| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.148817 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.145008 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.131322 |
| LOC112694756 | uncharaterized LOC112694756 | 0.111565 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0977226 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0887474 |
| POTEF | POTE ankyrin domain family, member F | 0.0809449 |
| CD44 | CD44 molecule (Indian blood group) | 0.0777799 |
| TMSB4X | thymosin beta 4, X-linked | 0.0770452 |
| DST | dystonin | 0.076913 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0750235 |
| PGK1 | phosphoglycerate kinase 1 | 0.0743353 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0738466 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0726259 |
| TXNIP | thioredoxin interacting protein | 0.0690343 |
| CAPRIN2 | caprin family member 2 | 0.0668756 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0649914 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0646822 |
| PODXL | podocalyxin-like | 0.0645776 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0611027 |
| RPL4 | ribosomal protein L4 | 0.0592568 |
| LDHA | lactate dehydrogenase A | 0.0580676 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0578642 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0577352 |
| PYGL | phosphorylase, glycogen, liver | 0.0568501 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0524588 |
| FMNL2 | formin-like 2 | 0.0513793 |
| HLA-B | major histocompatibility complex, class I, B | 0.0513078 |
| SPAG9 | sperm associated antigen 9 | 0.0510949 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0510074 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0501949 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0497564 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0487791 |
| SLK | STE20-like kinase | 0.0484333 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0482525 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0482474 |
| MT1X | metallothionein 1X | 0.047959 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0471089 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0458849 |
| ARRDC3 | arrestin domain containing 3 | 0.0457523 |
| SDC4 | syndecan 4 | 0.0455698 |
| EREG | epiregulin | 0.044753 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0444123 |
| PKM | pyruvate kinase, muscle | 0.0442663 |
| SEC24A | SEC24 family member A | 0.0442385 |
| HMGA1 | high mobility group AT-hook 1 | 0.0439681 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0426945 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0423017 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.042239 |
| EMP1 | epithelial membrane protein 1 | 0.0409508 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0407597 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0405512 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0388279 |
| APP | amyloid beta (A4) precursor protein | 0.0386127 |
| RUNX1 | runt-related transcription factor 1 | 0.038461 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0376771 |
| MT1E | metallothionein 1E | 0.0367294 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0362791 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0350581 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0346245 |
| PCDH1 | protocadherin 1 | 0.0345366 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0341997 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.034151 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.034077 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0339945 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0337867 |
| RPL3 | ribosomal protein L3 | 0.0335932 |
| ENO1 | enolase 1, (alpha) | 0.0335093 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0330731 |
| UBC | ubiquitin C | 0.0328438 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0325368 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.032413 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0324021 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0321418 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0319621 |
| RPL18 | ribosomal protein L18 | 0.0318169 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0315252 |
| HLA-A | major histocompatibility complex, class I, A | 0.0312522 |
| KRT18 | keratin 18, type I | 0.0311794 |
| KLF6 | Kruppel-like factor 6 | 0.0311764 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0310329 |
| MYO9B | myosin IXB | 0.0310301 |
| SIK3 | SIK family kinase 3 | 0.0307224 |
| PLIN2 | perilipin 2 | 0.030522 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0300986 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0299699 |
| PDE10A | phosphodiesterase 10A | 0.0298344 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0293187 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.029235 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0285547 |
| ECE1 | endothelin converting enzyme 1 | 0.0281906 |
| SET | SET nuclear proto-oncogene | 0.0281765 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0280399 |
| BRD2 | bromodomain containing 2 | 0.0280124 |
| RPS18 | ribosomal protein S18 | 0.0276708 |
| SFTPA2 | surfactant protein A2 | 0.0272623 |
| PLEC | plectin | 0.0272125 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0270123 |
| TP63 | tumor protein p63 | 0.0266074 |
| PLK2 | polo-like kinase 2 | 0.0261586 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.0997452 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0906986 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.084453 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0637029 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0602445 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0575508 |
| CENPF | centromere protein F, 350/400kDa | -0.0563981 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0556242 |
| EXOC4 | exocyst complex component 4 | -0.05217 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0519219 |
| HDAC9 | histone deacetylase 9 | -0.0499004 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.047913 |
| TOP1 | topoisomerase (DNA) I | -0.0472036 |
| EFNA5 | ephrin-A5 | -0.045267 |
| ACTG1 | actin gamma 1 | -0.0451837 |
| RTN4 | reticulon 4 | -0.0447347 |
| RPL35A | ribosomal protein L35a | -0.0434159 |
| VMP1 | vacuole membrane protein 1 | -0.0412989 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0412217 |
| RAD51B | RAD51 paralog B | -0.0376499 |
| RPLP1 | ribosomal protein, large, P1 | -0.0368591 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0338441 |
| MKI67 | marker of proliferation Ki-67 | -0.0330717 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0329418 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0318952 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0301588 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0299485 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0298486 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.02933 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0293056 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0292493 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0290956 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0279196 |
| RBM25 | RNA binding motif protein 25 | -0.0271188 |
| SBF2 | SET binding factor 2 | -0.0270908 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0267713 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0266676 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0263951 |
| GNAS | GNAS complex locus | -0.0262723 |
| CFDP1 | craniofacial development protein 1 | -0.025855 |
| ANK2 | ankyrin 2, neuronal | -0.0257052 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0253526 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0251924 |
| VIM | vimentin | -0.024897 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0248646 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0248379 |
| URI1 | URI1, prefoldin-like chaperone | -0.0245929 |
| SMAD3 | SMAD family member 3 | -0.0245928 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0245868 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0243556 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0242998 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0242559 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0240956 |
| THOC2 | THO complex 2 | -0.0236776 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0235072 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0234919 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0234597 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0233332 |
| RPS19 | ribosomal protein S19 | -0.023298 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0232951 |
| SCFD1 | sec1 family domain containing 1 | -0.0231892 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0230999 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0229759 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0229315 |
| MT2A | metallothionein 2A | -0.0228122 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0228117 |
| BPTF | bromodomain PHD finger transcription factor | -0.0225977 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0225782 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0225504 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0224651 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0223664 |
| METTL15 | methyltransferase like 15 | -0.0223568 |
| ECT2 | epithelial cell transforming 2 | -0.0223551 |
| RRBP1 | ribosome binding protein 1 | -0.0223108 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | -0.022299 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0220479 |
| CENPE | centromere protein E, 312kDa | -0.0220416 |
| ARF4 | ADP-ribosylation factor 4 | -0.0219539 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0218142 |
| CCDC91 | coiled-coil domain containing 91 | -0.0217928 |
| COG5 | component of oligomeric golgi complex 5 | -0.0215688 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0215661 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0215574 |
| FOXK1 | forkhead box K1 | -0.0214933 |
| RPS29 | ribosomal protein S29 | -0.0213641 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0212885 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0211418 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0210574 |
| OGA | O-GlcNAcase | -0.0209268 |
| DPH6 | diphthamine biosynthesis 6 | -0.0206302 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0205868 |
| KIF14 | kinesin family member 14 | -0.020334 |
| ZNF292 | zinc finger protein 292 | -0.0201938 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0200867 |
| WDR33 | WD repeat domain 33 | -0.0200458 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.019877 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0197679 |
| LMAN1 | lectin, mannose-binding, 1 | -0.019728 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0197011 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0196219 |
