| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.124405 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.11618 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.110517 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0890909 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0887245 |
| LDHA | lactate dehydrogenase A | 0.080624 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0801392 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0708124 |
| PIGR | polymeric immunoglobulin receptor | 0.0689886 |
| TXNIP | thioredoxin interacting protein | 0.0684728 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0642871 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0625177 |
| LMO7 | LIM domain 7 | 0.0617523 |
| H1-0 | H1.0 linker histone | 0.0584244 |
| PGK1 | phosphoglycerate kinase 1 | 0.0538788 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0529608 |
| CANX | calnexin | 0.0505202 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0493843 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0481221 |
| HDLBP | high density lipoprotein binding protein | 0.0451609 |
| EPCAM | epithelial cell adhesion molecule | 0.044477 |
| DSPP | dentin sialophosphoprotein | 0.0434501 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0425259 |
| GOLGA4 | golgin A4 | 0.0421948 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0413052 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0409396 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0407847 |
| AHNAK | AHNAK nucleoprotein | 0.036887 |
| NEBL | nebulette | 0.0361936 |
| RPL4 | ribosomal protein L4 | 0.035178 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0349267 |
| EREG | epiregulin | 0.0347485 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.034072 |
| KRT8 | keratin 8, type II | 0.0339439 |
| APP | amyloid beta (A4) precursor protein | 0.0337949 |
| KRT18 | keratin 18, type I | 0.0318159 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0316573 |
| PLEC | plectin | 0.0312801 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0307227 |
| PDZD8 | PDZ domain containing 8 | 0.0306066 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0303481 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0303145 |
| MED13 | mediator complex subunit 13 | 0.0300404 |
| UBC | ubiquitin C | 0.0296522 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0288337 |
| SHROOM3 | shroom family member 3 | 0.0280014 |
| CLTC | clathrin, heavy chain (Hc) | 0.0279702 |
| CD2AP | CD2-associated protein | 0.0279522 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0275108 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0273367 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0271484 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0269433 |
| WDR45B | WD repeat domain 45B | 0.0267236 |
| TMSB4X | thymosin beta 4, X-linked | 0.0261551 |
| ANXA1 | annexin A1 | 0.0260717 |
| NEK7 | NIMA-related kinase 7 | 0.0254568 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0250628 |
| RPL3 | ribosomal protein L3 | 0.0249161 |
| TXNRD1 | thioredoxin reductase 1 | 0.0248431 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0247565 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0244164 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0239662 |
| TPD52 | tumor protein D52 | 0.0238012 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0231962 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.023159 |
| ATXN1 | ataxin 1 | 0.0230027 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0228731 |
| EHF | ets homologous factor | 0.0228369 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0226582 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0226319 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0226223 |
| EXPH5 | exophilin 5 | 0.0224947 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0224344 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0223521 |
| CD164 | CD164 molecule, sialomucin | 0.0223439 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0218991 |
| ANO6 | anoctamin 6 | 0.0218892 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0218105 |
| RPL18 | ribosomal protein L18 | 0.0214579 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0211737 |
| USP6NL | USP6 N-terminal like | 0.0211541 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0210407 |
| ERBIN | erbb2 interacting protein | 0.0210357 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.020831 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0208043 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.020776 |
| FAM13A | family with sequence similarity 13, member A | 0.0207346 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0207268 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0205792 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0203364 |
| LAMC2 | laminin, gamma 2 | 0.0201773 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0200418 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.0199615 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0198459 |
| DSG2 | desmoglein 2 | 0.0198081 |
| NCKAP1 | NCK-associated protein 1 | 0.0197647 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0196956 |
| ARF1 | ADP-ribosylation factor 1 | 0.0195829 |
| DNM2 | dynamin 2 | 0.0195441 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0194647 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.219208 |
| PTMA | prothymosin, alpha | -0.209651 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.204156 |
| VCL | vinculin | -0.127542 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0985555 |
| MYO1E | myosin IE | -0.0805723 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0787074 |
| AREG | amphiregulin | -0.0723356 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0695845 |
| RPS6 | ribosomal protein S6 | -0.065974 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0600611 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.058544 |
| RPS12 | ribosomal protein S12 | -0.0542684 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0539123 |
| RPL9 | ribosomal protein L9 | -0.0535107 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0515653 |
| RPL35A | ribosomal protein L35a | -0.0501038 |
| RAD51B | RAD51 paralog B | -0.0500959 |
| LAMA4 | laminin, alpha 4 | -0.0495703 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0490978 |
| FHIT | fragile histidine triad | -0.0482235 |
| RPLP1 | ribosomal protein, large, P1 | -0.0468633 |
| ONECUT3 | one cut homeobox 3 | -0.0452217 |
| RPL37A | ribosomal protein L37a | -0.0447425 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0440993 |
| RPS8 | ribosomal protein S8 | -0.0431656 |
| FLNB | filamin B, beta | -0.0418499 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0412386 |
| RNF217 | ring finger protein 217 | -0.0403167 |
| RPL31 | ribosomal protein L31 | -0.0402267 |
| DENND1A | DENN/MADD domain containing 1A | -0.0401401 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0399546 |
| ANTXR2 | anthrax toxin receptor 2 | -0.038967 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0384761 |
| TNS4 | tensin 4 | -0.0382299 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0378985 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0365199 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0364731 |
| GPHN | gephyrin | -0.0364388 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.035943 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0353534 |
| RPL13A | ribosomal protein L13a | -0.0343215 |
| IER3 | immediate early response 3 | -0.0338017 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.033445 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0331502 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0326446 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0325929 |
| ACTG1 | actin gamma 1 | -0.0322743 |
| LSAMP | limbic system-associated membrane protein | -0.0319054 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0317442 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.031258 |
| RPS17 | ribosomal protein S17 | -0.030073 |
| RPL23 | ribosomal protein L23 | -0.0293728 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0289284 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0289115 |
| RPS3 | ribosomal protein S3 | -0.0288597 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0287931 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0285154 |
| EGFR | epidermal growth factor receptor | -0.0282873 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0277327 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0275878 |
| RPS19 | ribosomal protein S19 | -0.0275489 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0270958 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0269653 |
| RCOR1 | REST corepressor 1 | -0.0267078 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0262907 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0261783 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0261721 |
| HMGA1 | high mobility group AT-hook 1 | -0.0256793 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0249563 |
| INTS6 | integrator complex subunit 6 | -0.0246568 |
| CLDN4 | claudin 4 | -0.0242081 |
| HMGB1 | high mobility group box 1 | -0.0241418 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0240987 |
| EFNB2 | ephrin-B2 | -0.0237629 |
| DIAPH2 | diaphanous-related formin 2 | -0.0235946 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0233755 |
| ECT2 | epithelial cell transforming 2 | -0.0232819 |
| RPS2 | ribosomal protein S2 | -0.0232095 |
| ABR | active BCR-related | -0.0230863 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0230392 |
| RPL26 | ribosomal protein L26 | -0.023026 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0227976 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0226716 |
| TFF1 | trefoil factor 1 | -0.0226411 |
| CMIP | c-Maf inducing protein | -0.0226203 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0226135 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0224753 |
| VMP1 | vacuole membrane protein 1 | -0.0224485 |
| CALB1 | calbindin 1, 28kDa | -0.0221814 |
| CUX1 | cut-like homeobox 1 | -0.0221403 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0221216 |
| RPS27A | ribosomal protein S27a | -0.0220795 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0217807 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0217143 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0214692 |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | -0.0214506 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0213676 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0212412 |
| TPM1 | tropomyosin 1 (alpha) | -0.0209249 |
