| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.158733 |
| TMSB10 | thymosin beta 10 | 0.117594 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0868939 |
| FMNL2 | formin-like 2 | 0.0661747 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0592873 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0568219 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.054482 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0543978 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0527052 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0488589 |
| FLNB | filamin B, beta | 0.0478092 |
| HLA-B | major histocompatibility complex, class I, B | 0.0463567 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0460473 |
| RPL4 | ribosomal protein L4 | 0.0452727 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.044453 |
| HLA-A | major histocompatibility complex, class I, A | 0.0436854 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0431445 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0429913 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0416056 |
| COPA | coatomer protein complex, subunit alpha | 0.0412068 |
| MT1X | metallothionein 1X | 0.0401561 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0358608 |
| PYGL | phosphorylase, glycogen, liver | 0.0350109 |
| RPL31 | ribosomal protein L31 | 0.0338838 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0338776 |
| RPL13A | ribosomal protein L13a | 0.03341 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0327693 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.032683 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0315957 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0311796 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.030743 |
| RPL37A | ribosomal protein L37a | 0.0306234 |
| RPL35A | ribosomal protein L35a | 0.0302706 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.029826 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0291696 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0268619 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0268329 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0264101 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0263275 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0257206 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0255523 |
| SDC4 | syndecan 4 | 0.0251181 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0250715 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0247406 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0242457 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.024154 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0232387 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0231674 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0229669 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0227039 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0224755 |
| FAM107B | family with sequence similarity 107, member B | 0.0221451 |
| NDRG1 | N-myc downstream regulated 1 | 0.0217256 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0214242 |
| MYO1E | myosin IE | 0.0213933 |
| APP | amyloid beta (A4) precursor protein | 0.0213461 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0205276 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0205258 |
| CYTH1 | cytohesin 1 | 0.0197985 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0197125 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0195987 |
| SNX14 | sorting nexin 14 | 0.0194719 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0194548 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0194317 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.019296 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0191023 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0189609 |
| INTS6 | integrator complex subunit 6 | 0.0189223 |
| CTBP2 | C-terminal binding protein 2 | 0.0185247 |
| KIF13A | kinesin family member 13A | 0.018021 |
| AHNAK | AHNAK nucleoprotein | 0.0179078 |
| RSF1 | remodeling and spacing factor 1 | 0.0178588 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0178311 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0176648 |
| CUL3 | cullin 3 | 0.0176406 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0176075 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0175692 |
| ACTN1 | actinin, alpha 1 | 0.0174511 |
| MT1F | metallothionein 1F | 0.0174168 |
| CDK13 | cyclin-dependent kinase 13 | 0.0173613 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0171656 |
| HMOX1 | heme oxygenase 1 | 0.0170264 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0168469 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0167815 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0163699 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0163014 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0161876 |
| ANGPTL4 | angiopoietin-like 4 | 0.0161268 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0161072 |
| CSNK1E | casein kinase 1, epsilon | 0.0160798 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.015501 |
| PSEN1 | presenilin 1 | 0.0154855 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0152414 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.0150752 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0150261 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.014868 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0148667 |
| HLA-E | major histocompatibility complex, class I, E | 0.0147866 |
| DENND5A | DENN/MADD domain containing 5A | 0.0147011 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 0.0146121 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | -0.249126 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.221768 |
| TXNRD1 | thioredoxin reductase 1 | -0.178799 |
| PM20D1 | peptidase M20 domain containing 1 | -0.165156 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.121362 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.115677 |
| FGB | fibrinogen beta chain | -0.102577 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.102366 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0952401 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0841855 |
| RTN4 | reticulon 4 | -0.0835165 |
| TPM3 | tropomyosin 3 | -0.0760711 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0728452 |
| PTMA | prothymosin, alpha | -0.0712991 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0687813 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0646651 |
| RPS2 | ribosomal protein S2 | -0.0644775 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0621227 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0606472 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0585212 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0569712 |
| FTL | ferritin, light polypeptide | -0.0559996 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0552447 |
| IGF2 | insulin-like growth factor 2 | -0.0538057 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0536655 |
| WDR43 | WD repeat domain 43 | -0.0529245 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0525698 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0518816 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0518634 |
| ACTG1 | actin gamma 1 | -0.0511459 |
| KIF5B | kinesin family member 5B | -0.0495882 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0490083 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0487987 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0482678 |
| MKI67 | marker of proliferation Ki-67 | -0.0469409 |
| YBX3 | Y box binding protein 3 | -0.0459781 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0432306 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0430475 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0429948 |
| WWOX | WW domain containing oxidoreductase | -0.0429602 |
| CENPF | centromere protein F, 350/400kDa | -0.0415835 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0413219 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0412013 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0409472 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0402868 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0394747 |
| RPL7 | ribosomal protein L7 | -0.0393043 |
| CANX | calnexin | -0.038806 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0386226 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0374426 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0372944 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0356994 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0351984 |
| PFDN2 | prefoldin subunit 2 | -0.0348755 |
| RPL19 | ribosomal protein L19 | -0.0346204 |
| TMEM123 | transmembrane protein 123 | -0.0338174 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0337438 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0335956 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -0.0333238 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0332781 |
| CLTC | clathrin, heavy chain (Hc) | -0.03317 |
| TPX2 | TPX2, microtubule-associated | -0.0331316 |
| YBX1 | Y box binding protein 1 | -0.0315357 |
| SRGN | serglycin | -0.0313952 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0311317 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0307661 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0307512 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0306538 |
| RPS6 | ribosomal protein S6 | -0.0304986 |
| S100A6 | S100 calcium binding protein A6 | -0.0302067 |
| DENND4A | DENN/MADD domain containing 4A | -0.0298688 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0295565 |
| RBM39 | RNA binding motif protein 39 | -0.0295316 |
| ENO1 | enolase 1, (alpha) | -0.0294996 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0294929 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0293278 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0287988 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0282242 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0281495 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0280947 |
| RHEB | Ras homolog enriched in brain | -0.0275932 |
| GOLT1B | golgi transport 1B | -0.0275633 |
| VMP1 | vacuole membrane protein 1 | -0.0274144 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0274134 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0269174 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0267906 |
| ASPH | aspartate beta-hydroxylase | -0.0267672 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0266556 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0266466 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0263743 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0263004 |
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | -0.0259532 |
| USP3 | ubiquitin specific peptidase 3 | -0.0257941 |
| ANLN | anillin, actin binding protein | -0.025754 |
| RAB10 | RAB10, member RAS oncogene family | -0.0255501 |
| XPO1 | exportin 1 | -0.0255049 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.025263 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0252536 |
| MATR3 | matrin 3 | -0.0251029 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0247708 |
