Tucatinib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucatinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucatinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 0.13897
SLTM SAFB-like, transcription modulator 0.136155
EGFR epidermal growth factor receptor 0.117323
SMAD3 SMAD family member 3 0.0919834
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0889171
SOD2 superoxide dismutase 2, mitochondrial 0.0771145
GRAMD1B GRAM domain containing 1B 0.0767173
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0766535
CEMIP cell migration inducing protein, hyaluronan binding 0.0749402
HSPA8 heat shock 70kDa protein 8 0.0683484
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0678771
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0670237
ELL2 elongation factor, RNA polymerase II, 2 0.06625
CES1 carboxylesterase 1 0.0627984
MCL1 myeloid cell leukemia 1 0.061442
RNF213 ring finger protein 213 0.0571597
MYH9 myosin, heavy chain 9, non-muscle 0.0566505
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0556299
MYOF myoferlin 0.0551661
RUNX1 runt-related transcription factor 1 0.0508202
THSD4 thrombospondin, type I, domain containing 4 0.0506291
TBC1D22A TBC1 domain family, member 22A 0.0504071
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0475757
CXCL8 chemokine (C-X-C motif) ligand 8 0.0470986
MCTP1 multiple C2 domains, transmembrane 1 0.0467914
ARRDC3 arrestin domain containing 3 0.0455746
AGO2 argonaute RISC catalytic component 2 0.0448135
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0443407
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.041492
FNDC3B fibronectin type III domain containing 3B 0.041358
SAMD4A sterile alpha motif domain containing 4A 0.0413312
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0410316
PLEC plectin 0.0402113
RPL4 ribosomal protein L4 0.0390827
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.038476
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.037828
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0372585
MAP7 microtubule-associated protein 7 0.0371586
GPHN gephyrin 0.0356646
KIAA1217 KIAA1217 0.0348815
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0345522
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0338352
EPAS1 endothelial PAS domain protein 1 0.0337661
MSN moesin 0.033335
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0326764
MACF1 microtubule-actin crosslinking factor 1 0.0323447
PDE4D phosphodiesterase 4D, cAMP-specific 0.0320194
ANO6 anoctamin 6 0.0320107
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0310708
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0310636
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0310561
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0310088
SPAG9 sperm associated antigen 9 0.03095
GRB10 growth factor receptor-bound protein 10 0.0289288
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0282447
RPL3 ribosomal protein L3 0.0280052
RAD51B RAD51 paralog B 0.027549
PM20D1 peptidase M20 domain containing 1 0.0275399
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0273261
CSNK1A1 casein kinase 1, alpha 1 0.0269375
SP100 SP100 nuclear antigen 0.0267079
GLS2 glutaminase 2 (liver, mitochondrial) 0.0264922
CUL4A cullin 4A 0.0264019
ANKRD12 ankyrin repeat domain 12 0.0260388
ATP13A3 ATPase type 13A3 0.025991
ENO1 enolase 1, (alpha) 0.0259294
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0258675
DSCAM Down syndrome cell adhesion molecule 0.0257097
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0256411
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.025463
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.025278
GPC6 glypican 6 0.0246721
BMP6 bone morphogenetic protein 6 0.0246687
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.024056
NPAS2 neuronal PAS domain protein 2 0.0237243
DENND4A DENN/MADD domain containing 4A 0.0236949
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.023455
JMJD1C jumonji domain containing 1C 0.0228373
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0224167
FNIP1 folliculin interacting protein 1 0.0223152
PTPRJ protein tyrosine phosphatase, receptor type, J 0.022264
DTNA dystrobrevin, alpha 0.0221782
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0221662
SLC35F5 solute carrier family 35, member F5 0.0220678
ADAM9 ADAM metallopeptidase domain 9 0.0220661
NAMPT nicotinamide phosphoribosyltransferase 0.0220191
ZNF638 zinc finger protein 638 0.0219939
NPTX1 neuronal pentraxin I 0.0219708
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0218011
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0217873
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0217748
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0216894
MX1 MX dynamin-like GTPase 1 0.021613
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0210896
RAB7A RAB7A, member RAS oncogene family 0.0210322
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0209736
SHB Src homology 2 domain containing adaptor protein B 0.0207119
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0206244
CSNK1E casein kinase 1, epsilon 0.0205301
ADAR adenosine deaminase, RNA-specific 0.0205183

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.132235
LMO7 LIM domain 7 -0.121449
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.109254
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102403
TMSB10 thymosin beta 10 -0.0820406
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0753324
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0678791
PATJ PATJ crumbs cell polarity complex component -0.0660944
LAMC2 laminin, gamma 2 -0.0653559
ACTG1 actin gamma 1 -0.0588096
FTL ferritin, light polypeptide -0.0580998
PTMA prothymosin, alpha -0.0537464
BRWD1 bromodomain and WD repeat domain containing 1 -0.0503824
HDLBP high density lipoprotein binding protein -0.0496544
SCEL sciellin -0.0435678
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0431892
NDRG1 N-myc downstream regulated 1 -0.041906
PTPRM protein tyrosine phosphatase, receptor type, M -0.0416369
ASPH aspartate beta-hydroxylase -0.0401725
TPT1 tumor protein, translationally-controlled 1 -0.0391177
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0390587
CANX calnexin -0.0389392
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0383997
AHNAK AHNAK nucleoprotein -0.0373692
DSPP dentin sialophosphoprotein -0.036937
PDIA3 protein disulfide isomerase family A, member 3 -0.0364646
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0338653
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0336482
SEPTIN2 septin 2 -0.033545
LAMA4 laminin, alpha 4 -0.0333284
EIF1 eukaryotic translation initiation factor 1 -0.0330426
RAB1A RAB1A, member RAS oncogene family -0.0327893
TMEM165 transmembrane protein 165 -0.0321935
RPL35A ribosomal protein L35a -0.0318381
ZBTB20 zinc finger and BTB domain containing 20 -0.0312007
CAMTA1 calmodulin binding transcription activator 1 -0.0307231
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.030385
AGR2 anterior gradient 2 -0.0302698
S100P S100 calcium binding protein P -0.0294295
CST3 cystatin C -0.0293523
SMIM14 small integral membrane protein 14 -0.0292847
HM13 histocompatibility (minor) 13 -0.0288742
RIN2 Ras and Rab interactor 2 -0.0281711
RAB27B RAB27B, member RAS oncogene family -0.0281615
MAML3 mastermind-like 3 (Drosophila) -0.0275902
WASF2 WAS protein family, member 2 -0.0274426
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0272267
FLNB filamin B, beta -0.0271
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0269457
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0267436
ZMYND8 zinc finger, MYND-type containing 8 -0.0265595
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0263205
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.025927
LMAN1 lectin, mannose-binding, 1 -0.0258413
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0257886
OSMR oncostatin M receptor -0.0255538
CUX1 cut-like homeobox 1 -0.0255379
LAMB3 laminin, beta 3 -0.0252362
GM2A GM2 ganglioside activator -0.02481
SEC31A SEC31 homolog A (S. cerevisiae) -0.0247869
ZMYM2 zinc finger, MYM-type 2 -0.0247583
GOLGB1 golgin B1 -0.024627
SEC61G Sec61 gamma subunit -0.0244987
NBEAL1 neurobeachin-like 1 -0.0241607
MKI67 marker of proliferation Ki-67 -0.0236859
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0236838
RPLP1 ribosomal protein, large, P1 -0.0231621
AKR1C1 aldo-keto reductase family 1, member C1 -0.0231262
RAB10 RAB10, member RAS oncogene family -0.0223575
KDM5B lysine (K)-specific demethylase 5B -0.0221202
NT5C2 5'-nucleotidase, cytosolic II -0.0218282
GARS1 glycyl-tRNA synthetase 1 -0.0218047
TMF1 TATA element modulatory factor 1 -0.0217604
PERP PERP, TP53 apoptosis effector -0.0217495
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0216727
SRP54 signal recognition particle 54kDa -0.0216276
NCOA3 nuclear receptor coactivator 3 -0.021617
HMGA1 high mobility group AT-hook 1 -0.0212339
ARHGAP32 Rho GTPase activating protein 32 -0.0211335
AKAP9 A kinase (PRKA) anchor protein 9 -0.0211195
TNRC6B trinucleotide repeat containing 6B -0.0209766
SEC24D SEC24 family member D -0.0209642
KMT2A lysine (K)-specific methyltransferase 2A -0.0208752
S100A11 S100 calcium binding protein A11 -0.0208475
RCOR1 REST corepressor 1 -0.0208403
RIOK3 RIO kinase 3 -0.020791
TBL1X transducin (beta)-like 1X-linked -0.0202367
S100A6 S100 calcium binding protein A6 -0.0201651
ESRP1 epithelial splicing regulatory protein 1 -0.020151
MGAT4C MGAT4 family, member C -0.0199776
MYO1D myosin ID -0.0199523
RPL34 ribosomal protein L34 -0.0198481
SPIRE1 spire-type actin nucleation factor 1 -0.0198318
GCC2 GRIP and coiled-coil domain containing 2 -0.0196914
PDLIM5 PDZ and LIM domain 5 -0.0195978
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0194532
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0192001
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0191836
SRPRA SRP receptor subunit alpha -0.019083
HYOU1 hypoxia up-regulated 1 -0.0190298