| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.281891 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.234953 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.204167 |
| NAV2 | neuron navigator 2 | 0.11504 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.10309 |
| CADM1 | cell adhesion molecule 1 | 0.0890394 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0878618 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0860539 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0775028 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0753857 |
| HDAC9 | histone deacetylase 9 | 0.075215 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0727851 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0690066 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0642316 |
| FNIP1 | folliculin interacting protein 1 | 0.0538888 |
| PGK1 | phosphoglycerate kinase 1 | 0.0525251 |
| SFTPA2 | surfactant protein A2 | 0.0522064 |
| MYOF | myoferlin | 0.0520979 |
| FMNL2 | formin-like 2 | 0.0517145 |
| FN1 | fibronectin 1 | 0.0516619 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0487114 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0483112 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0465596 |
| DST | dystonin | 0.0463464 |
| ATXN1 | ataxin 1 | 0.0430795 |
| ARRDC3 | arrestin domain containing 3 | 0.0429636 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0429305 |
| RPL4 | ribosomal protein L4 | 0.0416143 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.041241 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0408475 |
| CD44 | CD44 molecule (Indian blood group) | 0.0403925 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0397862 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0397787 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0381419 |
| APP | amyloid beta (A4) precursor protein | 0.0379955 |
| SPAG9 | sperm associated antigen 9 | 0.0376767 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0373081 |
| RPL3 | ribosomal protein L3 | 0.0372427 |
| GPC6 | glypican 6 | 0.0369101 |
| LDHA | lactate dehydrogenase A | 0.0365245 |
| MXI1 | MAX interactor 1, dimerization protein | 0.036183 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0361077 |
| HELZ | helicase with zinc finger | 0.0359939 |
| TMSB4X | thymosin beta 4, X-linked | 0.0358653 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0354502 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0345127 |
| FBXO32 | F-box protein 32 | 0.0342646 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0339053 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0336585 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0335317 |
| COL5A1 | collagen, type V, alpha 1 | 0.0333267 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0324825 |
| FLNA | filamin A, alpha | 0.0323775 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0323633 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0322979 |
| ANXA1 | annexin A1 | 0.0322216 |
| CDH13 | cadherin 13 | 0.0318542 |
| ANO6 | anoctamin 6 | 0.0315029 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0314643 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0313813 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0312601 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0312497 |
| ZNF292 | zinc finger protein 292 | 0.0312353 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0311168 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.031063 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0309843 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0307794 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0302685 |
| PLIN2 | perilipin 2 | 0.0292906 |
| NDRG1 | N-myc downstream regulated 1 | 0.0289706 |
| RUNX1 | runt-related transcription factor 1 | 0.0289223 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.028895 |
| KIAA1217 | KIAA1217 | 0.0288284 |
| ADM | adrenomedullin | 0.0287018 |
| DUSP10 | dual specificity phosphatase 10 | 0.0285694 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0283527 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0281313 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0279654 |
| PRELID2 | PRELI domain containing 2 | 0.0276754 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0275538 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0273233 |
| NONO | non-POU domain containing, octamer-binding | 0.0273193 |
| MORF4L2 | mortality factor 4 like 2 | 0.0272013 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0261501 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0260756 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0256425 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0256061 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.025553 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0255365 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0253965 |
| SNX9 | sorting nexin 9 | 0.0253808 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0253242 |
| SDC4 | syndecan 4 | 0.0251934 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0251444 |
| PDE10A | phosphodiesterase 10A | 0.0250922 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0248083 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0245403 |
| RND3 | Rho family GTPase 3 | 0.024411 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0243808 |
| JMJD1C | jumonji domain containing 1C | 0.0241578 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.125413 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.123388 |
| FRMD4A | FERM domain containing 4A | -0.109034 |
| BICC1 | BicC family RNA binding protein 1 | -0.0918471 |
| GLIS3 | GLIS family zinc finger 3 | -0.0892423 |
| VIM | vimentin | -0.086961 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0838771 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0727869 |
| HMGA2 | high mobility group AT-hook 2 | -0.0574101 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.056002 |
| RTN4 | reticulon 4 | -0.0502853 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0467427 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0465811 |
| VMP1 | vacuole membrane protein 1 | -0.0460491 |
| PTMA | prothymosin, alpha | -0.0446832 |
| NABP1 | nucleic acid binding protein 1 | -0.0443431 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0436444 |
| IER3 | immediate early response 3 | -0.0433847 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0424142 |
| FTL | ferritin, light polypeptide | -0.0423721 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0410996 |
| PALLD | palladin, cytoskeletal associated protein | -0.0375814 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0358977 |
| EGR1 | early growth response 1 | -0.0357525 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0338699 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0332887 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0327668 |
| RPLP1 | ribosomal protein, large, P1 | -0.0314109 |
| GNAS | GNAS complex locus | -0.0313748 |
| KYNU | kynureninase | -0.0302732 |
| RPL37A | ribosomal protein L37a | -0.0300348 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0298837 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0293481 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0293168 |
| TOP1 | topoisomerase (DNA) I | -0.028822 |
| THBS1 | thrombospondin 1 | -0.0286684 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0283172 |
| FAM20C | family with sequence similarity 20, member C | -0.0282827 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0282774 |
| MKI67 | marker of proliferation Ki-67 | -0.0282091 |
| THOC2 | THO complex 2 | -0.0280644 |
| CTSD | cathepsin D | -0.0277552 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0275629 |
| SLC38A2 | solute carrier family 38, member 2 | -0.027328 |
| RAI14 | retinoic acid induced 14 | -0.0272163 |
| HDAC8 | histone deacetylase 8 | -0.0266246 |
| ACTG1 | actin gamma 1 | -0.0263954 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0263843 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.02636 |
| RPS6 | ribosomal protein S6 | -0.0262069 |
| RRBP1 | ribosome binding protein 1 | -0.0256287 |
| OSMR | oncostatin M receptor | -0.0255506 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.025504 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0251526 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.0245261 |
| CDK17 | cyclin-dependent kinase 17 | -0.0244916 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0243789 |
| RPL35A | ribosomal protein L35a | -0.024251 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.024198 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0238216 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0235453 |
| CENPF | centromere protein F, 350/400kDa | -0.0235038 |
| FBXO11 | F-box protein 11 | -0.0234524 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0234318 |
| TMEM41B | transmembrane protein 41B | -0.0232589 |
| TNNC1 | troponin C type 1 (slow) | -0.0231713 |
| JAK2 | Janus kinase 2 | -0.0230718 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0228367 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0226313 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0222794 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0222585 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0220079 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0219746 |
| IL6 | interleukin 6 | -0.0215975 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0212569 |
| HLA-A | major histocompatibility complex, class I, A | -0.0212201 |
| TXNRD1 | thioredoxin reductase 1 | -0.0210916 |
| SMAD2 | SMAD family member 2 | -0.0209759 |
| TPM4 | tropomyosin 4 | -0.0206969 |
| NCOA7 | nuclear receptor coactivator 7 | -0.020571 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0202883 |
| CLMP | CXADR-like membrane protein | -0.0202391 |
| EHBP1 | EH domain binding protein 1 | -0.020156 |
| RIGI | RNA sensor RIG-I | -0.0198794 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0197067 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0195767 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0192754 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0192547 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0191761 |
| STK17A | serine/threonine kinase 17a | -0.0190154 |
| GOPC | golgi-associated PDZ and coiled-coil motif containing | -0.0188801 |
| RBM39 | RNA binding motif protein 39 | -0.018777 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.018655 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.018522 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0184506 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0183752 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0183574 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0181064 |
| DIAPH3 | diaphanous-related formin 3 | -0.0180664 |
| KRT19 | keratin 19, type I | -0.018047 |
