Tucatinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucatinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucatinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.10231
SAMD4A sterile alpha motif domain containing 4A 0.094294
SVIL supervillin 0.082116
FN1 fibronectin 1 0.079164
ERRFI1 ERBB receptor feedback inhibitor 1 0.0753091
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0741948
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0637967
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.047979
ATXN1 ataxin 1 0.0477338
PDLIM5 PDZ and LIM domain 5 0.04739
AKAP12 A kinase (PRKA) anchor protein 12 0.0466125
TRIO trio Rho guanine nucleotide exchange factor 0.0456195
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0454653
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0452588
GRB10 growth factor receptor-bound protein 10 0.0437187
ASPH aspartate beta-hydroxylase 0.0425891
MYH9 myosin, heavy chain 9, non-muscle 0.0405357
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0374052
EXT1 exostosin glycosyltransferase 1 0.0370755
LRMDA leucine rich melanocyte differentiation associated 0.0370414
FNDC3B fibronectin type III domain containing 3B 0.0345923
MBNL2 muscleblind-like splicing regulator 2 0.0345276
DTNA dystrobrevin, alpha 0.0336269
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0327614
FAT1 FAT atypical cadherin 1 0.0327224
FOXP1 forkhead box P1 0.0324152
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0318485
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0307695
LPP LIM domain containing preferred translocation partner in lipoma 0.0302457
LOC112694756 uncharaterized LOC112694756 0.0296573
GMDS GDP-mannose 4,6-dehydratase 0.029555
FAM107B family with sequence similarity 107, member B 0.0295398
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0291908
KIAA1217 KIAA1217 0.0291133
HSPA1B heat shock 70kDa protein 1B 0.0285505
RPL4 ribosomal protein L4 0.027859
MBNL1 muscleblind-like splicing regulator 1 0.0277136
KYNU kynureninase 0.0273108
SDC4 syndecan 4 0.0272599
DST dystonin 0.0270668
RPL3 ribosomal protein L3 0.0266672
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0263734
PAWR PRKC, apoptosis, WT1, regulator 0.0260938
FRMD5 FERM domain containing 5 0.0260602
MACF1 microtubule-actin crosslinking factor 1 0.0254091
SMAD3 SMAD family member 3 0.0251097
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0245673
TNS1 tensin 1 0.0244523
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0236359
ZEB1 zinc finger E-box binding homeobox 1 0.0227304
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0225958
ANO6 anoctamin 6 0.022277
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0218566
EHBP1 EH domain binding protein 1 0.0216253
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0209056
PLEC plectin 0.0205796
HSPA8 heat shock 70kDa protein 8 0.0205054
DSPP dentin sialophosphoprotein 0.0204476
GCLC glutamate-cysteine ligase, catalytic subunit 0.0202722
PPARD peroxisome proliferator-activated receptor delta 0.0201801
RASA2 RAS p21 protein activator 2 0.0197421
DIAPH1 diaphanous-related formin 1 0.0193994
AFF1 AF4/FMR2 family, member 1 0.0193233
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0193004
SESTD1 SEC14 and spectrin domains 1 0.0192891
ZBTB20 zinc finger and BTB domain containing 20 0.0190329
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0190281
ARHGAP21 Rho GTPase activating protein 21 0.0187886
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0183255
TLE4 transducin-like enhancer of split 4 0.0180357
TBC1D22A TBC1 domain family, member 22A 0.0178883
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0178595
MALRD1 MAM and LDL receptor class A domain containing 1 0.0178068
CRY1 cryptochrome circadian clock 1 0.0174977
FMNL2 formin-like 2 0.0173658
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0173221
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0172951
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0169957
RUNX1 runt-related transcription factor 1 0.0169271
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0167872
AFDN afadin, adherens junction formation factor 0.0164265
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0163496
FNIP1 folliculin interacting protein 1 0.0162868
ADARB1 adenosine deaminase, RNA-specific, B1 0.0161779
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0161339
USP34 ubiquitin specific peptidase 34 0.0161193
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0160759
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0158887
FLNB filamin B, beta 0.0158739
LCOR ligand dependent nuclear receptor corepressor 0.0158417
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0157514
INTS6 integrator complex subunit 6 0.0156602
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0155316
USP47 ubiquitin specific peptidase 47 0.0154354
ADAM9 ADAM metallopeptidase domain 9 0.015352
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0151711
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0149272
SYNE1 spectrin repeat containing, nuclear envelope 1 0.014858
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0147791
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0145567

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.308028
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.221191
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.196665
MT2A metallothionein 2A -0.112988
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105371
APOA2 apolipoprotein A-II -0.103195
RPS6 ribosomal protein S6 -0.0909611
TPT1 tumor protein, translationally-controlled 1 -0.0900725
FTL ferritin, light polypeptide -0.0805407
GPC3 glypican 3 -0.0744233
RPLP1 ribosomal protein, large, P1 -0.0730906
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0720484
RPL11 ribosomal protein L11 -0.0674737
RPL37A ribosomal protein L37a -0.0649759
RPS8 ribosomal protein S8 -0.0637116
ENO1 enolase 1, (alpha) -0.0622165
AHSG alpha-2-HS-glycoprotein -0.060868
RPS12 ribosomal protein S12 -0.0607019
RPL35A ribosomal protein L35a -0.0581346
RPS19 ribosomal protein S19 -0.0576355
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0570649
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0548564
TRIM26 tripartite motif containing 26 -0.0534336
APOB apolipoprotein B -0.0519331
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0505301
APOE apolipoprotein E -0.0505216
RPS24 ribosomal protein S24 -0.0496086
FBF1 Fas (TNFRSF6) binding factor 1 -0.0494694
RPL23 ribosomal protein L23 -0.0482889
RPS27A ribosomal protein S27a -0.0473542
RPL34 ribosomal protein L34 -0.0467709
PTMA prothymosin, alpha -0.044457
RPL31 ribosomal protein L31 -0.0435525
RPL12 ribosomal protein L12 -0.0423486
GNAS GNAS complex locus -0.0419966
RPLP2 ribosomal protein, large, P2 -0.041723
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0383541
RACK1 receptor for activated C kinase 1 -0.0380213
EML4 echinoderm microtubule associated protein like 4 -0.0370883
RPS3 ribosomal protein S3 -0.0369733
RPLP0 ribosomal protein, large, P0 -0.0360647
RRBP1 ribosome binding protein 1 -0.0359443
AMBP alpha-1-microglobulin/bikunin precursor -0.0358976
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0354951
RPS29 ribosomal protein S29 -0.0353563
RPS14 ribosomal protein S14 -0.0342792
TMSB10 thymosin beta 10 -0.0342494
HMGA1 high mobility group AT-hook 1 -0.0341451
IER3 immediate early response 3 -0.0338869
GDF15 growth differentiation factor 15 -0.0335966
APOA1 apolipoprotein A-I -0.0334365
ETFB electron-transfer-flavoprotein, beta polypeptide -0.031924
RPL26 ribosomal protein L26 -0.0316937
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0312234
RPS25 ribosomal protein S25 -0.030549
RPS21 ribosomal protein S21 -0.0301709
RPS23 ribosomal protein S23 -0.029995
RPL9 ribosomal protein L9 -0.0292257
B2M beta-2-microglobulin -0.0290686
RPS13 ribosomal protein S13 -0.0283992
RPL19 ribosomal protein L19 -0.0282047
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.027358
RPL37 ribosomal protein L37 -0.0272869
EGR1 early growth response 1 -0.0271246
S100A9 S100 calcium binding protein A9 -0.0270714
LYZ lysozyme -0.0267458
TM4SF1 transmembrane 4 L six family member 1 -0.0261274
CPE carboxypeptidase E -0.0260014
RPL28 ribosomal protein L28 -0.0255242
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0254961
TPM4 tropomyosin 4 -0.0253447
RPS16 ribosomal protein S16 -0.0251697
KTN1 kinectin 1 (kinesin receptor) -0.0250308
EIF1 eukaryotic translation initiation factor 1 -0.0249445
NAP1L1 nucleosome assembly protein 1-like 1 -0.0248782
CALR calreticulin -0.0244536
RPL32 ribosomal protein L32 -0.0244054
TMEM123 transmembrane protein 123 -0.024382
RPL13A ribosomal protein L13a -0.0241751
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0241346
RBM39 RNA binding motif protein 39 -0.0237209
RPS5 ribosomal protein S5 -0.0235175
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.023145
RPS17 ribosomal protein S17 -0.0230668
A2M alpha-2-macroglobulin -0.0229334
PDIA3 protein disulfide isomerase family A, member 3 -0.0227612
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0227364
KPNB1 karyopherin (importin) beta 1 -0.0225373
RPL27A ribosomal protein L27a -0.0224121
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0223343
RPL30 ribosomal protein L30 -0.0221472
RPL7 ribosomal protein L7 -0.0220468
CP ceruloplasmin (ferroxidase) -0.022043
APOC1 apolipoprotein C-I -0.0220104
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0220013
RPL5 ribosomal protein L5 -0.0215282
RPS11 ribosomal protein S11 -0.0212533
RPL7A ribosomal protein L7a -0.0208581
CST3 cystatin C -0.0207624
RPL10A ribosomal protein L10a -0.0206148