| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.0802543 |
| MTSS1 | metastasis suppressor 1 | 0.0745123 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0573002 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0563581 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0549302 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0504513 |
| NAV2 | neuron navigator 2 | 0.0493814 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.047318 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0460668 |
| CD44 | CD44 molecule (Indian blood group) | 0.0451208 |
| RAI14 | retinoic acid induced 14 | 0.043703 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0429952 |
| PLEC | plectin | 0.0381701 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0381137 |
| PTK2 | protein tyrosine kinase 2 | 0.037631 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0374868 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0363626 |
| EFNA5 | ephrin-A5 | 0.0324545 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0323379 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.031164 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0307517 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0305981 |
| HMGA2 | high mobility group AT-hook 2 | 0.0300762 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0299905 |
| ASPH | aspartate beta-hydroxylase | 0.0294447 |
| LAMC2 | laminin, gamma 2 | 0.0290052 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0289851 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0286353 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0282342 |
| FNIP1 | folliculin interacting protein 1 | 0.0276531 |
| JMJD1C | jumonji domain containing 1C | 0.0274991 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0273243 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0265795 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0262052 |
| HSPA8 | heat shock 70kDa protein 8 | 0.026063 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0255616 |
| DST | dystonin | 0.0248236 |
| AOPEP | aminopeptidase O (putative) | 0.0244231 |
| PLS3 | plastin 3 | 0.0239756 |
| SULF2 | sulfatase 2 | 0.0239545 |
| ANO6 | anoctamin 6 | 0.0236 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0232117 |
| CDK6 | cyclin-dependent kinase 6 | 0.0231767 |
| EXOC4 | exocyst complex component 4 | 0.0231656 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0227965 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.022772 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0224119 |
| MYOF | myoferlin | 0.0220653 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | 0.0220413 |
| HDAC9 | histone deacetylase 9 | 0.0219758 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0219523 |
| INTS6 | integrator complex subunit 6 | 0.0216447 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0216062 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0215498 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0212296 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0210679 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0210224 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0209017 |
| PODXL | podocalyxin-like | 0.0203016 |
| RNF217 | ring finger protein 217 | 0.0202739 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0200429 |
| FRMD6 | FERM domain containing 6 | 0.0199583 |
| SMAD3 | SMAD family member 3 | 0.019557 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0194536 |
| H1-0 | H1.0 linker histone | 0.0193893 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0191726 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0189591 |
| MEF2A | myocyte enhancer factor 2A | 0.0185881 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0185209 |
| SIK3 | SIK family kinase 3 | 0.0183103 |
| RASAL2 | RAS protein activator like 2 | 0.0178725 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0177012 |
| AMOTL1 | angiomotin like 1 | 0.0175396 |
| RAD51B | RAD51 paralog B | 0.0175339 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.017156 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0169892 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.01695 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0169389 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0166586 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0164626 |
| AHNAK | AHNAK nucleoprotein | 0.0163218 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.016262 |
| CALB1 | calbindin 1, 28kDa | 0.0162601 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0160757 |
| BARX2 | BARX homeobox 2 | 0.0155951 |
| SMYD3 | SET and MYND domain containing 3 | 0.01527 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0147672 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0147601 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0146127 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0145255 |
| GPR176 | G protein-coupled receptor 176 | 0.0143391 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0142333 |
| SLK | STE20-like kinase | 0.0139999 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0139725 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0139281 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0139164 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0138304 |
| CNTNAP3 | contactin associated protein-like 3 | 0.0137763 |
| ITGB8 | integrin, beta 8 | 0.0135471 |
| MTAP | methylthioadenosine phosphorylase | 0.0134838 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.122297 |
| NDRG1 | N-myc downstream regulated 1 | -0.0900547 |
| PTMA | prothymosin, alpha | -0.0854366 |
| TMSB10 | thymosin beta 10 | -0.0699414 |
| FLNB | filamin B, beta | -0.0658761 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0656457 |
| B2M | beta-2-microglobulin | -0.0655957 |
| CLU | clusterin | -0.0625229 |
| ENO1 | enolase 1, (alpha) | -0.0558075 |
| MT2A | metallothionein 2A | -0.0543729 |
| KRT17 | keratin 17, type I | -0.0464366 |
| GOLGA4 | golgin A4 | -0.0463977 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0448247 |
| RPLP1 | ribosomal protein, large, P1 | -0.0441057 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0439757 |
| RPS21 | ribosomal protein S21 | -0.041883 |
| STC1 | stanniocalcin 1 | -0.0406011 |
| RPLP2 | ribosomal protein, large, P2 | -0.0390147 |
| LMNA | lamin A/C | -0.0365591 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0357808 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0356289 |
| S100A6 | S100 calcium binding protein A6 | -0.0354388 |
| RPS8 | ribosomal protein S8 | -0.0349201 |
| S100A10 | S100 calcium binding protein A10 | -0.0343934 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0341731 |
| RPS6 | ribosomal protein S6 | -0.0333439 |
| HLA-B | major histocompatibility complex, class I, B | -0.0313577 |
| RPS19 | ribosomal protein S19 | -0.0313035 |
| GNAS | GNAS complex locus | -0.0312648 |
| RPS3 | ribosomal protein S3 | -0.0311337 |
| RPL23 | ribosomal protein L23 | -0.0309188 |
| RPS13 | ribosomal protein S13 | -0.0304869 |
| POTEF | POTE ankyrin domain family, member F | -0.0297136 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0284499 |
| HM13 | histocompatibility (minor) 13 | -0.0280513 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0274954 |
| UBC | ubiquitin C | -0.0270921 |
| S100A9 | S100 calcium binding protein A9 | -0.027067 |
| RPS27A | ribosomal protein S27a | -0.0270223 |
| RPS12 | ribosomal protein S12 | -0.0265891 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0264007 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0263044 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0261088 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0253784 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0252936 |
| RPL35A | ribosomal protein L35a | -0.0248941 |
| ITGA6 | integrin, alpha 6 | -0.0248872 |
| RPL8 | ribosomal protein L8 | -0.0247108 |
| SERINC3 | serine incorporator 3 | -0.0244471 |
| YBX3 | Y box binding protein 3 | -0.0242508 |
| KRT6A | keratin 6A, type II | -0.0242094 |
| FTL | ferritin, light polypeptide | -0.0241648 |
| RPS14 | ribosomal protein S14 | -0.0240706 |
| CALR | calreticulin | -0.0240346 |
| PLAT | plasminogen activator, tissue | -0.0239209 |
| PKM | pyruvate kinase, muscle | -0.023901 |
| IGF2 | insulin-like growth factor 2 | -0.023836 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0238156 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0237653 |
| RPL11 | ribosomal protein L11 | -0.0236166 |
| SULF1 | sulfatase 1 | -0.0235716 |
| WASF2 | WAS protein family, member 2 | -0.0234837 |
| PGK1 | phosphoglycerate kinase 1 | -0.0233719 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.023131 |
| FOXO1 | forkhead box O1 | -0.0229286 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0229021 |
| RPL34 | ribosomal protein L34 | -0.0228717 |
| S100A2 | S100 calcium binding protein A2 | -0.0227523 |
| YBX1 | Y box binding protein 1 | -0.0224611 |
| TPM4 | tropomyosin 4 | -0.022437 |
| RTN4 | reticulon 4 | -0.0222577 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0220651 |
| RPS25 | ribosomal protein S25 | -0.0217779 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0216087 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0213426 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0211122 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0209459 |
| LDHA | lactate dehydrogenase A | -0.0209379 |
| BCL2L1 | BCL2-like 1 | -0.020671 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0205923 |
| RPS27 | ribosomal protein S27 | -0.0205922 |
| RPL12 | ribosomal protein L12 | -0.0202974 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0201356 |
| CD99 | CD99 molecule | -0.0196342 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0195337 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0194723 |
| RBM39 | RNA binding motif protein 39 | -0.0192623 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0190563 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.0188816 |
| S100A11 | S100 calcium binding protein A11 | -0.0188468 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.018678 |
| RPL37A | ribosomal protein L37a | -0.0185978 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0185679 |
| HLA-A | major histocompatibility complex, class I, A | -0.0185483 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0182933 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0180162 |
| RPL36 | ribosomal protein L36 | -0.0178442 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0177727 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0176749 |
| PFN1 | profilin 1 | -0.0176662 |
