Tucidinostat_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucidinostat_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.244134
TIMP3 TIMP metallopeptidase inhibitor 3 0.151435
LMO7 LIM domain 7 0.123757
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.114497
PALM2AKAP2 PALM2 and AKAP2 fusion 0.105703
PDE4D phosphodiesterase 4D, cAMP-specific 0.0967004
SLC35F3 solute carrier family 35, member F3 0.0962807
PDLIM5 PDZ and LIM domain 5 0.08275
MTSS1 metastasis suppressor 1 0.0602174
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.060201
HMGA2 high mobility group AT-hook 2 0.0561645
AHNAK AHNAK nucleoprotein 0.0549505
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0531239
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.052375
INTS6 integrator complex subunit 6 0.0521572
ALCAM activated leukocyte cell adhesion molecule 0.0510797
RASAL2 RAS protein activator like 2 0.0504341
PSD3 pleckstrin and Sec7 domain containing 3 0.0489593
DPYD dihydropyrimidine dehydrogenase 0.0488715
RABGAP1L RAB GTPase activating protein 1-like 0.0475103
ABI3BP ABI family, member 3 (NESH) binding protein 0.0469743
ANO1 anoctamin 1, calcium activated chloride channel 0.0462057
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0460742
EXT1 exostosin glycosyltransferase 1 0.0460476
GRB10 growth factor receptor-bound protein 10 0.0453256
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.042854
AKAP13 A kinase (PRKA) anchor protein 13 0.0408562
KLF5 Kruppel-like factor 5 (intestinal) 0.04039
HSPG2 heparan sulfate proteoglycan 2 0.0400182
RNF217 ring finger protein 217 0.0387457
PALLD palladin, cytoskeletal associated protein 0.0379292
MECOM MDS1 and EVI1 complex locus 0.0366418
SULF2 sulfatase 2 0.0361682
RIGI RNA sensor RIG-I 0.0336007
LAMC2 laminin, gamma 2 0.0335622
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0320325
THSD4 thrombospondin, type I, domain containing 4 0.0308944
ZSWIM6 zinc finger, SWIM-type containing 6 0.0308238
RAD51B RAD51 paralog B 0.0306996
HDAC9 histone deacetylase 9 0.0305282
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0295236
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0291309
PRSS23 protease, serine, 23 0.0290651
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0285835
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.02826
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0282481
BCAR3 breast cancer anti-estrogen resistance 3 0.0280069
MTAP methylthioadenosine phosphorylase 0.0274721
AMOTL1 angiomotin like 1 0.0258184
TNS3 tensin 3 0.025537
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0249101
FTH1 ferritin, heavy polypeptide 1 0.0248205
CSMD2 CUB and Sushi multiple domains 2 0.0244691
KIAA1671 KIAA1671 0.0244496
EFNA5 ephrin-A5 0.0244135
MACF1 microtubule-actin crosslinking factor 1 0.0244072
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0243489
UTRN utrophin 0.0242233
RCOR1 REST corepressor 1 0.0237542
SMYD3 SET and MYND domain containing 3 0.0236742
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0234262
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0233467
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0231722
PLS3 plastin 3 0.0231142
EGFR epidermal growth factor receptor 0.0228149
CALB1 calbindin 1, 28kDa 0.022642
MPRIP myosin phosphatase Rho interacting protein 0.0225568
DST dystonin 0.0225349
JMJD1C jumonji domain containing 1C 0.0224396
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0221884
DGKH diacylglycerol kinase, eta 0.0213634
PLXNA2 plexin A2 0.0211032
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0210561
AGO2 argonaute RISC catalytic component 2 0.0207252
EXOC4 exocyst complex component 4 0.0206863
ZEB1 zinc finger E-box binding homeobox 1 0.0203696
TENM4 teneurin transmembrane protein 4 0.0199176
SOX5 SRY (sex determining region Y)-box 5 0.0198379
ZMYND8 zinc finger, MYND-type containing 8 0.0195253
CUX1 cut-like homeobox 1 0.019321
MEGF6 multiple EGF-like-domains 6 0.0193024
CTBP2 C-terminal binding protein 2 0.0192271
FRMD4B FERM domain containing 4B 0.0190005
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0188507
LPP LIM domain containing preferred translocation partner in lipoma 0.0185792
IFI44L interferon-induced protein 44-like 0.0183394
CDK6 cyclin-dependent kinase 6 0.0181392
SVIL supervillin 0.0179931
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0179473
ZC3H12C zinc finger CCCH-type containing 12C 0.017595
SIK3 SIK family kinase 3 0.0172905
DOK5 docking protein 5 0.0171881
CRACDL CRACD like 0.017163
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0169151
ABLIM3 actin binding LIM protein family, member 3 0.0168357
CNTNAP3 contactin associated protein-like 3 0.0167984
DPYSL2 dihydropyrimidinase-like 2 0.0167625
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0166787
LAMA4 laminin, alpha 4 0.0166778
PODXL podocalyxin-like 0.0166765

decreased expression

Symbol Name Standardized Value
CLU clusterin -0.137399
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136513
NAMPT nicotinamide phosphoribosyltransferase -0.105912
NDRG1 N-myc downstream regulated 1 -0.104572
MEF2A myocyte enhancer factor 2A -0.0727646
MT2A metallothionein 2A -0.0708831
B2M beta-2-microglobulin -0.0662145
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0661002
CUL4B cullin 4B -0.0642987
GOLGA4 golgin A4 -0.0632354
RPS21 ribosomal protein S21 -0.0611797
PTMA prothymosin, alpha -0.0596643
TMSB10 thymosin beta 10 -0.0583555
RBM39 RNA binding motif protein 39 -0.0560538
CEMIP cell migration inducing protein, hyaluronan binding -0.0558304
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0546722
PLAT plasminogen activator, tissue -0.0543216
KMT2E lysine (K)-specific methyltransferase 2E -0.0529565
DSTN destrin (actin depolymerizing factor) -0.0518855
ITCH itchy E3 ubiquitin protein ligase -0.0518674
ANLN anillin, actin binding protein -0.0515884
PGK1 phosphoglycerate kinase 1 -0.0512966
KTN1 kinectin 1 (kinesin receptor) -0.0489833
FLNB filamin B, beta -0.0485165
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0481631
MYOF myoferlin -0.0473314
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0467414
KRT17 keratin 17, type I -0.0450582
ARRDC3 arrestin domain containing 3 -0.0448475
RPS2 ribosomal protein S2 -0.0442847
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0437579
ENO1 enolase 1, (alpha) -0.0428734
LOC112694756 uncharaterized LOC112694756 -0.0426621
LMNA lamin A/C -0.0422317
TMSB4X thymosin beta 4, X-linked -0.0416505
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0415168
RPLP2 ribosomal protein, large, P2 -0.0413336
LDHA lactate dehydrogenase A -0.040801
CANX calnexin -0.0404866
RPS6 ribosomal protein S6 -0.0403206
POTEF POTE ankyrin domain family, member F -0.0400273
BCL2L1 BCL2-like 1 -0.0398725
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0387131
SERINC3 serine incorporator 3 -0.0386773
RPS13 ribosomal protein S13 -0.0382413
S100A10 S100 calcium binding protein A10 -0.0377943
OGA O-GlcNAcase -0.0375539
RPL11 ribosomal protein L11 -0.0374301
RPS3 ribosomal protein S3 -0.037368
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0369792
IGF2 insulin-like growth factor 2 -0.0368099
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0365066
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0363185
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0354055
PKM pyruvate kinase, muscle -0.0348163
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0343552
KDM3A lysine (K)-specific demethylase 3A -0.034277
COG5 component of oligomeric golgi complex 5 -0.0340537
MYH9 myosin, heavy chain 9, non-muscle -0.0338443
AKAP9 A kinase (PRKA) anchor protein 9 -0.0336414
ZNF292 zinc finger protein 292 -0.0331963
ITGA6 integrin, alpha 6 -0.0321946
PRRC2C proline-rich coiled-coil 2C -0.0320286
KDM6A lysine (K)-specific demethylase 6A -0.0319341
TPX2 TPX2, microtubule-associated -0.0316229
SUCO SUN domain containing ossification factor -0.0316147
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0307965
GNAS GNAS complex locus -0.0306857
RIN2 Ras and Rab interactor 2 -0.0306174
YBX3 Y box binding protein 3 -0.030563
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0305196
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0304327
RPS8 ribosomal protein S8 -0.0303876
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0299136
EFHD2 EF-hand domain family, member D2 -0.0297742
ACBD3 acyl-CoA binding domain containing 3 -0.0293281
RPL7 ribosomal protein L7 -0.0290797
SRP54 signal recognition particle 54kDa -0.0287819
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0286183
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0286093
BZW2 basic leucine zipper and W2 domains 2 -0.0283489
PDLIM1 PDZ and LIM domain 1 -0.0282207
RPS12 ribosomal protein S12 -0.0280922
PNISR PNN-interacting serine/arginine-rich protein -0.0280348
EIF1 eukaryotic translation initiation factor 1 -0.0280321
COPB1 coatomer protein complex, subunit beta 1 -0.0278028
ANXA2 annexin A2 -0.0277509
CD99 CD99 molecule -0.0277043
GARS1 glycyl-tRNA synthetase 1 -0.0274929
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0272952
WASF2 WAS protein family, member 2 -0.0270486
RPS19 ribosomal protein S19 -0.0268334
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0267673
SEC31A SEC31 homolog A (S. cerevisiae) -0.0266946
IFITM3 interferon induced transmembrane protein 3 -0.0266455
S100A2 S100 calcium binding protein A2 -0.0265791
RAB6A RAB6A, member RAS oncogene family -0.0264703
YBX1 Y box binding protein 1 -0.0263231
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0259996
LMAN1 lectin, mannose-binding, 1 -0.0259414