Tucatinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucatinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucatinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.122394
TRIO trio Rho guanine nucleotide exchange factor 0.0878235
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0848147
FN1 fibronectin 1 0.0806371
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0760256
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0717354
NAMPT nicotinamide phosphoribosyltransferase 0.0672225
ELL2 elongation factor, RNA polymerase II, 2 0.0636182
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0621642
SPAG9 sperm associated antigen 9 0.0619075
KYNU kynureninase 0.061707
ESYT2 extended synaptotagmin-like protein 2 0.0592242
GRAMD1B GRAM domain containing 1B 0.0569798
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0562396
EEF2 eukaryotic translation elongation factor 2 0.0552163
MYOF myoferlin 0.0548314
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0541869
PDE10A phosphodiesterase 10A 0.0501271
AGTPBP1 ATP/GTP binding protein 1 0.0495748
CREB5 cAMP responsive element binding protein 5 0.0475731
FNDC3A fibronectin type III domain containing 3A 0.047382
HSPA8 heat shock 70kDa protein 8 0.0472519
SOD2 superoxide dismutase 2, mitochondrial 0.0463087
CDH13 cadherin 13 0.0462101
ABLIM1 actin binding LIM protein 1 0.0453588
TGFBR1 transforming growth factor, beta receptor 1 0.0451386
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0447643
TM4SF1 transmembrane 4 L six family member 1 0.0445711
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0427119
TXNRD1 thioredoxin reductase 1 0.0425087
DOCK4 dedicator of cytokinesis 4 0.0424432
ERRFI1 ERBB receptor feedback inhibitor 1 0.0422527
FNIP1 folliculin interacting protein 1 0.0417641
SMAD2 SMAD family member 2 0.0405342
ZEB2 zinc finger E-box binding homeobox 2 0.039987
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.039845
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0397169
DGKD diacylglycerol kinase, delta 130kDa 0.039494
CLTC clathrin, heavy chain (Hc) 0.0382889
CD109 CD109 molecule 0.0374887
CANX calnexin 0.0368148
CD44 CD44 molecule (Indian blood group) 0.0362882
EZR ezrin 0.0355875
CXCL8 chemokine (C-X-C motif) ligand 8 0.0334688
SAMD4A sterile alpha motif domain containing 4A 0.0333245
PSD3 pleckstrin and Sec7 domain containing 3 0.0328957
ASPH aspartate beta-hydroxylase 0.0325041
USP9X ubiquitin specific peptidase 9, X-linked 0.0324286
CTIF CBP80/20-dependent translation initiation factor 0.0320928
PDLIM5 PDZ and LIM domain 5 0.0317553
ANXA1 annexin A1 0.0316503
RPL4 ribosomal protein L4 0.0314609
PLCB4 phospholipase C, beta 4 0.0311919
FLNB filamin B, beta 0.0310558
ITPRID2 ITPR interacting domain containing 2 0.0309138
NBEAL1 neurobeachin-like 1 0.0304025
HDLBP high density lipoprotein binding protein 0.0299757
USP34 ubiquitin specific peptidase 34 0.0299547
ZC3H11A zinc finger CCCH-type containing 11A 0.0297034
PGK1 phosphoglycerate kinase 1 0.0294131
MYO10 myosin X 0.0285722
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0285488
AKAP13 A kinase (PRKA) anchor protein 13 0.0280972
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0279969
NBAS neuroblastoma amplified sequence 0.0275202
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0269431
EXT1 exostosin glycosyltransferase 1 0.0269419
SMOC1 SPARC related modular calcium binding 1 0.0268997
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0267978
MORF4L2 mortality factor 4 like 2 0.0265739
FNDC3B fibronectin type III domain containing 3B 0.0265105
LDHA lactate dehydrogenase A 0.0255106
COL8A1 collagen, type VIII, alpha 1 0.0248233
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0248067
COPA coatomer protein complex, subunit alpha 0.024794
LAMA1 laminin, alpha 1 0.0246775
LIMCH1 LIM and calponin homology domains 1 0.0245787
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0243894
DNER delta/notch-like EGF repeat containing 0.0243754
CHD1 chromodomain helicase DNA binding protein 1 0.0243612
LOC112694756 uncharaterized LOC112694756 0.0242918
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0242826
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0242588
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0240352
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0237954
AHNAK AHNAK nucleoprotein 0.0237711
IQGAP1 IQ motif containing GTPase activating protein 1 0.023708
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.023701
PDIA4 protein disulfide isomerase family A, member 4 0.0234061
PALLD palladin, cytoskeletal associated protein 0.0233941
CTBP2 C-terminal binding protein 2 0.0232419
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0231723
FMNL2 formin-like 2 0.0229753
SH3KBP1 SH3-domain kinase binding protein 1 0.0229683
KMT2C lysine (K)-specific methyltransferase 2C 0.02295
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0227657
BIRC6 baculoviral IAP repeat containing 6 0.0225851
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0223222
NCAM1 neural cell adhesion molecule 1 0.0222359
ANO6 anoctamin 6 0.0222076

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.131329
PTMA prothymosin, alpha -0.115635
RPS12 ribosomal protein S12 -0.108751
RPL37A ribosomal protein L37a -0.104735
RPLP1 ribosomal protein, large, P1 -0.0951391
TMSB10 thymosin beta 10 -0.0943751
RPL35A ribosomal protein L35a -0.092018
RPS6 ribosomal protein S6 -0.0900225
TPT1 tumor protein, translationally-controlled 1 -0.0851204
RPL31 ribosomal protein L31 -0.0774069
RPL26 ribosomal protein L26 -0.071331
RPS8 ribosomal protein S8 -0.0712137
RPS3 ribosomal protein S3 -0.0706944
FTL ferritin, light polypeptide -0.0684261
RPL9 ribosomal protein L9 -0.0665543
RPL13A ribosomal protein L13a -0.06231
IGFBP3 insulin-like growth factor binding protein 3 -0.0591829
RPS27A ribosomal protein S27a -0.0582087
RPS19 ribosomal protein S19 -0.0577963
NALF1 NALCN channel auxiliary factor 1 -0.0576017
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0570021
RPL12 ribosomal protein L12 -0.0487704
RPL23 ribosomal protein L23 -0.0486332
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0483679
RPS29 ribosomal protein S29 -0.0471797
RPS27 ribosomal protein S27 -0.0448552
RPS24 ribosomal protein S24 -0.0435452
COL5A2 collagen, type V, alpha 2 -0.0430845
RPL36 ribosomal protein L36 -0.0425922
RPL36A ribosomal protein L36a -0.0417547
RPLP2 ribosomal protein, large, P2 -0.0416562
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.038951
RPS25 ribosomal protein S25 -0.0387992
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0387323
RPS17 ribosomal protein S17 -0.038245
VCL vinculin -0.038168
RPS14 ribosomal protein S14 -0.0380693
RPL11 ribosomal protein L11 -0.0373663
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.036691
GNAS GNAS complex locus -0.0364242
RPL7A ribosomal protein L7a -0.0360698
HLA-A major histocompatibility complex, class I, A -0.0357697
DOCK5 dedicator of cytokinesis 5 -0.0348092
RTN1 reticulon 1 -0.0346839
RPS23 ribosomal protein S23 -0.034598
RPL37 ribosomal protein L37 -0.0339996
RPS13 ribosomal protein S13 -0.0339839
RPS16 ribosomal protein S16 -0.0313172
AKAP12 A kinase (PRKA) anchor protein 12 -0.0304743
RPL19 ribosomal protein L19 -0.0300835
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.029986
MT2A metallothionein 2A -0.0284925
HLA-B major histocompatibility complex, class I, B -0.0284595
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0282959
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0282153
WSB1 WD repeat and SOCS box containing 1 -0.0281643
RPS2 ribosomal protein S2 -0.0270839
RACK1 receptor for activated C kinase 1 -0.0269311
RPL34 ribosomal protein L34 -0.0267784
RPL35 ribosomal protein L35 -0.025721
S100A6 S100 calcium binding protein A6 -0.025093
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0249802
EIF1 eukaryotic translation initiation factor 1 -0.024788
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.024666
NAP1L1 nucleosome assembly protein 1-like 1 -0.0243041
RPL30 ribosomal protein L30 -0.0242395
CTSL cathepsin L -0.0228926
RPL5 ribosomal protein L5 -0.0228322
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0227739
SOX4 SRY (sex determining region Y)-box 4 -0.0220512
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0217348
RPS21 ribosomal protein S21 -0.0212257
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0206395
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0206206
RPL27 ribosomal protein L27 -0.0206194
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0205585
RPS10 ribosomal protein S10 -0.0205134
TPM4 tropomyosin 4 -0.0202449
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0202207
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0201648
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0195438
P3H2 prolyl 3-hydroxylase 2 -0.0193064
B2M beta-2-microglobulin -0.0192682
RPS20 ribosomal protein S20 -0.0189335
IER3 immediate early response 3 -0.018869
VDAC1 voltage-dependent anion channel 1 -0.01881
MAML3 mastermind-like 3 (Drosophila) -0.0185767
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0185701
RPL10A ribosomal protein L10a -0.018125
ATP5F1E ATP synthase F1 subunit epsilon -0.0180755
PLAUR plasminogen activator, urokinase receptor -0.0180331
TMX4 thioredoxin-related transmembrane protein 4 -0.0176806
RPL28 ribosomal protein L28 -0.0176691
BCAS3 breast carcinoma amplified sequence 3 -0.0176392
ISG15 ISG15 ubiquitin-like modifier -0.0176174
ENO1 enolase 1, (alpha) -0.017534
RPS11 ribosomal protein S11 -0.0173618
RPLP0 ribosomal protein, large, P0 -0.0168158
RPS5 ribosomal protein S5 -0.0168109
EIF5B eukaryotic translation initiation factor 5B -0.0166187