Tucidinostat_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucidinostat_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.101531
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0804441
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0774821
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0729882
NLGN1 neuroligin 1 0.0707033
CCN2 cellular communication network factor 2 0.0686588
PCBP2 poly(rC) binding protein 2 0.0626899
ANXA1 annexin A1 0.0621522
ANKRD12 ankyrin repeat domain 12 0.0581176
JMJD1C jumonji domain containing 1C 0.0553571
YBX3 Y box binding protein 3 0.0525377
PRDX1 peroxiredoxin 1 0.0427521
SPATS2 spermatogenesis associated, serine-rich 2 0.0392828
EGR1 early growth response 1 0.0377365
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0356313
TPM3 tropomyosin 3 0.0355548
EHBP1 EH domain binding protein 1 0.0355423
DPYD dihydropyrimidine dehydrogenase 0.0348732
RTN4 reticulon 4 0.0340393
RASAL2 RAS protein activator like 2 0.0333555
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.031272
RRM2 ribonucleotide reductase M2 0.0310557
SYT1 synaptotagmin I 0.0303899
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0297976
TGM2 transglutaminase 2 0.0297275
AKAP12 A kinase (PRKA) anchor protein 12 0.0295483
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0287356
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0283081
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0282223
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0280811
PHF21A PHD finger protein 21A 0.0274254
KDM2A lysine (K)-specific demethylase 2A 0.027316
CARD16 caspase recruitment domain family, member 16 0.027139
MACF1 microtubule-actin crosslinking factor 1 0.0267543
CCSER1 coiled-coil serine-rich protein 1 0.0265588
ANKRD17 ankyrin repeat domain 17 0.0264776
VMP1 vacuole membrane protein 1 0.0260643
MED12L mediator complex subunit 12-like 0.025153
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0245195
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0243816
NEBL nebulette 0.0243354
FSTL5 follistatin-like 5 0.0241653
NALF1 NALCN channel auxiliary factor 1 0.0241071
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0237611
TBC1D5 TBC1 domain family, member 5 0.0236355
ZNF292 zinc finger protein 292 0.0235827
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0234818
KDM4C lysine (K)-specific demethylase 4C 0.0230344
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0229986
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0227699
BABAM2 BRISC and BRCA1 A complex member 2 0.0226757
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0226293
SMC4 structural maintenance of chromosomes 4 0.0225691
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0225052
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0221495
FAM168A family with sequence similarity 168, member A 0.0219767
UTRN utrophin 0.0216468
BIRC6 baculoviral IAP repeat containing 6 0.0212836
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0209323
MBNL1 muscleblind-like splicing regulator 1 0.0206941
FBXL7 F-box and leucine-rich repeat protein 7 0.0205682
NHSL1 NHS-like 1 0.0202234
USP34 ubiquitin specific peptidase 34 0.0201829
BCLAF1 BCL2-associated transcription factor 1 0.0197644
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0194539
GCG glucagon 0.0193237
KSR2 kinase suppressor of ras 2 0.0192482
EPHA6 EPH receptor A6 0.0192255
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0192113
GSK3B glycogen synthase kinase 3 beta 0.0192089
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0191975
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0191831
PCDH9 protocadherin 9 0.0191256
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0190771
ASXL2 additional sex combs like transcriptional regulator 2 0.0189799
MED13L mediator complex subunit 13-like 0.0189673
UBC ubiquitin C 0.0189041
CSMD3 CUB and Sushi multiple domains 3 0.0188983
MYADM myeloid-associated differentiation marker 0.0188293
TSPAN5 tetraspanin 5 0.0188245
MAP1B microtubule-associated protein 1B 0.018673
INTS6 integrator complex subunit 6 0.018634
ACLY ATP citrate lyase 0.0186244
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0185128
CEP192 centrosomal protein 192kDa 0.0184569
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0184489
PICALM phosphatidylinositol binding clathrin assembly protein 0.0182608
FLNB filamin B, beta 0.0181933
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.018045
PFN1 profilin 1 0.0179915
ZSWIM6 zinc finger, SWIM-type containing 6 0.0179609
MSN moesin 0.0178971
MTCL1 microtubule crosslinking factor 1 0.0176993
POTEF POTE ankyrin domain family, member F 0.0176259
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0174596
DTNA dystrobrevin, alpha 0.0174055
RABGAP1L RAB GTPase activating protein 1-like 0.0172668
TRA2B transformer 2 beta homolog (Drosophila) 0.017169
MARCHF4 membrane associated ring-CH-type finger 4 0.0171561
MAML3 mastermind-like 3 (Drosophila) 0.01715

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.273747
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.218532
TMSB10 thymosin beta 10 -0.165181
PDE4D phosphodiesterase 4D, cAMP-specific -0.121575
RPL35A ribosomal protein L35a -0.0784192
RPLP1 ribosomal protein, large, P1 -0.0740648
MMP12 matrix metallopeptidase 12 -0.0673705
EIF1 eukaryotic translation initiation factor 1 -0.0661994
FTL ferritin, light polypeptide -0.0636403
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0621694
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0612647
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0603389
TPT1 tumor protein, translationally-controlled 1 -0.0572284
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0559089
LOC112694756 uncharaterized LOC112694756 -0.0550299
RPL23 ribosomal protein L23 -0.0545699
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0534862
BIRC3 baculoviral IAP repeat containing 3 -0.0528006
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0506427
RPL19 ribosomal protein L19 -0.0501711
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0488889
AHNAK AHNAK nucleoprotein -0.0488755
KDM3A lysine (K)-specific demethylase 3A -0.0476918
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0474729
ACTG1 actin gamma 1 -0.0468128
DLC1 DLC1 Rho GTPase activating protein -0.0467874
BCHE butyrylcholinesterase -0.0465707
ZNF217 zinc finger protein 217 -0.0451449
RPLP0 ribosomal protein, large, P0 -0.0434935
KLF6 Kruppel-like factor 6 -0.0433876
SLC38A2 solute carrier family 38, member 2 -0.0428508
CANX calnexin -0.04188
RPS19 ribosomal protein S19 -0.0418639
RPS6 ribosomal protein S6 -0.0418224
RPL26 ribosomal protein L26 -0.0412229
YBX1 Y box binding protein 1 -0.0409823
RPS20 ribosomal protein S20 -0.0409598
RPLP2 ribosomal protein, large, P2 -0.0405849
RPL12 ribosomal protein L12 -0.0396264
ADGRG6 adhesion G protein-coupled receptor G6 -0.0395632
RPL38 ribosomal protein L38 -0.0387455
SLC38A1 solute carrier family 38, member 1 -0.0382324
SQSTM1 sequestosome 1 -0.0381331
RACK1 receptor for activated C kinase 1 -0.0377465
HSPA8 heat shock 70kDa protein 8 -0.0374981
RPL34 ribosomal protein L34 -0.037107
TMEM123 transmembrane protein 123 -0.035713
CCND1 cyclin D1 -0.0354788
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.035161
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0350813
RPS27A ribosomal protein S27a -0.034622
RPS16 ribosomal protein S16 -0.0342829
EDARADD EDAR-associated death domain -0.0336326
MTAP methylthioadenosine phosphorylase -0.0331015
PTMA prothymosin, alpha -0.0325172
TXNRD1 thioredoxin reductase 1 -0.0317246
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0316751
CXADR coxsackie virus and adenovirus receptor -0.0306376
RPS5 ribosomal protein S5 -0.0303732
GNAS GNAS complex locus -0.0302586
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.03019
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0299058
TAS2R14 taste receptor, type 2, member 14 -0.029304
KIF5B kinesin family member 5B -0.0292887
PCDH7 protocadherin 7 -0.0288204
VCL vinculin -0.028676
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0285557
RPL6 ribosomal protein L6 -0.0285081
RPS14 ribosomal protein S14 -0.0281735
TNPO1 transportin 1 -0.0279007
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0275772
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0274417
RPS27 ribosomal protein S27 -0.0273704
RPL27A ribosomal protein L27a -0.0271704
RPL36A ribosomal protein L36a -0.027122
NPC1 Niemann-Pick disease, type C1 -0.0269393
NEK7 NIMA-related kinase 7 -0.0267144
MKI67 marker of proliferation Ki-67 -0.0266782
MYL12B myosin, light chain 12B, regulatory -0.0266356
ARF1 ADP-ribosylation factor 1 -0.0263782
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.0262344
WDR45B WD repeat domain 45B -0.0260668
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0259297
AFG3L2 AFG3-like AAA ATPase 2 -0.0257769
RPL39 ribosomal protein L39 -0.0257653
RPS24 ribosomal protein S24 -0.0255817
RPL7 ribosomal protein L7 -0.0255083
RPL11 ribosomal protein L11 -0.0254369
RAD21 RAD21 homolog (S. pombe) -0.0251337
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0247971
CLTC clathrin, heavy chain (Hc) -0.0246411
OGA O-GlcNAcase -0.02461
RSL1D1 ribosomal L1 domain containing 1 -0.0242515
PCNP PEST proteolytic signal containing nuclear protein -0.0242505
YAP1 Yes-associated protein 1 -0.0241097
RPL8 ribosomal protein L8 -0.0240591
RPS23 ribosomal protein S23 -0.0239477
RPL36 ribosomal protein L36 -0.0237918
RPL37 ribosomal protein L37 -0.0234943
RPS21 ribosomal protein S21 -0.0234721