Tucidinostat_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucidinostat_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.160185
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0951777
GRAMD1B GRAM domain containing 1B 0.0935654
SMAD3 SMAD family member 3 0.0904254
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0871245
THSD4 thrombospondin, type I, domain containing 4 0.0826394
FAM13A family with sequence similarity 13, member A 0.0801181
PDE4D phosphodiesterase 4D, cAMP-specific 0.0783482
NAMPT nicotinamide phosphoribosyltransferase 0.0782314
CXCL8 chemokine (C-X-C motif) ligand 8 0.0771048
FNDC3B fibronectin type III domain containing 3B 0.075281
SLTM SAFB-like, transcription modulator 0.0720841
ELL2 elongation factor, RNA polymerase II, 2 0.0705759
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0666044
RUNX1 runt-related transcription factor 1 0.0647322
SPAG9 sperm associated antigen 9 0.0617854
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0608442
KMT2E lysine (K)-specific methyltransferase 2E 0.0580224
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0535346
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0520671
ENO1 enolase 1, (alpha) 0.0502391
LOC112694756 uncharaterized LOC112694756 0.048441
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0479128
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0473079
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0468824
JMJD1C jumonji domain containing 1C 0.0461475
PDE8A phosphodiesterase 8A 0.0460228
ARRDC3 arrestin domain containing 3 0.04574
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0434523
MAP7 microtubule-associated protein 7 0.0414157
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0405397
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0401057
CEMIP cell migration inducing protein, hyaluronan binding 0.0398716
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0390584
MYOF myoferlin 0.0387748
BRD2 bromodomain containing 2 0.0385718
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0382714
GPHN gephyrin 0.0376262
PM20D1 peptidase M20 domain containing 1 0.0370095
GSK3B glycogen synthase kinase 3 beta 0.0368235
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0367864
HELZ helicase with zinc finger 0.0363943
TSC22D2 TSC22 domain family, member 2 0.0357827
RPLP1 ribosomal protein, large, P1 0.0354994
ANKRD37 ankyrin repeat domain 37 0.0353859
CSNK1A1 casein kinase 1, alpha 1 0.0351589
SAMD4A sterile alpha motif domain containing 4A 0.0350402
PKM pyruvate kinase, muscle 0.0349075
ANXA2 annexin A2 0.0346167
INTS6 integrator complex subunit 6 0.0343764
MACF1 microtubule-actin crosslinking factor 1 0.0342813
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0338352
UBC ubiquitin C 0.0337705
AKAP12 A kinase (PRKA) anchor protein 12 0.0333628
HILPDA hypoxia inducible lipid droplet-associated 0.0332957
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0325987
NAP1L1 nucleosome assembly protein 1-like 1 0.0323179
RAB7A RAB7A, member RAS oncogene family 0.0314617
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.030329
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.030285
UVRAG UV radiation resistance associated 0.030066
ERRFI1 ERBB receptor feedback inhibitor 1 0.0299825
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0298965
PTMA prothymosin, alpha 0.0292106
RNMT RNA (guanine-7-) methyltransferase 0.0289453
MSN moesin 0.0287247
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.028423
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0284188
DTNA dystrobrevin, alpha 0.028347
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0280605
KCMF1 potassium channel modulatory factor 1 0.0280433
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0279399
BIRC3 baculoviral IAP repeat containing 3 0.0278546
GRB10 growth factor receptor-bound protein 10 0.0277429
BHLHE40 basic helix-loop-helix family, member e40 0.0274571
KDM2A lysine (K)-specific demethylase 2A 0.0274336
RNF145 ring finger protein 145 0.0270606
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0270135
DSCAM Down syndrome cell adhesion molecule 0.0266332
HBP1 HMG-box transcription factor 1 0.0265775
RNF213 ring finger protein 213 0.0264159
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0261843
KTN1 kinectin 1 (kinesin receptor) 0.0258058
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0257678
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0255038
ATP13A3 ATPase type 13A3 0.0254185
UBA6 ubiquitin-like modifier activating enzyme 6 0.0253008
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0250651
ZNF638 zinc finger protein 638 0.0249487
ZSWIM6 zinc finger, SWIM-type containing 6 0.0248363
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0246917
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0245942
SRRM2 serine/arginine repetitive matrix 2 0.0243868
MCL1 myeloid cell leukemia 1 0.0243156
TPD52 tumor protein D52 0.0242271
RBM39 RNA binding motif protein 39 0.0241556
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0240301
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0239594
AGO2 argonaute RISC catalytic component 2 0.0239165
BCAR3 breast cancer anti-estrogen resistance 3 0.0238661

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.241714
LAMC2 laminin, gamma 2 -0.0944552
TXNRD1 thioredoxin reductase 1 -0.0940139
PATJ PATJ crumbs cell polarity complex component -0.0717354
TMSB10 thymosin beta 10 -0.0688055
ASPH aspartate beta-hydroxylase -0.0619766
LMO7 LIM domain 7 -0.0532912
HDLBP high density lipoprotein binding protein -0.0522851
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0497038
ACTG1 actin gamma 1 -0.0472577
OSMR oncostatin M receptor -0.0471111
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0450165
CAMTA1 calmodulin binding transcription activator 1 -0.0394829
ZBTB20 zinc finger and BTB domain containing 20 -0.0346077
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0344677
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0332972
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0325564
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0321813
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0309461
S100P S100 calcium binding protein P -0.0306752
MKI67 marker of proliferation Ki-67 -0.0294255
SPIRE1 spire-type actin nucleation factor 1 -0.0290665
SCEL sciellin -0.0278523
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0274113
RIN2 Ras and Rab interactor 2 -0.0260077
HM13 histocompatibility (minor) 13 -0.0244206
SPTSSA serine palmitoyltransferase, small subunit A -0.0236679
GM2A GM2 ganglioside activator -0.023515
SMIM14 small integral membrane protein 14 -0.0232147
MT1X metallothionein 1X -0.0231062
MYO1D myosin ID -0.0230775
ADGRF1 adhesion G protein-coupled receptor F1 -0.0230067
TES testin LIM domain protein -0.0228452
MGAT4C MGAT4 family, member C -0.0226412
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0226251
CST3 cystatin C -0.0221746
TPT1 tumor protein, translationally-controlled 1 -0.022158
LIPH lipase, member H -0.0217356
ARHGAP32 Rho GTPase activating protein 32 -0.0210921
ARCN1 archain 1 -0.0208443
KRT18 keratin 18, type I -0.0207711
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0205774
BRWD1 bromodomain and WD repeat domain containing 1 -0.0205393
AKR1C1 aldo-keto reductase family 1, member C1 -0.0200417
RSF1 remodeling and spacing factor 1 -0.0195079
NDE1 nudE neurodevelopment protein 1 -0.0193469
AGR2 anterior gradient 2 -0.0192989
RAB27B RAB27B, member RAS oncogene family -0.0189136
CLDN12 claudin 12 -0.018898
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0187608
FMN1 formin 1 -0.0181039
SEPTIN2 septin 2 -0.0179643
SH3D19 SH3 domain containing 19 -0.01774
ZC3H11A zinc finger CCCH-type containing 11A -0.017673
MGST1 microsomal glutathione S-transferase 1 -0.0175466
KIAA0232 KIAA0232 -0.0172068
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0170654
SCFD1 sec1 family domain containing 1 -0.0169498
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0169031
PERP PERP, TP53 apoptosis effector -0.016888
MAML3 mastermind-like 3 (Drosophila) -0.0168647
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0168548
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0168081
MYL12B myosin, light chain 12B, regulatory -0.0166731
MON2 MON2 homolog (S. cerevisiae) -0.0166134
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0165842
LAMA4 laminin, alpha 4 -0.0165718
S100A9 S100 calcium binding protein A9 -0.0165615
AREG amphiregulin -0.0161955
RAP2B RAP2B, member of RAS oncogene family -0.0161476
DSPP dentin sialophosphoprotein -0.0160941
RIOK3 RIO kinase 3 -0.0159849
SENP5 SUMO1/sentrin specific peptidase 5 -0.0157506
WDR49 WD repeat domain 49 -0.0157414
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0156394
WARS1 tryptophanyl-tRNA synthetase 1 -0.0156372
CLTC clathrin, heavy chain (Hc) -0.0153108
SEC24D SEC24 family member D -0.0152847
CP ceruloplasmin (ferroxidase) -0.0152027
HLA-B major histocompatibility complex, class I, B -0.0151602
NT5C2 5'-nucleotidase, cytosolic II -0.0150836
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0150783
TM9SF3 transmembrane 9 superfamily member 3 -0.0150443
S100A6 S100 calcium binding protein A6 -0.014847
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0148149
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0147794
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.0146975
GOLGA3 golgin A3 -0.0146564
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0145708
FAF2 Fas associated factor family member 2 -0.0144456
ESRP1 epithelial splicing regulatory protein 1 -0.0144172
TSHZ2 teashirt zinc finger homeobox 2 -0.0143999
SRPRA SRP receptor subunit alpha -0.0140762
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.014043
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0139681
PDIA5 protein disulfide isomerase family A, member 5 -0.0137726
MYO6 myosin VI -0.0136635
LMAN1 lectin, mannose-binding, 1 -0.0136435
AEBP2 AE binding protein 2 -0.0135841
TMED2 transmembrane emp24 domain trafficking protein 2 -0.0134582