Tucidinostat_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tucidinostat perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tucidinostat_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.0953164
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0933235
FNDC3B fibronectin type III domain containing 3B 0.0838071
CXCL8 chemokine (C-X-C motif) ligand 8 0.0762932
TRIO trio Rho guanine nucleotide exchange factor 0.0674919
IL6 interleukin 6 0.0643801
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0616214
POTEF POTE ankyrin domain family, member F 0.0481705
BRD2 bromodomain containing 2 0.0444425
PRELID2 PRELI domain containing 2 0.0439065
TPST1 tyrosylprotein sulfotransferase 1 0.0428861
ZSWIM6 zinc finger, SWIM-type containing 6 0.0412757
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0405916
SOD2 superoxide dismutase 2, mitochondrial 0.0404787
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0404359
VEGFA vascular endothelial growth factor A 0.0401252
LIMS1 LIM and senescent cell antigen-like domains 1 0.0399043
NAV1 neuron navigator 1 0.038084
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.038054
LPP LIM domain containing preferred translocation partner in lipoma 0.0379499
RUNX1 runt-related transcription factor 1 0.0372716
NCOR2 nuclear receptor corepressor 2 0.0372291
IGFBP3 insulin-like growth factor binding protein 3 0.0371049
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0366916
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0366049
COL5A1 collagen, type V, alpha 1 0.0362817
PHF21A PHD finger protein 21A 0.0359471
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0358375
MYH9 myosin, heavy chain 9, non-muscle 0.0345861
FNIP1 folliculin interacting protein 1 0.0343222
FBXL7 F-box and leucine-rich repeat protein 7 0.0340842
INTS6 integrator complex subunit 6 0.0340452
DST dystonin 0.0339048
TENT5A terminal nucleotidyltransferase 5A 0.0338443
F3 coagulation factor III (thromboplastin, tissue factor) 0.0338076
NBAS neuroblastoma amplified sequence 0.0335289
VEGFC vascular endothelial growth factor C 0.0324658
CLIC4 chloride intracellular channel 4 0.0315394
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0313821
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0304958
PDIA3 protein disulfide isomerase family A, member 3 0.0294968
MSN moesin 0.0292214
GRB10 growth factor receptor-bound protein 10 0.0287149
NABP1 nucleic acid binding protein 1 0.0286288
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0283088
PTGES2 prostaglandin E synthase 2 0.0281128
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0279902
EGFR epidermal growth factor receptor 0.0277465
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0276179
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0275722
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0274078
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0270265
MMP12 matrix metallopeptidase 12 0.0270068
BASP1 brain abundant, membrane attached signal protein 1 0.0265264
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0263872
SAMD4A sterile alpha motif domain containing 4A 0.0263462
RAD51B RAD51 paralog B 0.0261396
LSAMP limbic system-associated membrane protein 0.0261282
SBF2 SET binding factor 2 0.026064
NFE2L1 nuclear factor, erythroid 2-like 1 0.026039
DPYSL2 dihydropyrimidinase-like 2 0.0259482
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.025442
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0250267
OPTN optineurin 0.0246635
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0245086
KDM3B lysine (K)-specific demethylase 3B 0.0241366
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0238934
MYO1E myosin IE 0.0237978
TNIP1 TNFAIP3 interacting protein 1 0.0236933
OSBPL8 oxysterol binding protein-like 8 0.0236837
FGFR1 fibroblast growth factor receptor 1 0.0235969
FER fer (fps/fes related) tyrosine kinase 0.023507
TMF1 TATA element modulatory factor 1 0.0231715
RAI14 retinoic acid induced 14 0.0229605
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0228398
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0227799
FAM13B family with sequence similarity 13, member B 0.0227607
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0224546
INSIG2 insulin induced gene 2 0.022403
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0223458
ANKHD1 ankyrin repeat and KH domain containing 1 0.0222385
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0221492
COPB1 coatomer protein complex, subunit beta 1 0.0220994
RNF145 ring finger protein 145 0.0220369
AAK1 AP2 associated kinase 1 0.0219703
MAGT1 magnesium transporter 1 0.0219187
CANX calnexin 0.0218931
CDH13 cadherin 13 0.0218806
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0218141
CUX1 cut-like homeobox 1 0.0217707
ZNF638 zinc finger protein 638 0.0217479
KTN1 kinectin 1 (kinesin receptor) 0.0216509
ATG7 autophagy related 7 0.0215941
MXI1 MAX interactor 1, dimerization protein 0.021572
PSD3 pleckstrin and Sec7 domain containing 3 0.0215071
SLTM SAFB-like, transcription modulator 0.021451
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0213748
MCL1 myeloid cell leukemia 1 0.0213042
PDIA5 protein disulfide isomerase family A, member 5 0.0212953
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0212308

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181018
TMSB10 thymosin beta 10 -0.176886
MT2A metallothionein 2A -0.127101
COL6A3 collagen, type VI, alpha 3 -0.107384
HLA-B major histocompatibility complex, class I, B -0.105863
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0941994
MT1X metallothionein 1X -0.0779728
VIM vimentin -0.0743896
TGFBI transforming growth factor, beta-induced, 68kDa -0.0713573
LOX lysyl oxidase -0.069117
LOXL2 lysyl oxidase-like 2 -0.0665387
B2M beta-2-microglobulin -0.0580147
LOC112694756 uncharaterized LOC112694756 -0.0522886
ANXA2 annexin A2 -0.0512769
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0496249
NAMPT nicotinamide phosphoribosyltransferase -0.0485571
COL1A1 collagen, type I, alpha 1 -0.0482779
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0480702
COL1A2 collagen, type I, alpha 2 -0.0424341
H3-3B H3.3 histone B -0.0420442
CAV1 caveolin 1, caveolae protein, 22kDa -0.0416106
TMSB4X thymosin beta 4, X-linked -0.040483
IGFBP7 insulin-like growth factor binding protein 7 -0.0403344
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0402681
UBE2H ubiquitin-conjugating enzyme E2H -0.0393344
CADM1 cell adhesion molecule 1 -0.0382376
FKBP10 FK506 binding protein 10, 65 kDa -0.0381348
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0367567
NCOA3 nuclear receptor coactivator 3 -0.0366747
TAGLN2 transgelin 2 -0.0366429
SMAD3 SMAD family member 3 -0.0353465
TXNIP thioredoxin interacting protein -0.0349427
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0347832
CLTC clathrin, heavy chain (Hc) -0.0334372
RPL35A ribosomal protein L35a -0.0332908
PTMA prothymosin, alpha -0.0330448
AKAP9 A kinase (PRKA) anchor protein 9 -0.0322781
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0308665
FAF1 Fas (TNFRSF6) associated factor 1 -0.0304926
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0301689
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0301474
RPL34 ribosomal protein L34 -0.030076
SRPK2 SRSF protein kinase 2 -0.0299948
NRP1 neuropilin 1 -0.029905
SLC38A1 solute carrier family 38, member 1 -0.0297508
STC1 stanniocalcin 1 -0.0286603
PXMP2 peroxisomal membrane protein 2, 22kDa -0.0286492
MBD5 methyl-CpG binding domain protein 5 -0.0285438
RNF24 ring finger protein 24 -0.0284109
HLA-C major histocompatibility complex, class I, C -0.0283439
COL6A2 collagen, type VI, alpha 2 -0.0283247
RPL23 ribosomal protein L23 -0.0282646
COL3A1 collagen, type III, alpha 1 -0.027198
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0270601
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.027038
OGA O-GlcNAcase -0.0269409
CUL3 cullin 3 -0.0269017
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.026635
TPI1 triosephosphate isomerase 1 -0.0265141
RPS19 ribosomal protein S19 -0.0264607
HPCAL1 hippocalcin-like 1 -0.0262072
AHNAK AHNAK nucleoprotein -0.0261042
FSCN1 fascin actin-bundling protein 1 -0.0258678
AFTPH aftiphilin -0.0257612
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0253965
BRWD3 bromodomain and WD repeat domain containing 3 -0.0249694
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0246055
VCL vinculin -0.0245915
ANKRD12 ankyrin repeat domain 12 -0.024556
NRXN3 neurexin 3 -0.0245164
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0244359
CFDP1 craniofacial development protein 1 -0.0242116
AOPEP aminopeptidase O (putative) -0.0241968
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0241416
SEPTIN10 septin 10 -0.0240831
PCM1 pericentriolar material 1 -0.0238692
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0238002
ANKRD17 ankyrin repeat domain 17 -0.0237529
PHKB phosphorylase kinase, beta -0.0233404
RPL15 ribosomal protein L15 -0.0230906
SAR1A secretion associated, Ras related GTPase 1A -0.023068
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0229203
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0227595
RPL31 ribosomal protein L31 -0.0225924
CNOT8 CCR4-NOT transcription complex, subunit 8 -0.0224484
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0223872
NKTR natural killer cell triggering receptor -0.0223824
ZNF133 zinc finger protein 133 -0.0223695
CD44 CD44 molecule (Indian blood group) -0.0223529
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0223413
VMP1 vacuole membrane protein 1 -0.0219257
ARRDC3 arrestin domain containing 3 -0.0217806
RAP1B RAP1B, member of RAS oncogene family -0.0217613
UFM1 ubiquitin-fold modifier 1 -0.0216525
DIAPH3 diaphanous-related formin 3 -0.0216111
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0213138
RPS24 ribosomal protein S24 -0.0212015
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.02111
LONP2 lon peptidase 2, peroxisomal -0.0210978
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0209059