Tucatinib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucatinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucatinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0879432
MYH9 myosin, heavy chain 9, non-muscle 0.0724805
HSPA8 heat shock 70kDa protein 8 0.0711725
ZSWIM6 zinc finger, SWIM-type containing 6 0.0684775
PLEC plectin 0.0627425
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0615511
TRIO trio Rho guanine nucleotide exchange factor 0.0582318
NAV2 neuron navigator 2 0.0551536
RPL4 ribosomal protein L4 0.0544396
EXT1 exostosin glycosyltransferase 1 0.0492077
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0474109
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0440599
FNDC3B fibronectin type III domain containing 3B 0.0431077
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0405901
LOC112694756 uncharaterized LOC112694756 0.0385532
ELL2 elongation factor, RNA polymerase II, 2 0.0378561
EEF2 eukaryotic translation elongation factor 2 0.0369127
DTNA dystrobrevin, alpha 0.033044
ARRDC3 arrestin domain containing 3 0.0323934
TJP1 tight junction protein 1 0.0320293
SGMS2 sphingomyelin synthase 2 0.0316692
FHIT fragile histidine triad 0.0311849
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0303352
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0298928
BRD2 bromodomain containing 2 0.0297644
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.029689
RUNX1 runt-related transcription factor 1 0.0291948
CLTC clathrin, heavy chain (Hc) 0.0285599
MYO5B myosin VB 0.0281516
USP9X ubiquitin specific peptidase 9, X-linked 0.0280906
EGR1 early growth response 1 0.0273519
RPL3 ribosomal protein L3 0.0273004
POTEF POTE ankyrin domain family, member F 0.0271009
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0269053
FNIP1 folliculin interacting protein 1 0.0265619
KIAA1217 KIAA1217 0.0257106
HSPA1B heat shock 70kDa protein 1B 0.0255524
PPARD peroxisome proliferator-activated receptor delta 0.0254145
GLS2 glutaminase 2 (liver, mitochondrial) 0.0252912
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0252805
DSPP dentin sialophosphoprotein 0.0248452
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0244867
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0242367
OCLN occludin 0.0241462
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0238286
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0237766
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0236779
PGBD5 piggyBac transposable element derived 5 0.0230346
SAMD4A sterile alpha motif domain containing 4A 0.0228222
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0228
SMAD3 SMAD family member 3 0.0227946
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0223962
SFPQ splicing factor proline/glutamine-rich 0.0222376
APP amyloid beta (A4) precursor protein 0.0219585
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0215722
MACC1 metastasis associated in colon cancer 1 0.0211278
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0209087
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0200956
MX1 MX dynamin-like GTPase 1 0.0200334
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0199437
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0198526
MYO10 myosin X 0.0195052
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0193018
TUFT1 tuftelin 1 0.0188588
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0188446
GRB10 growth factor receptor-bound protein 10 0.0188296
DIAPH1 diaphanous-related formin 1 0.0187849
SEC31A SEC31 homolog A (S. cerevisiae) 0.0187737
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0187402
MSN moesin 0.0186532
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0184126
WWTR1 WW domain containing transcription regulator 1 0.0182941
AHNAK AHNAK nucleoprotein 0.0181473
SON SON DNA binding protein 0.0180185
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0179682
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0179528
PTK2 protein tyrosine kinase 2 0.0179039
AKAP13 A kinase (PRKA) anchor protein 13 0.0178704
ARHGAP20 Rho GTPase activating protein 20 0.0177552
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0176738
PDLIM5 PDZ and LIM domain 5 0.0175613
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0175156
ARHGAP26 Rho GTPase activating protein 26 0.0174432
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0174125
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0173377
AGO2 argonaute RISC catalytic component 2 0.0169868
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0169456
COPA coatomer protein complex, subunit alpha 0.016785
CTBP2 C-terminal binding protein 2 0.0166745
EFNA5 ephrin-A5 0.0165587
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0165506
AFF1 AF4/FMR2 family, member 1 0.0165292
WNK1 WNK lysine deficient protein kinase 1 0.0161953
MED13 mediator complex subunit 13 0.0161546
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0160158
CTNND1 catenin (cadherin-associated protein), delta 1 0.0158381
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0157842
ATF3 activating transcription factor 3 0.0157577
USP53 ubiquitin specific peptidase 53 0.0156101
SEPTIN11 septin 11 0.0155691

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.270176
PTMA prothymosin, alpha -0.259136
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195444
TMSB10 thymosin beta 10 -0.121671
S100A6 S100 calcium binding protein A6 -0.106831
RPLP1 ribosomal protein, large, P1 -0.101719
RPL35A ribosomal protein L35a -0.101704
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.100373
TPT1 tumor protein, translationally-controlled 1 -0.089678
LAMB3 laminin, beta 3 -0.0879336
ACTG1 actin gamma 1 -0.0792966
NDRG1 N-myc downstream regulated 1 -0.0714309
S100A10 S100 calcium binding protein A10 -0.0671935
RPL34 ribosomal protein L34 -0.0660544
RPL23 ribosomal protein L23 -0.0653527
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0651359
RPS8 ribosomal protein S8 -0.0623821
IFI27 interferon, alpha-inducible protein 27 -0.0606483
RPS19 ribosomal protein S19 -0.0574826
RPS6 ribosomal protein S6 -0.057133
HMGA1 high mobility group AT-hook 1 -0.0571242
TPM4 tropomyosin 4 -0.0562334
WSB1 WD repeat and SOCS box containing 1 -0.0555435
EIF1 eukaryotic translation initiation factor 1 -0.0549168
RPLP2 ribosomal protein, large, P2 -0.0546398
CSTB cystatin B (stefin B) -0.0545451
MT2A metallothionein 2A -0.0543801
RPS29 ribosomal protein S29 -0.0522579
LMO7 LIM domain 7 -0.0519893
ISG15 ISG15 ubiquitin-like modifier -0.0515856
NPEPPS aminopeptidase puromycin sensitive -0.0490134
SOX4 SRY (sex determining region Y)-box 4 -0.0486454
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0472829
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0472054
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0470427
IFITM3 interferon induced transmembrane protein 3 -0.0461895
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0448437
BASP1 brain abundant, membrane attached signal protein 1 -0.0437375
VIM vimentin -0.0432914
CCND1 cyclin D1 -0.0426954
RPL37A ribosomal protein L37a -0.0424977
GNAS GNAS complex locus -0.0421289
C15ORF48 chromosome 15 open reading frame 48 -0.0416508
RPS13 ribosomal protein S13 -0.0415585
RPL12 ribosomal protein L12 -0.0415271
IGFBP3 insulin-like growth factor binding protein 3 -0.0413788
IFI6 interferon, alpha-inducible protein 6 -0.0402026
RPS3 ribosomal protein S3 -0.0400738
RPS27 ribosomal protein S27 -0.0396318
CD2AP CD2-associated protein -0.0389808
SLC38A1 solute carrier family 38, member 1 -0.0389382
TM4SF1 transmembrane 4 L six family member 1 -0.0388661
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0384277
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0379312
FAM162A family with sequence similarity 162, member A -0.0378591
RPS23 ribosomal protein S23 -0.0374489
BZW1 basic leucine zipper and W2 domains 1 -0.0372068
S100A9 S100 calcium binding protein A9 -0.0365278
RPS14 ribosomal protein S14 -0.0363957
HLA-B major histocompatibility complex, class I, B -0.0363809
TOP1 topoisomerase (DNA) I -0.0362966
RPL36 ribosomal protein L36 -0.0361459
SACK1A scaffolding CK1 anchoring protein A -0.0355249
RPL31 ribosomal protein L31 -0.0352273
RPL9 ribosomal protein L9 -0.035161
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0348539
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0341505
HLA-A major histocompatibility complex, class I, A -0.033462
RPL8 ribosomal protein L8 -0.0333731
RPS25 ribosomal protein S25 -0.033002
IFITM1 interferon induced transmembrane protein 1 -0.0324027
NAMPT nicotinamide phosphoribosyltransferase -0.0321755
EPCAM epithelial cell adhesion molecule -0.0309769
RACK1 receptor for activated C kinase 1 -0.0309241
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0302386
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0298095
TPI1 triosephosphate isomerase 1 -0.0295057
AREG amphiregulin -0.0293909
RPS27A ribosomal protein S27a -0.0293617
H3-3B H3.3 histone B -0.0289931
RPS16 ribosomal protein S16 -0.0289068
RPL36A ribosomal protein L36a -0.0287676
KPNB1 karyopherin (importin) beta 1 -0.0286014
RPL11 ribosomal protein L11 -0.0277283
RPS24 ribosomal protein S24 -0.0275236
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0274922
LMAN1 lectin, mannose-binding, 1 -0.0273583
RRBP1 ribosome binding protein 1 -0.0273223
RPL26 ribosomal protein L26 -0.0273075
G0S2 G0/G1 switch 2 -0.0270832
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0269875
DSTN destrin (actin depolymerizing factor) -0.0263704
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0262768
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0261069
RPL37 ribosomal protein L37 -0.0260113
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0256291
HSPB1 heat shock 27kDa protein 1 -0.0255684
F3 coagulation factor III (thromboplastin, tissue factor) -0.0254171
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0252341
HLA-E major histocompatibility complex, class I, E -0.02482