| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | 0.123453 |
| EZR | ezrin | 0.088664 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0704058 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0649744 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0628408 |
| RPL3 | ribosomal protein L3 | 0.0514481 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0510271 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.05077 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0468707 |
| POTEF | POTE ankyrin domain family, member F | 0.0466438 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0451313 |
| TXNIP | thioredoxin interacting protein | 0.0442221 |
| RPL4 | ribosomal protein L4 | 0.042886 |
| RBM25 | RNA binding motif protein 25 | 0.0424592 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0417783 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0408924 |
| TXNRD1 | thioredoxin reductase 1 | 0.0408345 |
| TJP1 | tight junction protein 1 | 0.0400286 |
| ZNF608 | zinc finger protein 608 | 0.0395655 |
| ZNF292 | zinc finger protein 292 | 0.0390071 |
| PDGFC | platelet derived growth factor C | 0.0387296 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0384951 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0380069 |
| PLK2 | polo-like kinase 2 | 0.0368763 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0356463 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0346335 |
| GOLGA4 | golgin A4 | 0.0343719 |
| RTN4 | reticulon 4 | 0.0339323 |
| USP47 | ubiquitin specific peptidase 47 | 0.0313178 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0296615 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0295637 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0294464 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0288638 |
| LONRF2 | LON peptidase N-terminal domain and ring finger 2 | 0.0280034 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0275132 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0272648 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0270538 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0270251 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0267627 |
| TMSB4X | thymosin beta 4, X-linked | 0.026677 |
| CRY1 | cryptochrome circadian clock 1 | 0.0264508 |
| YAP1 | Yes-associated protein 1 | 0.0260759 |
| SLMAP | sarcolemma associated protein | 0.0256903 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0255899 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0251907 |
| AMOTL2 | angiomotin like 2 | 0.0247708 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0241299 |
| MATR3 | matrin 3 | 0.0240998 |
| DIAPH1 | diaphanous-related formin 1 | 0.024058 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0240289 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0235227 |
| BRD2 | bromodomain containing 2 | 0.0234865 |
| COPA | coatomer protein complex, subunit alpha | 0.0233583 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0233411 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0231263 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0229677 |
| ANXA1 | annexin A1 | 0.022704 |
| NBAS | neuroblastoma amplified sequence | 0.0226167 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0224373 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0219373 |
| TBK1 | TANK-binding kinase 1 | 0.0219284 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0218811 |
| JUN | jun proto-oncogene | 0.0218603 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0218561 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0218548 |
| SON | SON DNA binding protein | 0.0218358 |
| ATOSA | atos homolog A | 0.0216861 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0213868 |
| H1-4 | H1.4 linker histone, cluster member | 0.0212494 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0211702 |
| RLF | rearranged L-myc fusion | 0.0211631 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0209912 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0207429 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0206977 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0206905 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0204801 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0204001 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0200801 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.02006 |
| RANBP2 | RAN binding protein 2 | 0.020034 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0198926 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.019884 |
| CEP85L | centrosomal protein 85kDa-like | 0.0196248 |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.0195765 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0195149 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0193111 |
| PLCE1 | phospholipase C, epsilon 1 | 0.0191332 |
| NUP58 | nucleoporin 58 | 0.0190706 |
| RAB18 | RAB18, member RAS oncogene family | 0.0189818 |
| CCNL1 | cyclin L1 | 0.0188927 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.018816 |
| BRD4 | bromodomain containing 4 | 0.0187092 |
| RIOK3 | RIO kinase 3 | 0.0186842 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.018586 |
| PCBP2 | poly(rC) binding protein 2 | 0.0184761 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.0184584 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0184199 |
| LATS2 | large tumor suppressor kinase 2 | 0.0181108 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0181105 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0180612 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.228048 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.190194 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.130808 |
| BMP10 | bone morphogenetic protein 10 | -0.125943 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.110449 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.098386 |
| AHNAK | AHNAK nucleoprotein | -0.0938808 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0881496 |
| VCL | vinculin | -0.0877236 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0843407 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0773116 |
| PRELID2 | PRELI domain containing 2 | -0.0729825 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0718096 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0690187 |
| CCND1 | cyclin D1 | -0.0657561 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0646438 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0626782 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0552032 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0543309 |
| EFNA5 | ephrin-A5 | -0.054077 |
| INTS6 | integrator complex subunit 6 | -0.0513073 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0499309 |
| FOXP1 | forkhead box P1 | -0.048355 |
| GLI3 | GLI family zinc finger 3 | -0.0478261 |
| RPS8 | ribosomal protein S8 | -0.0475012 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.046898 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0463739 |
| RPL35A | ribosomal protein L35a | -0.0455806 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0455135 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0441339 |
| NAV2 | neuron navigator 2 | -0.0415021 |
| ENO1 | enolase 1, (alpha) | -0.039207 |
| RPL9 | ribosomal protein L9 | -0.0389117 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0387464 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.038259 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0379586 |
| RPL34 | ribosomal protein L34 | -0.0370167 |
| PDE7B | phosphodiesterase 7B | -0.0366065 |
| GLI2 | GLI family zinc finger 2 | -0.0364277 |
| PARD3 | par-3 family cell polarity regulator | -0.0359924 |
| NBEA | neurobeachin | -0.0352801 |
| HJURP | Holliday junction recognition protein | -0.0352338 |
| NEBL | nebulette | -0.0351257 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.034607 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0340453 |
| MKI67 | marker of proliferation Ki-67 | -0.0339269 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0338323 |
| KIAA1958 | KIAA1958 | -0.032861 |
| ASPH | aspartate beta-hydroxylase | -0.0327673 |
| NFIA | nuclear factor I/A | -0.0323891 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0319993 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.031984 |
| RPLP1 | ribosomal protein, large, P1 | -0.0317505 |
| ACTG1 | actin gamma 1 | -0.0312795 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0312302 |
| S100A4 | S100 calcium binding protein A4 | -0.0311132 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0310766 |
| RPS24 | ribosomal protein S24 | -0.0308073 |
| RPL31 | ribosomal protein L31 | -0.030414 |
| DENND1A | DENN/MADD domain containing 1A | -0.0298097 |
| SCFD1 | sec1 family domain containing 1 | -0.0293439 |
| EHBP1 | EH domain binding protein 1 | -0.0279949 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0278842 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0278762 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0277677 |
| CUX1 | cut-like homeobox 1 | -0.027666 |
| RAD51B | RAD51 paralog B | -0.0271854 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.0270972 |
| RPL19 | ribosomal protein L19 | -0.0269199 |
| AEBP2 | AE binding protein 2 | -0.0265232 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.026376 |
| SMYD3 | SET and MYND domain containing 3 | -0.0262349 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0261509 |
| RPL23 | ribosomal protein L23 | -0.0257763 |
| RAD18 | RAD18 E3 ubiquitin protein ligase | -0.0257594 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0257036 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.0256814 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0255951 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0255472 |
| S100A6 | S100 calcium binding protein A6 | -0.0253282 |
| CLIC4 | chloride intracellular channel 4 | -0.0252254 |
| RACK1 | receptor for activated C kinase 1 | -0.0250832 |
| RPL37A | ribosomal protein L37a | -0.0246129 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0241026 |
| RPL36 | ribosomal protein L36 | -0.0238349 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0237037 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0235916 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0234328 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0233644 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0231614 |
| EGFR | epidermal growth factor receptor | -0.0231469 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0231462 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.023042 |
| PRSS23 | protease, serine, 23 | -0.0229839 |
| CEP350 | centrosomal protein 350kDa | -0.0228707 |
| GPATCH8 | G patch domain containing 8 | -0.0227605 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.0226551 |
| UBE3C | ubiquitin protein ligase E3C | -0.0225064 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0224911 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0223254 |
