| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
190 genes differentially expressed following the Tucatinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.183122 |
| SLC38A2 | solute carrier family 38, member 2 | 0.165791 |
| RPL4 | ribosomal protein L4 | 0.134946 |
| NAV2 | neuron navigator 2 | 0.132005 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.127966 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.123281 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.121778 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.116666 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.108659 |
| VCL | vinculin | 0.0990902 |
| EFNA5 | ephrin-A5 | 0.0980129 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0904465 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0904459 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0877997 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0845013 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0836153 |
| ATXN1 | ataxin 1 | 0.0817774 |
| CUX1 | cut-like homeobox 1 | 0.0778259 |
| SNX25 | sorting nexin 25 | 0.0762778 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0756915 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.073359 |
| SVIL | supervillin | 0.0729396 |
| RHOA | ras homolog family member A | 0.0714673 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0705029 |
| RRBP1 | ribosome binding protein 1 | 0.0699768 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.069676 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0685867 |
| JAK1 | Janus kinase 1 | 0.0667146 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0658964 |
| GOLGA4 | golgin A4 | 0.0642123 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0633817 |
| PGM3 | phosphoglucomutase 3 | 0.062843 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0627819 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0623994 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0615501 |
| MYO1E | myosin IE | 0.0606012 |
| HMGA2 | high mobility group AT-hook 2 | 0.0582429 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0581714 |
| SMAD3 | SMAD family member 3 | 0.0578841 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0578302 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0578205 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.056314 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0539226 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0537126 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0531086 |
| ENO1 | enolase 1, (alpha) | 0.0525764 |
| EZR | ezrin | 0.0521724 |
| ANXA2 | annexin A2 | 0.0517537 |
| DST | dystonin | 0.0517234 |
| RAD51B | RAD51 paralog B | 0.0477035 |
| EGFR | epidermal growth factor receptor | 0.0464149 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0464089 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.043957 |
| LMO7 | LIM domain 7 | 0.0438119 |
| ACTN4 | actinin, alpha 4 | 0.0437342 |
| SMYD3 | SET and MYND domain containing 3 | 0.0414823 |
| TMSB10 | thymosin beta 10 | 0.0401455 |
| TMEM165 | transmembrane protein 165 | 0.0394149 |
| MYOF | myoferlin | 0.0391345 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0374843 |
| PKM | pyruvate kinase, muscle | 0.0351536 |
| ITGA6 | integrin, alpha 6 | 0.033922 |
| TPM4 | tropomyosin 4 | 0.0315338 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0304011 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0293881 |
| GPC6 | glypican 6 | 0.0270603 |
| GOLGB1 | golgin B1 | 0.0259809 |
| BPTF | bromodomain PHD finger transcription factor | 0.0240327 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0238197 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0226799 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0222816 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0209643 |
| STC1 | stanniocalcin 1 | 0.0193332 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0182023 |
| HLA-B | major histocompatibility complex, class I, B | 0.018 |
| LDHA | lactate dehydrogenase A | 0.0168247 |
| PTK2 | protein tyrosine kinase 2 | 0.0166066 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0165605 |
| HDAC9 | histone deacetylase 9 | 0.0163271 |
| TENM3 | teneurin transmembrane protein 3 | 0.0161075 |
| FTL | ferritin, light polypeptide | 0.0139117 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0121666 |
| VMP1 | vacuole membrane protein 1 | 0.0118842 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0118691 |
| FMNL2 | formin-like 2 | 0.0111991 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0110314 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0109334 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0109305 |
| OGA | O-GlcNAcase | 0.00900688 |
| CANX | calnexin | 0.00815121 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.00749716 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.007097 |
| PRRC2C | proline-rich coiled-coil 2C | 0.00602868 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.00550129 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.00425879 |
| NCOA3 | nuclear receptor coactivator 3 | 0.00211082 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00180642 |
| FN1 | fibronectin 1 | 8.81686E-4 |
| RBM39 | RNA binding motif protein 39 | 2.07323E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.184623 |
| VIM | vimentin | -0.168379 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.144846 |
| LAMA4 | laminin, alpha 4 | -0.14278 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.111366 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.110156 |
| PTMA | prothymosin, alpha | -0.109798 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.105909 |
| RPS8 | ribosomal protein S8 | -0.105843 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.103477 |
| RSF1 | remodeling and spacing factor 1 | -0.0998622 |
| SPAG9 | sperm associated antigen 9 | -0.0960445 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0924308 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0921632 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0870173 |
| SLTM | SAFB-like, transcription modulator | -0.0851183 |
| MAP4 | microtubule-associated protein 4 | -0.0834668 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0824579 |
| MT2A | metallothionein 2A | -0.0818092 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0776377 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0722088 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0719992 |
| RPLP1 | ribosomal protein, large, P1 | -0.0710533 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0706476 |
| FAM13A | family with sequence similarity 13, member A | -0.0694866 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0682326 |
| RPS6 | ribosomal protein S6 | -0.0670164 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0639098 |
| IGF2 | insulin-like growth factor 2 | -0.0633991 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0605988 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0590516 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0586281 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0584916 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0578237 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0572666 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0552268 |
| ARRDC3 | arrestin domain containing 3 | -0.0545 |
| SEPTIN9 | septin 9 | -0.0535774 |
| YBX3 | Y box binding protein 3 | -0.0532011 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0516679 |
| MCL1 | myeloid cell leukemia 1 | -0.0507495 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0505698 |
| NDRG1 | N-myc downstream regulated 1 | -0.0497024 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0483213 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0464123 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0441777 |
| RPL23 | ribosomal protein L23 | -0.0428981 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0427969 |
| PRELID2 | PRELI domain containing 2 | -0.0424049 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0414203 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0405615 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0400881 |
| TXNRD1 | thioredoxin reductase 1 | -0.0398204 |
| JMJD1C | jumonji domain containing 1C | -0.0394727 |
| RAB10 | RAB10, member RAS oncogene family | -0.0393584 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0391121 |
| RPS3 | ribosomal protein S3 | -0.0334856 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0321717 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.031213 |
| RUNX1 | runt-related transcription factor 1 | -0.02708 |
| NFIA | nuclear factor I/A | -0.0247198 |
| PGK1 | phosphoglycerate kinase 1 | -0.0246381 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0243929 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0243727 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0235902 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0231796 |
| ASPH | aspartate beta-hydroxylase | -0.0231788 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0231028 |
| RTN4 | reticulon 4 | -0.0230672 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0227988 |
| USP34 | ubiquitin specific peptidase 34 | -0.0226332 |
| SBF2 | SET binding factor 2 | -0.0223905 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0223345 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0213169 |
| CD44 | CD44 molecule (Indian blood group) | -0.0201137 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0199484 |
| PDE8A | phosphodiesterase 8A | -0.0167953 |
| PRKCA | protein kinase C, alpha | -0.0156879 |
| RORA | RAR-related orphan receptor A | -0.0147293 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0143506 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0143405 |
| B2M | beta-2-microglobulin | -0.0130277 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0101195 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.00911089 |
| FNIP1 | folliculin interacting protein 1 | -0.00743517 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.00681515 |
| MYO6 | myosin VI | -0.00661988 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.00643581 |
| RPL31 | ribosomal protein L31 | -0.00545413 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.00100235 |
| POTEF | POTE ankyrin domain family, member F | -7.24487E-4 |
