Tucatinib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucatinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucatinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT17 keratin 17, type I 0.192156
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.145088
NDRG1 N-myc downstream regulated 1 0.122906
FN1 fibronectin 1 0.10157
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0997256
LDHA lactate dehydrogenase A 0.0696195
ENO1 enolase 1, (alpha) 0.0677311
PDE4D phosphodiesterase 4D, cAMP-specific 0.0627442
LOC112694756 uncharaterized LOC112694756 0.0615722
SPAG9 sperm associated antigen 9 0.0604298
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0555494
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0549953
TPT1 tumor protein, translationally-controlled 1 0.0513487
AHNAK AHNAK nucleoprotein 0.0471906
RPS19 ribosomal protein S19 0.0457023
SFTPA2 surfactant protein A2 0.0444788
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0440632
ANKHD1 ankyrin repeat and KH domain containing 1 0.0439449
TMSB10 thymosin beta 10 0.042906
PDIA3 protein disulfide isomerase family A, member 3 0.0420699
RPL4 ribosomal protein L4 0.0419347
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0416295
HMGA2 high mobility group AT-hook 2 0.0414103
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0411528
BZW1 basic leucine zipper and W2 domains 1 0.0405603
MBNL1 muscleblind-like splicing regulator 1 0.0402617
HSPA8 heat shock 70kDa protein 8 0.0387972
FTL ferritin, light polypeptide 0.0384098
EXT1 exostosin glycosyltransferase 1 0.0376109
ERRFI1 ERBB receptor feedback inhibitor 1 0.037395
TRIO trio Rho guanine nucleotide exchange factor 0.0373761
ANXA1 annexin A1 0.0365871
ITPRID2 ITPR interacting domain containing 2 0.0349339
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0346522
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0345095
RTN4 reticulon 4 0.0339276
SMYD3 SET and MYND domain containing 3 0.0337211
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0334992
EZR ezrin 0.0332856
RNF24 ring finger protein 24 0.0329943
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0328823
RPL11 ribosomal protein L11 0.0327001
CLTC clathrin, heavy chain (Hc) 0.0324223
CANX calnexin 0.0323549
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0323138
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0318843
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.031567
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0312968
FAF1 Fas (TNFRSF6) associated factor 1 0.0311112
FLNB filamin B, beta 0.0307908
GRAMD1B GRAM domain containing 1B 0.0306586
MYH9 myosin, heavy chain 9, non-muscle 0.0306451
SRPK2 SRSF protein kinase 2 0.0304646
DUSP12 dual specificity phosphatase 12 0.0290928
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0288943
NAP1L1 nucleosome assembly protein 1-like 1 0.0286537
LOC102724023 ES1 protein homolog, mitochondrial 0.0285333
SEC31A SEC31 homolog A (S. cerevisiae) 0.0284578
TSC22D2 TSC22 domain family, member 2 0.0282676
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0282274
RPS6 ribosomal protein S6 0.0281849
MCL1 myeloid cell leukemia 1 0.0281645
WDFY2 WD repeat and FYVE domain containing 2 0.0279899
MBNL2 muscleblind-like splicing regulator 2 0.0279055
EEF2 eukaryotic translation elongation factor 2 0.0278705
IRS2 insulin receptor substrate 2 0.0276615
OXR1 oxidation resistance 1 0.0275801
SEPTIN10 septin 10 0.0275044
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.027464
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0272232
KIF13A kinesin family member 13A 0.0268671
JMJD1C jumonji domain containing 1C 0.0268262
TM4SF1 transmembrane 4 L six family member 1 0.0268194
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0268126
CHD1 chromodomain helicase DNA binding protein 1 0.0262735
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0259723
FAM107B family with sequence similarity 107, member B 0.0259648
FMNL2 formin-like 2 0.0258589
JUN jun proto-oncogene 0.0255395
LAMA4 laminin, alpha 4 0.0253745
SND1 staphylococcal nuclease and tudor domain containing 1 0.0252856
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0250522
RACK1 receptor for activated C kinase 1 0.0248771
VMP1 vacuole membrane protein 1 0.0245577
S100A6 S100 calcium binding protein A6 0.0243649
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0243392
BAIAP2L1 BAI1-associated protein 2-like 1 0.0242587
RPS11 ribosomal protein S11 0.0241619
MT2A metallothionein 2A 0.0240796
PRKCA protein kinase C, alpha 0.0239004
STC1 stanniocalcin 1 0.0238877
KDM5B lysine (K)-specific demethylase 5B 0.0238574
ZCCHC7 zinc finger, CCHC domain containing 7 0.0238113
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0238069
ADM adrenomedullin 0.0238051
FUS FUS RNA binding protein 0.023798
RPS8 ribosomal protein S8 0.0237412
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0235761
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0235723
PTK2 protein tyrosine kinase 2 0.0232893

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.160026
MUC16 mucin 16, cell surface associated -0.127592
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.123845
LMO7 LIM domain 7 -0.0992265
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0972199
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0955867
SAMD4A sterile alpha motif domain containing 4A -0.0940593
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0796247
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.075157
ANKRD36C ankyrin repeat domain 36C -0.0709234
ATOSA atos homolog A -0.0682816
LAMC2 laminin, gamma 2 -0.0678073
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0642114
KYNU kynureninase -0.058316
ANTXR2 anthrax toxin receptor 2 -0.0572712
TXNRD1 thioredoxin reductase 1 -0.0568723
PTPRM protein tyrosine phosphatase, receptor type, M -0.0533162
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0530446
RBM47 RNA binding motif protein 47 -0.0528379
PARD3 par-3 family cell polarity regulator -0.0526157
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0525117
KIF13B kinesin family member 13B -0.0505097
RCOR1 REST corepressor 1 -0.050441
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0483992
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0466418
EXOC6B exocyst complex component 6B -0.045135
FOSL2 FOS-like antigen 2 -0.0448978
CNKSR3 CNKSR family member 3 -0.0445824
ABHD17C abhydrolase domain containing 17C -0.0442726
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0437871
MACC1 metastasis associated in colon cancer 1 -0.0435282
EGFR epidermal growth factor receptor -0.0424183
TGFA transforming growth factor, alpha -0.0424051
AKAP13 A kinase (PRKA) anchor protein 13 -0.0409383
SPNS2 spinster homolog 2 (Drosophila) -0.0406949
SCEL sciellin -0.0406341
CEMIP cell migration inducing protein, hyaluronan binding -0.0401017
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0399173
SLMAP sarcolemma associated protein -0.0398854
ESYT2 extended synaptotagmin-like protein 2 -0.0383438
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0370915
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0365673
ASPH aspartate beta-hydroxylase -0.0365332
ATP13A3 ATPase type 13A3 -0.0362792
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0362354
MED13L mediator complex subunit 13-like -0.0355812
USP34 ubiquitin specific peptidase 34 -0.03522
LRPPRC leucine-rich pentatricopeptide repeat containing -0.034356
FHIT fragile histidine triad -0.033749
CLDN7 claudin 7 -0.0333194
BIRC6 baculoviral IAP repeat containing 6 -0.0332306
AGFG1 ArfGAP with FG repeats 1 -0.0330093
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0329541
BMAL2 basic helix-loop-helix ARNT like 2 -0.0323868
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0316607
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.0316311
SAMD9 sterile alpha motif domain containing 9 -0.0315
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0314582
IGF1R insulin-like growth factor 1 receptor -0.0313216
NEBL nebulette -0.0311114
TNRC18 trinucleotide repeat containing 18 -0.0310636
GOLM2 golgi membrane protein 2 -0.03055
ARFIP1 ADP-ribosylation factor interacting protein 1 -0.030508
GCC2 GRIP and coiled-coil domain containing 2 -0.0304998
MCU mitochondrial calcium uniporter -0.0297845
ATF6 activating transcription factor 6 -0.0297576
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0294788
CAPN2 calpain 2, (m/II) large subunit -0.0292871
IGF2 insulin-like growth factor 2 -0.0290736
TMEM165 transmembrane protein 165 -0.0290479
SBF2 SET binding factor 2 -0.0290464
TJP2 tight junction protein 2 -0.0289643
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0289526
MTUS1 microtubule associated tumor suppressor 1 -0.0289518
MCPH1 microcephalin 1 -0.0288587
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.028558
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0284681
SHB Src homology 2 domain containing adaptor protein B -0.0282921
AKAP9 A kinase (PRKA) anchor protein 9 -0.0278603
ACTN4 actinin, alpha 4 -0.0278351
ZNF185 zinc finger protein 185 (LIM domain) -0.0277849
MUC13 mucin 13, cell surface associated -0.0276096
NCOR2 nuclear receptor corepressor 2 -0.0273961
UBE3A ubiquitin protein ligase E3A -0.0272838
GPATCH2L G patch domain containing 2-like -0.0271587
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0265316
GSK3B glycogen synthase kinase 3 beta -0.0263206
MLPH melanophilin -0.0259582
ZNF638 zinc finger protein 638 -0.0259031
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0258777
FNDC3B fibronectin type III domain containing 3B -0.0257188
TNS1 tensin 1 -0.0257018
SP100 SP100 nuclear antigen -0.0256767
STEAP4 STEAP family member 4 -0.0256367
PLSCR1 phospholipid scramblase 1 -0.0256359
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0254967
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.02532
BCL2L1 BCL2-like 1 -0.0250349
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0250125
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0249953