0251568 |
| RPS8 | ribosomal protein S8 | -0.0250204 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0249714 |
| RPS27 | ribosomal protein S27 | -0.0247802 |
| RPL12 | ribosomal protein L12 | -0.0246928 |
| RBM39 | RNA binding motif protein 39 | -0.0245127 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.024113 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0240292 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0239947 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.023806 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0237001 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.023099 |
| FN1 | fibronectin 1 | -0.022903 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -0.0229019 |
| RPLP2 | ribosomal protein, large, P2 | -0.0228342 |
| VCL | vinculin | -0.0227576 |
| ACTG1 | actin gamma 1 | -0.0227243 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0225981 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0225235 |
| RPL9 | ribosomal protein L9 | -0.0223613 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0223026 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0222902 |
| SMC4 | structural maintenance of chromosomes 4 | -0.022273 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0221101 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0219082 |
| GNAS | GNAS complex locus | -0.0218907 |
| JUN | jun proto-oncogene | -0.0218292 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.021731 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0217185 |
| DIAPH3 | diaphanous-related formin 3 | -0.0216744 |
| S100P | S100 calcium binding protein P | -0.0215883 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0214332 |
| RPS17 | ribosomal protein S17 | -0.0214083 |
| RPS23 | ribosomal protein S23 | -0.0212502 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0210087 |
| MKI67 | marker of proliferation Ki-67 | -0.0209571 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0205128 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0204489 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0203905 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0203892 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0203644 |
| HLA-C | major histocompatibility complex, class I, C | -0.0202485 |
| RBM25 | RNA binding motif protein 25 | -0.0202182 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0202035 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0200889 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0199848 |
