| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.215172 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.197667 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.128747 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.123241 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0909661 |
| FN1 | fibronectin 1 | 0.0811662 |
| NRXN3 | neurexin 3 | 0.0756656 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0750659 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0695449 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0682321 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.06436 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0641635 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0639932 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0604174 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0601092 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0576774 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0574773 |
| COL5A1 | collagen, type V, alpha 1 | 0.0548645 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0539567 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0487408 |
| FAM13A | family with sequence similarity 13, member A | 0.0466542 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0441833 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0418846 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0415103 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0409335 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0407098 |
| ANO6 | anoctamin 6 | 0.039444 |
| ARRDC3 | arrestin domain containing 3 | 0.0394236 |
| LOXL2 | lysyl oxidase-like 2 | 0.0383888 |
| CDH13 | cadherin 13 | 0.0381118 |
| RUNX1 | runt-related transcription factor 1 | 0.0376269 |
| EGFR | epidermal growth factor receptor | 0.0372477 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0369719 |
| AHNAK | AHNAK nucleoprotein | 0.0364158 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.036307 |
| FNIP1 | folliculin interacting protein 1 | 0.0359188 |
| HDLBP | high density lipoprotein binding protein | 0.0356742 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0352953 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0351451 |
| PRELID2 | PRELI domain containing 2 | 0.0350091 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0347132 |
| CADM1 | cell adhesion molecule 1 | 0.0329303 |
| CD44 | CD44 molecule (Indian blood group) | 0.0328535 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0324488 |
| VEGFC | vascular endothelial growth factor C | 0.0318001 |
| FLNA | filamin A, alpha | 0.0317545 |
| SDC4 | syndecan 4 | 0.031671 |
| KYNU | kynureninase | 0.0314095 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0308478 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0305659 |
| CA12 | carbonic anhydrase XII | 0.0299093 |
| PLEC | plectin | 0.0297944 |
| DPYD | dihydropyrimidine dehydrogenase | 0.029633 |
| CANX | calnexin | 0.029277 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0290925 |
| NDRG1 | N-myc downstream regulated 1 | 0.0288294 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0287008 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0286916 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0283835 |
| PGM3 | phosphoglucomutase 3 | 0.0282831 |
| SEC24D | SEC24 family member D | 0.0277228 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0275623 |
| ECE1 | endothelin converting enzyme 1 | 0.0265775 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0265107 |
| YEATS2 | YEATS domain containing 2 | 0.0262866 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0259772 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0254353 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0253166 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | 0.0248563 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0246875 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0245067 |
| GOLGB1 | golgin B1 | 0.0244723 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.024142 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0240394 |
| PTGES2 | prostaglandin E synthase 2 | 0.023934 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0236955 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0236062 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.02311 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0230691 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0221096 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0220514 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0219554 |
| CALR | calreticulin | 0.021921 |
| SERINC1 | serine incorporator 1 | 0.0218912 |
| LAMB1 | laminin, beta 1 | 0.0217486 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0215353 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0215049 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0213776 |
| UBN2 | ubinuclein 2 | 0.0213239 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0213228 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0210954 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0210836 |
| CTSB | cathepsin B | 0.0210744 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0209535 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0207424 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0205889 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0204791 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.020469 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0202841 |
| COG5 | component of oligomeric golgi complex 5 | 0.0202237 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.230271 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.214094 |
| TMSB10 | thymosin beta 10 | -0.167919 |
| HLA-B | major histocompatibility complex, class I, B | -0.130166 |
| B2M | beta-2-microglobulin | -0.12893 |
| VIM | vimentin | -0.122182 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.109894 |
| COL1A2 | collagen, type I, alpha 2 | -0.0835469 |
| PTMA | prothymosin, alpha | -0.0813785 |
| FTL | ferritin, light polypeptide | -0.0680359 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0671051 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.061658 |
| RTN4 | reticulon 4 | -0.058836 |
| COL1A1 | collagen, type I, alpha 1 | -0.0555963 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.053532 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0528141 |
| ENO1 | enolase 1, (alpha) | -0.051394 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0487143 |
| HLA-C | major histocompatibility complex, class I, C | -0.0481873 |
| RPS6 | ribosomal protein S6 | -0.047717 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0462894 |
| ACTG1 | actin gamma 1 | -0.0451854 |
| S100A6 | S100 calcium binding protein A6 | -0.0445755 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0435976 |
| RPLP1 | ribosomal protein, large, P1 | -0.0389282 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.038465 |
| RPL37A | ribosomal protein L37a | -0.0379004 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0377637 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0377263 |
| RPL11 | ribosomal protein L11 | -0.035607 |
| CAVIN1 | caveolae associated protein 1 | -0.0355268 |
| RPS12 | ribosomal protein S12 | -0.0351487 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0346325 |
| TPM4 | tropomyosin 4 | -0.0343462 |
| MAP1B | microtubule-associated protein 1B | -0.0341029 |
| INHBA | inhibin, beta A | -0.0340694 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0337187 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0335904 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.033054 |
| VCL | vinculin | -0.0326629 |
| RPL19 | ribosomal protein L19 | -0.0322057 |
| UBC | ubiquitin C | -0.0321484 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0320732 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0318641 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0318353 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0314993 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0313796 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0313377 |
| CD63 | CD63 molecule | -0.0307978 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0307274 |
| EGR1 | early growth response 1 | -0.0305545 |
| IL6 | interleukin 6 | -0.0305218 |
| GPC6 | glypican 6 | -0.0304828 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0302473 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0300892 |
| RPL12 | ribosomal protein L12 | -0.0299867 |
| S100A10 | S100 calcium binding protein A10 | -0.0298087 |
| PDE10A | phosphodiesterase 10A | -0.0297683 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0293095 |
| RBM39 | RNA binding motif protein 39 | -0.0288697 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0282375 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.028197 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0279892 |
| PFN1 | profilin 1 | -0.0273844 |
| RPL35A | ribosomal protein L35a | -0.0271576 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0270701 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0268014 |
| TPI1 | triosephosphate isomerase 1 | -0.0265387 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0264006 |
| POTEF | POTE ankyrin domain family, member F | -0.0263816 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0260469 |
| H3-3B | H3.3 histone B | -0.0259909 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0257695 |
| RNF213 | ring finger protein 213 | -0.0255248 |
| RPL28 | ribosomal protein L28 | -0.0253576 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0253355 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0253248 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0248777 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0248689 |
| RPS8 | ribosomal protein S8 | -0.0246838 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0245559 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.024047 |
| DEK | DEK proto-oncogene | -0.0238473 |
| BBX | bobby sox homolog (Drosophila) | -0.023686 |
| ZNF292 | zinc finger protein 292 | -0.0234897 |
| RPS16 | ribosomal protein S16 | -0.0233932 |
| NEK7 | NIMA-related kinase 7 | -0.0233004 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0232666 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0231644 |
| RPS19 | ribosomal protein S19 | -0.0229703 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0227942 |
| GNAS | GNAS complex locus | -0.0227144 |
| TAGLN2 | transgelin 2 | -0.0226169 |
| NUP58 | nucleoporin 58 | -0.0223952 |
| RPL36 | ribosomal protein L36 | -0.0223848 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0223383 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0223041 |
| SEPTIN7 | septin 7 | -0.0222758 |
| WDR45B | WD repeat domain 45B | -0.0219817 |
| S100A9 | S100 calcium binding protein A9 | -0.0218298 |
