Tucatinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucatinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucatinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.141779
AKAP12 A kinase (PRKA) anchor protein 12 0.11744
PDE10A phosphodiesterase 10A 0.0810332
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0798958
PDE4D phosphodiesterase 4D, cAMP-specific 0.0775351
GRAMD1B GRAM domain containing 1B 0.0752194
MYH9 myosin, heavy chain 9, non-muscle 0.0664775
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0637994
EEF2 eukaryotic translation elongation factor 2 0.0636128
ATXN1 ataxin 1 0.0631605
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0581072
PRELID2 PRELI domain containing 2 0.0568218
ZCCHC7 zinc finger, CCHC domain containing 7 0.0552517
AEBP2 AE binding protein 2 0.0547454
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0539315
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0515032
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0512365
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0511145
USP34 ubiquitin specific peptidase 34 0.0510435
WWOX WW domain containing oxidoreductase 0.0506351
IGF1R insulin-like growth factor 1 receptor 0.0497088
MACF1 microtubule-actin crosslinking factor 1 0.0487564
ANO6 anoctamin 6 0.0486648
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0485411
TPM3 tropomyosin 3 0.0480803
AFF3 AF4/FMR2 family, member 3 0.0478135
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0460208
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0455869
FNDC3B fibronectin type III domain containing 3B 0.0452309
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0449016
THSD4 thrombospondin, type I, domain containing 4 0.0447701
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0444173
HSPA8 heat shock 70kDa protein 8 0.0433782
COPA coatomer protein complex, subunit alpha 0.0426836
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0404159
PRH1 proline-rich protein HaeIII subfamily 1 0.0402451
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0396179
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0386326
DOCK5 dedicator of cytokinesis 5 0.0385634
FMNL2 formin-like 2 0.0381811
GOLGB1 golgin B1 0.0377031
WNK1 WNK lysine deficient protein kinase 1 0.0375387
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0373194
PRKCE protein kinase C, epsilon 0.0370901
PHF21A PHD finger protein 21A 0.03679
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0367735
DST dystonin 0.0360218
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0354437
POTEF POTE ankyrin domain family, member F 0.0350914
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0349507
YAP1 Yes-associated protein 1 0.0346111
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0344723
ZNF638 zinc finger protein 638 0.0342763
MBD5 methyl-CpG binding domain protein 5 0.0339805
MACROD2 MACRO domain containing 2 0.0339558
CAMTA1 calmodulin binding transcription activator 1 0.0334152
EXOC6B exocyst complex component 6B 0.0332354
BRD2 bromodomain containing 2 0.0330348
YBX3 Y box binding protein 3 0.0329648
ATP11A ATPase, class VI, type 11A 0.0329616
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0327798
RICTOR RPTOR independent companion of MTOR, complex 2 0.0321592
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0321266
PCBP2 poly(rC) binding protein 2 0.0318796
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0316643
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0315862
SIK3 SIK family kinase 3 0.0312099
UBE2H ubiquitin-conjugating enzyme E2H 0.0310593
TAS2R14 taste receptor, type 2, member 14 0.0309323
INTS6 integrator complex subunit 6 0.0307354
ANKRD36 ankyrin repeat domain 36 0.030121
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0299809
RPL3 ribosomal protein L3 0.0299475
SVIL supervillin 0.0297976
RNF213 ring finger protein 213 0.0296287
AKAP9 A kinase (PRKA) anchor protein 9 0.0293354
SAMD4A sterile alpha motif domain containing 4A 0.0291128
EXOC4 exocyst complex component 4 0.0289804
RABGAP1L RAB GTPase activating protein 1-like 0.0289427
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0289144
SND1 staphylococcal nuclease and tudor domain containing 1 0.0285201
PYGL phosphorylase, glycogen, liver 0.0282838
SNAP25 synaptosomal-associated protein, 25kDa 0.0281971
LOC112694756 uncharaterized LOC112694756 0.028121
CCND2 cyclin D2 0.0280669
ZBTB1 zinc finger and BTB domain containing 1 0.0278957
PKM pyruvate kinase, muscle 0.0276732
RAD51B RAD51 paralog B 0.0272421
SMAD3 SMAD family member 3 0.0271657
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0270631
EML4 echinoderm microtubule associated protein like 4 0.0269353
CLIP1 CAP-GLY domain containing linker protein 1 0.0268763
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0268404
KDM2A lysine (K)-specific demethylase 2A 0.0267949
ERRFI1 ERBB receptor feedback inhibitor 1 0.0265164
DENND5B DENN/MADD domain containing 5B 0.0264293
NLGN1 neuroligin 1 0.0259146
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0258178
LPP LIM domain containing preferred translocation partner in lipoma 0.025439
TLN1 talin 1 0.0253878

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.148323
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14143
TXNRD1 thioredoxin reductase 1 -0.103232
EGR1 early growth response 1 -0.073289
PTMA prothymosin, alpha -0.0726715
RPLP1 ribosomal protein, large, P1 -0.0502381
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0499931
TM4SF1 transmembrane 4 L six family member 1 -0.0450347
RPL35A ribosomal protein L35a -0.0441072
RPL12 ribosomal protein L12 -0.0434264
MYL12B myosin, light chain 12B, regulatory -0.0433211
EIF1 eukaryotic translation initiation factor 1 -0.0396306
NABP1 nucleic acid binding protein 1 -0.0393374
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0377616
RTN4 reticulon 4 -0.0371324
VIM vimentin -0.0361205
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0356737
ACTG1 actin gamma 1 -0.0354605
RPL23 ribosomal protein L23 -0.0349437
RPS8 ribosomal protein S8 -0.034113
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0316334
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0315652
WSB1 WD repeat and SOCS box containing 1 -0.03075
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0306805
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0304535
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0303732
TPT1 tumor protein, translationally-controlled 1 -0.0297643
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0292838
CENPF centromere protein F, 350/400kDa -0.0285134
STC1 stanniocalcin 1 -0.0282911
RPL26 ribosomal protein L26 -0.028221
MKI67 marker of proliferation Ki-67 -0.0265211
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.026333
RPS27A ribosomal protein S27a -0.0260635
SMC4 structural maintenance of chromosomes 4 -0.0260608
RACK1 receptor for activated C kinase 1 -0.025803
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0256739
ZFR zinc finger RNA binding protein -0.0256252
RPS27 ribosomal protein S27 -0.0249132
BZW1 basic leucine zipper and W2 domains 1 -0.0248839
TMEM41B transmembrane protein 41B -0.0240624
IER3 immediate early response 3 -0.0238235
FTL ferritin, light polypeptide -0.0237653
H3-3B H3.3 histone B -0.0236721
MT2A metallothionein 2A -0.0234838
RPLP0 ribosomal protein, large, P0 -0.0230542
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0228772
RPL36A ribosomal protein L36a -0.0214203
RPS29 ribosomal protein S29 -0.0212701
RPS6 ribosomal protein S6 -0.0212402
HMGA1 high mobility group AT-hook 1 -0.0208312
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0207527
UBB ubiquitin B -0.0207333
RAD21 RAD21 homolog (S. pombe) -0.0206205
ATP5F1B ATP synthase F1 subunit beta -0.0203352
DIAPH3 diaphanous-related formin 3 -0.0202339
PHIP pleckstrin homology domain interacting protein -0.020208
RPL34 ribosomal protein L34 -0.0199345
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0194073
S100A6 S100 calcium binding protein A6 -0.0193306
VDAC1 voltage-dependent anion channel 1 -0.0192586
TPX2 TPX2, microtubule-associated -0.0192433
RPS3 ribosomal protein S3 -0.0191469
RPL31 ribosomal protein L31 -0.0189393
CENPE centromere protein E, 312kDa -0.0185984
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.018581
NAMPT nicotinamide phosphoribosyltransferase -0.0185564
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0185491
TPI1 triosephosphate isomerase 1 -0.018324
RPS24 ribosomal protein S24 -0.0181459
CAVIN1 caveolae associated protein 1 -0.0180313
RPLP2 ribosomal protein, large, P2 -0.0179907
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0179278
RHEB Ras homolog enriched in brain -0.0177758
DOCK3 dedicator of cytokinesis 3 -0.0177597
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0177114
RPL5 ribosomal protein L5 -0.0175509
LDHB lactate dehydrogenase B -0.01738
RIGI RNA sensor RIG-I -0.0170582
DEK DEK proto-oncogene -0.0170197
ELL2 elongation factor, RNA polymerase II, 2 -0.0169638
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0168549
RPL19 ribosomal protein L19 -0.0168318
LOC102724023 ES1 protein homolog, mitochondrial -0.0166991
S100A11 S100 calcium binding protein A11 -0.0166032
DUSP6 dual specificity phosphatase 6 -0.0165997
RASAL2 RAS protein activator like 2 -0.016514
TUBA1C tubulin, alpha 1c -0.0164798
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0164114
KPNB1 karyopherin (importin) beta 1 -0.0164011
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0163772
SQSTM1 sequestosome 1 -0.0161336
RPS15 ribosomal protein S15 -0.0160765
CCNL1 cyclin L1 -0.0160266
FLOT1 flotillin 1 -0.0159828
SGO2 shugoshin 2 -0.0159375
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0159287
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0159068
RPS16 ribosomal protein S16 -0.0156957
RB1CC1 RB1-inducible coiled-coil 1 -0.0156601