| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.150313 |
| COL11A1 | collagen, type XI, alpha 1 | 0.136465 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.130904 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.12589 |
| CADM2 | cell adhesion molecule 2 | 0.097945 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0914758 |
| COL5A2 | collagen, type V, alpha 2 | 0.0907704 |
| TSC22D2 | TSC22 domain family, member 2 | 0.09033 |
| HDAC9 | histone deacetylase 9 | 0.0863991 |
| ZNF292 | zinc finger protein 292 | 0.0793136 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0783605 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0747982 |
| PHIP | pleckstrin homology domain interacting protein | 0.0741096 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0684996 |
| MED13L | mediator complex subunit 13-like | 0.0650364 |
| RBM20 | RNA binding motif protein 20 | 0.0642276 |
| USP25 | ubiquitin specific peptidase 25 | 0.0630888 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0618441 |
| MEIS2 | Meis homeobox 2 | 0.0584279 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0578531 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0562227 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0557685 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0556974 |
| APP | amyloid beta (A4) precursor protein | 0.0548921 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0545804 |
| DST | dystonin | 0.0525474 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0495934 |
| ENAH | enabled homolog (Drosophila) | 0.0480521 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0467011 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0453165 |
| NTM | neurotrimin | 0.0437051 |
| TENM3 | teneurin transmembrane protein 3 | 0.0424494 |
| HMCN1 | hemicentin 1 | 0.0423194 |
| ATXN2 | ataxin 2 | 0.0417503 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0416314 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0415745 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0409448 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0404993 |
| TFRC | transferrin receptor | 0.0399596 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0397218 |
| ZNF217 | zinc finger protein 217 | 0.0395655 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0394685 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0394417 |
| LPIN2 | lipin 2 | 0.0388936 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0388176 |
| PRTG | protogenin | 0.0386453 |
| RREB1 | ras responsive element binding protein 1 | 0.0378632 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0374352 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0374223 |
| DOCK5 | dedicator of cytokinesis 5 | 0.037366 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0372908 |
| PARD3B | par-3 family cell polarity regulator beta | 0.03713 |
| UTRN | utrophin | 0.0370214 |
| NEBL | nebulette | 0.0367177 |
| RPL3 | ribosomal protein L3 | 0.0366656 |
| GPC3 | glypican 3 | 0.0365614 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0364022 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0362536 |
| PRELID2 | PRELI domain containing 2 | 0.0361685 |
| ZNF608 | zinc finger protein 608 | 0.0359996 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0354756 |
| TMSB4X | thymosin beta 4, X-linked | 0.0344847 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.033776 |
| COL3A1 | collagen, type III, alpha 1 | 0.0337526 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0336634 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0326685 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0325578 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0324201 |
| XPO1 | exportin 1 | 0.032094 |
| THBS1 | thrombospondin 1 | 0.0317184 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0316685 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0316405 |
| NRG1 | neuregulin 1 | 0.0314554 |
| PLPP1 | phospholipid phosphatase 1 | 0.0309481 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0305792 |
| CALR | calreticulin | 0.0305568 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0301574 |
| LRRC4C | leucine rich repeat containing 4C | 0.0296891 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0295668 |
| RPL4 | ribosomal protein L4 | 0.029092 |
| TENM2 | teneurin transmembrane protein 2 | 0.0290262 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0288838 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0288263 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0287645 |
| MED12L | mediator complex subunit 12-like | 0.0281795 |
| MEF2C | myocyte enhancer factor 2C | 0.0280799 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.02768 |
| CDH19 | cadherin 19, type 2 | 0.0273433 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0268682 |
| ITGAV | integrin, alpha V | 0.0266789 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0263676 |
| CNTN6 | contactin 6 | 0.0262609 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0261704 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0260497 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0258985 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0256627 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0255477 |
| TOX | thymocyte selection-associated high mobility group box | 0.0254985 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0249574 |
| PHF3 | PHD finger protein 3 | 0.0248995 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.110497 |
| VIM | vimentin | -0.0953038 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0894989 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0763806 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0745978 |
| H1-0 | H1.0 linker histone | -0.0585421 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0545684 |
| PEG10 | paternally expressed 10 | -0.0524524 |
| ANXA2 | annexin A2 | -0.0430061 |
| FOXP2 | forkhead box P2 | -0.0409264 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0388878 |
| DEK | DEK proto-oncogene | -0.037889 |
| RAD51B | RAD51 paralog B | -0.0369262 |
| FN1 | fibronectin 1 | -0.0350874 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0337847 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0333774 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0329053 |
| RPS8 | ribosomal protein S8 | -0.032731 |
| NOP58 | NOP58 ribonucleoprotein | -0.0325989 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0309999 |
| SRP54 | signal recognition particle 54kDa | -0.0307823 |
| ASPH | aspartate beta-hydroxylase | -0.0305582 |
| RTN4 | reticulon 4 | -0.0304708 |
| MKI67 | marker of proliferation Ki-67 | -0.0298819 |
| RPLP1 | ribosomal protein, large, P1 | -0.0294171 |
| NDRG1 | N-myc downstream regulated 1 | -0.0293435 |
| HMGB1 | high mobility group box 1 | -0.0289626 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0288726 |
| RPL11 | ribosomal protein L11 | -0.0287386 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.028479 |
| RPS6 | ribosomal protein S6 | -0.0278642 |
| GNAS | GNAS complex locus | -0.0274718 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0270074 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.02671 |
| HMGA1 | high mobility group AT-hook 1 | -0.0260365 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0258717 |
| PARD3 | par-3 family cell polarity regulator | -0.0256928 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0256552 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0253604 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.025192 |
| CENPF | centromere protein F, 350/400kDa | -0.0251524 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0251488 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0249024 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0238791 |
| RPS19 | ribosomal protein S19 | -0.0238034 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0236864 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0236751 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0236326 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0233232 |
| RPL31 | ribosomal protein L31 | -0.023281 |
| RPL19 | ribosomal protein L19 | -0.0230795 |
| RPL35A | ribosomal protein L35a | -0.022467 |
| RPS21 | ribosomal protein S21 | -0.0223749 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0221989 |
| RPL12 | ribosomal protein L12 | -0.0220407 |
| AHNAK | AHNAK nucleoprotein | -0.0219792 |
| RPL28 | ribosomal protein L28 | -0.0218437 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0215595 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0213707 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0212325 |
| FTL | ferritin, light polypeptide | -0.0212267 |
| SOD1 | superoxide dismutase 1, soluble | -0.0211827 |
| EFNA5 | ephrin-A5 | -0.02114 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0211296 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0208999 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0207768 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0205832 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0205356 |
| ZNF385D | zinc finger protein 385D | -0.0205112 |
| PNN | pinin, desmosome associated protein | -0.019933 |
| GPC6 | glypican 6 | -0.0198707 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0196535 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0196145 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0192871 |
| EMP1 | epithelial membrane protein 1 | -0.0192641 |
| TPX2 | TPX2, microtubule-associated | -0.0190618 |
| CANX | calnexin | -0.0189028 |
| AQR | aquarius intron-binding spliceosomal factor | -0.0184958 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0184458 |
| SGO2 | shugoshin 2 | -0.0183917 |
| RPLP2 | ribosomal protein, large, P2 | -0.0183175 |
| RPS5 | ribosomal protein S5 | -0.0182922 |
| CEP192 | centrosomal protein 192kDa | -0.0182666 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0182584 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0182362 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0181439 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0181421 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0181286 |
| KIAA1958 | KIAA1958 | -0.0180176 |
| RPL34 | ribosomal protein L34 | -0.0180101 |
| TPI1 | triosephosphate isomerase 1 | -0.0179598 |
| THRAP3 | thyroid hormone receptor associated protein 3 | -0.0178538 |
| GLO1 | glyoxalase I | -0.0178207 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0177881 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0177395 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0174785 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0174611 |
| ENO1 | enolase 1, (alpha) | -0.0174609 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0172452 |
| SQSTM1 | sequestosome 1 | -0.0171918 |
