Tucidinostat_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucidinostat_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KMT2E lysine (K)-specific methyltransferase 2E 0.0166824
PICALM phosphatidylinositol binding clathrin assembly protein 0.0141823
TFG TRK-fused gene 0.0140843
ELOVL5 ELOVL fatty acid elongase 5 0.0125501
HELZ helicase with zinc finger 0.0124221
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0120704
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0107698
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0107558
CCNL1 cyclin L1 0.0107047
ZNF292 zinc finger protein 292 0.0106619
UBA6 ubiquitin-like modifier activating enzyme 6 0.0105791
EPB41 erythrocyte membrane protein band 4.1 0.0104684
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0102566
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.010115
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.00964162
PHF21A PHD finger protein 21A 0.00948845
FAM13A family with sequence similarity 13, member A 0.00942715
GLS2 glutaminase 2 (liver, mitochondrial) 0.00940111
SRP54 signal recognition particle 54kDa 0.00908034
EPS8 epidermal growth factor receptor pathway substrate 8 0.00893851
SEC24A SEC24 family member A 0.00837394
VMP1 vacuole membrane protein 1 0.00824919
NAMPT nicotinamide phosphoribosyltransferase 0.00797418
KDM6A lysine (K)-specific demethylase 6A 0.00781589
TXNIP thioredoxin interacting protein 0.00777938
CCN2 cellular communication network factor 2 0.00774209
FAM168A family with sequence similarity 168, member A 0.00772501
RUSC2 RUN and SH3 domain containing 2 0.0076627
AUTS2 autism susceptibility candidate 2 0.00763204
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00761798
PRRC1 proline-rich coiled-coil 1 0.00752179
RIOK3 RIO kinase 3 0.00743346
COPA coatomer protein complex, subunit alpha 0.00711464
INSIG2 insulin induced gene 2 0.00705826
NOCT nocturnin 0.00697984
MORF4L2 mortality factor 4 like 2 0.00697799
RNMT RNA (guanine-7-) methyltransferase 0.00688594
DENND4A DENN/MADD domain containing 4A 0.00686121
PTBP2 polypyrimidine tract binding protein 2 0.00659059
FBXO42 F-box protein 42 0.00652254
KIF5C kinesin family member 5C 0.00644931
ARF4 ADP-ribosylation factor 4 0.00644671
HILPDA hypoxia inducible lipid droplet-associated 0.00642022
ATF7IP activating transcription factor 7 interacting protein 0.00639937
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00634912
PER1 period circadian clock 1 0.00633125
RLIM ring finger protein, LIM domain interacting 0.0063217
CDC73 cell division cycle 73 0.00627628
TMEM39A transmembrane protein 39A 0.00625414
SEC31A SEC31 homolog A (S. cerevisiae) 0.006221
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0062144
TBC1D23 TBC1 domain family, member 23 0.00620326
ORC4 origin recognition complex, subunit 4 0.00618887
DDIT4 DNA-damage-inducible transcript 4 0.0061718
POU2F1 POU class 2 homeobox 1 0.00612131
RLF rearranged L-myc fusion 0.00611497
ADAM17 ADAM metallopeptidase domain 17 0.0061102
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.00603425
TOM1L1 target of myb1 (chicken)-like 1 0.00602249
MIMS1 mitochondrial inner membrane scaffold 1 0.00601787
QKI QKI, KH domain containing, RNA binding 0.00595868
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0059574
COG6 component of oligomeric golgi complex 6 0.00595138
TSC22D2 TSC22 domain family, member 2 0.0059036
EEIG2 EEIG family member 2 0.00588802
ATOSA atos homolog A 0.00586976
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00584831
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00584057
KCTD3 potassium channel tetramerization domain containing 3 0.00565315
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00563543
AHR aryl hydrocarbon receptor 0.00562427
BHLHE40 basic helix-loop-helix family, member e40 0.00560096
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.00559454
NDRG1 N-myc downstream regulated 1 0.00559147
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.00557629
PDPK1 3-phosphoinositide dependent protein kinase 1 0.00555882
STC1 stanniocalcin 1 0.00551849
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.00551703
ARHGAP12 Rho GTPase activating protein 12 0.00550137
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00547015
CXCL8 chemokine (C-X-C motif) ligand 8 0.00541328
FOXO1 forkhead box O1 0.00541124
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0053935
TPD52 tumor protein D52 0.00538894
SUCO SUN domain containing ossification factor 0.00536868
ANK2 ankyrin 2, neuronal 0.00535341
KDM5B lysine (K)-specific demethylase 5B 0.00534959
ZMYM2 zinc finger, MYM-type 2 0.00534607
MAX MYC associated factor X 0.005282
CSF1 colony stimulating factor 1 (macrophage) 0.00524736
ZNF654 zinc finger protein 654 0.00524235
RAB6A RAB6A, member RAS oncogene family 0.00523928
DRAM1 DNA-damage regulated autophagy modulator 1 0.00519669
OPTN optineurin 0.00518686
ZCCHC7 zinc finger, CCHC domain containing 7 0.00517682
YEATS2 YEATS domain containing 2 0.00514313
RAB8B RAB8B, member RAS oncogene family 0.0051357
CYTH3 cytohesin 3 0.00509057
MIDEAS mitotic deacetylase associated SANT domain protein 0.00507833
ELP2 elongator acetyltransferase complex subunit 2 0.00507002

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.272752
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.266789
TPT1 tumor protein, translationally-controlled 1 -0.131506
AHNAK AHNAK nucleoprotein -0.101432
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0995125
VCL vinculin -0.0939716
RPS6 ribosomal protein S6 -0.0934497
RPL35A ribosomal protein L35a -0.0868333
PKM pyruvate kinase, muscle -0.0810904
PDE4D phosphodiesterase 4D, cAMP-specific -0.0797016
RPS8 ribosomal protein S8 -0.0770122
ACTG1 actin gamma 1 -0.0768189
PDE4B phosphodiesterase 4B, cAMP-specific -0.07098
EGFR epidermal growth factor receptor -0.0680977
RPLP1 ribosomal protein, large, P1 -0.067804
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0609925
FOXP1 forkhead box P1 -0.0602127
TMSB4X thymosin beta 4, X-linked -0.0598093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0592602
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0587683
RPL12 ribosomal protein L12 -0.0587556
RPL34 ribosomal protein L34 -0.0586615
CCND1 cyclin D1 -0.0583705
NBEA neurobeachin -0.05761
ENO1 enolase 1, (alpha) -0.0574718
EEF2 eukaryotic translation elongation factor 2 -0.0550773
RPL31 ribosomal protein L31 -0.0543673
RPL26 ribosomal protein L26 -0.0540027
RPLP0 ribosomal protein, large, P0 -0.0537109
S100A6 S100 calcium binding protein A6 -0.052485
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0522487
RPL23 ribosomal protein L23 -0.0497208
RPLP2 ribosomal protein, large, P2 -0.0491589
RPL11 ribosomal protein L11 -0.0471075
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0470546
RPS27A ribosomal protein S27a -0.0469266
RPS19 ribosomal protein S19 -0.0460674
RPL9 ribosomal protein L9 -0.0451603
ARL4C ADP-ribosylation factor-like 4C -0.0451571
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0447279
BMP10 bone morphogenetic protein 10 -0.0434349
RPS13 ribosomal protein S13 -0.0426147
DLG1 discs, large homolog 1 (Drosophila) -0.0425765
LDHA lactate dehydrogenase A -0.0421194
S100A4 S100 calcium binding protein A4 -0.0419873
ADAM10 ADAM metallopeptidase domain 10 -0.0414631
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0412962
RPL37A ribosomal protein L37a -0.0412435
NAP1L1 nucleosome assembly protein 1-like 1 -0.0405465
RPS21 ribosomal protein S21 -0.0403758
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0400163
RPS3 ribosomal protein S3 -0.0400128
RPL19 ribosomal protein L19 -0.0396216
RPS23 ribosomal protein S23 -0.0391286
LOC112694756 uncharaterized LOC112694756 -0.0391102
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0391029
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0379801
HSPB1 heat shock 27kDa protein 1 -0.0372952
RPL36 ribosomal protein L36 -0.0368486
S100A9 S100 calcium binding protein A9 -0.0363388
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0359001
GLI2 GLI family zinc finger 2 -0.0352454
RPS24 ribosomal protein S24 -0.0338709
RPL7A ribosomal protein L7a -0.0338663
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0337711
MKI67 marker of proliferation Ki-67 -0.0331537
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0316767
RACK1 receptor for activated C kinase 1 -0.0312844
ZEB1 zinc finger E-box binding homeobox 1 -0.0308934
S100A10 S100 calcium binding protein A10 -0.0308317
RPL27A ribosomal protein L27a -0.0307749
EZR ezrin -0.0306078
RPS25 ribosomal protein S25 -0.0304658
KPNB1 karyopherin (importin) beta 1 -0.0301675
RPL8 ribosomal protein L8 -0.0296835
MYL12B myosin, light chain 12B, regulatory -0.0295362
EBNA1BP2 EBNA1 binding protein 2 -0.0295275
EIF1 eukaryotic translation initiation factor 1 -0.0294836
TM4SF1 transmembrane 4 L six family member 1 -0.0291961
DIAPH3 diaphanous-related formin 3 -0.0291949
RPS12 ribosomal protein S12 -0.0291605
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0282184
RPL32 ribosomal protein L32 -0.02775
CAMKMT calmodulin-lysine N-methyltransferase -0.0276443
RPS14 ribosomal protein S14 -0.0276303
RPL5 ribosomal protein L5 -0.0274646
ZMYND8 zinc finger, MYND-type containing 8 -0.0274496
TPI1 triosephosphate isomerase 1 -0.027418
RPS11 ribosomal protein S11 -0.0273741
RPS17 ribosomal protein S17 -0.0273707
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0268999
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0268831
GNAS GNAS complex locus -0.0266047
POTEF POTE ankyrin domain family, member F -0.0264111
PFN1 profilin 1 -0.0261568
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0254325
RPL18 ribosomal protein L18 -0.0253837
TAS2R14 taste receptor, type 2, member 14 -0.0251087
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.025053
B2M beta-2-microglobulin -0.0249916