| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.54033 |
| COL6A3 | collagen, type VI, alpha 3 | 0.179122 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.157192 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.131853 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.119553 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.084421 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0840298 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0819324 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0788082 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0785447 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0776611 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0724962 |
| CD44 | CD44 molecule (Indian blood group) | 0.0685558 |
| FBN1 | fibrillin 1 | 0.0655601 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0585931 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0556816 |
| CADM1 | cell adhesion molecule 1 | 0.0536673 |
| CDH13 | cadherin 13 | 0.0527226 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0521638 |
| PLEC | plectin | 0.0517184 |
| COL5A1 | collagen, type V, alpha 1 | 0.0487616 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0485263 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.047953 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0421528 |
| GOLGB1 | golgin B1 | 0.0404746 |
| APP | amyloid beta (A4) precursor protein | 0.0400907 |
| COL3A1 | collagen, type III, alpha 1 | 0.039702 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0391554 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0361732 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0347052 |
| NAV2 | neuron navigator 2 | 0.0342338 |
| FNIP1 | folliculin interacting protein 1 | 0.0328259 |
| EXT1 | exostosin glycosyltransferase 1 | 0.032811 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0318669 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0318237 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0309488 |
| SDC2 | syndecan 2 | 0.0306986 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0299668 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.029918 |
| VCAN | versican | 0.0295217 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0292699 |
| MYO10 | myosin X | 0.0290867 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.028121 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0277089 |
| EGFR | epidermal growth factor receptor | 0.0275381 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.027005 |
| POTEF | POTE ankyrin domain family, member F | 0.026826 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0264666 |
| FAT1 | FAT atypical cadherin 1 | 0.0261053 |
| RPL3 | ribosomal protein L3 | 0.0256181 |
| SDC4 | syndecan 4 | 0.0252993 |
| ANO6 | anoctamin 6 | 0.0252398 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0246946 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.024361 |
| RND3 | Rho family GTPase 3 | 0.0243217 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0242478 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0240154 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0239851 |
| ANXA1 | annexin A1 | 0.0237985 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0235791 |
| ARRDC3 | arrestin domain containing 3 | 0.0233576 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0233135 |
| GLIS3 | GLIS family zinc finger 3 | 0.0233061 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0232915 |
| HSPA1B | heat shock 70kDa protein 1B | 0.023201 |
| SP100 | SP100 nuclear antigen | 0.023041 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0227094 |
| CMIP | c-Maf inducing protein | 0.0226961 |
| HDAC9 | histone deacetylase 9 | 0.0221282 |
| NEK10 | NIMA-related kinase 10 | 0.0220498 |
| XYLT1 | xylosyltransferase I | 0.0214353 |
| TMSB4X | thymosin beta 4, X-linked | 0.0213515 |
| BRD2 | bromodomain containing 2 | 0.0208971 |
| PGM3 | phosphoglucomutase 3 | 0.0206802 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0203449 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0202919 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0202292 |
| JUN | jun proto-oncogene | 0.0198986 |
| MLF1 | myeloid leukemia factor 1 | 0.0198981 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.019865 |
| ATXN1 | ataxin 1 | 0.0197769 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0197463 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0196756 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0195979 |
| MSN | moesin | 0.0194835 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0194626 |
| SQSTM1 | sequestosome 1 | 0.0194197 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0190574 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0189248 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0188019 |
| STC2 | stanniocalcin 2 | 0.0186227 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0186106 |
| HYOU1 | hypoxia up-regulated 1 | 0.0186085 |
| CALU | calumenin | 0.0185059 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0183947 |
| RPL4 | ribosomal protein L4 | 0.0181779 |
| FLNA | filamin A, alpha | 0.0181701 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.017807 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0177372 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0172235 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.13729 |
| COL1A1 | collagen, type I, alpha 1 | -0.108651 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0973352 |
| MT2A | metallothionein 2A | -0.0832656 |
| VIM | vimentin | -0.0716806 |
| PTMA | prothymosin, alpha | -0.0638259 |
| TMSB10 | thymosin beta 10 | -0.0574413 |
| ATP13A3 | ATPase type 13A3 | -0.0567526 |
| NDRG1 | N-myc downstream regulated 1 | -0.0561508 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0537346 |
| RRBP1 | ribosome binding protein 1 | -0.0422544 |
| FTL | ferritin, light polypeptide | -0.041762 |
| IER3 | immediate early response 3 | -0.0413732 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.040929 |
| RPL35A | ribosomal protein L35a | -0.0398591 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0385696 |
| HMGA2 | high mobility group AT-hook 2 | -0.0360303 |
| RPLP1 | ribosomal protein, large, P1 | -0.0340732 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0336655 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0334428 |
| STC1 | stanniocalcin 1 | -0.0328156 |
| RPS8 | ribosomal protein S8 | -0.032634 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0315011 |
| RTN4 | reticulon 4 | -0.0307267 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304134 |
| RPL11 | ribosomal protein L11 | -0.0298 |
| ZNF292 | zinc finger protein 292 | -0.0276856 |
| ANXA2 | annexin A2 | -0.0276846 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0262385 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0259398 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0258641 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0254626 |
| S100A9 | S100 calcium binding protein A9 | -0.0249659 |
| RPLP2 | ribosomal protein, large, P2 | -0.0249466 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0246893 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0242675 |
| CAVIN1 | caveolae associated protein 1 | -0.0241793 |
| RBM39 | RNA binding motif protein 39 | -0.0237978 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0237681 |
| HMGA1 | high mobility group AT-hook 1 | -0.023757 |
| RPL23 | ribosomal protein L23 | -0.0237178 |
| RPS6 | ribosomal protein S6 | -0.0236417 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0233861 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0229398 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0227292 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0225272 |
| PRELID2 | PRELI domain containing 2 | -0.0224621 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.021578 |
| USP3 | ubiquitin specific peptidase 3 | -0.0215682 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0215554 |
| GNAS | GNAS complex locus | -0.021489 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0208585 |
| ACTG1 | actin gamma 1 | -0.0207242 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.020006 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0198879 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0198499 |
| RPS24 | ribosomal protein S24 | -0.0196343 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0194518 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0190191 |
| SMAD3 | SMAD family member 3 | -0.0190074 |
| RPS19 | ribosomal protein S19 | -0.0189953 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0189885 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0189615 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.018693 |
| RPL8 | ribosomal protein L8 | -0.018475 |
| SEPTIN7 | septin 7 | -0.0183936 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0183771 |
| S100A6 | S100 calcium binding protein A6 | -0.0181273 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0180093 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.017878 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0177199 |
| RPL31 | ribosomal protein L31 | -0.0176958 |
| MAP1B | microtubule-associated protein 1B | -0.017647 |
| OGA | O-GlcNAcase | -0.0176154 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0176095 |
| RPL12 | ribosomal protein L12 | -0.0172834 |
| RPL36 | ribosomal protein L36 | -0.0172237 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0171302 |
| MKI67 | marker of proliferation Ki-67 | -0.0171238 |
| BPTF | bromodomain PHD finger transcription factor | -0.0170761 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0170341 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0170231 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0170059 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0169413 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0169205 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0166732 |
| CENPF | centromere protein F, 350/400kDa | -0.0164864 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0164791 |
| HAS2 | hyaluronan synthase 2 | -0.0164662 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.016449 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0162779 |
| LOXL2 | lysyl oxidase-like 2 | -0.0161857 |
| KLF6 | Kruppel-like factor 6 | -0.0161503 |
| RPS21 | ribosomal protein S21 | -0.015868 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0157606 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0151788 |
| FAM20C | family with sequence similarity 20, member C | -0.0151364 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | -0.0150899 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0150876 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0149389 |
