Tucidinostat_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucidinostat_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GLIS3 GLIS family zinc finger 3 0.0826072
AKAP12 A kinase (PRKA) anchor protein 12 0.082498
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0806184
IER3 immediate early response 3 0.0647184
HMGA2 high mobility group AT-hook 2 0.0628243
ADM adrenomedullin 0.0431967
IGFBP3 insulin-like growth factor binding protein 3 0.0414568
FRMPD4 FERM and PDZ domain containing 4 0.0387863
COL6A3 collagen, type VI, alpha 3 0.0368764
EFNA5 ephrin-A5 0.0357358
SDC4 syndecan 4 0.0342714
PLIN2 perilipin 2 0.0329251
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.031403
INTS6 integrator complex subunit 6 0.030682
BTG1 B-cell translocation gene 1, anti-proliferative 0.0300484
SAMD3 sterile alpha motif domain containing 3 0.0291353
TMEM132D transmembrane protein 132D 0.0291055
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0281241
AHNAK AHNAK nucleoprotein 0.0278141
COL6A2 collagen, type VI, alpha 2 0.0262429
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0262227
FBXO32 F-box protein 32 0.0261316
HDAC9 histone deacetylase 9 0.0246176
FTH1 ferritin, heavy polypeptide 1 0.0236794
HILPDA hypoxia inducible lipid droplet-associated 0.0227812
COL7A1 collagen, type VII, alpha 1 0.0225495
PRKG1 protein kinase, cGMP-dependent, type I 0.0224737
CXCL8 chemokine (C-X-C motif) ligand 8 0.0222241
RND3 Rho family GTPase 3 0.0221615
GDF15 growth differentiation factor 15 0.0217396
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0216753
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0216322
CDH13 cadherin 13 0.0205755
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0204651
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.020238
COL5A1 collagen, type V, alpha 1 0.0200886
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0199249
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0197932
UBASH3B ubiquitin associated and SH3 domain containing B 0.0197474
IL6 interleukin 6 0.0192263
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0189796
EPAS1 endothelial PAS domain protein 1 0.0186828
TRIM55 tripartite motif containing 55 0.018206
EFCAB13 EF-hand calcium binding domain 13 0.0177744
ANGPTL4 angiopoietin-like 4 0.0177652
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0177028
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0175927
ZC3H12B zinc finger CCCH-type containing 12B 0.0175471
KDM5B lysine (K)-specific demethylase 5B 0.017075
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0168119
COL6A1 collagen, type VI, alpha 1 0.0167026
KCNIP4 Kv channel interacting protein 4 0.0163617
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.016236
BICC1 BicC family RNA binding protein 1 0.0161161
TENM2 teneurin transmembrane protein 2 0.0157264
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.015515
THSD4 thrombospondin, type I, domain containing 4 0.0154133
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0151016
PDLIM5 PDZ and LIM domain 5 0.0149646
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0149243
NABP1 nucleic acid binding protein 1 0.0148726
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0148203
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0147639
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0147437
ARHGAP24 Rho GTPase activating protein 24 0.0145306
INHBA inhibin, beta A 0.0144758
LPP LIM domain containing preferred translocation partner in lipoma 0.0140748
TGFB1 transforming growth factor, beta 1 0.0139844
PTH2R parathyroid hormone 2 receptor 0.0137581
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0134443
TLE4 transducin-like enhancer of split 4 0.0134164
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0133865
WFDC10B WAP four-disulfide core domain 10B 0.0133419
AFF3 AF4/FMR2 family, member 3 0.0133214
JPH2 junctophilin 2 0.013303
ZFP36L1 ZFP36 ring finger protein-like 1 0.0132202
BNC2 basonuclin 2 0.0132057
ZBTB38 zinc finger and BTB domain containing 38 0.0131024
RGS17 regulator of G-protein signaling 17 0.0130919
IQCJ IQ motif containing J 0.013035
CEMIP cell migration inducing protein, hyaluronan binding 0.0130119
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.012977
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0129011
RNF213 ring finger protein 213 0.0128219
NCKAP5 NCK-associated protein 5 0.0127888
SDK1 sidekick cell adhesion molecule 1 0.0127825
DNAH11 dynein, axonemal, heavy chain 11 0.0127598
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0127367
AUTS2 autism susceptibility candidate 2 0.0124467
CCBE1 collagen and calcium binding EGF domains 1 0.0123387
RAD51B RAD51 paralog B 0.0122897
ABI3BP ABI family, member 3 (NESH) binding protein 0.0120649
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0120321
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.01197
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0118857
SH2B3 SH2B adaptor protein 3 0.0118525
CUX1 cut-like homeobox 1 0.0118438
SOX5 SRY (sex determining region Y)-box 5 0.0117995
SLIT2 slit homolog 2 (Drosophila) 0.0117611
EPS8 epidermal growth factor receptor pathway substrate 8 0.0115605

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.139971
MYH9 myosin, heavy chain 9, non-muscle -0.133583
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.122647
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.117125
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101173
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0938336
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0930586
NAV2 neuron navigator 2 -0.0886185
MT2A metallothionein 2A -0.0878421
RPS6 ribosomal protein S6 -0.0813246
MKI67 marker of proliferation Ki-67 -0.0756216
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0730372
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0698773
PTMA prothymosin, alpha -0.0685073
FN1 fibronectin 1 -0.0672806
CENPF centromere protein F, 350/400kDa -0.0660432
TMSB10 thymosin beta 10 -0.0655494
SLC38A1 solute carrier family 38, member 1 -0.0655023
SPAG9 sperm associated antigen 9 -0.0615347
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0601188
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0600074
B2M beta-2-microglobulin -0.0584195
GOLGA4 golgin A4 -0.0581677
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0569057
ELL2 elongation factor, RNA polymerase II, 2 -0.0559693
FTL ferritin, light polypeptide -0.054479
ARRDC3 arrestin domain containing 3 -0.054011
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0516573
FNDC3B fibronectin type III domain containing 3B -0.0514931
ANXA2 annexin A2 -0.0501099
ICAM1 intercellular adhesion molecule 1 -0.0488358
RB1CC1 RB1-inducible coiled-coil 1 -0.0473082
LAMP2 lysosomal-associated membrane protein 2 -0.0470509
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0464629
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0462157
RPS2 ribosomal protein S2 -0.0447616
EIF1 eukaryotic translation initiation factor 1 -0.0447101
TXNRD1 thioredoxin reductase 1 -0.0443967
ANLN anillin, actin binding protein -0.044072
TNIP1 TNFAIP3 interacting protein 1 -0.0438197
RTN4 reticulon 4 -0.0435026
OGA O-GlcNAcase -0.0433119
SOD2 superoxide dismutase 2, mitochondrial -0.0432753
ZNF292 zinc finger protein 292 -0.0432212
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0423881
MYOF myoferlin -0.0419625
RPL23 ribosomal protein L23 -0.0409135
PGK1 phosphoglycerate kinase 1 -0.0407727
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0405701
HLA-B major histocompatibility complex, class I, B -0.0405593
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0404819
PKM pyruvate kinase, muscle -0.0398584
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0397465
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0396114
DSTN destrin (actin depolymerizing factor) -0.0393284
SAA2 serum amyloid A2 -0.0392625
JMJD1C jumonji domain containing 1C -0.0387791
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0382442
EXT1 exostosin glycosyltransferase 1 -0.0378438
CD44 CD44 molecule (Indian blood group) -0.0377556
RPS3 ribosomal protein S3 -0.0374665
THBS1 thrombospondin 1 -0.0370085
EEF2 eukaryotic translation elongation factor 2 -0.037003
CLTC clathrin, heavy chain (Hc) -0.0364339
KIF4A kinesin family member 4A -0.0361742
RPL12 ribosomal protein L12 -0.0357823
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0355987
RPL7 ribosomal protein L7 -0.0354601
SFTPA2 surfactant protein A2 -0.0354037
CKAP5 cytoskeleton associated protein 5 -0.0353239
RPS12 ribosomal protein S12 -0.0351633
VIM vimentin -0.0351379
CADM1 cell adhesion molecule 1 -0.0350886
KLF6 Kruppel-like factor 6 -0.0348162
PRRC2C proline-rich coiled-coil 2C -0.034789
MATR3 matrin 3 -0.0347243
RPLP2 ribosomal protein, large, P2 -0.0347025
MSN moesin -0.0346491
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0346249
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0343138
PCBP2 poly(rC) binding protein 2 -0.0330347
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0328767
RPS19 ribosomal protein S19 -0.0327586
RPL19 ribosomal protein L19 -0.0327262
RPL36A ribosomal protein L36a -0.0327008
SBF2 SET binding factor 2 -0.0326696
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0325295
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0322948
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0321588
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 -0.0321195
ACTG1 actin gamma 1 -0.0317386
TPM4 tropomyosin 4 -0.0315875
PHIP pleckstrin homology domain interacting protein -0.0315765
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0314935
MX1 MX dynamin-like GTPase 1 -0.0313005
KTN1 kinectin 1 (kinesin receptor) -0.0312098
CCNL1 cyclin L1 -0.0311432
XPO1 exportin 1 -0.0307095
SYAP1 synapse associated protein 1 -0.0304436
LOC112694756 uncharaterized LOC112694756 -0.0302245