| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.22642 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.132233 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0941236 |
| LMO7 | LIM domain 7 | 0.0787685 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0670815 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0653209 |
| FNDC3B | fibronectin type III domain containing 3B | 0.064331 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.057178 |
| DSPP | dentin sialophosphoprotein | 0.0565708 |
| AHR | aryl hydrocarbon receptor | 0.0561279 |
| ATXN1 | ataxin 1 | 0.0487593 |
| ANXA1 | annexin A1 | 0.0473866 |
| HSPA8 | heat shock 70kDa protein 8 | 0.046423 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0437954 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0432462 |
| EXT1 | exostosin glycosyltransferase 1 | 0.042359 |
| AHNAK | AHNAK nucleoprotein | 0.0422135 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0413035 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0412516 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0410129 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0394959 |
| PGK1 | phosphoglycerate kinase 1 | 0.0394136 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0381854 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0380093 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0373705 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.037056 |
| CLTC | clathrin, heavy chain (Hc) | 0.0356202 |
| EZR | ezrin | 0.0351998 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0343158 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0342939 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0327508 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0317126 |
| TMC5 | transmembrane channel-like 5 | 0.0312072 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0311452 |
| TMSB4X | thymosin beta 4, X-linked | 0.0307082 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.030211 |
| COBL | cordon-bleu WH2 repeat protein | 0.0302037 |
| PLEC | plectin | 0.030124 |
| GOLGB1 | golgin B1 | 0.0298455 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0296951 |
| H1-0 | H1.0 linker histone | 0.0296507 |
| ZNF292 | zinc finger protein 292 | 0.0293867 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0282035 |
| FNIP1 | folliculin interacting protein 1 | 0.0281593 |
| KLHL29 | kelch-like family member 29 | 0.0280932 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.026702 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0266589 |
| RASEF | RAS and EF-hand domain containing | 0.0266343 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0265868 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0265438 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0264713 |
| HKDC1 | hexokinase domain containing 1 | 0.0263872 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0260771 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.025825 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0256316 |
| TES | testin LIM domain protein | 0.0248615 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0248012 |
| CANX | calnexin | 0.0247046 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0244981 |
| CD2AP | CD2-associated protein | 0.0244937 |
| POF1B | premature ovarian failure, 1B | 0.024294 |
| RNF213 | ring finger protein 213 | 0.0240483 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0230801 |
| LCN2 | lipocalin 2 | 0.0230577 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0226536 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0222514 |
| HDLBP | high density lipoprotein binding protein | 0.0222081 |
| EMP1 | epithelial membrane protein 1 | 0.021969 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.021727 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0216814 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0213781 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0213765 |
| MYOF | myoferlin | 0.021346 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0212836 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0212429 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0211662 |
| FAT1 | FAT atypical cadherin 1 | 0.0210093 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0207523 |
| ANO6 | anoctamin 6 | 0.0206747 |
| KIF16B | kinesin family member 16B | 0.0204615 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0204072 |
| SMAD3 | SMAD family member 3 | 0.020024 |
| FRMD5 | FERM domain containing 5 | 0.0198464 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0194464 |
| EXPH5 | exophilin 5 | 0.0193446 |
| HBP1 | HMG-box transcription factor 1 | 0.0191863 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.019014 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.018906 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.018799 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0187741 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0187416 |
| DST | dystonin | 0.0186638 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0183405 |
| CALU | calumenin | 0.0181685 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0181673 |
| EXOC4 | exocyst complex component 4 | 0.0181026 |
| MORF4L2 | mortality factor 4 like 2 | 0.0180517 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0180221 |
| MYO6 | myosin VI | 0.0179468 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | 0.0178606 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.124831 |
| NPSR1 | neuropeptide S receptor 1 | -0.121461 |
| PTMA | prothymosin, alpha | -0.0884966 |
| TMSB10 | thymosin beta 10 | -0.0745983 |
| RPL35A | ribosomal protein L35a | -0.0664035 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0596598 |
| S100A6 | S100 calcium binding protein A6 | -0.0588431 |
| RPS6 | ribosomal protein S6 | -0.0551027 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0550598 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0535517 |
| POTEF | POTE ankyrin domain family, member F | -0.0525603 |
| RPLP1 | ribosomal protein, large, P1 | -0.0498552 |
| S100A10 | S100 calcium binding protein A10 | -0.0495928 |
| FTL | ferritin, light polypeptide | -0.0491086 |
| RPL23 | ribosomal protein L23 | -0.0462581 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0412256 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0410365 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0403338 |
| RPS19 | ribosomal protein S19 | -0.039821 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0397916 |
| HMGA1 | high mobility group AT-hook 1 | -0.0396774 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0347944 |
| S100P | S100 calcium binding protein P | -0.0344023 |
| RPS3 | ribosomal protein S3 | -0.0324663 |
| B2M | beta-2-microglobulin | -0.0318898 |
| S100A11 | S100 calcium binding protein A11 | -0.0314849 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0295985 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0292004 |
| TPM4 | tropomyosin 4 | -0.0285058 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0284981 |
| RPL12 | ribosomal protein L12 | -0.0281676 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0268379 |
| S100A9 | S100 calcium binding protein A9 | -0.0259511 |
| RPL34 | ribosomal protein L34 | -0.0252092 |
| WWC1 | WW and C2 domain containing 1 | -0.0249799 |
| RPS8 | ribosomal protein S8 | -0.0249512 |
| RPS24 | ribosomal protein S24 | -0.0248738 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0247775 |
| PRSS3 | protease, serine, 3 | -0.0247606 |
| MUC1 | mucin 1, cell surface associated | -0.0247159 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0246259 |
| RPS25 | ribosomal protein S25 | -0.0245322 |
| KRT19 | keratin 19, type I | -0.0244568 |
| FLNB | filamin B, beta | -0.0240486 |
| RPL37A | ribosomal protein L37a | -0.0240335 |
| RPL31 | ribosomal protein L31 | -0.0238772 |
| RPS17 | ribosomal protein S17 | -0.0234432 |
| JUP | junction plakoglobin | -0.0234153 |
| LYZ | lysozyme | -0.0231028 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0227001 |
| KLK10 | kallikrein-related peptidase 10 | -0.022627 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0225661 |
| ACTG1 | actin gamma 1 | -0.0218463 |
| RPS12 | ribosomal protein S12 | -0.0217061 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0215319 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0215014 |
| ANXA2 | annexin A2 | -0.0214868 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0212697 |
| INSIG1 | insulin induced gene 1 | -0.0211776 |
| RRBP1 | ribosome binding protein 1 | -0.0210714 |
| EGR1 | early growth response 1 | -0.020986 |
| RPL11 | ribosomal protein L11 | -0.0208813 |
| GPX2 | glutathione peroxidase 2 | -0.0205872 |
| AREG | amphiregulin | -0.0203415 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0201851 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.0199218 |
| RPL26 | ribosomal protein L26 | -0.0198584 |
| PRKCA | protein kinase C, alpha | -0.0197047 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0193139 |
| RPL9 | ribosomal protein L9 | -0.019246 |
| RPS21 | ribosomal protein S21 | -0.0192265 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0190168 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0188892 |
| PFN1 | profilin 1 | -0.0188706 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0187791 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0187744 |
| CCNL1 | cyclin L1 | -0.0187383 |
| MUC17 | mucin 17, cell surface associated | -0.018601 |
| HLA-B | major histocompatibility complex, class I, B | -0.0183536 |
| RPS14 | ribosomal protein S14 | -0.018255 |
| RPS13 | ribosomal protein S13 | -0.0182313 |
| RPS27 | ribosomal protein S27 | -0.0182148 |
| ITGB4 | integrin, beta 4 | -0.0180225 |
| RPS29 | ribosomal protein S29 | -0.0180073 |
| RPL36 | ribosomal protein L36 | -0.0180048 |
| RPL8 | ribosomal protein L8 | -0.0178744 |
| RPL13A | ribosomal protein L13a | -0.0177648 |
| YBX1 | Y box binding protein 1 | -0.0177506 |
| RPLP2 | ribosomal protein, large, P2 | -0.0176734 |
| RPS16 | ribosomal protein S16 | -0.0176696 |
| RPL36A | ribosomal protein L36a | -0.0173926 |
| RPL5 | ribosomal protein L5 | -0.0172852 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0172499 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0171527 |
| FASN | fatty acid synthase | -0.0170388 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.017001 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0169584 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.016901 |
| RPL27 | ribosomal protein L27 | -0.0167976 |
| TFF2 | trefoil factor 2 | -0.0167233 |
