Tucidinostat_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucidinostat_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.26205
IGF2 insulin-like growth factor 2 0.141124
AKAP12 A kinase (PRKA) anchor protein 12 0.07849
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0690357
DST dystonin 0.0460804
SAMD4A sterile alpha motif domain containing 4A 0.0460538
FAM107B family with sequence similarity 107, member B 0.0458159
NDRG1 N-myc downstream regulated 1 0.0452137
INTS6 integrator complex subunit 6 0.0442707
PDLIM5 PDZ and LIM domain 5 0.0420243
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0407986
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.039272
MT2A metallothionein 2A 0.0357032
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0353408
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0347478
SERTAD2 SERTA domain containing 2 0.0325241
APLP2 amyloid beta (A4) precursor-like protein 2 0.0319054
VEGFA vascular endothelial growth factor A 0.0316999
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0314623
MBNL2 muscleblind-like splicing regulator 2 0.0303257
ADARB1 adenosine deaminase, RNA-specific, B1 0.025583
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0254381
TIMP1 TIMP metallopeptidase inhibitor 1 0.024904
TTC3 tetratricopeptide repeat domain 3 0.0248466
AFF1 AF4/FMR2 family, member 1 0.0242949
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0242185
ARHGAP26 Rho GTPase activating protein 26 0.0240797
RYBP RING1 and YY1 binding protein 0.0239288
ZSWIM6 zinc finger, SWIM-type containing 6 0.0238351
PALLD palladin, cytoskeletal associated protein 0.0235534
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0231042
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0230371
TIMP2 TIMP metallopeptidase inhibitor 2 0.022833
FLNB filamin B, beta 0.022165
NABP1 nucleic acid binding protein 1 0.0214448
EXT1 exostosin glycosyltransferase 1 0.0214379
MACF1 microtubule-actin crosslinking factor 1 0.0196956
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0196877
JARID2 jumonji, AT rich interactive domain 2 0.0196249
CCDC88A coiled-coil domain containing 88A 0.0190057
UBC ubiquitin C 0.0188325
FOXP1 forkhead box P1 0.0187639
POTEF POTE ankyrin domain family, member F 0.0187008
MYO6 myosin VI 0.0185251
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0184002
SORBS1 sorbin and SH3 domain containing 1 0.0182464
PLIN2 perilipin 2 0.0179365
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0176552
KYNU kynureninase 0.0175636
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0169235
SDC4 syndecan 4 0.0167854
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0167693
TNS1 tensin 1 0.0167159
ARL15 ADP-ribosylation factor-like 15 0.0166751
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0164506
EZR ezrin 0.0163664
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0162094
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0158605
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0158345
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0158066
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0157025
GRB10 growth factor receptor-bound protein 10 0.015691
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0156735
SRRM2 serine/arginine repetitive matrix 2 0.0155616
CYB5R3 cytochrome b5 reductase 3 0.0154344
STC2 stanniocalcin 2 0.0153767
HOMER1 homer scaffolding protein 1 0.0149151
FERMT2 fermitin family member 2 0.0147786
CADM1 cell adhesion molecule 1 0.0145812
SRRM1 serine/arginine repetitive matrix 1 0.0144897
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0144402
BRD2 bromodomain containing 2 0.014386
SVIL supervillin 0.0143074
IGFBP3 insulin-like growth factor binding protein 3 0.0142742
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0142579
FTL ferritin, light polypeptide 0.014243
TLE4 transducin-like enhancer of split 4 0.0142226
GLS2 glutaminase 2 (liver, mitochondrial) 0.0141661
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0138288
PCBP2 poly(rC) binding protein 2 0.0137694
PRKCA protein kinase C, alpha 0.0136845
GK glycerol kinase 0.013587
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0134844
RCOR1 REST corepressor 1 0.0133444
AKAP13 A kinase (PRKA) anchor protein 13 0.0133351
NUP58 nucleoporin 58 0.0132811
FAM13A family with sequence similarity 13, member A 0.0132635
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.0131646
CLIC4 chloride intracellular channel 4 0.0131516
PRKCE protein kinase C, epsilon 0.0131074
MCTP1 multiple C2 domains, transmembrane 1 0.0130656
SEPTIN9 septin 9 0.0129313
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0128116
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0127858
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.0127234
CAPRIN2 caprin family member 2 0.0126696
SKAP2 src kinase associated phosphoprotein 2 0.0125994
ATXN1 ataxin 1 0.0125956
SMYD3 SET and MYND domain containing 3 0.012556
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0125365

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.274902
FNDC3B fibronectin type III domain containing 3B -0.146073
GPC3 glypican 3 -0.123609
FN1 fibronectin 1 -0.11605
TPT1 tumor protein, translationally-controlled 1 -0.115747
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.105106
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0924925
ELL2 elongation factor, RNA polymerase II, 2 -0.0907293
MAML2 mastermind-like 2 (Drosophila) -0.0838992
TM4SF1 transmembrane 4 L six family member 1 -0.0835613
A2M alpha-2-macroglobulin -0.0797015
LRMDA leucine rich melanocyte differentiation associated -0.076313
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0743939
NKD1 naked cuticle homolog 1 (Drosophila) -0.069276
ZMYND8 zinc finger, MYND-type containing 8 -0.0646044
EML4 echinoderm microtubule associated protein like 4 -0.0621951
TRIM26 tripartite motif containing 26 -0.0608275
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0598534
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0594008
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0553852
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0552768
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0548024
NPAS2 neuronal PAS domain protein 2 -0.0530647
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0500711
RBM39 RNA binding motif protein 39 -0.0481878
AFDN afadin, adherens junction formation factor -0.0480683
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0471896
OSMR oncostatin M receptor -0.0467647
EHBP1 EH domain binding protein 1 -0.0466806
SESTD1 SEC14 and spectrin domains 1 -0.0465292
PEG3 paternally expressed 3 -0.0464569
RPS24 ribosomal protein S24 -0.0442174
SLC38A2 solute carrier family 38, member 2 -0.0439337
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.042267
GPC6 glypican 6 -0.0415896
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.041158
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0402855
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0401847
NRIP1 nuclear receptor interacting protein 1 -0.039934
CFB complement factor B -0.0392885
NCOA7 nuclear receptor coactivator 7 -0.0392091
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0387676
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0386934
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0385768
KIAA1217 KIAA1217 -0.0381188
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0378325
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0368252
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0365722
PTPRM protein tyrosine phosphatase, receptor type, M -0.0365379
MBNL3 muscleblind-like splicing regulator 3 -0.0352931
ACTN4 actinin, alpha 4 -0.0350841
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0348013
JMJD1C jumonji domain containing 1C -0.0347008
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0338111
KDM7A lysine (K)-specific demethylase 7A -0.0337752
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0337091
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0322061
ARL5A ADP-ribosylation factor-like 5A -0.0318273
IGF2R insulin-like growth factor 2 receptor -0.0318259
HLF hepatic leukemia factor -0.0314574
IGFBP1 insulin-like growth factor binding protein 1 -0.031343
MRTFA myocardin related transcription factor A -0.030957
TMEM123 transmembrane protein 123 -0.0308516
IGF1R insulin-like growth factor 1 receptor -0.0304475
FBF1 Fas (TNFRSF6) binding factor 1 -0.0303985
CRLS1 cardiolipin synthase 1 -0.0299876
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.029823
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0297737
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.029468
RRBP1 ribosome binding protein 1 -0.0291918
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0291075
ANKRD10 ankyrin repeat domain 10 -0.0290746
ITGAV integrin, alpha V -0.0280888
FAM135A family with sequence similarity 135, member A -0.0278308
TM9SF3 transmembrane 9 superfamily member 3 -0.0275585
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0274701
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0273375
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0273234
RPL26 ribosomal protein L26 -0.0270692
MSI2 musashi RNA-binding protein 2 -0.0270112
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0269325
MALT1 MALT1 paracaspase -0.0266755
ARHGAP5 Rho GTPase activating protein 5 -0.0266474
TLK1 tousled-like kinase 1 -0.0262758
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0261301
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0259685
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0259397
WDFY2 WD repeat and FYVE domain containing 2 -0.0257972
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0256937
NAP1L1 nucleosome assembly protein 1-like 1 -0.0253899
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0251952
ATP10A ATPase, class V, type 10A -0.0251289
DNAH17 dynein, axonemal, heavy chain 17 -0.0248443
TMSB10 thymosin beta 10 -0.0247596
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0246872
ZFHX3 zinc finger homeobox 3 -0.0245219
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0244956
SOX5 SRY (sex determining region Y)-box 5 -0.0244641
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0242859
RPL31 ribosomal protein L31 -0.0239397