Tucatinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucatinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucatinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.144282
FN1 fibronectin 1 0.134761
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.115213
NAMPT nicotinamide phosphoribosyltransferase 0.111147
ANKRD28 ankyrin repeat domain 28 0.0885514
FNDC3B fibronectin type III domain containing 3B 0.0778232
ZSWIM6 zinc finger, SWIM-type containing 6 0.0756484
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0754493
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0743817
SOD2 superoxide dismutase 2, mitochondrial 0.0694991
EXT1 exostosin glycosyltransferase 1 0.066045
SFTPA2 surfactant protein A2 0.0642969
ELL2 elongation factor, RNA polymerase II, 2 0.0631334
FAT1 FAT atypical cadherin 1 0.0584014
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0544641
RICTOR RPTOR independent companion of MTOR, complex 2 0.0503535
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0501859
MYH9 myosin, heavy chain 9, non-muscle 0.0499061
TRIO trio Rho guanine nucleotide exchange factor 0.0482513
CANX calnexin 0.0480977
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0477244
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0472878
TXNIP thioredoxin interacting protein 0.0470655
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0467733
SPAG9 sperm associated antigen 9 0.0456712
AHR aryl hydrocarbon receptor 0.0441076
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0427761
CD109 CD109 molecule 0.0418638
SUCO SUN domain containing ossification factor 0.040746
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0399639
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0389559
LCORL ligand dependent nuclear receptor corepressor-like 0.0382855
FAM13A family with sequence similarity 13, member A 0.038201
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0379042
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0377438
PELI1 pellino E3 ubiquitin protein ligase 1 0.0372882
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.037136
RLF rearranged L-myc fusion 0.036135
APP amyloid beta (A4) precursor protein 0.0358516
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0351276
HILPDA hypoxia inducible lipid droplet-associated 0.0341006
SEC23A Sec23 homolog A (S. cerevisiae) 0.0340829
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0338685
EMP1 epithelial membrane protein 1 0.033566
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0331663
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0329489
SIK3 SIK family kinase 3 0.0329263
FTH1 ferritin, heavy polypeptide 1 0.032788
UBC ubiquitin C 0.0325345
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0319671
LMNA lamin A/C 0.0318021
WAC WW domain containing adaptor with coiled-coil 0.0314108
RNF145 ring finger protein 145 0.031181
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0310971
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0306437
CLTC clathrin, heavy chain (Hc) 0.0303998
SMAD3 SMAD family member 3 0.0303911
LOC112694756 uncharaterized LOC112694756 0.0302967
SIRT1 sirtuin 1 0.0299018
RB1CC1 RB1-inducible coiled-coil 1 0.0298617
ANXA5 annexin A5 0.0298119
ATF3 activating transcription factor 3 0.0292813
H1-0 H1.0 linker histone 0.0292801
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0290753
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0289143
ZC3H12C zinc finger CCCH-type containing 12C 0.0288572
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0286692
TXNRD1 thioredoxin reductase 1 0.0286175
LIFR leukemia inhibitory factor receptor alpha 0.0285246
ARRDC3 arrestin domain containing 3 0.0284656
SSBP2 single-stranded DNA binding protein 2 0.0280195
SDC4 syndecan 4 0.0276866
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0276144
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0275702
CRY1 cryptochrome circadian clock 1 0.0274865
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0274631
BIRC3 baculoviral IAP repeat containing 3 0.0272485
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0271594
EREG epiregulin 0.0271174
HELZ helicase with zinc finger 0.0271135
TRAM1 translocation associated membrane protein 1 0.0269012
TENT2 terminal nucleotidyltransferase 2 0.026677
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0264396
ERRFI1 ERBB receptor feedback inhibitor 1 0.0263919
TM9SF3 transmembrane 9 superfamily member 3 0.0259939
SVIL supervillin 0.0256103
RASAL2 RAS protein activator like 2 0.0253995
DSTN destrin (actin depolymerizing factor) 0.0252702
PRRC2C proline-rich coiled-coil 2C 0.0251594
HSPA8 heat shock 70kDa protein 8 0.0249932
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0248762
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.024676
ATF6 activating transcription factor 6 0.0246088
OSMR oncostatin M receptor 0.0246016
WDR26 WD repeat domain 26 0.0245458
CAB39 calcium binding protein 39 0.024537
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0244757
DENND5B DENN/MADD domain containing 5B 0.0244289
KDM3A lysine (K)-specific demethylase 3A 0.0243957
ENAH enabled homolog (Drosophila) 0.0242413

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.280023
HMGA2 high mobility group AT-hook 2 -0.148514
EFNA5 ephrin-A5 -0.106321
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.100488
PTMA prothymosin, alpha -0.0834679
FTL ferritin, light polypeptide -0.0690608
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0668434
TMSB10 thymosin beta 10 -0.0620944
IFI27 interferon, alpha-inducible protein 27 -0.0611126
SYT1 synaptotagmin I -0.0582658
GLIS3 GLIS family zinc finger 3 -0.0552099
RPL35A ribosomal protein L35a -0.0490882
RPL31 ribosomal protein L31 -0.048763
TPT1 tumor protein, translationally-controlled 1 -0.0486592
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0482309
RPL37A ribosomal protein L37a -0.04815
RPS12 ribosomal protein S12 -0.0470798
VCL vinculin -0.0456028
INTS6 integrator complex subunit 6 -0.0446596
HMGA1 high mobility group AT-hook 1 -0.0436118
AKAP12 A kinase (PRKA) anchor protein 12 -0.0410514
ACTG1 actin gamma 1 -0.0388315
SOX4 SRY (sex determining region Y)-box 4 -0.038361
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0376315
ENO2 enolase 2 (gamma, neuronal) -0.0364319
RPL13A ribosomal protein L13a -0.0358961
TMEM156 transmembrane protein 156 -0.0356355
RAD51B RAD51 paralog B -0.0353532
WSB1 WD repeat and SOCS box containing 1 -0.034039
RPLP1 ribosomal protein, large, P1 -0.0336466
EGR1 early growth response 1 -0.033136
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0329616
RPS3 ribosomal protein S3 -0.0325731
RPS6 ribosomal protein S6 -0.0324031
AEBP2 AE binding protein 2 -0.031705
LRRC23 leucine rich repeat containing 23 -0.0311989
RPL9 ribosomal protein L9 -0.0310273
MT2A metallothionein 2A -0.0305849
LOC102724023 ES1 protein homolog, mitochondrial -0.0296655
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0291854
IGFBP3 insulin-like growth factor binding protein 3 -0.0291056
NDRG1 N-myc downstream regulated 1 -0.0285288
RPL26 ribosomal protein L26 -0.028339
MBD5 methyl-CpG binding domain protein 5 -0.0279908
RPS8 ribosomal protein S8 -0.0277337
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0269352
RPS29 ribosomal protein S29 -0.026848
VIM vimentin -0.0258191
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0257271
RPS27 ribosomal protein S27 -0.0255178
PDE4D phosphodiesterase 4D, cAMP-specific -0.0248664
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0247544
LOXL2 lysyl oxidase-like 2 -0.0247521
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0245589
RPL11 ribosomal protein L11 -0.0231506
RPS25 ribosomal protein S25 -0.0228194
RPL12 ribosomal protein L12 -0.0227494
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0224497
DNAH5 dynein, axonemal, heavy chain 5 -0.0223472
SKAP2 src kinase associated phosphoprotein 2 -0.0223365
POTEF POTE ankyrin domain family, member F -0.0220821
VEGFA vascular endothelial growth factor A -0.022046
IER3 immediate early response 3 -0.0219819
RPL28 ribosomal protein L28 -0.0218
HLA-B major histocompatibility complex, class I, B -0.0214368
RIGI RNA sensor RIG-I -0.0210972
RPS17 ribosomal protein S17 -0.0210932
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.021008
ZBTB20 zinc finger and BTB domain containing 20 -0.0206798
NRIP1 nuclear receptor interacting protein 1 -0.0206395
FAM20C family with sequence similarity 20, member C -0.0202644
HLA-A major histocompatibility complex, class I, A -0.0196316
HIPK2 homeodomain interacting protein kinase 2 -0.0194806
ZMYND8 zinc finger, MYND-type containing 8 -0.0194468
BICD1 bicaudal D homolog 1 (Drosophila) -0.019399
EFCAB13 EF-hand calcium binding domain 13 -0.0190288
IGFBP5 insulin-like growth factor binding protein 5 -0.0189072
ANKRD11 ankyrin repeat domain 11 -0.0186792
RCOR1 REST corepressor 1 -0.0186636
SOX5 SRY (sex determining region Y)-box 5 -0.0185786
NPAS2 neuronal PAS domain protein 2 -0.0185438
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0184389
NAV1 neuron navigator 1 -0.0183704
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0183431
AHRR aryl-hydrocarbon receptor repressor -0.018312
IFI6 interferon, alpha-inducible protein 6 -0.0182955
RBM47 RNA binding motif protein 47 -0.0181367
TRIP11 thyroid hormone receptor interactor 11 -0.0179677
ETV1 ets variant 1 -0.0177692
BPTF bromodomain PHD finger transcription factor -0.0177125
RPS16 ribosomal protein S16 -0.017678
RERE arginine-glutamic acid dipeptide (RE) repeats -0.017649
RPS27A ribosomal protein S27a -0.0176153
TPM4 tropomyosin 4 -0.0173637
RAI14 retinoic acid induced 14 -0.0173097
RPS19 ribosomal protein S19 -0.0171792
RPL23 ribosomal protein L23 -0.0169032
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0160975
RACK1 receptor for activated C kinase 1 -0.0160428
KRT19 keratin 19, type I -0.0159849