| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tucatinib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tucatinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FMNL2 | formin-like 2 | 0.0948495 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0776622 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.064012 |
| SMYD3 | SET and MYND domain containing 3 | 0.0577701 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0554829 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0553902 |
| HSPA8 | heat shock 70kDa protein 8 | 0.053247 |
| RPL4 | ribosomal protein L4 | 0.0494477 |
| ANO6 | anoctamin 6 | 0.0481439 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.047676 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0465655 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0465227 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0449203 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0432273 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0418947 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0409485 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0407796 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0405896 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0396717 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0394937 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0389493 |
| CLTC | clathrin, heavy chain (Hc) | 0.0370002 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0366079 |
| OGA | O-GlcNAcase | 0.0362384 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0360613 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0357344 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0352189 |
| OXSR1 | oxidative stress responsive 1 | 0.0350345 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0350279 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0346406 |
| MSN | moesin | 0.0342542 |
| PHF21A | PHD finger protein 21A | 0.0341763 |
| SMAD3 | SMAD family member 3 | 0.03408 |
| AFDN | afadin, adherens junction formation factor | 0.0336663 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0332678 |
| KIF1B | kinesin family member 1B | 0.0332223 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0330964 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0330071 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0325527 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0323979 |
| YAP1 | Yes-associated protein 1 | 0.0321746 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0319145 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0318217 |
| MYO9B | myosin IXB | 0.0316208 |
| MATR3 | matrin 3 | 0.0315972 |
| TJP1 | tight junction protein 1 | 0.0310124 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0307026 |
| MORF4L1 | mortality factor 4 like 1 | 0.030671 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0305642 |
| MED13L | mediator complex subunit 13-like | 0.0304026 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0301572 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0298193 |
| KIAA1958 | KIAA1958 | 0.0295259 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0294299 |
| IPO7 | importin 7 | 0.0290616 |
| FNIP1 | folliculin interacting protein 1 | 0.0287018 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0286637 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0286016 |
| CEP126 | centrosomal protein 126kDa | 0.0281732 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0281152 |
| ATXN1 | ataxin 1 | 0.0274266 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0273686 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0270611 |
| SEPTIN9 | septin 9 | 0.0268823 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0267972 |
| ZNF292 | zinc finger protein 292 | 0.0264747 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0259663 |
| DENND4A | DENN/MADD domain containing 4A | 0.0257671 |
| PCNX2 | pecanex 2 | 0.0257574 |
| RANBP9 | RAN binding protein 9 | 0.0253742 |
| EXOC5 | exocyst complex component 5 | 0.0253605 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0251431 |
| EFL1 | elongation factor like GTPase 1 | 0.0249702 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0248827 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0245666 |
| CDK6 | cyclin-dependent kinase 6 | 0.0243482 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0243445 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0242421 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0242043 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.024105 |
| KLF12 | Kruppel-like factor 12 | 0.023993 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0238459 |
| CPNE1 | copine I | 0.0237088 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0237055 |
| ATRN | attractin | 0.0236095 |
| CAPRIN2 | caprin family member 2 | 0.0234059 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0233777 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0232263 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0231638 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0230915 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0230915 |
| TUBB | tubulin, beta class I | 0.0227682 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0227319 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0227273 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | 0.022674 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0226618 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0226172 |
| DTNA | dystrobrevin, alpha | 0.022442 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0222546 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.022232 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.193478 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.176356 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.153568 |
| VIM | vimentin | -0.127869 |
| RIGI | RNA sensor RIG-I | -0.107083 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0820079 |
| HMGA2 | high mobility group AT-hook 2 | -0.077091 |
| RPLP1 | ribosomal protein, large, P1 | -0.0767062 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.074464 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0593465 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0577039 |
| DST | dystonin | -0.0560977 |
| RBM39 | RNA binding motif protein 39 | -0.0554936 |
| MT2A | metallothionein 2A | -0.052929 |
| CAVIN1 | caveolae associated protein 1 | -0.0527947 |
| RPL31 | ribosomal protein L31 | -0.0518221 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0488991 |
| NF1 | neurofibromin 1 | -0.0480329 |
| EFNA5 | ephrin-A5 | -0.0466073 |
| UBB | ubiquitin B | -0.0464828 |
| HLA-C | major histocompatibility complex, class I, C | -0.0445492 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0439216 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0431674 |
| RPL35A | ribosomal protein L35a | -0.0426651 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0424974 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0423445 |
| TPM4 | tropomyosin 4 | -0.0422325 |
| ACTG1 | actin gamma 1 | -0.0418265 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0401349 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0400456 |
| RSF1 | remodeling and spacing factor 1 | -0.0386584 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0381789 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0380558 |
| GNAS | GNAS complex locus | -0.0373127 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0367837 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0365876 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0364666 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0361208 |
| FBXO11 | F-box protein 11 | -0.0361197 |
| RPL26 | ribosomal protein L26 | -0.0359725 |
| MAP4 | microtubule-associated protein 4 | -0.0358304 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0356286 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0354627 |
| RIN2 | Ras and Rab interactor 2 | -0.0348238 |
| INTS6 | integrator complex subunit 6 | -0.0345747 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0342395 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0340633 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0337904 |
| TMSB10 | thymosin beta 10 | -0.0331985 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0324356 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0316886 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0311596 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0311003 |
| ASPH | aspartate beta-hydroxylase | -0.031059 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0309643 |
| DSTN | destrin (actin depolymerizing factor) | -0.0308602 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0308273 |
| LDHA | lactate dehydrogenase A | -0.0307891 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0306579 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0304957 |
| RAI14 | retinoic acid induced 14 | -0.0304047 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0299895 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0298537 |
| RPL9 | ribosomal protein L9 | -0.0298389 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0295298 |
| FAM3C | family with sequence similarity 3, member C | -0.0292519 |
| HDAC9 | histone deacetylase 9 | -0.0292013 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0289743 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0284856 |
| TPR | translocated promoter region, nuclear basket protein | -0.0283354 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0283155 |
| EGR1 | early growth response 1 | -0.0281133 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0279536 |
| RPL34 | ribosomal protein L34 | -0.0279093 |
| AHNAK | AHNAK nucleoprotein | -0.0278142 |
| NALCN | sodium leak channel, non selective | -0.0276866 |
| HM13 | histocompatibility (minor) 13 | -0.0275594 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0275273 |
| ZNF609 | zinc finger protein 609 | -0.0272884 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0270578 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0265663 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0265632 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0265438 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0265242 |
| HLA-E | major histocompatibility complex, class I, E | -0.0264616 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0260418 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0260398 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0259309 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0257677 |
| SEPTIN7 | septin 7 | -0.0256189 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | -0.025467 |
| UBE3A | ubiquitin protein ligase E3A | -0.0254365 |
| ATG7 | autophagy related 7 | -0.0253436 |
| ACTN1 | actinin, alpha 1 | -0.0253039 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0252712 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0252688 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0248614 |
| HLA-B | major histocompatibility complex, class I, B | -0.0248372 |
| ENO1 | enolase 1, (alpha) | -0.0248285 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0247976 |
