Tucidinostat_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucidinostat_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0598636
ANGPTL4 angiopoietin-like 4 0.0586437
FTL ferritin, light polypeptide 0.0406832
SPAG9 sperm associated antigen 9 0.0393574
RPS12 ribosomal protein S12 0.0365772
MT1X metallothionein 1X 0.0362211
PTMA prothymosin, alpha 0.0340453
RPS8 ribosomal protein S8 0.0331057
KMT2E lysine (K)-specific methyltransferase 2E 0.032593
GARS1 glycyl-tRNA synthetase 1 0.0323148
UBC ubiquitin C 0.0319522
FMNL2 formin-like 2 0.0296233
FLNB filamin B, beta 0.0274127
DDIT4 DNA-damage-inducible transcript 4 0.0271384
WSB1 WD repeat and SOCS box containing 1 0.0261614
TFRC transferrin receptor 0.0250953
ZNF292 zinc finger protein 292 0.0249875
RPS10 ribosomal protein S10 0.0245103
RPS3 ribosomal protein S3 0.0243161
RLF rearranged L-myc fusion 0.0233891
NAP1L1 nucleosome assembly protein 1-like 1 0.022521
RSRC2 arginine/serine-rich coiled-coil 2 0.0225001
TRA2A transformer 2 alpha homolog (Drosophila) 0.0221143
RPL11 ribosomal protein L11 0.0220927
RPL36 ribosomal protein L36 0.0217814
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0215498
NDRG1 N-myc downstream regulated 1 0.0215183
HILPDA hypoxia inducible lipid droplet-associated 0.0214924
RPL37A ribosomal protein L37a 0.0214391
SEPTIN7 septin 7 0.0214359
RBM39 RNA binding motif protein 39 0.0213233
RPS27A ribosomal protein S27a 0.0210972
YBX3 Y box binding protein 3 0.0202949
AKAP12 A kinase (PRKA) anchor protein 12 0.0201276
RAB7A RAB7A, member RAS oncogene family 0.0195643
WAC WW domain containing adaptor with coiled-coil 0.0190012
DSCAM Down syndrome cell adhesion molecule 0.0187084
AMBRA1 autophagy/beclin-1 regulator 1 0.0187016
EIF1 eukaryotic translation initiation factor 1 0.0184403
RPS6 ribosomal protein S6 0.0183469
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0181974
S100A6 S100 calcium binding protein A6 0.0181133
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0180811
RIOK3 RIO kinase 3 0.018041
KDM5B lysine (K)-specific demethylase 5B 0.0179649
FNBP1L formin binding protein 1-like 0.0179129
ANXA1 annexin A1 0.0176623
SEC24A SEC24 family member A 0.0175707
OGA O-GlcNAcase 0.017536
MATR3 matrin 3 0.0173698
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0172085
NOP58 NOP58 ribonucleoprotein 0.0171877
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0170855
RPL26 ribosomal protein L26 0.0170648
NPEPPS aminopeptidase puromycin sensitive 0.0170554
RNF145 ring finger protein 145 0.0168692
KLF6 Kruppel-like factor 6 0.0168109
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0167333
PUM1 pumilio RNA-binding family member 1 0.0166249
IFRD1 interferon-related developmental regulator 1 0.0165405
GLS2 glutaminase 2 (liver, mitochondrial) 0.0160834
MTF2 metal response element binding transcription factor 2 0.016057
NPR2 natriuretic peptide receptor 2 0.0160476
GOLGA4 golgin A4 0.0160086
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0158781
RPS2 ribosomal protein S2 0.015817
KCNK5 potassium channel, two pore domain subfamily K, member 5 0.0157793
BRD2 bromodomain containing 2 0.0157063
RPL23 ribosomal protein L23 0.0157016
TPD52 tumor protein D52 0.015652
WDR45B WD repeat domain 45B 0.0156435
BAIAP2L1 BAI1-associated protein 2-like 1 0.0156362
H1-0 H1.0 linker histone 0.0156056
PNISR PNN-interacting serine/arginine-rich protein 0.015302
KDM3A lysine (K)-specific demethylase 3A 0.0152548
KIF1B kinesin family member 1B 0.015108
ADM adrenomedullin 0.0151023
LMNA lamin A/C 0.0151019
TXNIP thioredoxin interacting protein 0.0150326
HBS1L HBS1-like translational GTPase 0.0147504
TMEM41B transmembrane protein 41B 0.0145115
DCAF6 DDB1 and CUL4 associated factor 6 0.0144392
RBM27 RNA binding motif protein 27 0.0143666
HOOK2 hook microtubule-tethering protein 2 0.0142916
PHF21A PHD finger protein 21A 0.0141699
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0141682
TFG TRK-fused gene 0.0141153
RYBP RING1 and YY1 binding protein 0.0140533
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0140134
RAB1A RAB1A, member RAS oncogene family 0.0139702
RPL12 ribosomal protein L12 0.0139043
KMT2C lysine (K)-specific methyltransferase 2C 0.0138233
RPL13A ribosomal protein L13a 0.0137985
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0136518
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0134988
STRN3 striatin, calmodulin binding protein 3 0.0134453
RPS19 ribosomal protein S19 0.0133525
ATXN2 ataxin 2 0.0132874
PDGFB platelet-derived growth factor beta polypeptide 0.013277
TPT1 tumor protein, translationally-controlled 1 0.0132713

decreased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) -0.140638
WARS1 tryptophanyl-tRNA synthetase 1 -0.11145
VIM vimentin -0.102615
TP63 tumor protein p63 -0.0808344
DST dystonin -0.0792853
TXNRD1 thioredoxin reductase 1 -0.0776502
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0776036
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0761764
SLC38A2 solute carrier family 38, member 2 -0.0722027
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0714601
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0708039
EHBP1 EH domain binding protein 1 -0.0617343
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0587292
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.052814
EFNA5 ephrin-A5 -0.0499485
CADM2 cell adhesion molecule 2 -0.0498549
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0490701
TSC22D1 TSC22 domain family, member 1 -0.0488036
RIGI RNA sensor RIG-I -0.0483045
CFAP299 cilia and flagella associated protein 299 -0.0480131
CANX calnexin -0.0450952
TNS3 tensin 3 -0.0449954
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0449736
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0448435
AHNAK AHNAK nucleoprotein -0.0446376
HLA-B major histocompatibility complex, class I, B -0.0437021
RUNX1 runt-related transcription factor 1 -0.0433194
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0431903
PDE10A phosphodiesterase 10A -0.0420158
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0396462
LOC112694756 uncharaterized LOC112694756 -0.0395711
WWTR1 WW domain containing transcription regulator 1 -0.038974
BCAR3 breast cancer anti-estrogen resistance 3 -0.0381644
PLSCR1 phospholipid scramblase 1 -0.0381613
DPYD dihydropyrimidine dehydrogenase -0.0379982
CENPF centromere protein F, 350/400kDa -0.0376527
CMIP c-Maf inducing protein -0.0373792
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0372421
RNF213 ring finger protein 213 -0.0368824
EXOC4 exocyst complex component 4 -0.0363292
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0363052
EPHA4 EPH receptor A4 -0.0358612
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0358135
MKI67 marker of proliferation Ki-67 -0.0357334
APP amyloid beta (A4) precursor protein -0.0353416
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0350304
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0323995
ACTG1 actin gamma 1 -0.0321901
ARHGAP5 Rho GTPase activating protein 5 -0.0317979
MACF1 microtubule-actin crosslinking factor 1 -0.031589
CAPN2 calpain 2, (m/II) large subunit -0.031254
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0309235
ZBTB38 zinc finger and BTB domain containing 38 -0.0308573
IFIH1 interferon induced with helicase C domain 1 -0.0307364
LDHA lactate dehydrogenase A -0.0298326
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0293019
GCLM glutamate-cysteine ligase, modifier subunit -0.0291519
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0284452
NT5E 5'-nucleotidase, ecto (CD73) -0.0283258
OSMR oncostatin M receptor -0.028059
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0279911
NCEH1 neutral cholesterol ester hydrolase 1 -0.0276229
SETX senataxin -0.0274471
RGS4 regulator of G-protein signaling 4 -0.0273755
VCL vinculin -0.0273388
MYOF myoferlin -0.0272842
BPTF bromodomain PHD finger transcription factor -0.0271987
USP34 ubiquitin specific peptidase 34 -0.0271058
DENND1A DENN/MADD domain containing 1A -0.0270911
TM4SF1 transmembrane 4 L six family member 1 -0.0269915
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0264439
SMYD3 SET and MYND domain containing 3 -0.0261517
AHNAK2 AHNAK nucleoprotein 2 -0.0260223
SP100 SP100 nuclear antigen -0.025934
ADGRG6 adhesion G protein-coupled receptor G6 -0.0256266
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0256016
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0255468
HDLBP high density lipoprotein binding protein -0.0255467
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0253061
ADAM10 ADAM metallopeptidase domain 10 -0.0249601
ZNF217 zinc finger protein 217 -0.0248942
NPAS2 neuronal PAS domain protein 2 -0.0247329
WDR27 WD repeat domain 27 -0.0246146
MBNL2 muscleblind-like splicing regulator 2 -0.0246119
EGR1 early growth response 1 -0.0241691
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0241235
CSMD3 CUB and Sushi multiple domains 3 -0.0240096
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0239043
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0237107
DOCK11 dedicator of cytokinesis 11 -0.0234576
EEF2 eukaryotic translation elongation factor 2 -0.0232356
IFI6 interferon, alpha-inducible protein 6 -0.0232251
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.023174
PLK2 polo-like kinase 2 -0.0228909
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0227185
LPP LIM domain containing preferred translocation partner in lipoma -0.0225659
STXBP5 syntaxin binding protein 5 (tomosyn) -0.022503
RASAL2 RAS protein activator like 2 -0.0224822
BIRC3 baculoviral IAP repeat containing 3 -0.0224471
CDK12 cyclin-dependent kinase 12 -0.022285