| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.214718 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.16705 |
| NAV2 | neuron navigator 2 | 0.111906 |
| SMAD3 | SMAD family member 3 | 0.108138 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0925673 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0881744 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0859234 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0846837 |
| VIM | vimentin | 0.0802116 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0782368 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0781969 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0781146 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0756619 |
| RPL4 | ribosomal protein L4 | 0.0734206 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0732831 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0712272 |
| USP34 | ubiquitin specific peptidase 34 | 0.0659875 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0641662 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0631563 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0613173 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0577029 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0571617 |
| MYO10 | myosin X | 0.0565511 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0565184 |
| CDCP1 | CUB domain containing protein 1 | 0.0562739 |
| LOX | lysyl oxidase | 0.0561029 |
| ANGPTL4 | angiopoietin-like 4 | 0.0546575 |
| LDHA | lactate dehydrogenase A | 0.0539472 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0524474 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0520311 |
| RPL3 | ribosomal protein L3 | 0.0513843 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0513212 |
| CA12 | carbonic anhydrase XII | 0.050397 |
| ECE1 | endothelin converting enzyme 1 | 0.0495069 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0480592 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0471458 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0465898 |
| ANO6 | anoctamin 6 | 0.0464825 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0458395 |
| EGFR | epidermal growth factor receptor | 0.0455357 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0451465 |
| FAM107B | family with sequence similarity 107, member B | 0.044613 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0446076 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0443708 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0443548 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0435638 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0425362 |
| PCBP2 | poly(rC) binding protein 2 | 0.0424697 |
| TGM2 | transglutaminase 2 | 0.0417695 |
| KYNU | kynureninase | 0.0404911 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0402976 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0402478 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0402169 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.04012 |
| TMSB4X | thymosin beta 4, X-linked | 0.0398246 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0397164 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0395997 |
| PLEC | plectin | 0.0393679 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0393506 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0390983 |
| ZNF638 | zinc finger protein 638 | 0.0390625 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0389434 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0387682 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0383538 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0380368 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0371089 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0350991 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0349105 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0338296 |
| SFTPA2 | surfactant protein A2 | 0.0337276 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0337036 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0334656 |
| ENO1 | enolase 1, (alpha) | 0.0332426 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0330325 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.032688 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0325394 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0316243 |
| PKM | pyruvate kinase, muscle | 0.0316224 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0316068 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.03159 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0315763 |
| APP | amyloid beta (A4) precursor protein | 0.0315278 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0314797 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0312392 |
| NOTCH2 | notch 2 | 0.0310512 |
| IL1R1 | interleukin 1 receptor, type I | 0.0306348 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0304466 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0301481 |
| H1-0 | H1.0 linker histone | 0.0297254 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0293885 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0293081 |
| UTRN | utrophin | 0.0292779 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0292453 |
| SEPTIN9 | septin 9 | 0.0291396 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0290905 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0290587 |
| EHBP1 | EH domain binding protein 1 | 0.0286042 |
| RUNX1 | runt-related transcription factor 1 | 0.028487 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0279798 |
| ITGAV | integrin, alpha V | 0.0275424 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | -0.126304 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.112545 |
| FAM20C | family with sequence similarity 20, member C | -0.0896167 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0895469 |
| GLCCI1 | glucocorticoid induced 1 | -0.0826333 |
| RBM39 | RNA binding motif protein 39 | -0.0753848 |
| PTMA | prothymosin, alpha | -0.0739078 |
| GPC6 | glypican 6 | -0.0687319 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.065782 |
| PRELID2 | PRELI domain containing 2 | -0.0637832 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0624553 |
| FTL | ferritin, light polypeptide | -0.0621178 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0601693 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0583922 |
| MECOM | MDS1 and EVI1 complex locus | -0.0582892 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.057204 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0554682 |
| IER3 | immediate early response 3 | -0.0536323 |
| RPLP1 | ribosomal protein, large, P1 | -0.05108 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0509314 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0472494 |
| RPL35A | ribosomal protein L35a | -0.0467651 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.043431 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0418596 |
| GNAS | GNAS complex locus | -0.0402533 |
| VCL | vinculin | -0.0394559 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0388987 |
| ZNF804A | zinc finger protein 804A | -0.0382725 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0380798 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0373767 |
| OGA | O-GlcNAcase | -0.0365573 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.036034 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0357226 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0354244 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0330923 |
| FBXO11 | F-box protein 11 | -0.0328682 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0328627 |
| NLK | nemo-like kinase | -0.0326181 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0322317 |
| ACTG1 | actin gamma 1 | -0.0313949 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0307354 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.030642 |
| VMP1 | vacuole membrane protein 1 | -0.0302701 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0302475 |
| HDAC4 | histone deacetylase 4 | -0.0295867 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0295841 |
| RPL37A | ribosomal protein L37a | -0.0295386 |
| RPS24 | ribosomal protein S24 | -0.0292029 |
| INTS6 | integrator complex subunit 6 | -0.0291158 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0286444 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0283894 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0283096 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0282863 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0282569 |
| CDK14 | cyclin-dependent kinase 14 | -0.0276701 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0272905 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0268688 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0264322 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0262864 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0259054 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.025683 |
| OXR1 | oxidation resistance 1 | -0.0256663 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0251483 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0240174 |
| RPL34 | ribosomal protein L34 | -0.0237698 |
| TMEM263 | transmembrane protein 263 | -0.0236038 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0235949 |
| DMXL1 | Dmx-like 1 | -0.0233783 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0230881 |
| RPS19 | ribosomal protein S19 | -0.0230359 |
| EGR1 | early growth response 1 | -0.0225717 |
| RAD51B | RAD51 paralog B | -0.0222947 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0216906 |
| YBX1 | Y box binding protein 1 | -0.0215569 |
| NABP1 | nucleic acid binding protein 1 | -0.0215473 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0215377 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0215134 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0215043 |
| TMSB10 | thymosin beta 10 | -0.0214162 |
| ANXA10 | annexin A10 | -0.0212739 |
| CFAP20DC | CFAP20 domain containing | -0.020877 |
| RPL23 | ribosomal protein L23 | -0.0207889 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0207233 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0204164 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0202558 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0197691 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0196924 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.019614 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0196099 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0195779 |
| RPL31 | ribosomal protein L31 | -0.0195594 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.019515 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0195098 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0194816 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0194355 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0193341 |
| SYT1 | synaptotagmin I | -0.0192336 |
| SP100 | SP100 nuclear antigen | -0.019231 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0190858 |
| RPL9 | ribosomal protein L9 | -0.0190553 |
